Gene: HCRTR1

3061
OX1R
hypocretin receptor 1
protein-coding
1p35.2
Ensembl:ENSG00000121764 MIM:602392 Vega:OTTHUMG00000003876 UniprotKB:O43613
NC_000001.11
PubMed
0   ANCO-SNPs
CD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.718e-1 (AD)  2.688e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADRA1D0.734
CRH0.696
KLHL140.694
FBLN70.685
FRMPD20.67
VWC20.669
OSTN0.658
SLC35G10.655
C8orf340.654
ELFN10.652

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.522
HVCN1-0.522
HEBP2-0.514
RARRES3-0.509
OTOS-0.504
TMEM176A-0.485
ITPKB-0.485
IFITM3-0.482
IFITM2-0.48
STON2-0.48

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09034SuvorexantSmall Molecule1030377-33-3Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4200621-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea"1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea binds to and results in decreased activity of HCRTR1 protein"11459658
C4200621-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea"1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea binds to and results in decreased activity of HCRTR1 protein"17638707|1973759
C4200621-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea"[1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea binds to and results in decreased activity of HCRTR1 protein] inhibits the reaction [Amphetamine results in increased secretion of Dopamine]"19737591
C4200621-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea"1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [HCRT protein results in increased expression of HCRTR1 mRNA]"22749989
C4200621-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea"1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea binds to and results in decreased activity of HCRTR1 protein"16357203|1965617
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HCRTR1 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HCRTR1 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HCRTR1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HCRTR1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HCRTR1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HCRTR1 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of HCRTR1 mRNA25088246
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of HCRTR1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HCRTR1 mRNA16483693
D000661Amphetamine"[1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea binds to and results in decreased activity of HCRTR1 protein] inhibits the reaction [Amphetamine results in increased secretion of Dopamine]"19737591
D001151ArsenicArsenic affects the methylation of HCRTR1 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of HCRTR1 mRNA15761015
D001640BicucullineBicuculline affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
D001640Bicuculline[Bicuculline co-treated with lead nitrate] affects the expression of HCRTR1 mRNA23246865
D001640Bicuculline[HCRT protein modified form co-treated with Bicuculline] affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
D001640Bicuculline[HCRT protein modified form co-treated with lead nitrate co-treated with Bicuculline] results in increased expression of HCRTR1 mRNA23246865
C006780bisphenol Abisphenol A results in increased methylation of HCRTR1 gene28505145
C062876cetrorelixcetrorelix results in decreased expression of HCRTR1 mRNA17638707
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HCRTR1 gene20938992
D003471CuprizoneCuprizone results in increased expression of HCRTR1 mRNA27523638
D004298Dopamine"[1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea binds to and results in decreased activity of HCRTR1 protein] inhibits the reaction [Amphetamine results in increased secretion of Dopamine]"19737591
D004317DoxorubicinDoxorubicin results in decreased expression of HCRTR1 mRNA16404146
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HCRTR1 gene20938992
D004397FonofosFonofos results in increased methylation of HCRTR1 promoter22847954
C017461lead nitrateBicuculline affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
C017461lead nitrate[Bicuculline co-treated with lead nitrate] affects the expression of HCRTR1 mRNA23246865
C017461lead nitrateHCRT protein modified form affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
C017461lead nitrate[HCRT protein modified form co-treated with Bicuculline] affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
C017461lead nitrate[HCRT protein modified form co-treated with lead nitrate co-treated with Bicuculline] results in increased expression of HCRTR1 mRNA23246865
C017461lead nitrate[HCRT protein modified form co-treated with lead nitrate co-treated with Muscimol] results in increased expression of HCRTR1 mRNA23246865
C017461lead nitrate[HCRT protein modified form co-treated with lead nitrate] results in increased expression of HCRTR1 mRNA23246865
C017461lead nitrate[HCRT protein modified form co-treated with Muscimol] affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
C017461lead nitratelead nitrate affects the expression of HCRTR1 mRNA23246865
C017461lead nitrateMuscimol affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
C017461lead nitrate[Muscimol co-treated with lead nitrate] affects the expression of HCRTR1 mRNA23246865
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HCRTR1 gene20938992
C048107milnacipranmilnacipran results in increased expression of HCRTR1 mRNA21157932
D009118Muscimol[HCRT protein modified form co-treated with lead nitrate co-treated with Muscimol] results in increased expression of HCRTR1 mRNA23246865
D009118Muscimol[HCRT protein modified form co-treated with Muscimol] affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
D009118MuscimolMuscimol affects the reaction [lead nitrate affects the expression of HCRTR1 mRNA]23246865
D009118Muscimol[Muscimol co-treated with lead nitrate] affects the expression of HCRTR1 mRNA23246865
D010278ParathionParathion results in increased methylation of HCRTR1 promoter22847954
D017374ParoxetineParoxetine results in increased expression of HCRTR1 mRNA21157932
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HCRTR1 mRNA"25510870
D010424PentobarbitalPentobarbital results in decreased expression of HCRTR1 mRNA17638707
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of HCRTR1 mRNA20136073
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HCRTR1 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of HCRTR1 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of HCRTR1 mRNA24780913
C012568terbufosterbufos results in increased methylation of HCRTR1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HCRTR1 mRNA21296121
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of HCRTR1 protein"25852303

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-TAS9491897  
GO:0016499orexin receptor activity-IDA26950369  
GO:0017046peptide hormone binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007218neuropeptide signaling pathway-IDA26950369  
GO:0007268chemical synaptic transmission-TAS9491897  
GO:0051480regulation of cytosolic calcium ion concentration-IDA26950369  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA26950369  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-389397Orexin and neuropeptides FF and QRFP bind to their respective receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20177882Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA. (2010 Apr)LeSage MGPsychopharmacology (Berl)
28667509Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic dopamine signaling. (2017 Sep)Levy KAPsychopharmacology (Berl)