| Probe | Locus(GRCh37) | Gene | Region | p-val | Trait | PubMed ID |
| cg08763102 | chr4:3079751 | HTT | 1.200e-18 | Smoking | 27651444 | |
| cg21121843 | chr4:3203982 | HTT | 1.200e-10 | Smoking | 27651444 | |
| cg15544235 | chr4:3080113 | HTT | 6.800e-8 | Smoking | 27651444 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| PI4KA | 0.966 |
| NEURL4 | 0.961 |
| ARHGEF11 | 0.96 |
| IQSEC2 | 0.958 |
| CAMTA2 | 0.957 |
| TAF6 | 0.956 |
| MTA3 | 0.953 |
| DENND1A | 0.951 |
| NISCH | 0.951 |
| BTBD9 | 0.95 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| OR4F5 | -0.556 |
| OR4F29 | -0.5 |
| TFPI2 | -0.454 |
| HEY2 | -0.44 |
| RAI14 | -0.439 |
| SNHG18 | -0.436 |
| SH2D1A | -0.435 |
| C9orf135 | -0.434 |
| MYL3 | -0.431 |
| SGMS2 | -0.422 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB09130 | Copper | Small Molecule | 7440-50-8 | Approved|Investigational | Target |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C016403 | 2,4-dinitrotoluene | "2,4-dinitrotoluene affects the expression of HTT mRNA" | 21346803 |
| C023514 | 2,6-dinitrotoluene | "2,6-dinitrotoluene affects the expression of HTT mRNA" | 21346803 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in decreased methylation of HTT gene | 27153756 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in increased expression of HTT mRNA | 19770486 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of HTT mRNA | 16483693 |
| D001280 | Atrazine | Atrazine results in decreased expression of HTT mRNA | 25929836 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of HTT mRNA | 26238291 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HTT mRNA" | 26238291 |
| D004958 | Estradiol | Estradiol affects the expression of HTT mRNA | 23557687 |
| C006780 | bisphenol A | bisphenol A affects the expression of HTT mRNA | 21786754 |
| C006780 | bisphenol A | bisphenol A results in increased expression of HTT mRNA | 29027980 |
| C006780 | bisphenol A | bisphenol A affects the expression of HTT mRNA | 21786754 |
| C006780 | bisphenol A | [bisphenol A co-treated with Genistein] results in increased methylation of HTT gene | 28505145 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of HTT mRNA | 25181051 |
| C006780 | bisphenol A | bisphenol A results in increased methylation of HTT gene | 28505145 |
| C000611646 | bisphenol F | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HTT mRNA | 28628672 |
| D002104 | Cadmium | HTT gene mutant form results in increased susceptibility to Cadmium | 19845833 |
| D002713 | Chlorine | [Ozone co-treated with Chlorine] affects the expression of HTT mRNA | 18636392 |
| D003300 | Copper | Copper promotes the reaction [HTT protein binds to HTT protein] | 17396163 |
| D003300 | Copper | HTT protein binds to and results in increased reduction of Copper | 17396163 |
| C017160 | cypermethrin | cypermethrin results in increased expression of HTT mRNA | 27704156 |
| D013759 | Dronabinol | Dronabinol results in decreased activity of HTT exon mutant form | 20929960 |
| C053562 | desflurane | desflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form] | 21059370 |
| D003907 | Dexamethasone | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HTT mRNA | 28628672 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of HTT mRNA | 27594783 |
| C000944 | dicrotophos | dicrotophos results in increased expression of HTT mRNA | 28302478 |
| C036042 | dicyclohexyl phthalate | dicyclohexyl phthalate results in decreased expression of HTT mRNA | 26924002 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of HTT mRNA | 25016146 |
| C024629 | dimethyl phthalate | dimethyl phthalate results in decreased expression of HTT mRNA | 26924002 |
| D004147 | Dioxins | Dioxins affects the expression of HTT mRNA | 20463971 |
| D004726 | Endosulfan | Endosulfan results in decreased expression of HTT mRNA | 26722802 |
| D004997 | Ethinyl Estradiol | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HTT mRNA | 17942748 |
| D005038 | Ethylnitrosourea | Ethylnitrosourea results in increased mutagenesis of HTT gene | 16495775 |
| D005419 | Flavonoids | Flavonoids results in increased expression of HTT mRNA | 18035473 |
| C030544 | formic acid | formic acid inhibits the reaction [HTT protein binds to HTT protein] | 11032734 |
| C001277 | geldanamycin | geldanamycin inhibits the reaction [HTT protein binds to HTT protein] | 11406612 |
| D019833 | Genistein | [bisphenol A co-treated with Genistein] results in increased methylation of HTT gene | 28505145 |
| D019271 | Hypoxanthine | [Hypoxanthine co-treated with HTT protein] results in increased abundance of Superoxides | 7491977 |
