Gene info: ID 3066

Gene: HDAC2

GENE ID: 3066

Synonyms: HD2|RPD3|YAF1

Description: histone deacetylase 2

Gene type: protein-coding

Location: 6q21

dbXrefs: Ensembl:ENSG00000196591 MIM:605164 Vega:OTTHUMG00000015411 UniprotKB:Q92769

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 25

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.847e-1 (AD) 9.029e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CSE1L	0.925
AMD1	0.922
UBE2G1	0.913
PSMC6	0.913
COPS2	0.91
ZC3H15	0.909
RNF34	0.909
RUFY3	0.908
COPS3	0.907
TMEM181	0.907

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.611
OR4F29	-0.594
MTRNR2L10	-0.344
MTRNR2L6	-0.338
MTRNR2L9	-0.337
SLC2A4	-0.329
ASB4	-0.303
KCNK5	-0.297
P2RY14	-0.297
CSAG1	-0.295

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00227	Lovastatin	Small Molecule	75330-75-5	Approved\|Investigational	Target
DB00277	Theophylline	Small Molecule	58-55-9	Approved	Target
DB00313	Valproic Acid	Small Molecule	99-66-1	Approved\|Investigational	Target
DB01223	Aminophylline	Small Molecule	317-34-0	Approved	Target
DB01303	Oxtriphylline	Small Molecule	4499-40-5	Approved	Target
DB02546	Vorinostat	Small Molecule	149647-78-9	Approved\|Investigational	Target
DB05223	Pracinostat	Small Molecule		Investigational	Target
DB06176	Romidepsin	Small Molecule	128517-07-7	Approved\|Investigational	Target
DB09091	Tixocortol	Small Molecule	61951-99-3	Approved\|Withdrawn	Target
DB11830	Mocetinostat	Small Molecule	726169-73-9	Investigational	Target
DB05015	Belinostat	Small Molecule	866323-14-0	Approved\|Investigational	Target
DB06603	Panobinostat	Small Molecule	404950-80-7	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C097949	1,25-dihydroxyvitamin D	"1,25-dihydroxyvitamin D inhibits the reaction [HDAC2 protein binds to CDC25A enhancer]"	23112173
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of HDAC2 mRNA"	19162173
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC2 mRNA"	21957481
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of HDAC2 mRNA]"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of HDAC2 mRNA]"	19414516
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane results in decreased expression of HDAC2 protein"	22800507
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC2 mRNA]"	24200994
D000171	Acrolein	Acrolein binds to HDAC2 protein	26481333
D000242	Cyclic AMP	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of HDAC2 mRNA]"	19414516
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HDAC2 mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HDAC2 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in increased expression of HDAC2 protein	16483693
C006632	arsenic trioxide	arsenic trioxide affects the expression of HDAC2 mRNA	25574600
C006632	arsenic trioxide	arsenic trioxide results in increased methylation of HDAC2 promoter	26046465
C015001	arsenite	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of HDAC2 mRNA	15894712
C015001	arsenite	arsenite results in decreased expression of HDAC2 mRNA	15894712
D001564	Benzo(a)pyrene	[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of HDAC2 mRNA	15894712
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HDAC2 mRNA	15894712
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HDAC2 mRNA	22228805
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein]	18421014
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of HDAC2 protein	18421014
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	CAT protein inhibits the reaction [[SOD2 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of HDAC2 protein]	24973648
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	[SOD2 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of HDAC2 protein	24973648
D001599	Berberine	Berberine results in decreased expression of HDAC2 mRNA	27311644
D004958	Estradiol	Estradiol affects the expression of HDAC2 mRNA	22952798
D004958	Estradiol	Estradiol inhibits the reaction [sodium arsenite results in increased expression of HDAC2 mRNA]	22952798
C006780	bisphenol A	bisphenol A affects the methylation of HDAC2 promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of HDAC2 mRNA	28496034
C006780	bisphenol A	bisphenol A results in increased expression of HDAC2 protein	24333847\|2849603
C006780	bisphenol A	bisphenol A results in decreased expression of HDAC2 mRNA	25181051
C006780	bisphenol A	HDAC2 mutant form inhibits the reaction [bisphenol A results in decreased expression of SLC12A5 mRNA]	23440186
C013418	bromfenacoum	bromfenacoum results in increased expression of HDAC2 protein	28903499
C018475	butyraldehyde	butyraldehyde results in decreased expression of HDAC2 mRNA	26079696
D002087	Butyrates	Butyrates results in decreased activity of HDAC2 protein	22338096
C584509	C646 compound	C646 compound results in decreased activity of HDAC2 protein	26718586
D002110	Caffeine	Caffeine results in increased expression of HDAC2 mRNA	24717552
D002211	Capsaicin	Capsaicin results in increased expression of HDAC2 mRNA	16278290
D002251	Carbon Tetrachloride	Carbon Tetrachloride deficiency inhibits the reaction [Carbon Tetrachloride results in increased expression of HDAC2 mRNA]	27396813
D002251	Carbon Tetrachloride	Carbon Tetrachloride deficiency inhibits the reaction [Carbon Tetrachloride results in increased expression of HDAC2 protein]	27396813
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HDAC2 mRNA	27396813
