Gene: HCK

3055
JTK9|p59Hck|p61Hck
HCK proto-oncogene, Src family tyrosine kinase
protein-coding
20q11.21
Ensembl:ENSG00000101336 MIM:142370 Vega:OTTHUMG00000032204 UniprotKB:P08631
NG_029471.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.518e-1 (AD)  1.339e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPI10.95
ABI30.949
FCGR3A0.945
CD300A0.945
SASH30.945
FCGR2A0.942
ITGB20.942
LAIR10.941
FCGR1A0.94
PTPN60.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.486
NEUROD6-0.464
ST6GAL2-0.456
WNT7A-0.455
TMEM179-0.454
MARCH4-0.451
RTN4R-0.446
EXTL1-0.443
ATP2C2-0.439
ATOH7-0.438

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB018091-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineSmall MoleculeExperimentalTarget
DB01962PhosphonotyrosineSmall Molecule21820-51-9ExperimentalTarget
DB04216QuercetinSmall Molecule117-39-5Experimental|InvestigationalTarget
DB06616BosutinibSmall Molecule380843-75-4ApprovedTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HCK mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of HCK mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of HCK protein"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HCK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HCK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HCK mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of HCK mRNA"21346803
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of and results in increased activity of HCK protein]"15772366
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of HCK mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HCK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HCK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HCK mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of HCK mRNA17562736
C412373AG 1879AG 1879 results in decreased activity of HCK protein25980585
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of HCK mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HCK mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HCK mRNA24449571
C015001arsenitearsenite results in increased methylation of HCK promoter23974009
D017639Asbestos, Amosite"Asbestos, Amosite results in increased activity of HCK protein"29112861
D001241AspirinAspirin results in decreased expression of HCK mRNA15928584
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA]15477007
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of HCK mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of HCK gene25435355
C006780bisphenol Abisphenol A results in decreased expression of HCK mRNA25594700
C006780bisphenol Abisphenol A affects the expression of HCK mRNA25181051
D002084Butylated HydroxytolueneButylated Hydroxytoluene affects the expression of HCK mRNA18539377
D002104CadmiumCadmium results in decreased expression of HCK mRNA24376830
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNA12634122
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HCK mRNA25993096
D000074262Canola OilCanola Oil metabolite results in decreased expression of HCK mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HCK mRNA27339419
D002509CephaloridineCephaloridine results in increased expression of HCK mRNA18500788
D002737ChloropreneChloroprene results in decreased expression of HCK mRNA23125180
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNA12634122
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of HCK mRNA28472532
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNA12634122
C018021cobaltous chloridecobaltous chloride results in increased expression of HCK mRNA23052192
D003471CuprizoneCuprizone results in increased expression of HCK mRNA27523638
D000069439DasatinibDasatinib results in decreased phosphorylation of HCK protein18180381
C014347decitabinedecitabine affects the methylation of HCK promoter17344919
C014347decitabine[decitabine affects the methylation of HCK promoter] which affects the expression of HCK mRNA17344919|1734491
C014347decitabinedecitabine results in increased expression of HCK protein17344919
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of HCK protein20181660
C007262deoxynivalenol"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of and results in increased activity of HCK protein]"15772366
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of and results in increased activity of HCK protein15772366
C007262deoxynivalenolHCK protein affects the reaction [deoxynivalenol results in increased activity of CASP3 protein]15772366
C007262deoxynivalenolHCK protein affects the reaction [deoxynivalenol results in increased expression of TNF protein]15772366
C007262deoxynivalenolHCK protein affects the susceptibility to deoxynivalenol22491426
D003907DexamethasoneDexamethasone results in increased expression of HCK mRNA21041162
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HCK mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of HCK mRNA27594783
D004008DiclofenacDiclofenac results in increased expression of HCK mRNA26934552
D004041Dietary FatsDietary Fats results in decreased expression of HCK mRNA18042831
C058705diethyl malatediethyl malate affects the expression of HCK mRNA24814887
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of HCK mRNA21041162
D002117CalcitriolCalcitriol results in decreased expression of HCK mRNA26485663
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of HCK mRNA25380136
C118739entinostatentinostat results in increased expression of HCK mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HCK mRNA"27188386
D004967EstrogensEstrogens promotes the reaction [HCK protein binds to CBL protein]10092522
D009240N-Formylmethionine Leucyl-PhenylalanineN-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of HCK protein25980585
D005839GentamicinsGentamicins results in increased expression of HCK mRNA22061828
D017313FenretinideFenretinide results in increased expression of HCK mRNA28973697
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HCK mRNA25613284
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNA12634122
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of HCK mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HCK mRNA27339419
D008627Mercuric ChlorideMercuric Chloride results in increased activity of HCK protein14551197
D008627Mercuric ChlorideMercuric Chloride promotes the reaction [HCK protein results in increased phosphorylation of CBL protein]10092522
D008627Mercuric ChlorideMercuric Chloride results in increased activity of HCK protein10092522
D008727MethotrexateMethotrexate affects the expression of HCK mRNA18502557
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HCK mRNA23519560
