Gene: HBB

3043
CD113t-C|beta-globin
hemoglobin subunit beta
protein-coding
11p15.4
Ensembl:ENSG00000244734 MIM:141900 Vega:OTTHUMG00000066678 UniprotKB:P68871
NG_000007.3
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.093e-1 (AD)  8.165e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HBA20.953
HBA10.839
ALAS20.761
HBD0.737
S100A90.641
STOM0.624
MYL12A0.623
IFITM20.622
S100A80.613
GNG50.604

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RCOR2-0.519
ABCC12-0.508
CALHM1-0.507
HAS1-0.507
RTP1-0.505
GPR61-0.504
PIP5KL1-0.499
LRTM2-0.496
ADAMTS8-0.494
SLC32A1-0.494

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00893Iron DextranSmall Molecule9004-66-4ApprovedTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB021264-Carboxycinnamic AcidSmall MoleculeExperimentalTarget
DB074272-[(2-methoxy-5-methylphenoxy)methyl]pyridineSmall MoleculeExperimentalTarget
DB074284-[(5-methoxy-2-methylphenoxy)methyl]pyridineSmall MoleculeExperimentalTarget
DB07645SEBACIC ACIDSmall MoleculeExperimentalTarget
DB080772-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACIDSmall MoleculeExperimentalTarget
DB082622,6-dicarboxynaphthaleneSmall Molecule1141-38-4ExperimentalTarget
DB08486EfaproxiralSmall Molecule131179-95-8InvestigationalTarget
DB086321,3,5-BENZENETRICARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB09112Nitrous acidSmall Molecule7782-77-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB09140OxygenSmall Molecule7782-44-7ApprovedTarget
DB09147Ferric pyrophosphateSmall Molecule10058-44-3ExperimentalTarget
DB09517Sodium ferric gluconate complexSmall Molecule34089-81-1ApprovedTarget
DB13995Ferric pyrophosphate citrateSmall Molecule1802359-96-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of HBB protein22527513
C0166141-nitronaphthalene1-nitronaphthalene metabolite binds to HBB protein16453347
C0269422,6-diisocyanatotoluene"2,6-diisocyanatotoluene binds to HBB protein"8728499
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"HBB protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"14691983
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"kaempferol inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]"14691983
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"Quercetin inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]"14691983
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of HBB mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of HBB protein"25670856
C0114215-chloro-2-methyl-4-isothiazolin-3-one5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of HBB protein29267982
D012435S-Adenosylhomocysteinecatechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA]24141029
D012435S-Adenosylhomocysteine[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA24141029
D012436S-Adenosylmethioninecatechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA]24141029
D012436S-Adenosylmethionine[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA24141029
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HBB gene27153756
C000188alachloralachlor binds to HBB protein10075819
D000499AllylamineAllylamine results in increased expression of HBB mRNA15910882
D000638AmiodaroneAmiodarone affects the expression of HBB mRNA19483382
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HBB mRNA24449571
C006632arsenic trioxidearsenic trioxide affects the expression of HBB mRNA20458559
D001280Atrazine[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of HBB mRNA16532367
D001553BenzbromaroneBenzbromarone affects the expression of HBB mRNA19483382
D001554BenzeneBenzene results in increased expression of HBB mRNA20036648
D001554BenzeneBenzene affects the expression of HBB mRNA15878777
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HBB mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HBB mRNA16624371
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HBB mRNA16488489
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of HBB mRNA17404688
C006780bisphenol Abisphenol A results in increased expression of HBB mRNA16624371
C006780bisphenol Abisphenol A results in increased expression of HBB mRNA24465770
C006780bisphenol Abisphenol A affects the expression of HBB mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of HBB protein24552547
C006780bisphenol Abisphenol A results in increased expression of HBB mRNA27257137
D001761BleomycinBleomycin affects the expression of HBB protein25933445
C032036bromobenzenebromobenzene metabolite binds to HBB protein17305373
D002104CadmiumCadmium results in decreased expression of HBB mRNA20447699
D002104CadmiumCadmium results in increased expression of HBB mRNA23369406
D002104CadmiumHBB protein binds to Cadmium23896426
D002104CadmiumCadmium results in decreased expression of HBB mRNA17327699
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HBB mRNA17327699|2599309
D000074262Canola OilCanola Oil metabolite results in increased expression of HBB mRNA27363782
D002244CarbonCarbon inhibits the reaction [lead nitrate results in increased expression of HBB mRNA]18346799
