Gene info: ID 306

Gene: ANXA3

GENE ID: 306

Synonyms: ANX3

Description: annexin A3

Gene type: protein-coding

Location: 4q21.21

dbXrefs: Ensembl:ENSG00000138772 MIM:106490 Vega:OTTHUMG00000130198 UniprotKB:P12429

RefSeq: NC_000004.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.687e-1 (AD) 6.492e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC2A1	0.808
NOSTRIN	0.769
VWF	0.758
PAQR5	0.732
FGR	0.728
KANK3	0.727
OMD	0.723
CD34	0.723
ATP10A	0.72
ERG	0.72

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CRH	-0.395
GGN	-0.387
KCNG1	-0.377
FLRT1	-0.365
CPLX3	-0.344
SPATA2L	-0.336
SHH	-0.333
PTHLH	-0.332
ST8SIA2	-0.331
SST	-0.33

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB03994	Ethanolamine	Small Molecule	141-43-5	Experimental	Target
DB09095	Difluocortolone	Small Molecule	2607-06-9	Approved\|Investigational\|Withdrawn	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of ANXA3 mRNA"	19162173
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of ANXA3 protein"	21673325
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ANXA3 mRNA"	19167446
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ANXA3 mRNA"	21346803
C024709	2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone	"2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to ANXA3 protein"	16533022
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of ANXA3 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of ANXA3 mRNA"	26238291
D000082	Acetaminophen	Acetaminophen results in decreased expression of ANXA3 mRNA	26690555
D000082	Acetaminophen	Acetaminophen results in increased expression of ANXA3 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of ANXA3 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of ANXA3 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ANXA3 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ANXA3 mRNA	27153756
D000393	Air Pollutants	Air Pollutants analog results in increased expression of ANXA3 mRNA	21757418
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ANXA3 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of ANXA3 mRNA"	22863853
C023650	aniline	aniline results in increased nitrosation of ANXA3 protein	21708182
D001151	Arsenic	Arsenic affects the methylation of ANXA3 gene	25304211
C006632	arsenic trioxide	ANXA3 protein results in decreased susceptibility to arsenic trioxide	20707922
D001194	Asbestos	Asbestos results in decreased expression of ANXA3 mRNA	22398240
D001554	Benzene	Benzene results in increased expression of ANXA3 mRNA	15120971\|1512265
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of ANXA3 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ANXA3 mRNA	26238291
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ANXA3 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ANXA3 mRNA	22228805\|2261060
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ANXA3 mRNA"	26238291
D004958	Estradiol	Estradiol results in decreased expression of ANXA3 mRNA	25321415
D004958	Estradiol	Estradiol results in increased expression of ANXA3 mRNA	19484750
D004958	Estradiol	Estradiol results in increased expression of ANXA3 mRNA	15289156\|1948475
C095105	bexarotene	[bexarotene co-treated with Tamoxifen] results in decreased expression of ANXA3 mRNA	17630414
C110172	BHTOH-QM	BHTOH-QM binds to ANXA3 protein	16533022
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of ANXA3 mRNA	27685785
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ANXA3 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of ANXA3 mRNA	29275510
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ANXA3 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of ANXA3 mRNA	25181051
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of ANXA3 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased methylation of ANXA3 gene	28505145
D001761	Bleomycin	Bleomycin results in decreased expression of ANXA3 protein	25933445
C013418	bromfenacoum	bromfenacoum results in increased expression of ANXA3 protein	28903499
D002065	Buspirone	Buspirone results in decreased expression of ANXA3 mRNA	24136188
C018475	butyraldehyde	butyraldehyde results in increased expression of ANXA3 mRNA	26079696
C584509	C646 compound	C646 compound results in increased expression of ANXA3 mRNA	26191083
D002104	Cadmium	Cadmium results in increased expression of ANXA3 mRNA	24376830
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ANXA3 protein	26220685
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of ANXA3 mRNA	22110744
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ANXA3 mRNA	25993096
D002220	Carbamazepine	Carbamazepine affects the expression of ANXA3 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ANXA3 mRNA	27339419
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of ANXA3 mRNA	18071240
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ANXA3 mRNA	16644059
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ANXA3 mRNA	18182385
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ANXA3 protein	18182385
D002251	Carbon Tetrachloride	HGF protein affects the reaction [Carbon Tetrachloride results in increased expression of ANXA3 mRNA]	18182385
C010063	carbonyl sulfide	carbonyl sulfide results in increased expression of ANXA3 mRNA	19395590
D002713	Chlorine	Chlorine results in increased expression of ANXA3 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of ANXA3 mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of ANXA3 mRNA	23650126
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of ANXA3 mRNA	26272509
C100187	chloropicrin	chloropicrin results in decreased expression of ANXA3 mRNA	28476498
C100187	chloropicrin	chloropicrin results in increased expression of ANXA3 mRNA	26352163
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANXA3 mRNA	20938992
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ANXA3 mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ANXA3 mRNA	24386269
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ANXA3 mRNA	24386269
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of ANXA3 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ANXA3 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ANXA3 mRNA"	19167446
D003471	Cuprizone	Cuprizone results in increased expression of ANXA3 mRNA	27523638
D016572	Cyclosporine	Cyclosporine results in decreased expression of ANXA3 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of ANXA3 mRNA	20106945\|2163298
