Gene: HDAC1

3065
GON-10|HD1|RPD3|RPD3L1
histone deacetylase 1
protein-coding
1p35.2-p35.1
Ensembl:ENSG00000116478 MIM:601241 Vega:OTTHUMG00000007529 UniprotKB:Q13547
NG_047018.1
PubMed
0   ANCO-SNPs
CD|ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.724e-1 (AD)  7.628e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTTG1IP0.906
NECAP20.902
SCAMP20.894
ARAF0.884
ATP6V0E10.877
SERPINB60.877
MAPRE10.872
NFE2L20.872
SZRD10.872
CTDSP10.87

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALHM1-0.546
ABCC12-0.534
KCNB2-0.531
PPEF1-0.528
FBLN7-0.521
GABRG3-0.518
SLC7A4-0.512
ADRA1D-0.51
KCNH5-0.506
KCNS2-0.506

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01169Arsenic trioxideSmall Molecule1327-53-3Approved|InvestigationalTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB02546VorinostatSmall Molecule149647-78-9Approved|InvestigationalTarget
DB05223PracinostatSmall MoleculeInvestigationalTarget
DB06176RomidepsinSmall Molecule128517-07-7Approved|InvestigationalTarget
DB08868FingolimodSmall Molecule162359-55-9Approved|InvestigationalTarget
DB11830MocetinostatSmall Molecule726169-73-9InvestigationalTarget
DB12565AbexinostatSmall Molecule783355-60-2InvestigationalTarget
DB05015BelinostatSmall Molecule866323-14-0Approved|InvestigationalTarget
DB06603PanobinostatSmall Molecule404950-80-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of HDAC1 mRNA"26377693
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC1 mRNA"21957481
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC1 mRNA]"24200994
C4539633-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide analog results in decreased activity of HDAC1 protein11960489
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in increased expression of HDAC1 mRNA21957481
C0757734-phenylbutyric acid[4-phenylbutyric acid affects the acetylation of HDAC1 protein] which affects the expression of TUBB3 protein18497984
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole affects the expression of HDAC1 mRNA"22745752
C5466076,2',4'-trimethoxyflavone"6,2',4'-trimethoxyflavone promotes the reaction [HDAC1 protein binds to IL6 promoter]"21104991
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of HDAC1 mRNA"19936915
D000082AcetaminophenAcetaminophen results in decreased expression of HDAC1 mRNA21420995
D020106AcrylamideAcrylamide affects the expression of HDAC1 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HDAC1 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of HDAC1 protein16483693
D000661AmphetamineHDAC1 gene mutant form promotes the reaction [Amphetamine results in increased expression of FOS mRNA]18632938
D000661AmphetamineAmphetamine promotes the reaction [HDAC1 protein binds to FOS promoter]18632938
C030419andrographolideandrographolide results in decreased expression of HDAC1 protein28651835
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HDAC1 mRNA24449571
C006632arsenic trioxidearsenic trioxide promotes the reaction [[TGIF1 protein co-treated with HDAC1 protein] binds to CDKN1A promoter]18210215
C006632arsenic trioxidearsenic trioxide promotes the reaction [[TGIF1 protein co-treated with HDAC1 protein] results in decreased expression of CDKN1A mRNA]18210215
C006632arsenic trioxide[arsenic trioxide results in increased phosphorylation of JUN protein] which binds to HDAC1 protein20074581
C006632arsenic trioxide[[arsenic trioxide results in increased phosphorylation of JUN protein] which binds to HDAC1 protein] which binds to CDKN1A promoter20074581
C006632arsenic trioxide[Valproic Acid co-treated with arsenic trioxide] results in decreased expression of HDAC1 mRNA25815518
D001241AspirinAspirin results in increased expression of HDAC1 mRNA15456535
D001542BenomylBenomyl results in decreased activity of HDAC1 protein25543211
C037689benzamidebenzamide analog results in decreased activity of HDAC1 protein19362838
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of HDAC1 mRNA16269432
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of HDAC1 protein19389873
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HDAC1 mRNA16269432
D001564Benzo(a)pyreneBenzo(a)pyrene inhibits the reaction [[DNMT1 protein binds to HDAC1 protein] which binds to CYP1A1 promoter]17682057
D001564Benzo(a)pyreneBenzo(a)pyrene inhibits the reaction [HDAC1 protein binds to CYP1A1 promoter]14625279
D001564Benzo(a)pyreneChromium inhibits the reaction [Benzo(a)pyrene inhibits the reaction [HDAC1 protein binds to CYP1A1 promoter]]14625279|1768205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HDAC1 protein26358852
