Gene: HCCS

3052
CCHL|LSDMCA1|MCOPS7|MLS
holocytochrome c synthase
protein-coding
Xp22.2
Ensembl:ENSG00000004961 MIM:300056 Vega:OTTHUMG00000021128 UniprotKB:P53701
NG_016460.1
PubMed
0   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBQLN10.957
BTBD100.953
PGK10.952
DYNC1LI10.952
PPP2R5E0.95
AFTPH0.949
MOAP10.947
GARS0.946
ATP6V1C10.946
MAP2K40.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.508
OR4F29-0.464
MYOM1-0.45
MYL3-0.44
CSAG1-0.435
ASB4-0.428
HEY2-0.412
SH2D1A-0.412
STON2-0.409
COPZ2-0.406

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HCCS mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HCCS mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HCCS mRNA"20816883
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of HCCS protein26194647
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of HCCS mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HCCS mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HCCS gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HCCS mRNA27153756
D001280AtrazineAtrazine results in decreased expression of HCCS mRNA22378314
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of HCCS mRNA]22228805
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of HCCS mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HCCS mRNA15034205|1977048
C044887beta-methylcholinebeta-methylcholine affects the expression of HCCS mRNA21179406
C006780bisphenol Abisphenol A affects the expression of HCCS mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of HCCS mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of HCCS mRNA26079696
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of HCCS mRNA17585979
D002994ClofibrateClofibrate results in increased expression of HCCS mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HCCS mRNA]17585979
D019327Copper SulfateCopper Sulfate results in increased expression of HCCS mRNA19549813
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HCCS protein23301498
D005485FlutamideFlutamide results in increased expression of HCCS mRNA24136188
D005839GentamicinsGentamicins results in decreased expression of HCCS mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of HCCS mRNA20044591
D008727MethotrexateMethotrexate affects the expression of HCCS mRNA18502557
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of HCCS mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HCCS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HCCS mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of HCCS mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of HCCS mRNA24236059
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HCCS mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of HCCS mRNA18301758
D010936Plant ExtractsPlant Extracts results in increased expression of HCCS mRNA23557933
C059514resveratrolresveratrol results in increased expression of HCCS protein25505154
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of HCCS mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HCCS mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HCCS mRNA15034205
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of HCCS mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of HCCS mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of HCCS mRNA19448997
D014635Valproic AcidValproic Acid affects the expression of HCCS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of HCCS gene29154799
D014635Valproic AcidValproic Acid results in increased expression of HCCS mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HCCS gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of HCCS mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004408holocytochrome-c synthase activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009887animal organ morphogenesis-TAS8661044  
GO:0018063cytochrome c-heme linkage-IBA21873635  
GO:0055114oxidation-reduction process-TAS8661044  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA11827457  
GO:0005743mitochondrial inner membrane-IEA-  
KEGG ID KEGG Term
hsa00860Porphyrin and chlorophyll metabolism
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25418332Development of risk scoring system for stratifying population for hepatocellular carcinoma screening. (2015 Jun)Hung YCHepatology
15946497[Molecular genetic and epigenetic mechanisms of hepatocarcinogenesis]. (2005 Jun)Xue KXAi Zheng
12845670Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis. (2003 Sep 1)Edamoto YInt J Cancer
25843735A comparison of patients with hepatitis B- or hepatitis C-based advanced-stage hepatocellular carcinoma. (2015 Apr)Carr BISemin Oncol
13129558Treatment of hepatocellular carcinoma using percutaneous radiofrequency thermoablation: results and outcomes in 56 patients. (2003 Sep-Oct)Giovannini MJ Gastrointest Surg
25765471Impact of epidermal growth factor receptor protein and gene alteration on Taiwanese hepatocellular carcinomas. (2015 Sep)Su YHJ Gastroenterol Hepatol