Gene: SERPIND1

3053
D22S673|HC2|HCF2|HCII|HLS2|LS2|THPH10
serpin family D member 1
protein-coding
22q11.21
Ensembl:ENSG00000099937 MIM:142360 Vega:OTTHUMG00000150755 UniprotKB:P05546
NG_012076.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.585e-1 (AD)  3.040e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
INSRR0.803
SLC13A40.79
SLC22A80.786
CDC20B0.762
ABI3BP0.749
MYOCD0.744
SLC22A20.741
OR51E10.738
TMEM30B0.738
ITIH30.733

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NANOS3-0.357
NXPH3-0.271
NTNG2-0.249
YBX2-0.248
HPSE2-0.238
PAH-0.236
RNF182-0.234
SOHLH1-0.231
HHATL-0.225
TMEM221-0.225

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00407ArdeparinSmall Molecule9005-49-6Approved|Investigational|WithdrawnTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB06271SulodexideBiotechDrug57821-29-1Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB09258BemiparinSmall Molecule91449-79-5Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of SERPIND1 mRNA"18711122
C0264861,2,5,6-dibenzanthracene"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of SERPIND1 mRNA"18711122
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SERPIND1 mRNA"18711122
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SERPIND1 mRNA"28903501
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of SERPIND1 mRNA20566314
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of SERPIND1 mRNA"21920950
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SERPIND1 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SERPIND1 mRNA]"19467301
C0293704-toluidine4-toluidine results in decreased expression of SERPIND1 mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of SERPIND1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SERPIND1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SERPIND1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SERPIND1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SERPIND1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SERPIND1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SERPIND1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SERPIND1 mRNA16483693
D001104ArbutinArbutin results in decreased expression of SERPIND1 mRNA17103032
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SERPIND1 mRNA19770486
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SERPIND1 mRNA"18711122
D004958EstradiolEstradiol results in decreased expression of SERPIND1 mRNA20106945
C095105bexarotenebexarotene results in decreased expression of SERPIND1 mRNA16648578
C006780bisphenol Abisphenol A results in increased expression of SERPIND1 mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of SERPIND1 mRNA24534842
C006780bisphenol Abisphenol A results in decreased expression of SERPIND1 mRNA25181051
D002104CadmiumSERPIND1 protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SERPIND1 mRNA18213484
D019256Cadmium ChlorideCadmium Chloride affects the expression of SERPIND1 mRNA22110744
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of SERPIND1 mRNA27344345
D002793Cholic Acids[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of SERPIND1 mRNA27344345
D002793Cholic Acids[Methyltestosterone co-treated with Cholic Acids] affects the expression of SERPIND1 mRNA27344345
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SERPIND1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SERPIND1 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of SERPIND1 mRNA24386269
D003300CopperSERPIND1 protein binds to Copper23896426
D003300CopperCopper results in decreased expression of SERPIND1 mRNA25646894
D019327Copper SulfateCopper Sulfate results in decreased expression of SERPIND1 mRNA19549813
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of SERPIND1 mRNA27344345
D016572CyclosporineCyclosporine results in decreased expression of SERPIND1 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of SERPIND1 mRNA23830897
D003871Dermatan Sulfate[Dermatan Sulfate co-treated with SERPIND1 protein] results in decreased activity of F2 protein11805133
C041517dibenzo(a,l)pyrene"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of SERPIND1 mRNA"18711122
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SERPIND1 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of SERPIND1 mRNA19467301
C014476diethyl maleatediethyl maleate results in decreased expression of SERPIND1 mRNA25270620
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SERPIND1 mRNA28943392
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of SERPIND1 mRNA27638505
D004147DioxinsDioxins affects the expression of SERPIND1 mRNA20463971
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of SERPIND1 mRNA27344345
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of SERPIND115669648
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SERPIND1 mRNA17942748
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased expression of SERPIND1 protein15318540
D005419FlavonoidsFlavonoids results in decreased expression of SERPIND1 mRNA18035473
C007738fluoranthene"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of SERPIND1 mRNA"18711122
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of SERPIND1 mRNA]15016801