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]17927689
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]17927689
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein]17927689
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Particulate Matter results in increased degradation of HDAC1 protein]17395887
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Vehicle Emissions results in increased degradation of HDAC1 protein]17395887
D004958EstradiolEstradiol inhibits the reaction [sodium arsenite results in increased expression of HDAC1 mRNA]22952798
D004958EstradiolEstradiol results in decreased expression of HDAC1 mRNA16029874|2337363
D004958EstradiolEstradiol results in increased expression of HDAC1 mRNA22952798
D004958Estradiolsodium arsenite inhibits the reaction [Estradiol results in increased expression of HDAC1 mRNA]22952798
D004958Estradiol[Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [HDAC1 protein binds to BRCA1 promoter]16489025
C006780bisphenol Abisphenol A affects the expression of HDAC1 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of HDAC1 promoter27334623
C006780bisphenol Abisphenol A affects the expression of HDAC1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of HDAC1 mRNA25181051|2689883
C006780bisphenol AHDAC1 mutant form inhibits the reaction [bisphenol A results in decreased expression of SLC12A5 mRNA]23440186
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of HDAC1 mRNA12419474
D002087ButyratesButyrates results in decreased activity of HDAC1 protein15930892
D002087ButyratesButyrates results in decreased activity of HDAC1 protein22338096
D020148Butyric AcidButyric Acid inhibits the reaction [HDAC1 protein binds to CYP1A1 enhancer]27830268
D020148Butyric Acid"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 mRNA]"24792773
D020148Butyric Acid"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 protein]"24792773
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HDAC1 mRNA23644582
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HDAC1 mRNA18804290
D002110CaffeineCaffeine results in increased expression of HDAC1 mRNA24717552
D002220CarbamazepineCarbamazepine affects the expression of HDAC1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HDAC1 mRNA27396813
C006963chlamydocinchlamydocin analog results in decreased activity of HDAC1 protein16439135
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of HDAC1 mRNA18804290
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HDAC1 gene20938992
D002857ChromiumChromium inhibits the reaction [Benzo(a)pyrene inhibits the reaction [HDAC1 protein binds to CYP1A1 promoter]]14625279|1768205
D002857ChromiumChromium promotes the reaction [[DNMT1 protein binds to HDAC1 protein] which binds to CYP1A1 promoter]17682057
D002857ChromiumChromium promotes the reaction [HDAC1 protein binds to CYP1A1 promoter]17682057
D002857ChromiumHDAC1 protein affects the reaction [Chromium results in decreased expression of CYP1A1 mRNA]17682057
C074702chromium hexavalent ionchromium hexavalent ion promotes the reaction [HDAC1 protein binds to CDH1 promoter]23518002
C019304ciprofibrateciprofibrate results in increased expression of HDAC1 mRNA12771043
C018021cobaltous chloridecobaltous chloride inhibits the reaction [HDAC1 protein binds to HIF1A promoter]19714248
C030973cupric oxidecupric oxide results in decreased phosphorylation of HDAC1 protein25470785
D003474Curcuminbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]17927689
D003474Curcuminbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]17927689
D003474Curcuminbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein]17927689
D003474CurcuminCurcumin affects the localization of HDAC1 protein17927689
D003474CurcuminCurcumin analog results in decreased expression of HDAC1 mRNA26409325
D003474CurcuminCurcumin results in decreased expression of HDAC1 mRNA17927689
D003474CurcuminCurcumin results in decreased expression of HDAC1 protein17927689|1816130
D016572CyclosporineCyclosporine results in decreased expression of HDAC1 mRNA20106945|2556210
C014347decitabinedecitabine inhibits the reaction [HDAC1 protein binds to ABCG2 promoter]16954373
C014347decitabinedecitabine inhibits the reaction [HDAC1 protein binds to BUB1B promoter]17464181
C014347decitabinedecitabine inhibits the reaction [HDAC1 protein binds to CDKN1A promoter]16043219
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of HDAC1 protein23352502