D003676	Deferoxamine	Deferoxamine results in decreased expression of ANXA3 protein	19515424
D003676	Deferoxamine	ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ANXA3 protein]	19515424
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ANXA3 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ANXA3 mRNA	28628672
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ANXA3 mRNA	16054899
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of ANXA3 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of ANXA3 mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of ANXA3 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of ANXA3 mRNA	27392435
D004041	Dietary Fats	Dietary Fats results in increased expression of ANXA3 mRNA	22609946
C014476	diethyl maleate	diethyl maleate results in decreased expression of ANXA3 mRNA	21161181
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of ANXA3 mRNA	24535843
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of ANXA3 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of ANXA3 mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of ANXA3 mRNA	15289156
D002117	Calcitriol	Calcitriol results in increased expression of ANXA3 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of ANXA3 mRNA	21592394
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of ANXA3 mRNA"	27840820
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of ANXA3 mRNA	25380136
D004298	Dopamine	Dopamine results in increased expression of ANXA3 protein	24675778
D000431	Ethanol	Ethanol results in increased expression of ANXA3 mRNA	17920746
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ANXA3 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ANXA3 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANXA3 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ANXA3 mRNA	17557909
D015025	Zearalenone	Zearalenone results in decreased expression of ANXA3 protein	25058043
C540355	fenamidone	fenamidone results in increased expression of ANXA3 mRNA	27029645
D011345	Fenofibrate	Fenofibrate results in decreased expression of ANXA3 protein	20118634
C013531	ferric ammonium citrate	ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ANXA3 protein]	19515424
C000499	ferric oxide	ferric oxide analog results in decreased expression of ANXA3 mRNA	25086211
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of ANXA3 mRNA	17317680
D015073	2-Acetylaminofluorene	TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ANXA3 mRNA]	17317680
D015073	2-Acetylaminofluorene	[Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of ANXA3 mRNA	18071240
D005472	Fluorouracil	Fluorouracil results in increased expression of ANXA3 mRNA	17039268
D005480	Flurbiprofen	Flurbiprofen results in increased expression of ANXA3 mRNA	16949054
D005485	Flutamide	Flutamide results in decreased expression of ANXA3 mRNA	24136188\|2479361
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANXA3 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of ANXA3 mRNA	27664576
D005620	Freund's Adjuvant	[Urethane co-treated with Freund's Adjuvant] results in decreased expression of ANXA3 mRNA	12400877
D019833	Genistein	ESR2 promotes the reaction [Genistein results in decreased expression of ANXA3 protein]	20884965
D019833	Genistein	Genistein results in decreased expression of ANXA3 protein	20884965
D019833	Genistein	Genistein results in increased expression of ANXA3 mRNA	15289156
C103280	goniothalamin	goniothalamin results in increased cleavage of ANXA3 protein	18771661
D006118	Griseofulvin	Griseofulvin affects the expression of ANXA3 mRNA	12735108
D017313	Fenretinide	Fenretinide results in increased expression of ANXA3 mRNA	28973697
D006820	Hyaluronic Acid	Hyaluronic Acid analog results in decreased expression of ANXA3 protein	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of ANXA3 protein	23178681
D007052	Ibuprofen	Ibuprofen affects the expression of ANXA3 mRNA	17070997
C492448	ICG 001	ICG 001 results in increased expression of ANXA3 mRNA	26191083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ANXA3 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ANXA3 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANXA3 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ANXA3 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ANXA3 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ANXA3 mRNA	16054899
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of ANXA3 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ANXA3 mRNA	24796395
D007649	Ketamine	Ketamine results in decreased expression of ANXA3 mRNA	20080153
C045463	leflunomide	leflunomide results in increased expression of ANXA3 mRNA	28988120
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of ANXA3 mRNA	25613284
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of ANXA3 mRNA	20359477
D008095	Lithocholic Acid	Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA3 mRNA]	20359477
D008154	Lucanthone	Lucanthone results in decreased expression of ANXA3 mRNA	21148553
C042720	mercuric bromide	mercuric bromide results in increased expression of ANXA3 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
D008694	Methamphetamine	Methamphetamine results in decreased expression of ANXA3 protein	19826936
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANXA3 mRNA	20938992
C005219	methyl cellosolve	methyl cellosolve results in increased expression of ANXA3 mRNA	21061450
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ANXA3 mRNA	23179753
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ANXA3 mRNA	23179753\|2627250
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of ANXA3 protein	24675778
D015735	Mifepristone	Mifepristone results in decreased expression of ANXA3 mRNA	25972201
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of ANXA3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ANXA3 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of ANXA3 mRNA	25380136
C051752	nefazodone	nefazodone results in decreased expression of ANXA3 mRNA	24136188
C029938	nickel sulfate	nickel sulfate results in decreased expression of ANXA3 mRNA	22714537
C012655	nimesulide	nimesulide results in decreased expression of ANXA3 mRNA	24136188
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of ANXA3 mRNA	17616710
