Gene: HBD

3045
-
hemoglobin subunit delta
protein-coding
11p15.4
Ensembl:ENSG00000223609 MIM:142000 Vega:OTTHUMG00000066674 UniprotKB:P02042
NG_000007.3
PubMed
0   ANCO-SNPs
ND|AD
16   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.057e-1 (AD)  7.822e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HBA20.773
ALAS20.739
HBB0.737
HBA10.731
CST70.657
SLC4A10.637
VNN20.609
IL18RAP0.6
IL1R20.599
FCGR3B0.596

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.515
KCNG1-0.499
TMEM121-0.498
FLRT1-0.481
RCOR2-0.48
HAS1-0.476
FAM57B-0.472
CYP46A1-0.47
CHRNA4-0.468
TMEM240-0.467

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HBD gene27153756
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of HBD mRNA17404688
C006780bisphenol Abisphenol A results in decreased expression of HBD mRNA29275510
D003010ClorgylineClorgyline results in increased expression of HBD mRNA19691856
D003703DemecolcineDemecolcine results in decreased expression of HBD mRNA23649840
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HBD protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HBD mRNA23550701
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of HBD mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of HBD mRNA23649840
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HBD mRNA21889194
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HBD mRNA23649840
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of HBD mRNA17560707
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of HBD mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of HBD mRNA18070364
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HBD mRNA25895662
D014212TretinoinTretinoin results in increased expression of HBD mRNA16249480
D014635Valproic AcidValproic Acid affects the expression of HBD mRNA25979313
D014750VincristineVincristine results in decreased expression of HBD mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004601peroxidase activityCONTRIBUTES_TOIBA21873635  
GO:0005344oxygen carrier activity-IBA21873635  
GO:0005344oxygen carrier activity-IEA-  
GO:0005515protein binding-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0019825oxygen binding-IBA21873635  
GO:0019825oxygen binding-IEA-  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IEA-  
GO:0031720haptoglobin bindingCONTRIBUTES_TOIBA21873635  
GO:0031721hemoglobin alpha binding-IBA21873635  
GO:0043177organic acid binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007596blood coagulation-TAS-  
GO:0015671oxygen transport-IEA-  
GO:0042744hydrogen peroxide catabolic process-IBA21873635  
GO:0051291protein heterooligomerization-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005833hemoglobin complex-IBA21873635  
GO:0005833hemoglobin complex-IEA-  
GO:0031838haptoglobin-hemoglobin complex-IBA21873635  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa05143African trypanosomiasis
hsa05144Malaria
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29033092Comparison of IL-1beta, TNF-alpha, hBD-2, and hBD-3 Expression in the Dental Pulp of Smokers Versus Nonsmokers. (2017 Dec)Ghattas Ayoub CJ Endod
8591101Evaluation of the effects of various factors on the serum alpha hydroxybutyrate dehydrogenase activity in young females. (1995 Nov)Imaki MAppl Human Sci
21635782Sputum and nasal lavage lung-specific biomarkers before and after smoking cessation. (2011 Jun 2)Bouloukaki IBMC Pulm Med
27191801Salivary antimicrobial defensins in pregnancy. (2016 Oct)Gursoy MJ Clin Periodontol
24266697The expression of the estrogen receptor in obese patients with high breast density (HBD). (2014 Jan)Souza MAGynecol Endocrinol
21199162Cigarette smoke modulates PGE(2) and host defence against Moraxella catarrhalis infection in human airway epithelial cells. (2011 Apr)Zhang WRespirology
25635179Effects of whole cigarette smoke on human beta defensins expression and secretion by oral mucosal epithelial cells. (2015)Wang WMTob Induc Dis
23051183Prognostic value of plasma human beta-defensin 2 level on short-term clinical outcomes in patients with community-acquired pneumonia: a preliminary study. (2013 Apr)Liu SRespir Care
23000304Enhanced expression of human beta-defensin 2 in peripheral lungs of patients with chronic obstructive pulmonary disease. (2012 Dec)Liao ZPeptides
18852155Suppression of pulmonary innate host defence in smokers. (2009 Feb)Herr CThorax
23721053Gingival crevicular fluid levels of human beta-defensin-2 and cathelicidin in smoker and non-smoker patients: a cross-sectional study. (2014 Jun)Ertugrul ASJ Periodontal Res
29132311Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. (2017 Nov 13)Wang WBMC Genomics
22885022Gene expression of human beta defensins-1 and -2 is significantly reduced in non-inflamed keratinized oral tissue of smokers. (2012 Nov)Wolgin MJ Dent
23046822Clinical application of human beta-defensin and CD14 gene polymorphism in evaluating the status of chronic inflammation. (2012 Sep 19)Loo WTJ Transl Med
25968832Cigarette Smoke Modulates NOD1 Signal Pathway and Human beta Defensins Expression in Human Oral Mucosa. (2015)Qian YJCell Physiol Biochem
18201443The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and human beta-defensin 2 by sinonasal epithelial cells. (2007 Nov-Dec)Lee WKAm J Rhinol