D003907DexamethasoneHDAC1 protein affects the reaction [Dexamethasone results in decreased expression of IGSF9 mRNA]27645313
D003907DexamethasoneHDAC1 protein affects the reaction [Dexamethasone results in decreased expression of MEX3A mRNA]27645313
D003907Dexamethasone[HDAC1 protein co-treated with HDAC2 protein] affects the reaction [Dexamethasone results in decreased expression of CDON mRNA]27645313
D003907Dexamethasone[HDAC1 protein co-treated with HDAC2 protein] affects the reaction [Dexamethasone results in decreased expression of IGSF9 mRNA]27645313
D003907Dexamethasone[HDAC1 protein co-treated with HDAC2 protein] affects the reaction [Dexamethasone results in decreased expression of MEX3A mRNA]27645313
D003907DexamethasoneHDAC1 protein inhibits the reaction [Dexamethasone results in increased expression of UCP3 mRNA]17884810
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HDAC1 mRNA17361019|2126653
D002945CisplatinCisplatin inhibits the reaction [[HDAC1 protein co-treated with TP63 protein modified form] binds to BBC3 promoter]21527555
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of HDAC1 mRNA26924002
D004052DiethylnitrosamineAHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of HDAC1 mRNA]19996281
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of HDAC1 mRNA19996281
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HDAC1 mRNA12771043
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 protein"21294050
D0151279,10-Dimethyl-1,2-benzanthracene"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 protein]"21294050
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 mRNA"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 protein"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 mRNA]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 protein]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 mRNA]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 protein]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 mRNA]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 protein]"24792773
C024629dimethyl phthalatedimethyl phthalate affects the expression of HDAC1 mRNA26924002
D004147DioxinsDioxins affects the expression of HDAC1 mRNA20463971
D004317DoxorubicinDoxorubicin promotes the reaction [HDAC1 protein binds to BIRC5 promoter]17124180
D004317DoxorubicinDoxorubicin results in increased expression of HDAC1 mRNA28865727
D004726EndosulfanEndosulfan results in increased expression of HDAC1 mRNA29054638
D004726EndosulfanEndosulfan results in increased expression of HDAC1 protein29054638
C031818enterotoxin B, staphylococcal"3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC1 mRNA]"24200994
C031818enterotoxin B, staphylococcal"enterotoxin B, staphylococcal results in increased expression of HDAC1 mRNA"24200994
C031818enterotoxin B, staphylococcal"indole-3-carbinol inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC1 mRNA]"24200994
C118739entinostatentinostat results in increased expression of HDAC1 mRNA27188386
C118739entinostatentinostat results in decreased activity of HDAC1 protein25699604
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HDAC1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HDAC1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDAC1 mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of HDAC121154115
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride metabolite binds to HDAC1 protein24859201
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein]24859201
D000068876Fingolimod HydrochlorideSPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]24859201
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride metabolite results in decreased activity of HDAC1 protein24859201
D000068876Fingolimod HydrochlorideS1PR1 protein inhibits the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]24859201
D000068876Fingolimod HydrochlorideS1PR1 protein modified form inhibits the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]24859201
D000068876Fingolimod Hydrochloridevorinostat inhibits the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]24859201
D005472FluorouracilFluorouracil inhibits the reaction [TCF7L2 protein binds to HDAC1 protein]25178657
D005472Fluorouracil[HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of MBP mRNA]]25178657
D005472Fluorouracil[HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of OLIG2 mRNA]]25178657
D005485FlutamideFlutamide results in decreased expression of HDAC1 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HDAC1 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of HDAC1 mRNA19167457