| D007213 | Indomethacin | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HTT mRNA | 28628672 |
| D007213 | Indomethacin | Indomethacin results in decreased expression of HTT mRNA | 28201806 |
| D007501 | Iron | HTT protein mutant form results in decreased uptake of Iron | 20547568 |
| D015056 | 1-Methyl-3-isobutylxanthine | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HTT mRNA | 28628672 |
| D007530 | Isoflurane | Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form] | 21059370 |
| D007530 | Isoflurane | xestospongin C inhibits the reaction [Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]] | 21059370 |
| C561695 | (+)-JQ1 compound | (+)-JQ1 compound results in increased expression of HTT mRNA | 24796395 |
| D007783 | Lactones | Lactones promotes the reaction [HTT protein binds to HTT protein] | 11032734 |
| D007854 | Lead | Lead results in decreased phosphorylation of HTT protein | 22345308 |
| D007854 | Lead | Lead results in increased expression of HTT protein | 22345308 |
| C008261 | lead acetate | lead acetate results in increased expression of HTT mRNA | 24260418 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides results in decreased expression of HTT mRNA | 12057914 |
| D008345 | Manganese | HTT gene mutant form results in decreased abundance of Manganese | 19845833 |
| D008345 | Manganese | HTT gene mutant form results in decreased susceptibility to Manganese | 19845833 |
| D008345 | Manganese | HTT protein mutant form inhibits the reaction [Manganese results in decreased expression of UBQLN1 protein] | 22191580 |
| D008345 | Manganese | HTT protein mutant form inhibits the reaction [Manganese results in increased expression of NEFL protein] | 22191580 |
| D008345 | Manganese | HTT protein mutant form results in decreased uptake of Manganese | 20547568 |
| D008345 | Manganese | Manganese inhibits the reaction [HTT protein mutant form affects the expression of SAE1 protein] | 22191580 |
| D008345 | Manganese | Manganese results in decreased phosphorylation of and results in increased expression of HTT protein | 25099302 |
| C025340 | manganese chloride | HTT affects the susceptibility to manganese chloride | 22363539 |
| D008911 | Minocycline | Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP1 protein] | 12930891 |
| D008911 | Minocycline | Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP3 protein] | 12930891 |
| D008911 | Minocycline | Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein] | 12930891 |
| D008911 | Minocycline | Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP9 protein] | 12930891 |
| D008911 | Minocycline | Minocycline inhibits the reaction [HTT protein mutant form results in increased cleavage of and results in increased activity of BID protein] | 12930891 |
| D008911 | Minocycline | Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of and results in increased localization of AIFM1 protein] | 12930891 |
| D008911 | Minocycline | Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of CYCS protein] | 12930891 |
| D008911 | Minocycline | Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein] | 12930891 |
| C517284 | monomethyl phthalate | monomethyl phthalate results in decreased expression of HTT mRNA | 26924002 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon analog results in increased expression of HTT mRNA" | 25554681 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon results in increased expression of HTT mRNA" | 25554681 |
| C028007 | nickel monoxide | nickel monoxide results in increased expression of HTT mRNA | 19167457 |
| D010126 | Ozone | [Ozone co-treated with Chlorine] affects the expression of HTT mRNA | 18636392 |
| D010269 | Paraquat | HTT protein affects the susceptibility to Paraquat | 24634145 |
| C006253 | pirinixic acid | pirinixic acid results in decreased expression of HTT mRNA | 20813756 |
| D011285 | Pregnenolone Carbonitrile | Pregnenolone Carbonitrile results in increased expression of HTT mRNA | 19162173 |
| C035988 | procymidone | procymidone results in decreased expression of HTT mRNA | 15686871 |
| C009250 | sevoflurane | sevoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form] | 21059370 |
| D012834 | Silver | Silver results in decreased expression of HTT mRNA | 26551752 |
| D012999 | Soman | Soman results in increased expression of HTT mRNA | 19281266 |
| D013481 | Superoxides | [Hypoxanthine co-treated with HTT protein] results in increased abundance of Superoxides | 7491977 |