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HBB mRNA16624371
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HBB mRNA15963578
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HBB mRNA15963578
C034221catechol[catechol co-treated with Hemin] results in increased expression of HBB mRNA24141029
C034221catecholcatechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA]24141029
C034221catecholcatechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA]24141029
C034221catecholcatechol promotes the reaction [Hemin results in increased expression of HBB mRNA]28552822
C034221catecholcatechol results in decreased methylation of HBB promoter23022512
C034221catecholcatechol results in increased expression of HBB mRNA23022512|2855282
C034221catecholCOMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]24141029
C034221catecholHemin promotes the reaction [catechol results in increased expression of HBB mRNA]28552822
C007020chlorophyllin"[chlorophyllin co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of HBB mRNA"22485181
D004390ChlorpyrifosChlorpyrifos results in decreased expression of HBB mRNA16624371
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of HBB mRNA20008804
C012843cinnamic aldehydecinnamic aldehyde results in increased metabolism of HBB protein29267982
D002994ClofibrateClofibrate results in decreased expression of HBB mRNA16081524
D002994ClofibrateClofibrate affects the expression of HBB mRNA19483382
D003300CopperHBB protein binds to Copper23896426
C009160cyclonitecyclonite results in decreased expression of HBB mRNA20965580
C014347decitabinedecitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]23973255
C014347decitabinedecitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]]23973255
C014347decitabinedecitabine affects the acetylation of HBB gene19576949
D016190CarboplatinCarboplatin results in decreased expression of HBB mRNA21296123
C088674dibromoacetic aciddibromoacetic acid results in decreased expression of HBB mRNA21046364
D002945CisplatinCisplatin results in decreased expression of HBB mRNA21296123
D004008DiclofenacDiclofenac results in increased expression of HBB protein14565772
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of HBB mRNA16624371
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HBB mRNA18164116
D0151279,10-Dimethyl-1,2-benzanthracene"[chlorophyllin co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of HBB mRNA"22485181
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of HBB mRNA"27840820
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of HBB mRNA21296123
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased metabolism of HBB protein29267982
D004237Diuron[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of HBB mRNA16532367
D004317DoxorubicinDoxorubicin results in decreased expression of HBB mRNA19915844
D004726EndosulfanEndosulfan results in decreased expression of HBB mRNA16624371
C071192entacaponeentacapone binds to HBB protein19783845
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of HBB protein20805001
D000431EthanolEthanol results in decreased expression of HBB mRNA17920746
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HBB mRNA16624371
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HBB mRNA16174780
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HBB protein20381887
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HBB mRNA15953391|1617478
D005001EthionineEthionine affects the expression of HBB mRNA19483382
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of HBB mRNA23649840
D015025ZearalenoneZearalenone results in decreased expression of HBB mRNA17557909
D005278FenitrothionFenitrothion results in decreased expression of HBB mRNA16624371
D005472FluorouracilFluorouracil affects the splicing of HBB mRNA17169984
D005485FlutamideFlutamide results in decreased expression of HBB mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of HBB mRNA23649840
D005663FuransFurans analog inhibits the reaction [Glucose binds to HBB protein]28911973
D005947GlucoseFurans analog inhibits the reaction [Glucose binds to HBB protein]28911973
D005947GlucoseGlucose binds to HBB protein28911973
C010974glyphosateglyphosate results in increased expression of HBB mRNA16532367
D006427Hemin[catechol co-treated with Hemin] results in increased expression of HBB mRNA24141029
D006427Hemincatechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA]24141029
D006427Hemincatechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA]24141029
D006427Hemincatechol promotes the reaction [Hemin results in increased expression of HBB mRNA]28552822
D006427HeminCOMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]24141029
D006427Hemindecitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]23973255
D006427Hemindecitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]]23973255
D006427HeminHemin promotes the reaction [catechol results in increased expression of HBB mRNA]28552822