C039281furanfuran results in increased methylation of HDAC1 gene22079235
D019833GenisteinGenistein results in decreased expression of HDAC1 protein23593078
D005839GentamicinsGentamicins results in increased expression of HDAC1 protein19141081|2355823
D005839GentamicinsGentamicins results in increased expression of HDAC1 mRNA22061828
C055305ginsenoside Rh2ginsenoside Rh2 results in decreased expression of HDAC1 protein26482938
D005937Glucaric Acid"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 mRNA]"24792773
D005937Glucaric Acid"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 protein]"24792773
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of HDAC1 mRNA12419474
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of HDAC1 mRNA27655674
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of HDAC1 protein27655674
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [HDAC1 protein binds to CTCF promoter]24558376
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [[HDAC1 protein binds to CTCF promoter] which results in decreased expression of CTCF]24558376
C027185indirubinindirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]18344322
C027185indirubin[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]18344322
C027185indirubintetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]18344322
C016517indole-3-carbinol"indole-3-carbinol inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC1 mRNA]"24200994
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[HDAC1 mutant form co-treated with IL1B protein] results in increased expression of CXCL2 mRNA]25606026
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [HDAC1 mutant form results in increased expression of CXCL12 mRNA]25606026
C527895largazolelargazole results in decreased activity of HDAC1 protein21936551
D007854LeadLead affects the expression of HDAC1 mRNA28903495
D007854Lead[HDAC1 protein co-treated with HDAC2 protein] inhibits the reaction [Lead results in decreased expression of NOTCH2 protein]29301062
D007854LeadLead promotes the reaction [HDAC1 protein binds to HDAC2 protein]29301062
D001556LindaneLindane results in increased expression of HDAC1 mRNA18804290
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [HDAC1 protein binds to CCL20 promoter]26259605
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [HDAC1 protein binds to CYP1A1 promoter]26259605
D018021Lithium ChlorideLithium Chloride inhibits the reaction [HDAC1 protein binds to GCG promoter]19582394
D018021Lithium ChlorideLithium Chloride inhibits the reaction [HDAC1 protein binds to GIP promoter]19582394
D008148LovastatinLovastatin results in increased expression of HDAC1 mRNA20493250
D008345ManganeseManganese promotes the reaction [RELA protein binds to HDAC1 protein]24469401
D008345ManganeseManganese promotes the reaction [YY1 protein binds to HDAC1 protein]24469401
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HDAC1 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of HDAC1 mRNA24449571
C013598methoxyacetic acidmethoxyacetic acid results in decreased activity of HDAC1 protein15103026
D008748MethylcholanthreneMethylcholanthrene results in increased expression of HDAC1 mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HDAC1 mRNA20061341
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of HDAC1 mRNA27544571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of HDAC1 mRNA"20188158
C523184mocetinostatmocetinostat results in decreased expression of HDAC1 protein26378038
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of HDAC1 mRNA23891734
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of HDAC1 protein23891734
C406082monomethylarsonous acidvorinostat inhibits the reaction [monomethylarsonous acid results in increased expression of HDAC1 mRNA]23891734
C517284monomethyl phthalatemonomethyl phthalate affects the expression of HDAC1 mRNA26924002
C000621033napabucasinnapabucasin results in decreased expression of HDAC1 mRNA25605917
C028007nickel monoxidenickel monoxide results in decreased expression of HDAC1 mRNA19167457
D009538NicotineNicotine results in increased expression of HDAC1 mRNA24709674
C042670N-vinyl-2-pyrrolidinone[N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of HDAC1 mRNA22037397
C025589ochratoxin Aochratoxin A results in increased expression of HDAC1 mRNA29080797
C025589ochratoxin Aochratoxin A results in increased expression of HDAC1 protein29080797
C025589ochratoxin Apanobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]29080797
