Gene: HCRT

3060
NRCLP1|OX|PPOX
hypocretin neuropeptide precursor
protein-coding
17q21.2
Ensembl:ENSG00000161610 MIM:602358 Vega:OTTHUMG00000180107 UniprotKB:O43612
NG_011448.1
PubMed
0   ANCO-SNPs
CD|ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.394e-1 (AD)  5.170e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19057309chr17:40337590HCRTPromoter5.825e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTP0.98
LHX50.977
FOXB10.977
HMX20.969
C22orf420.964
SIM10.964
NTS0.962
FEZF10.95
HMX30.945
SIX60.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MGLL-0.379
LZTS1-0.357
RGS5-0.341
SHANK3-0.34
CYTH3-0.338
MLLT6-0.334
SLC17A7-0.334
KCNH3-0.331
MGAT5B-0.322
DDN-0.317

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03088Pidolic AcidSmall Molecule98-79-3Approved|Experimental|InvestigationalTarget
ID Drug Name Action PubMed
C4200621-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea"1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [HCRT protein results in increased expression of HCRTR1 mRNA]"22749989
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of HCRT mRNA"19114083
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of HCRT mRNA"23829299
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HCRT mRNA16483693
D001151ArsenicArsenic affects the expression of HCRT protein24675094
D001151ArsenicArsenic affects the methylation of HCRT gene25304211
D001280AtrazineAtrazine results in increased expression of HCRT mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HCRT mRNA21839799
D001640Bicuculline[HCRT protein modified form co-treated with Bicuculline] affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
D001640Bicuculline[HCRT protein modified form co-treated with Bicuculline] affects the susceptibility to lead nitrate23246865
D001640Bicuculline[HCRT protein modified form co-treated with lead nitrate co-treated with Bicuculline] results in increased expression of HCRTR1 mRNA23246865
D001640Bicucullinelead nitrate affects the susceptibility to [Bicuculline co-treated with HCRT protein modified form]23246865
C006780bisphenol Abisphenol A results in decreased expression of HCRT mRNA25181051
D002211CapsaicinCapsaicin results in increased expression of HCRT protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of HCRT protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of HCRT protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of HCRT protein]22150557
D003042CocaineCocaine affects the expression of HCRT mRNA18990547
D003042CocaineMethadone affects the reaction [Cocaine affects the expression of HCRT mRNA]18990547
D003471CuprizoneCuprizone results in increased expression of HCRT mRNA26577399
D003520CyclophosphamideCyclophosphamide affects the localization of HCRT protein17881193
D003520CyclophosphamideCyclophosphamide results in decreased expression of HCRT mRNA19666069
D013759DronabinolDronabinol results in decreased expression of HCRT mRNA24223797
D013759Dronabinol"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Dronabinol results in decreased expression of HCRT mRNA]"24223797
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HCRT mRNA17361019
D004041Dietary FatsDietary Fats results in increased expression of HCRT mRNA25016146
D004041Dietary FatsDietary Fats results in decreased expression of HCRT mRNA18721800
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HCRT mRNA15212814
C069837fullerene C60fullerene C60 results in increased expression of HCRT mRNA19167457
C524573JNJ 10397049JNJ 10397049 inhibits the reaction [HCRT protein results in increased expression of HCRTR2 mRNA]22749989
C017461lead nitrateHCRT protein modified form affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
C017461lead nitrateHCRT protein modified form affects the susceptibility to lead nitrate23246865
C017461lead nitrate[HCRT protein modified form co-treated with Bicuculline] affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
C017461lead nitrate[HCRT protein modified form co-treated with Bicuculline] affects the susceptibility to lead nitrate23246865
C017461lead nitrate[HCRT protein modified form co-treated with lead nitrate co-treated with Bicuculline] results in increased expression of HCRTR1 mRNA23246865
C017461lead nitrate[HCRT protein modified form co-treated with lead nitrate co-treated with Muscimol] results in increased expression of HCRTR1 mRNA23246865
C017461lead nitrate[HCRT protein modified form co-treated with lead nitrate] results in increased expression of HCRTR1 mRNA23246865
C017461lead nitrate[HCRT protein modified form co-treated with Muscimol] affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
C017461lead nitrate[HCRT protein modified form co-treated with Muscimol] affects the susceptibility to lead nitrate23246865
C017461lead nitratelead nitrate affects the activity of HCRT protein modified form23246865
C017461lead nitratelead nitrate affects the susceptibility to [Bicuculline co-treated with HCRT protein modified form]23246865
C017461lead nitratelead nitrate affects the susceptibility to [Muscimol co-treated with HCRT protein modified form]23246865
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of HCRT mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HCRT21874869
D008691MethadoneMethadone affects the reaction [Cocaine affects the expression of HCRT mRNA]18990547
D008694MethamphetamineMethamphetamine results in increased methylation of HCRT promoter26307267
D008694MethamphetamineMethamphetamine affects the expression of HCRT mRNA19564919
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of HCRT mRNA19564919
D008727MethotrexateMethotrexate results in decreased expression of HCRT mRNA17400583
D008727MethotrexateMethotrexate affects the expression of HCRT mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Dronabinol results in decreased expression of HCRT mRNA]"24223797
D009118Muscimol[HCRT protein modified form co-treated with lead nitrate co-treated with Muscimol] results in increased expression of HCRTR1 mRNA23246865
D009118Muscimol[HCRT protein modified form co-treated with Muscimol] affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
D009118Muscimol[HCRT protein modified form co-treated with Muscimol] affects the susceptibility to lead nitrate23246865
D009118Muscimollead nitrate affects the susceptibility to [Muscimol co-treated with HCRT protein modified form]23246865
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of HCRT protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of HCRT protein]22150557
D009569Nitric OxideHCRT results in increased abundance of Nitric Oxide18378017
C410127PCB 180PCB 180 results in increased expression of HCRT mRNA23829299
D015232DinoprostoneHCRT results in increased abundance of Dinoprostone18378017
D015232Dinoprostone[HCRT results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone18378017
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of HCRT mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of HCRT mRNA20813756
D011374ProgesteroneHCRT protein results in decreased secretion of Progesterone22749989
C030984pyrenepyrene results in decreased expression of HCRT mRNA23656968
C028815salmon calcitoninsalmon calcitonin results in decreased expression of HCRT mRNA12686383
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of HCRT mRNA19564919
C534628SCH 23390SCH 23390 results in decreased expression of HCRT mRNA19564919
D018038Sodium SeleniteSodium Selenite results in increased expression of HCRT mRNA18175754
D012999SomanSoman results in increased expression of HCRT mRNA19281266
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of HCRT protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of HCRT protein]22150557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HCRT mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of HCRT mRNA15977195