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of HCK mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased activity of HCK protein"29112861
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of HCK mRNA25380136
D009532NickelNickel results in decreased expression of HCK mRNA23195993
D009532NickelNickel results in increased expression of HCK mRNA25583101
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine results in decreased expression of HCK mRNA12102619
D010098OxycodoneOxycodone results in decreased expression of HCK mRNA23439660
D010126OzoneOzone results in decreased expression of HCK mRNA16330353
D000073878Palm OilPalm Oil results in decreased expression of HCK mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HCK mRNA"27188386
C006253pirinixic acidpirinixic acid results in decreased expression of HCK mRNA17426115
C545373ponatinibponatinib results in decreased activity of HCK protein19878872
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA]15477007
C059514resveratrolresveratrol results in decreased expression of HCK mRNA15280659
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of HCK mRNA25905778
C059514resveratrolresveratrol results in increased expression of HCK mRNA25905778
D012834SilverSilver results in decreased expression of HCK mRNA27131904
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNA12634122
D012999SomanSoman results in increased expression of HCK mRNA19281266
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of HCK mRNA25905778
C016766sulforafansulforafan results in increased expression of HCK mRNA26833863
D013605T-2 ToxinT-2 Toxin results in increased expression of HCK mRNA26141394
C061133tamibarotenetamibarotene results in increased expression of HCK mRNA15498508
C004648testosterone enanthatetestosterone enanthate affects the expression of HCK mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HCK mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HCK mRNA21041162|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HCK mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HCK mRNA21215274
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA15477007
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HCK mRNA23519560
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HCK mRNA25613284
D013853ThioacetamideThioacetamide results in increased methylation of HCK promoter27914986
D014212TretinoinTretinoin results in increased expression of HCK mRNA15498508|1605412
D014212TretinoinTretinoin results in decreased expression of HCK mRNA16604517
C012589trichostatin Atrichostatin A results in increased expression of HCK mRNA24935251
C030665triphenyltintriphenyltin results in increased expression of HCK protein12788061
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HCK mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HCK mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HCK mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HCK gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of HCK mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001784phosphotyrosine residue binding-IPI20624904  
GO:0004713protein tyrosine kinase activity-EXP10861086  16921024  
GO:0004713protein tyrosine kinase activity-IMP10092522  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IBA21873635  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005515protein binding-IPI7859737  10849448  11278465  11741929  12029088  14993658  
15491611  15784897  16273093  16374509  16636290  17141806  
18042718  19234535  20670214  22641034  23397142  24658140  
24728074  24860872  25416956  25469238  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002522leukocyte migration involved in immune response-TAS18538446  
GO:0002758innate immune response-activating signal transduction-TAS18538446  
GO:0006468protein phosphorylation-TAS3496523  
GO:0006954inflammatory response-IEA-  
GO:0007155cell adhesion-TAS18538446  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0007229integrin-mediated signaling pathway-TAS18538446  
GO:0007498mesoderm development-TAS3453117  
GO:0008284positive regulation of cell proliferation-IMP10092522  
GO:0008360regulation of cell shape-IMP10092522  11904303  
GO:0018108peptidyl-tyrosine phosphorylation-IMP10092522  
GO:0019221cytokine-mediated signaling pathway-TAS18538446  
GO:0030154cell differentiation-IBA21873635  
GO:0030838positive regulation of actin filament polymerization-TAS18538446  
GO:0031663lipopolysaccharide-mediated signaling pathway-TAS18538446  
GO:0038083peptidyl-tyrosine autophosphorylation-IBA21873635  
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TAS-  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0043066negative regulation of apoptotic process-IMP17535448  
GO:0043299leukocyte degranulation-TAS18538446  
GO:0045087innate immune response-IBA21873635  
GO:0045728respiratory burst after phagocytosis-TAS18538446  
GO:0046777protein autophosphorylation-IMP10092522  
GO:0050690regulation of defense response to virus by virus-TAS-  
GO:0050727regulation of inflammatory response-TAS18538446  
GO:0050764regulation of phagocytosis-IMP11904303  
GO:0051090regulation of DNA-binding transcription factor activity-IMP17535448  
GO:0060333interferon-gamma-mediated signaling pathway-TAS18538446  
GO:0071801regulation of podosome assembly-IDA15998323  
GO:2000251positive regulation of actin cytoskeleton reorganization-IDA15998323  
GO:2000251positive regulation of actin cytoskeleton reorganization-IMP11904303  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005764lysosome-IDA15998323  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-TAS-  
GO:0005884actin filamentcolocalizes_withIDA15998323  
GO:0005886plasma membrane-IDA-  
GO:0005901caveola-IDA7791757  
GO:0005925focal adhesion-IMP11904303  
GO:0030133transport vesicle-IEA-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IBA21873635  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IMP11904303  
GO:0042995cell projection-IEA-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1643685DiseaseTAS
R-HSA-164944Nef and signal transductionTAS
R-HSA-164952The role of Nef in HIV-1 replication and disease pathogenesisTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029481FCGR activationTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingIEA
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-912631Regulation of signaling by CBLIEA
R-HSA-912631Regulation of signaling by CBLTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10223202Decreased expression of glutathione S-transferase M1 in HPV16-transfected human cervical keratinocytes in culture. (1999 Apr)Chen CCarcinogenesis
17024369Association of Hck genetic polymorphisms with gene expression and COPD. (2007 Jan)Zhang XHum Genet