C025589ochratoxin Apanobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein]29080797
D009828Oleanolic AcidOleanolic Acid results in decreased expression of HDAC1 protein20726234
D010100OxygenOxygen deficiency results in increased expression of HDAC1 protein22711276
D010100OxygenValproic Acid inhibits the reaction [Oxygen deficiency results in increased expression of HDAC1 protein]22711276
D010100Oxygenvorinostat inhibits the reaction [Oxygen deficiency results in increased expression of HDAC1 protein]22711276
C496932panobinostatpanobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]29080797
C496932panobinostatpanobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein]29080797
C496932panobinostatpanobinostat results in decreased activity of HDAC1 protein21634430
D052638Particulate Matterbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Particulate Matter results in increased degradation of HDAC1 protein]17395887
D052638Particulate MatterHDAC1 protein inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein]17395887
D052638Particulate MatterParticulate Matter results in increased degradation of HDAC1 protein17395887
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of HDAC1 mRNA19095052
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of HDAC1 mRNA23948077
D010416PentachlorophenolPentachlorophenol results in increased expression of HDAC1 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HDAC1 mRNA18804290
D010654PhenylbutyratesPhenylbutyrates results in decreased activity of HDAC1 protein17341628
D010795Phthalic AcidsPhthalic Acids results in increased expression of HDAC1 mRNA21061450
D010867Pimelic AcidsPimelic Acids analog results in decreased activity of HDAC1 protein20098685
D010936Plant ExtractsPlant Extracts results in increased expression of HDAC1 protein18709356
C472086polyphenon Epolyphenon E results in decreased expression of HDAC1 protein23285096
C472086polyphenon ETP53 mutant form promotes the reaction [polyphenon E results in decreased expression of HDAC1 protein]23285096
D011189Potassium ChloridePotassium Chloride inhibits the reaction [HDAC1 protein binds to BDNF promoter]14593183
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione results in decreased expression of HDAC1 protein"23593078
D011374ProgesteroneProgesterone results in decreased expression of HDAC1 mRNA18037150
D011794Quercetin"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 protein]"21294050
C059514resveratrolHDAC1 protein promotes the reaction [resveratrol results in decreased expression of ZBTB7A mRNA]25875864
C059514resveratrolresveratrol inhibits the reaction [SP1 protein binds to HDAC1 protein]25875864
C059514resveratrolresveratrol promotes the reaction [HDAC1 protein binds to SP1 protein]25875864
C059514resveratrolresveratrol promotes the reaction [HDAC1 protein binds to ZBTB7A promoter]25875864
C059514resveratrolresveratrol results in decreased expression of HDAC1 protein23593078
C059514resveratrol[resveratrol results in decreased expression of MTA1 protein] inhibits the reaction [MTA1 protein binds to HDAC1 protein]19810103
C059514resveratrol[[resveratrol results in decreased expression of MTA1 protein] inhibits the reaction [MTA1 protein binds to HDAC1 protein]] which results in increased acetylation of and results in increased activity of TP53 protein19810103
C059514resveratrolresveratrol results in increased expression of HDAC1 mRNA22610192
C087123romidepsinromidepsin results in decreased activity of HDAC1 protein25699604
C557525SB939 compoundSB939 compound results in decreased activity of HDAC1 protein21634430
C009277sodium arsenatesodium arsenate results in increased expression of HDAC1 protein26193056
C017947sodium arseniteEstradiol inhibits the reaction [sodium arsenite results in increased expression of HDAC1 mRNA]22952798
C017947sodium arsenitesodium arsenite inhibits the reaction [Estradiol results in increased expression of HDAC1 mRNA]22952798
C017947sodium arsenitesodium arsenite results in increased expression of HDAC1 mRNA22952798
D012999SomanSoman results in increased expression of HDAC1 mRNA19281266
C025462sulindac sulfidesulindac sulfide results in decreased expression of HDAC1 mRNA16184548
D013629TamoxifenTamoxifen promotes the reaction [HDAC1 protein binds to FOXM1 promoter]20208560
C021751tanshinoneindirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]18344322
C021751tanshinone[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]18344322