D006427HeminHemin results in increased expression of HBB mRNA21414390|2397325
D006427Heminhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]21414390|2397325
D006427Heminhydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]21414390
D006427HeminPhenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]21414390|2397325
D006427Hemin[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA24141029
D006427Hemin[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA24141029
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in decreased expression of HBB mRNA17183730
C031927hydroquinonedecitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]23973255
C031927hydroquinonehydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]21414390|2397325
C013038hydroxyhydroquinonehydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]21414390
C016517indole-3-carbinolindole-3-carbinol affects the expression of HBB mRNA21396975
C028904isoproturon[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of HBB mRNA16532367
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of HBB protein17337753
C006552kaempferol"kaempferol inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]"14691983
D007854LeadHBB protein binds to Lead23896426
C008261lead acetatelead acetate results in increased expression of HBB mRNA22641619
C017461lead nitratelead nitrate results in decreased expression of HBB mRNA16624371
C017461lead nitratelead nitrate results in increased expression of HBB mRNA16624371
C017461lead nitrateCarbon inhibits the reaction [lead nitrate results in increased expression of HBB mRNA]18346799
C017461lead nitratelead nitrate results in increased expression of HBB mRNA18346799
C018584linaloollinalool results in decreased expression of HBB mRNA20536181
D000069349LinezolidLinezolid results in decreased expression of HBB mRNA21296123
D015122MercaptopurineMercaptopurine results in decreased expression of HBB mRNA23358152
D008713MethimazoleMethimazole results in increased expression of HBB mRNA17403546
D008727MethotrexateMethotrexate results in decreased expression of HBB mRNA24136188
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HBB protein25809596
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HBB mRNA23649840
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased methylation of HBB protein15655799
D008770MethylnitrosoureaMethylnitrosourea results in increased carbamoylation of HBB protein15655799
C576094methylsulfonyl benzothiazolemethylsulfonyl benzothiazole binds to HBB protein26675335
D009281NaphthalenesNaphthalenes results in increased expression of HBB protein17337753
D009532NickelHBB protein binds to Nickel23896426
D009532NickelNickel results in decreased expression of HBB mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of HBB mRNA19167457
C017557nickel subsulfidenickel subsulfide results in decreased expression of HBB mRNA21086188
D005996NitroglycerinNitroglycerin results in increased expression of HBB mRNA12187120
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of HBB protein19716841
C025256nonylphenolnonylphenol results in increased expression of HBB mRNA16624371
D009853OmeprazoleOmeprazole affects the expression of HBB mRNA19483382
D010100OxygenOxygen deficiency results in increased expression of HBB mRNA20447699
D010100OxygenHBB protein binds to Oxygen5773089
D010100OxygenHBB protein polymorphism binds to Oxygen5773089
D010269ParaquatParaquat results in decreased expression of HBB mRNA16624371
C551803PCI 32765PCI 32765 binds to HBB protein26675335
C494474perchlorateperchlorate results in increased expression of HBB mRNA17403546
D019800Phenoldecitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]]23973255
D019800PhenolPhenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]21414390|2397325
C006253pirinixic acidpirinixic acid affects the expression of HBB mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of HBB mRNA19162173
D011192Potassium DichromatePotassium Dichromate results in decreased expression of HBB mRNA16624371
D011192Potassium DichromatePotassium Dichromate results in increased expression of HBB mRNA16624371
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of HBB mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of HBB mRNA17404688|1807036
D011441PropylthiouracilPropylthiouracil affects the expression of HBB mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of HBB mRNA24780913
D011441PropylthiouracilPropylthiouracil results in increased expression of HBB mRNA17403546
C030984pyrenepyrene results in decreased expression of HBB mRNA15963578
D011794Quercetin"Quercetin inhibits the reaction [HBB gene polymorphism results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]"14691983
C059514resveratrolresveratrol results in increased expression of HBB mRNA24526417
D012402RotenoneRotenone results in decreased expression of HBB mRNA19013527|1947999
C541923sandostatinLARsandostatinLAR results in decreased expression of HBB mRNA17210224
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HBB mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of HBB mRNA19072884