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of ANXA3 protein	19716841
C025256	nonylphenol	nonylphenol results in increased expression of ANXA3 protein	19260726
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of ANXA3 mRNA	20971185
C025589	ochratoxin A	ochratoxin A results in increased expression of ANXA3 mRNA	18417182
C030110	oxaliplatin	oxaliplatin results in decreased expression of ANXA3 mRNA	25729387
D010098	Oxycodone	Oxycodone results in decreased expression of ANXA3 mRNA	23439660
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of ANXA3 mRNA	18636392
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of ANXA3 mRNA	26272509
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of ANXA3 mRNA	26705709
C046012	pentanal	pentanal results in increased expression of ANXA3 mRNA	26079696
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of ANXA3 protein	26178269
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of ANXA3 mRNA	19162173
D010634	Phenobarbital	Phenobarbital affects the expression of ANXA3 mRNA	19136022
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of ANXA3 mRNA	26272509
D010795	Phthalic Acids	Phthalic Acids results in increased expression of ANXA3 mRNA	21061450
C006253	pirinixic acid	pirinixic acid affects the expression of ANXA3 mRNA	19136022
C006253	pirinixic acid	pirinixic acid results in decreased expression of ANXA3 mRNA	19162173
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of ANXA3 mRNA	22714537
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of ANXA3 protein	20332019
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA3 mRNA]	20359477
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of ANXA3 mRNA	19162173
D011374	Progesterone	Progesterone results in increased expression of ANXA3 mRNA	23018184
D011374	Progesterone	Progesterone results in decreased expression of ANXA3 mRNA	21540246
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of ANXA3 mRNA	27029645
D011794	Quercetin	Quercetin affects the expression of ANXA3 mRNA	21632981
C059514	resveratrol	resveratrol results in increased cleavage of ANXA3 protein	23088850
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of ANXA3 mRNA	25905778
C059514	resveratrol	resveratrol results in increased expression of ANXA3 mRNA	25905778
C116926	rofecoxib	rofecoxib results in increased expression of ANXA3 mRNA	17070997
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ANXA3 mRNA	16054899
D012402	Rotenone	Rotenone affects the expression of ANXA3 mRNA	23186747
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of ANXA3 mRNA	25895662
D019821	Simvastatin	Simvastatin results in decreased expression of ANXA3 mRNA	17428261
D019821	Simvastatin	Simvastatin results in decreased expression of ANXA3 protein	14973129
D012906	Smoke	Smoke results in decreased expression of ANXA3 mRNA	21095227
C017947	sodium arsenite	sodium arsenite results in decreased expression of ANXA3 mRNA	22714537
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of ANXA3 protein	27548804
D012999	Soman	Soman results in increased expression of ANXA3 mRNA	19281266
D053260	Soot	Soot results in increased expression of ANXA3 protein modified form	24464499
D053260	Soot	Soot results in increased expression of ANXA3 mRNA	26551751
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of ANXA3 mRNA	25905778
D013311	Streptozocin	Streptozocin results in increased expression of ANXA3 protein	21136691
D013311	Streptozocin	Trientine inhibits the reaction [Streptozocin results in increased expression of ANXA3 protein]	21136691
D014284	Triiodothyronine	Triiodothyronine results in increased expression of ANXA3 mRNA	22281776
D013629	Tamoxifen	Tamoxifen affects the expression of ANXA3 mRNA	17555576
D013629	Tamoxifen	[bexarotene co-treated with Tamoxifen] results in decreased expression of ANXA3 mRNA	17630414
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of ANXA3 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of ANXA3 mRNA	21592394
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of ANXA3 mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ANXA3 mRNA	26238291
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ANXA3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANXA3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ANXA3 mRNA	15667827
D013755	Tetradecanoylphorbol Acetate	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ANXA3 mRNA	16979875
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANXA3 mRNA	25613284
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of ANXA3 mRNA	28943392
C009495	titanium dioxide	titanium dioxide results in increased expression of ANXA3 mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of ANXA3 mRNA	28065790
D014212	Tretinoin	Tretinoin results in increased expression of ANXA3 mRNA	21934132
C032910	triadimefon	triadimefon results in decreased expression of ANXA3 mRNA	26705709
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of ANXA3 mRNA	24935251\|2627250
D014266	Trientine	Trientine inhibits the reaction [Streptozocin results in increased expression of ANXA3 protein]	21136691
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ANXA3 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of ANXA3 mRNA	29024780
C057693	troglitazone	troglitazone results in decreased expression of ANXA3 protein	21315101
D014520	Urethane	Urethane results in decreased expression of ANXA3 mRNA	28818685
D014520	Urethane	[Urethane co-treated with Freund's Adjuvant] results in decreased expression of ANXA3 mRNA	12400877
D014520	Urethane	Urethane results in decreased expression of ANXA3 mRNA	12400877
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ANXA3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of ANXA3 mRNA	28001369\|2915479
D014635	Valproic Acid	Valproic Acid results in increased expression of ANXA3 mRNA	23179753\|2438349
D014640	Vancomycin	Vancomycin results in decreased expression of ANXA3 mRNA	18930951
C025643	vinclozolin	vinclozolin results in increased expression of ANXA3 mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of ANXA3 mRNA	26682919
C111237	vorinostat	vorinostat results in decreased expression of ANXA3 mRNA	17593366
C111237	vorinostat	vorinostat results in decreased expression of ANXA3 protein	17593366
D015032	Zinc	Zinc affects the expression of ANXA3 mRNA	16979875
D015032	Zinc	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ANXA3 mRNA	16979875