C021751tanshinone[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]18344322
C021751tanshinonetetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]18344322
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of HDAC1 mRNA20189893
C534735tetraarsenic tetrasulfideindirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]18344322
C534735tetraarsenic tetrasulfide[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]18344322
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]18344322
D013749TetrachlorodibenzodioxinHDAC1 mutant form inhibits the reaction [[IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL6 mRNA]20511231
D013749Tetrachlorodibenzodioxin[IL1B protein co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [HDAC1 protein binds to IL6 promoter]20511231
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [HDAC1 protein binds to BRCA1 promoter]16489025
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [HDAC1 protein binds to BRCA1 promoter]16489025
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [HDAC1 protein binds to CYP1A1 promoter]17652329
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDAC1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HDAC1 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HDAC1 mRNA22493514
D013806TheophyllineTheophylline results in increased activity of HDAC1 protein12070353
D013806TheophyllineTheophylline results in increased expression of HDAC1 protein12070353|1533779
D013876ThiophenesThiophenes analog promotes the reaction [Tretinoin results in increased expression of HDAC1 mRNA]16140955
C067071trapoxin Btrapoxin B results in decreased activity of HDAC1 protein15930892
D014212TretinoinThiophenes analog promotes the reaction [Tretinoin results in increased expression of HDAC1 mRNA]16140955
D014212TretinoinTretinoin results in increased expression of HDAC1 mRNA16140955
C012589trichostatin Atrichostatin A results in decreased activity of HDAC1 protein15103026|1592795
C012589trichostatin Atrichostatin A results in decreased expression of HDAC1 protein23285096
C012589trichostatin Atrichostatin A results in decreased activity of HDAC1 protein25699604
C001899triptolidetriptolide results in increased expression of HDAC1 mRNA23639586
C000602704UF010 compoundUF010 compound results in decreased activity of HDAC1 protein25699604
D014635Valproic AcidValproic Acid affects the expression of HDAC1 mRNA25979313
D014635Valproic Acid[Valproic Acid co-treated with arsenic trioxide] results in decreased expression of HDAC1 mRNA25815518
D014635Valproic AcidValproic Acid results in decreased activity of HDAC1 protein15103026
D014635Valproic AcidValproic Acid results in increased expression of HDAC1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid inhibits the reaction [Oxygen deficiency results in increased expression of HDAC1 protein]22711276
D001335Vehicle Emissionsbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Vehicle Emissions results in increased degradation of HDAC1 protein]17395887
D001335Vehicle EmissionsHDAC1 protein inhibits the reaction [Vehicle Emissions results in increased expression of PTGS2 protein]17395887
D001335Vehicle EmissionsVehicle Emissions results in increased degradation of HDAC1 protein17395887
C025643vinclozolinvinclozolin results in decreased expression of HDAC1 mRNA18042343|2355583
D014750VincristineVincristine results in decreased expression of HDAC1 protein27474498
D009536Niacinamide"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 mRNA]"24792773
D009536Niacinamide"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of HDAC1 protein]"24792773
D014810Vitamin EVitamin E results in increased expression of HDAC1 mRNA19244175
C111237vorinostatvorinostat inhibits the reaction [monomethylarsonous acid results in increased expression of HDAC1 mRNA]23891734
C111237vorinostatvorinostat results in decreased activity of HDAC1 protein15930892
C111237vorinostatvorinostat inhibits the reaction [Oxygen deficiency results in increased expression of HDAC1 protein]22711276
C111237vorinostatvorinostat inhibits the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]24859201
C111237vorinostatvorinostat inhibits the reaction [HDAC1 protein binds to BMF promoter]25321483
C111237vorinostatvorinostat inhibits the reaction [HDAC1 protein binds to CDKN1A promoter]16043219
C111237vorinostatvorinostat inhibits the reaction [S1PR1 protein binds to HDAC1 protein]24859201
C111237vorinostatvorinostat results in decreased activity of HDAC1 protein17988634|2485920
