Gene: HCRTR2

3062
OX2R
hypocretin receptor 2
protein-coding
6p12.1
Ensembl:ENSG00000137252 MIM:602393 Vega:OTTHUMG00000016150 UniprotKB:O43614
NG_012447.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.861e-1 (AD)  1.438e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XKR40.637
FLRT10.634
LRRTM30.634
ZDHHC230.63
KHDRBS20.626
TENM30.624
PTPRR0.623
SLC7A40.621
BMPER0.62
C22orf240.618

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NID1-0.477
RNF135-0.476
TNFRSF10D-0.467
CSAG1-0.451
SLC2A4-0.451
C1QTNF1-0.449
RAB13-0.449
IMPA2-0.449
IRAK3-0.444
TRIP10-0.443

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09034SuvorexantSmall Molecule1030377-33-3Approved|InvestigationalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HCRTR2 mRNA"19114083
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HCRTR2 mRNA19038236
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HCRTR2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HCRTR2 mRNA16483693
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of HCRTR2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of HCRTR2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of HCRTR2 mRNA25181051
C062876cetrorelixcetrorelix results in decreased expression of HCRTR2 mRNA17638707
D003042CocaineCocaine affects the expression of HCRTR2 protein17623047
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HCRTR2 mRNA21266533
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of HCRTR2 mRNA28871463
C039281furanfuran results in increased methylation of HCRTR2 gene22079235
C524573JNJ 10397049JNJ 10397049 binds to and results in decreased activity of HCRTR2 protein17638707
C524573JNJ 10397049JNJ 10397049 inhibits the reaction [HCRT protein results in increased expression of HCRTR2 mRNA]22749989
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to HCRTR2 promoter]20348232
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of HCRTR2 mRNA17475336
C048107milnacipranmilnacipran results in increased expression of HCRTR2 mRNA21157932
D017374ParoxetineParoxetine results in increased expression of HCRTR2 mRNA21157932
D010424PentobarbitalPentobarbital results in decreased expression of HCRTR2 mRNA17638707
D011441PropylthiouracilPropylthiouracil results in increased expression of HCRTR2 mRNA24780913
D013629TamoxifenTamoxifen results in decreased expression of HCRTR2 mRNA15590111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HCRTR2 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HCRTR2 mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of HCRTR2 mRNA15977195
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of HCRTR2 mRNA28973375
D044005TetrahydroisoquinolinesTetrahydroisoquinolines binds to and results in decreased activity of HCRTR2 protein19656173
D014635Valproic AcidValproic Acid results in increased expression of HCRTR2 mRNA24383497

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0008188neuropeptide receptor activity-TAS9491897  
GO:0016499orexin receptor activity-IBA21873635  
GO:0016499orexin receptor activity-IDA26950369  
GO:0017046peptide hormone binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0007218neuropeptide signaling pathway-IDA26950369  
GO:0007268chemical synaptic transmission-TAS9491897  
GO:0007631feeding behavior-IBA21873635  
GO:0010840regulation of circadian sleep/wake cycle, wakefulness-ISS-  
GO:0022410circadian sleep/wake cycle process-IEA-  
GO:0045187regulation of circadian sleep/wake cycle, sleep-IBA21873635  
GO:0051480regulation of cytosolic calcium ion concentration-IDA26950369  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA26950369  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-389397Orexin and neuropeptides FF and QRFP bind to their respective receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One
20177882Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA. (2010 Apr)LeSage MGPsychopharmacology (Berl)