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005509	calcium ion binding	-	IEA	-
GO:0005544	calcium-dependent phospholipid binding	-	IDA	2138016 2138632
GO:0019834	phospholipase A2 inhibitor activity	-	IEA	-
GO:0048306	calcium-dependent protein binding	-	IPI	15226301

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006909	phagocytosis	-	IDA	9497492
GO:0010595	positive regulation of endothelial cell migration	-	IDA	16236264
GO:0021766	hippocampus development	-	IEA	-
GO:0031100	animal organ regeneration	-	IEA	-
GO:0042742	defense response to bacterium	-	IDA	9497492
GO:0043086	negative regulation of catalytic activity	-	IEA	-
GO:0043312	neutrophil degranulation	-	IDA	9550422
GO:0045766	positive regulation of angiogenesis	-	IDA	16236264
GO:0051054	positive regulation of DNA metabolic process	-	IEA	-
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IDA	16236264
GO:0051384	response to glucocorticoid	-	IEA	-
GO:0070848	response to growth factor	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	17205602
GO:0005829	cytosol	-	IDA	-
GO:0005886	plasma membrane	-	IDA	7526843
GO:0016020	membrane	-	IDA	17205602
GO:0030424	axon	-	IEA	-
GO:0030425	dendrite	-	IEA	-
GO:0030670	phagocytic vesicle membrane	-	IDA	7526843
GO:0042581	specific granule	-	IDA	7526843
GO:0043025	neuronal cell body	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23577190	PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. (2013)	Suzuki T	PLoS One