D014859WarfarinWarfarin results in increased expression of HDAC1 mRNA20493250
C009684withaferin Awithaferin A results in decreased expression of HDAC1 protein23593078
C063449zileutonzileuton results in decreased expression of HDAC1 mRNA12883083
D015032ZincZinc binds to and results in increased activity of HDAC1 protein16439135

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-ISS-  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA bindingcontributes_toHDA16217013  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA18974119  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingcontributes_toHDA16217013  
GO:0001046core promoter sequence-specific DNA binding-IDA23629966  
GO:0001085RNA polymerase II transcription factor binding-IPI18936100  
GO:0001103RNA polymerase II repressing transcription factor binding-IPI22926524  
GO:0002039p53 binding-IPI23629966  
GO:0003700DNA-binding transcription factor activity-TAS8646880  
GO:0003714transcription corepressor activity-IDA15919722  
GO:0004407histone deacetylase activity-IDA16762839  
GO:0004407histone deacetylase activity-IMP17996965  19182791  
GO:0004407histone deacetylase activity-TAS12711221  
GO:0005515protein binding-IPI9150135  9468139  9468140  10220385  10228159  10779361  
10846170  10898795  11006275  11013263  11259576  11553631  
11559788  11641274  11739383  11863372  11931769  12176973  
12192000  12202768  12482978  12529400  12670868  12711603  
12730668  12847090  14752048  15016378  15140878  15273251  
15298701  15316101  15361834  15919722  15970276  16287849  
16291753  16306601  16511565  16540471  16766265  16919237  
16959611  16964284  17000776  17172643  17245431  17318229  
17636019  17704056  17872950  17895379  17939992  17956988  
17996965  18003922  18093978  18451879  18722353  18854353  
18936100  19049980  19081374  19182791  19343227  19497860  
19505873  19703393  20075864  20127688  20363964  20562920  
20693977  21030595  21258344  21549307  21983900  22113938  
22366686  22416134  22615382  22720776  23752268  24048479  
24514149  25123934  25241761  25314079  26028330  26496610  
26816381  27593931  27616479  27705803  28179136  28977666  
GO:0008134transcription factor binding-IPI15509593  16569215  18850004  18974119  
GO:0008134transcription factor binding-TAS12711221  
GO:0019213deacetylase activity-ISS-  
GO:0019899enzyme binding-IPI11062478  11136718  11641274  
GO:0031492nucleosomal DNA bindingcontributes_toHDA16217013  
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)-IEA-  
GO:0033558protein deacetylase activity-IDA17172643  23629966  
GO:0033558protein deacetylase activity-IMP19182791  
GO:0033613activating transcription factor binding-IPI20590529  
GO:0042826histone deacetylase binding-IPI12590135  28046085  
GO:0044212transcription regulatory region DNA binding-IDA16731528  
GO:0047485protein N-terminus binding-IDA17150957  
GO:0051059NF-kappaB binding-IPI17785205  
GO:0070491repressing transcription factor binding-IPI16731528  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA18854353  
GO:0000122negative regulation of transcription by RNA polymerase II-IGI18936100  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP18850004  
GO:0000122negative regulation of transcription by RNA polymerase II-TAS-  
GO:0006325chromatin organization-TAS12711221  
GO:0006338chromatin remodeling-IC16762839  17827154  
GO:0006346methylation-dependent chromatin silencing-IGI23770133  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006476protein deacetylation-IDA17172643  23629966  
GO:0007596blood coagulation-TAS-  
GO:0008284positive regulation of cell proliferation-IMP18347167  
GO:0009913epidermal cell differentiation-ISS-  
GO:0010629negative regulation of gene expression-IMP16581785  
GO:0010832negative regulation of myotube differentiationNOTIMP10983972  
GO:0010870positive regulation of receptor biosynthetic process-IMP18316616  
GO:0016032viral process-IEA-  
GO:0016575histone deacetylation-IMP19182791  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0042475odontogenesis of dentin-containing tooth-ISS-  
GO:0042733embryonic digit morphogenesis-ISS-  
GO:0043044ATP-dependent chromatin remodeling-HDA16217013  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0043922negative regulation by host of viral transcription-IMP16540471  
GO:0045652regulation of megakaryocyte differentiation-TAS-  
GO:0045892negative regulation of transcription, DNA-templated-IMP18247378  18974119  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA16762839  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16762839  