| C020806 | tetrabromobisphenol A | tetrabromobisphenol A results in increased expression of HTT mRNA | 28970181 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of HTT mRNA | 21570461|2821309 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HTT mRNA | 17942748 |
| D013792 | Thalidomide | Thalidomide results in increased expression of HTT mRNA | 28892372 |
| D014050 | Toluene | HTT gene polymorphism affects the susceptibility to Toluene | 28013218 |
| C015559 | trimellitic anhydride | trimellitic anhydride results in increased expression of HTT mRNA | 19042947 |
| C016805 | tris(1,3-dichloro-2-propyl)phosphate | "tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HTT mRNA" | 26179874 |
| D014635 | Valproic Acid | Valproic Acid results in increased methylation of HTT gene | 29154799 |
| C025643 | vinclozolin | vinclozolin affects the expression of HTT mRNA | 19015723|2303416 |
| C025643 | vinclozolin | vinclozolin results in decreased expression of HTT mRNA | 15686871 |
| C511704 | xestospongin C | xestospongin C inhibits the reaction [Isoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form]] | 21059370 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0002039 | p53 binding | - | IPI | 10823891 |
| GO:0005515 | protein binding | - | IPI | 7477378 9285789 9668110 9798945 10823891 11137014 11988536 12873381 15383276 15603740 15654337 16115810 17161366 17500595 17548833 17947297 18192679 18615096 19240112 19498170 20417604 20515468 22119730 22835334 23275563 23303669 24705354 25686248 26198635 28445460 29466333 |
| GO:0005522 | profilin binding | - | IPI | 18573880 |
| GO:0019900 | kinase binding | - | IPI | 25686248 |
| GO:0031072 | heat shock protein binding | - | IPI | 21909508 |
| GO:0034452 | dynactin binding | - | IPI | 18922795 |
| GO:0042802 | identical protein binding | - | IPI | 19487684 22119730 23275563 25848931 |
| GO:0044325 | ion channel binding | - | IDA | 12873381 |
| GO:0045505 | dynein intermediate chain binding | - | IDA | 20515468 |
| GO:0048487 | beta-tubulin binding | - | IDA | 11870213 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0000132 | establishment of mitotic spindle orientation | - | IMP | 20696378 |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | - | IMP | 20515468 |
| GO:0006915 | apoptotic process | - | IEA | - |
| GO:0007030 | Golgi organization | - | IMP | 20515468 |
| GO:0031587 | positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | - | IDA | 12873381 |
| GO:0031648 | protein destabilization | - | IMP | 17947297 |
| GO:0042297 | vocal learning | - | IMP | 26436900 |
| GO:0043065 | positive regulation of apoptotic process | - | IDA | 17947297 |
| GO:0043666 | regulation of phosphoprotein phosphatase activity | - | IMP | 21562226 |
| GO:0045724 | positive regulation of cilium assembly | - | IMP | 21985783 |
| GO:0047496 | vesicle transport along microtubule | - | IMP | 20515468 |
| GO:1903599 | positive regulation of autophagy of mitochondrion | - | IMP | 25686248 |
| GO:1904504 | positive regulation of lipophagy | - | IMP | 25686248 |
| GO:1905289 | regulation of CAMKK-AMPK signaling cascade | - | IMP | 21768291 |
| GO:1905337 | positive regulation of aggrephagy | - | IMP | 25686248 |
| GO:2000479 | regulation of cAMP-dependent protein kinase activity | - | IMP | 21768291 |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | - | IMP | 19240112 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005634 | nucleus | - | IDA | 12783847 15654337 17704510 |
| GO:0005634 | nucleus | - | IMP | 17947297 |
| GO:0005654 | nucleoplasm | - | IDA | - |
| GO:0005737 | cytoplasm | - | IDA | 7748555 15064418 15654337 |
| GO:0005737 | cytoplasm | - | IMP | 17947297 |
| GO:0005770 | late endosome | - | IDA | 17704510 |
| GO:0005776 | autophagosome | - | IDA | 17704510 |
| GO:0005783 | endoplasmic reticulum | - | IDA | 17704510 |
| GO:0005794 | Golgi apparatus | - | IDA | 15837803 |
| GO:0005814 | centriole | - | IDA | 21985783 |
| GO:0005829 | cytosol | - | IDA | 20515468 |
| GO:0016234 | inclusion body | - | IMP | 17947297 |
| GO:0030424 | axon | - | IDA | 7748555 |
| GO:0030425 | dendrite | - | IDA | 7748555 |
| GO:0030659 | cytoplasmic vesicle membrane | - | IDA | 7748555 |
| GO:0032991 | protein-containing complex | - | IDA | 18922795 |
| GO:0032991 | protein-containing complex | - | IMP | 17947297 |
| GO:0048471 | perinuclear region of cytoplasm | - | IMP | 17947297 |
| GO:0048471 | perinuclear region of cytoplasm | - | ISS | - |
| KEGG ID | KEGG Term |
|---|---|
| hsa05016 | Huntington's disease |
| Reactome ID | Reactome Term | Evidence |
|---|
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