Gene: HBM

3042
HBAP2|HBK
hemoglobin subunit mu
protein-coding
16p13.3
Ensembl:ENSG00000206177 MIM:609639 Vega:OTTHUMG00000059926 UniprotKB:Q6B0K9
NG_000006.1
PubMed
0   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.808e-1 (AD)  6.340e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CA10.72
AHSP0.683
SLC4A10.683
ALAS20.646
SPTA10.581
APOBEC3A0.559
LILRA30.534
IL1R20.527
GZMB0.521
HBA10.513

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIAA1024-0.294
TOX3-0.29
KLK7-0.287
SPHKAP-0.285
ROBO2-0.285
SYT15-0.283
KCNC2-0.279
KIT-0.274
PPP1R1C-0.274
COL21A1-0.274

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of HBM mRNA22230336
D014635Valproic AcidValproic Acid results in increased methylation of HBM gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004601peroxidase activityCONTRIBUTES_TOIBA21873635  
GO:0005344oxygen carrier activity-IBA21873635  
GO:0005344oxygen carrier activity-IEA-  
GO:0005515protein binding-IBA21873635  
GO:0019825oxygen binding-IBA21873635  
GO:0019825oxygen binding-IEA-  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IEA-  
GO:0031720haptoglobin bindingCONTRIBUTES_TOIBA21873635  
GO:0043177organic acid binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015671oxygen transport-IEA-  
GO:0042744hydrogen peroxide catabolic process-IBA21873635  
GO:0051291protein heterooligomerization-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005833hemoglobin complex-IBA21873635  
GO:0005833hemoglobin complex-IEA-  
GO:0031838haptoglobin-hemoglobin complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18260147Effect of nicotine in matrix mineralization by human bone marrow and Saos-2 cells cultured on the surface of plasma-sprayed titanium implants. (2009 Jan)Pereira MLJ Biomed Mater Res A
24868163Blood and urine levels of heavy metal pollutants in female and male patients with coronary artery disease. (2014)Sponder MVasc Health Risk Manag
24204073Health insurance is associated with preventive care but not personal health behaviors. (2013 Nov-Dec)Jerant AJ Am Board Fam Med
26730345The Effect of an Educational Program Based on Health Belief Model on Preventing Osteoporosis in Women. (2015)Jeihooni AKInt J Prev Med
19302365Health beliefs toward cardiovascular risk reduction in patients admitted to chest pain observation units. (2009 May)Katz DAAcad Emerg Med