GO:0060766negative regulation of androgen receptor signaling pathway-IDA15919722  
GO:0060789hair follicle placode formation-ISS-  
GO:0061029eyelid development in camera-type eye-ISS-  
GO:0061198fungiform papilla formation-ISS-  
GO:0070932histone H3 deacetylation-IDA12590135  
GO:0070933histone H4 deacetylation-IDA12590135  
GO:0090090negative regulation of canonical Wnt signaling pathway-IGI18936100  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000118histone deacetylase complex-TAS12711221  
GO:0000785chromatin-IDA16731528  
GO:0000790nuclear chromatin-HDA16217013  
GO:0000790nuclear chromatin-IDA22926524  23629966  23770133  
GO:0005634nucleus-IDA10846170  18347167  18936100  
GO:0005654nucleoplasm-IDA22720776  22926524  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-TAS12711221  
GO:0005829cytosol-IDA18326024  
GO:0016580Sin3 complex-IDA17827154  
GO:0016581NuRD complex-IDA17827154  19644445  22926524  
GO:0032991protein-containing complex-HDA16217013  
GO:0032991protein-containing complex-IDA28046085  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04330Notch signaling pathway
hsa05016Huntington's disease
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1362277Transcription of E2F targets under negative control by DREAM complexIEA
R-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1IEA
R-HSA-1538133G0 and Early G1IEA
R-HSA-1538133G0 and Early G1TAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1640170Cell CycleIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-193670p75NTR negatively regulates cell cycle via SC1IEA
R-HSA-193704p75 NTR receptor-mediated signallingIEA
R-HSA-195253Degradation of beta-catenin by the destruction complexIEA
R-HSA-195253Degradation of beta-catenin by the destruction complexTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerTAS
R-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activityTAS
R-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionTAS
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3214815HDACs deacetylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-427389ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionIEA
R-HSA-427413NoRC negatively regulates rRNA expressionIEA
R-HSA-453279Mitotic G1-G1/S phasesIEA
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-4551638SUMOylation of chromatin organization proteinsTAS
R-HSA-4641265Repression of WNT target genesIEA
R-HSA-4641265Repression of WNT target genesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-5250913Positive epigenetic regulation of rRNA expressionIEA
R-HSA-5250941Negative epigenetic regulation of rRNA expressionIEA
R-HSA-539107Activation of E2F1 target genes at G1/SIEA
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6804758Regulation of TP53 Activity through AcetylationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-6807070PTEN RegulationTAS
R-HSA-69205G1/S-Specific TranscriptionIEA
R-HSA-69206G1/S TransitionIEA
R-HSA-69278Cell Cycle, MitoticIEA
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-73762RNA Polymerase I Transcription InitiationTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-73887Death Receptor SignallingIEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-9006925Intracellular signaling by second messengersIEA
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24762689[Protein expressions of HDAC1 and DNMT1 in non-small-cell lung cancer and its clinical significance]. (2014 Mar 4)Feng YZhonghua Yi Xue Za Zhi
23475113Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. (2013 Apr)Kennedy PJNat Neurosci
19596925O6-Methylguanine-DNA methyltransferase hypermethylation modulated by 17beta-estradiol in lung cancer cells. (2009 Jul)Lai JCAnticancer Res
24781734Social isolation-induced epigenetic changes in midbrain of adult mice. (2014 Apr)Siuda DJ Physiol Pharmacol
24789730Nicotine inhibits the proliferation by upregulation of nitric oxide and increased HDAC1 in mouse neural stem cells. (2014 Sep)Lee HIn Vitro Cell Dev Biol Anim
24551070Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling. (2014)Zou JYPLoS One
20337574The natural tumor suppressor protein maspin and potential application in non small cell lung cancer. (2010 Jun)Lonardo FCurr Pharm Des
27959513Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia. (2017 Mar 15)Schroeder FAACS Chem Neurosci
28798030Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons. (2017 Oct)Bohnsack JPJ Pharmacol Exp Ther