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of HBB mRNA16214533
C013690styrene oxidestyrene oxide binds to HBB protein11948819
D014284TriiodothyronineTriiodothyronine results in increased expression of HBB mRNA15953391
D014284TriiodothyronineTriiodothyronine results in increased expression of HBB mRNA17403546
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HBB mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HBB mRNA15652763
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HBB mRNA16054898
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HBB mRNA15644576|2121527
D013853ThioacetamideThioacetamide affects the expression of HBB mRNA19483382
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of HBB protein27189315
C066340tolcaponetolcapone binds to HBB protein19783845
D014050TolueneToluene results in decreased expression of HBB mRNA22166486
D014050TolueneToluene results in increased expression of HBB mRNA22166486
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate binds to HBB protein"8728499
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of HBB gene27618143
C022884undecaneundecane results in increased expression of HBB protein17337753
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in decreased expression of HBB mRNA17183730
D014635Valproic AcidValproic Acid results in decreased expression of HBB mRNA29154799
D014635Valproic AcidValproic Acid results in decreased expression of HBB mRNA23665938
C025643vinclozolinvinclozolin results in decreased expression of HBB mRNA22570695
C025643vinclozolinvinclozolin results in increased expression of HBB mRNA23034163
D014750VincristineVincristine results in decreased expression of HBB mRNA23649840
D015215ZidovudineZidovudine results in decreased expression of HBB mRNA10651068
D015032ZincHBB protein binds to Zinc23896426
D015034Zinc OxideZinc Oxide analog results in decreased expression of HBB mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of HBB mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004601peroxidase activityCONTRIBUTES_TOIBA21873635  
GO:0004601peroxidase activitycontributes_toIDA19740759  
GO:0005344oxygen carrier activity-IBA21873635  
GO:0005344oxygen carrier activity-NAS1301199  11747442  
GO:0005515protein binding-IBA21873635  
GO:0005515protein binding-IPI1552945  6683087  9441940  9830011  9894000  10390349  
10930828  11159543  11724557  15835899  16169070  
GO:0019825oxygen binding-IBA21873635  
GO:0019825oxygen binding-IDA11747442  28066926  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IEA-  
GO:0030492hemoglobin binding-IDA1512262  
GO:0031720haptoglobin bindingCONTRIBUTES_TOIBA21873635  
GO:0031720haptoglobin bindingcontributes_toIDA19740759  
GO:0031721hemoglobin alpha binding-IBA21873635  
GO:0043177organic acid binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-TAS-  
GO:0007596blood coagulation-TAS-  
GO:0008217regulation of blood pressure-IEA-  
GO:0010942positive regulation of cell death-IDA19740759  
GO:0015671oxygen transport-NAS1301199  11747442  
GO:0015671oxygen transport-TAS1540659  
GO:0015701bicarbonate transport-TAS-  
GO:0030185nitric oxide transport-NAS8292032  
GO:0042542response to hydrogen peroxide-IDA19740759  
GO:0042744hydrogen peroxide catabolic process-IBA21873635  
GO:0042744hydrogen peroxide catabolic process-IDA19740759  
GO:0043312neutrophil degranulation-TAS-  
GO:0045429positive regulation of nitric oxide biosynthetic process-NAS7965120  
GO:0050880regulation of blood vessel size-IEA-  
GO:0051291protein heterooligomerization-IBA21873635  
GO:0051291protein heterooligomerization-IDA19740759  
GO:0070293renal absorption-IMP18465053  18974585  
GO:0070527platelet aggregation-HMP23382103  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA21805676  
GO:0005829cytosol-TAS-  
GO:0005833hemoglobin complex-IBA21873635  
GO:0005833hemoglobin complex-IDA19740759  
GO:0005833hemoglobin complex-NAS1301199  10588683  
GO:0005833hemoglobin complex-TAS1540659  
GO:0031838haptoglobin-hemoglobin complex-IBA21873635  
GO:0031838haptoglobin-hemoglobin complex-IDA19740759  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0071682endocytic vesicle lumen-TAS-  
GO:0072562blood microparticle-HDA22516433  
GO:1904724tertiary granule lumen-TAS-  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa05143African trypanosomiasis
hsa05144Malaria
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1237044Erythrocytes take up carbon dioxide and release oxygenTAS
R-HSA-1247673Erythrocytes take up oxygen and release carbon dioxideTAS
R-HSA-1480926O2/CO2 exchange in erythrocytesTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2168880Scavenging of heme from plasmaTAS
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27189315The human placental proteome is affected by maternal smoking. (2016 Aug)Huuskonen PReprod Toxicol
24482100Hereditary gene mutations in Korean patients with isolated erythrocytosis. (2014 Jun)Jang JHAnn Hematol