D005485FlutamideFlutamide results in decreased expression of SERPIND1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of SERPIND1 mRNA24793618
C039281furanfuran results in decreased expression of SERPIND1 mRNA25539665
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of SERPIND115669648
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of SERPIND1 mRNA20566314
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SERPIND1 mRNA26752646
C410337K 7174K 7174 results in decreased expression of SERPIND1 mRNA24086573
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SERPIND1 mRNA26378955
D008627Mercuric ChlorideMercuric Chloride affects the expression of SERPIND1 mRNA20353558
D008777Methyltestosterone[Methyltestosterone co-treated with Cholic Acids] affects the expression of SERPIND1 mRNA27344345
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SERPIND1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SERPIND1 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of SERPIND1 mRNA24136188
D009532NickelSERPIND1 protein binds to Nickel23896426
D009532NickelNickel results in increased expression of SERPIND1 mRNA12540486
D009532NickelNickel results in increased expression of SERPIND1 mRNA24084258
C022838nickel chloridenickel chloride affects the expression of SERPIND1 mRNA22110744
C012655nimesulidenimesulide results in decreased expression of SERPIND1 mRNA24136188
D010100OxygenOxygen deficiency results in decreased expression of SERPIND1 mRNA26516004
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of SERPIND1 mRNA23567314
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of SERPIND1 mRNA23567314
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of SERPIND1 mRNA23602845
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of SERPIND1 mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of SERPIND1 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SERPIND1 mRNA20936131
C076994perfluorooctane sulfonic acidPPARA protein inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of SERPIND1 mRNA]20936131
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SERPIND1 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of SERPIND1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SERPIND1 mRNA18467677
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of SERPIND1 mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SERPIND1 mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of SERPIND1 mRNA18445702
D010936Plant ExtractsPlant Extracts results in decreased expression of SERPIND1 mRNA23557933
D028321Plant PreparationsPlant Preparations results in decreased expression of SERPIND1 protein28284660
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SERPIND1 mRNA23608068
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of SERPIND1 mRNA25626140
D011794QuercetinQuercetin results in decreased expression of SERPIND1 mRNA21632981
C503991quercetin 3,7,3',4'-tetrasulfate"quercetin 3,7,3',4'-tetrasulfate inhibits the reaction [SERPIND1 protein results in increased degradation of F2 protein]"11958811
C503991quercetin 3,7,3',4'-tetrasulfate"quercetin 3,7,3',4'-tetrasulfate results in increased activity of SERPIND1 protein"11958811
C503992quercetin 3-acetyl-7,3',4'-trisulfate"quercetin 3-acetyl-7,3',4'-trisulfate promotes the reaction [SERPIND1 protein results in increased degradation of F2 protein]"11958811
C503992quercetin 3-acetyl-7,3',4'-trisulfate"quercetin 3-acetyl-7,3',4'-trisulfate results in increased activity of SERPIND1 protein"11958811
C016104sodium bichromatesodium bichromate affects the expression of SERPIND1 mRNA22110744
D053260SootSoot results in increased expression of SERPIND1 mRNA22461453
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SERPIND1 mRNA26378955
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of SERPIND1 mRNA15885361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SERPIND1 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SERPIND1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SERPIND1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SERPIND1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SERPIND1 mRNA21215274|2172422
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SERPIND1 mRNA28943392
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SERPIND1 mRNA20133372
C012589trichostatin Atrichostatin A results in decreased expression of SERPIND1 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SERPIND1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of SERPIND1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of SERPIND1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SERPIND1 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased expression of SERPIND1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SERPIND1 gene25560391
D015032ZincSERPIND1 protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-TAS2647747  
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0008201heparin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006935chemotaxis-IEA-  
GO:0007596blood coagulation-TAS-  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-140837Intrinsic Pathway of Fibrin Clot FormationTAS
R-HSA-140875Common Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22659451Molecular signature of smoking in human lung tissues. (2012 Aug 1)Bosse YCancer Res