Gene: HBE1

3046
HBE
hemoglobin subunit epsilon 1
protein-coding
11p15.4
Ensembl:ENSG00000213931 MIM:142100 Vega:OTTHUMG00000066675 UniprotKB:P02100
NG_000007.3
PubMed
0   ANCO-SNPs
ND
2   
5.952e-1 (AD)  5.261e-1 (ND)   (Frontal_Cortex)
5.045e-1 (AD)  2.314e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16279158chr11:5291214HBE1Promoter5.268e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRAME0.804
HOXB90.756
IGF2BP10.746
CTCFL0.742
MAGEB20.738
SSX10.737
PAGE50.733
ACSM30.733
MAGEC20.727
RHAG0.717

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DIO2-0.228
ARSF-0.223
LHFPL1-0.211
WNT7B-0.209
BTBD17-0.205
GDF11-0.198
C1QL2-0.197
PPP1R3C-0.193
NKX6-1-0.192
CTF1-0.192

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of HBE1 protein22527513
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of HBE1 mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of HBE1 mRNA"23829299
D000082AcetaminophenAcetaminophen results in decreased expression of HBE1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HBE1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HBE1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of HBE1 mRNA25929836
C487081belinostatbelinostat results in decreased expression of HBE1 mRNA27188386
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HBE1 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of HBE1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of HBE1 mRNA15901920
C018475butyraldehydebutyraldehyde results in increased expression of HBE1 mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of HBE1 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride affects the expression of HBE1 mRNA18804290
C014347decitabinedecitabine affects the acetylation of HBE1 gene19576949
C014347decitabinedecitabine promotes the reaction [HIST3H3 protein modified form binds to HBE1 promoter]17696208
C014347decitabinedecitabine promotes the reaction [HIST4H4 protein modified form binds to HBE1 promoter]17696208
C014347decitabinedecitabine results in decreased methylation of HBE1 promoter17696208
C118739entinostatentinostat results in decreased expression of HBE1 mRNA27188386
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of HBE1 mRNA24534155
D005472FluorouracilFluorouracil results in decreased expression of HBE1 protein15352031
D005472FluorouracilHBE1 protein affects the susceptibility to Fluorouracil15352031
D005557FormaldehydeFormaldehyde results in decreased expression of HBE1 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of HBE1 mRNA19167457
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of HBE1 mRNA18804290
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of HBE1 mRNA25729387
C410127PCB 180PCB 180 results in increased expression of HBE1 mRNA23829299
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of HBE1 mRNA23948077
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of HBE1 mRNA23602845
C005556propionaldehydepropionaldehyde results in increased expression of HBE1 mRNA26079696
D018038Sodium SeleniteSodium Selenite results in decreased expression of HBE1 mRNA18175754
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of HBE1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of HBE1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of HBE1 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of HBE1 gene27618143
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of HBE1 mRNA29024780
D014635Valproic AcidValproic Acid results in increased expression of HBE1 mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004601peroxidase activityCONTRIBUTES_TOIBA21873635  
GO:0005344oxygen carrier activity-IBA21873635  
GO:0005344oxygen carrier activity-IEA-  
GO:0005515protein binding-IBA21873635  
GO:0005515protein binding-IPI11159543  
GO:0019825oxygen binding-IBA21873635  
GO:0019825oxygen binding-IEA-  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IEA-  
GO:0031720haptoglobin bindingCONTRIBUTES_TOIBA21873635  
GO:0031721hemoglobin alpha binding-IBA21873635  
GO:0031721hemoglobin alpha binding-IEA-  
GO:0043177organic acid binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007596blood coagulation-TAS-  
GO:0014070response to organic cyclic compound-IEA-  
GO:0015671oxygen transport-IEA-  
GO:0042744hydrogen peroxide catabolic process-IBA21873635  
GO:0051291protein heterooligomerization-IBA21873635  
GO:0051291protein heterooligomerization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005833hemoglobin complex-IBA21873635  
GO:0005833hemoglobin complex-IEA-  
GO:0031838haptoglobin-hemoglobin complex-IBA21873635  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24024160Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1. (2013)Randall MJRedox Biol
20060927Exacerbation of tobacco smoke mediated apoptosis by resveratrol: an unexpected consequence of its antioxidant action. (2011 Jul)Zhang HInt J Biochem Cell Biol