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005184neuropeptide hormone activity-IEA-  
GO:0031771type 1 hypocretin receptor binding-IEA-  
GO:0031772type 2 hypocretin receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001659temperature homeostasis-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0007218neuropeptide signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-TAS9419374  
GO:0008156negative regulation of DNA replication-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0042755eating behavior-IEA-  
GO:0043267negative regulation of potassium ion transport-IEA-  
GO:0046928regulation of neurotransmitter secretion-IEA-  
GO:0051928positive regulation of calcium ion transport-IEA-  
GO:0051970negative regulation of transmission of nerve impulse-IEA-  
GO:0051971positive regulation of transmission of nerve impulse-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005791rough endoplasmic reticulum-IEA-  
GO:0008021synaptic vesicle-TAS9419374  
GO:0030054cell junction-IEA-  
GO:0030141secretory granule-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0098794postsynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-389397Orexin and neuropeptides FF and QRFP bind to their respective receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26564129Smoking, Alcohol, Drug Use, Abuse and Dependence in Narcolepsy and Idiopathic Hypersomnia: A Case-Control Study. (2016 Mar 1)Barateau LSleep
11972464Emphysema in heavy smokers with normal chest radiography. Detection and quantification by HCRT. (2002 Jan)Sashidhar KActa Radiol
27567312Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-administration and Stress-Induced Reinstatement in Rats. (2017 Apr 1)Schmeichel BEBiol Psychiatry
19529922Hypocretin mechanisms in nicotine addiction: evidence and speculation. (2009 Sep)Corrigall WAPsychopharmacology (Berl)
20177882Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA. (2010 Apr)LeSage MGPsychopharmacology (Berl)
24407199Blockade of hypocretin receptor-1 preferentially prevents cocaine seeking: comparison with natural reward seeking. (2014 May 7)Martin-Fardon RNeuroreport
27540003Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2. (2016 Nov)Matzeu AJ Pharmacol Exp Ther