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HDAC2 protein	27396813
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of HDAC2 mRNA	23650126
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HDAC2 gene	20938992
D003474	Curcumin	Curcumin analog results in decreased expression of HDAC2 mRNA	26409325
D003474	Curcumin	Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of HDAC2 protein]	18421014
D003474	Curcumin	Curcumin inhibits the reaction [Smoke results in decreased activity of HDAC2 protein]	18421014
D003474	Curcumin	Curcumin inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein]	18421014
D016572	Cyclosporine	Cyclosporine results in decreased expression of HDAC2 mRNA	19770486
C014347	decitabine	decitabine results in decreased expression of HDAC2 mRNA	17908484
C007262	deoxynivalenol	deoxynivalenol affects the phosphorylation of HDAC2 protein	23352502
D003907	Dexamethasone	[HDAC1 protein co-treated with HDAC2 protein] affects the reaction [Dexamethasone results in decreased expression of CDON mRNA]	27645313
D003907	Dexamethasone	[HDAC1 protein co-treated with HDAC2 protein] affects the reaction [Dexamethasone results in decreased expression of IGSF9 mRNA]	27645313
D003907	Dexamethasone	[HDAC1 protein co-treated with HDAC2 protein] affects the reaction [Dexamethasone results in decreased expression of MEX3A mRNA]	27645313
D003907	Dexamethasone	[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [TGFB1 protein results in increased expression of HDAC2 protein]	27396813
C000944	dicrotophos	dicrotophos results in decreased expression of HDAC2 mRNA	28302478
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HDAC2 protein	25280772
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of HDAC2 mRNA	24316720
D004237	Diuron	Diuron results in decreased expression of HDAC2 mRNA	21551480
D004317	Doxorubicin	Doxorubicin inhibits the reaction [HDAC2 protein binds to CCNE1 promoter]	25124555
D004317	Doxorubicin	Doxorubicin promotes the reaction [HDAC2 protein binds to TP73 promoter]	25124555
D004317	Doxorubicin	SETD7 protein promotes the reaction [Doxorubicin inhibits the reaction [HDAC2 protein binds to CCNE1 promoter]]	25124555
D004317	Doxorubicin	SETD7 protein promotes the reaction [Doxorubicin promotes the reaction [HDAC2 protein binds to TP73 promoter]]	25124555
C031818	enterotoxin B, staphylococcal	"3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC2 mRNA]"	24200994
C031818	enterotoxin B, staphylococcal	"enterotoxin B, staphylococcal results in increased expression of HDAC2 mRNA"	24200994
C031818	enterotoxin B, staphylococcal	"indole-3-carbinol inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC2 mRNA]"	24200994
C118739	entinostat	entinostat results in decreased activity of HDAC2 protein	25699604
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HDAC2 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of HDAC2 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HDAC2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDAC2 mRNA	17942748
D000068876	Fingolimod Hydrochloride	Fingolimod Hydrochloride metabolite results in decreased activity of HDAC2 protein	24859201
D005472	Fluorouracil	Fluorouracil inhibits the reaction [TCF7L2 protein binds to HDAC2 protein]	25178657
D005472	Fluorouracil	[HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of MBP mRNA]]	25178657
D005472	Fluorouracil	[HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of OLIG2 mRNA]]	25178657
D005473	Fluoxetine	Fluoxetine affects the reaction [sodium arsenate affects the expression of HDAC2 protein]	24952232
D005473	Fluoxetine	Fluoxetine results in increased expression of HDAC2 mRNA	16670375
D005473	Fluoxetine	Fluoxetine results in increased expression of HDAC2 protein	16670375
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HDAC2 gene	20938992
C069837	fullerene C60	fullerene C60 results in decreased expression of HDAC2 mRNA	19167457
C039281	furan	furan results in increased methylation of HDAC2 gene	22079235
C055305	ginsenoside Rh2	ginsenoside Rh2 results in decreased expression of HDAC2 protein	26482938
D005897	Glafenine	Glafenine results in decreased expression of HDAC2 mRNA	24136188
D006861	Hydrogen Peroxide	Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of HDAC2 protein]	18421014
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased activity of HDAC2 protein	18421014
D006877	Hydroxamic Acids	Hydroxamic Acids analog binds to and results in decreased activity of HDAC2 protein	19084294
D006918	Hydroxyurea	Hydroxyurea promotes the reaction [Valproic Acid results in decreased expression of HDAC2 protein]	17653085
C016517	indole-3-carbinol	"indole-3-carbinol inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC2 mRNA]"	24200994
D015056	1-Methyl-3-isobutylxanthine	[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [TGFB1 protein results in increased expression of HDAC2 protein]	27396813
C544151	jinfukang	jinfukang results in decreased expression of HDAC2 mRNA	27392435
D007854	Lead	Lead affects the expression of HDAC2 mRNA	28903495
D007854	Lead	EZH2 protein inhibits the reaction [Lead results in increased expression of HDAC2 mRNA]	29301062
D007854	Lead	EZH2 protein inhibits the reaction [Lead results in increased expression of HDAC2 protein]	29301062
D007854	Lead	[HDAC1 protein co-treated with HDAC2 protein] inhibits the reaction [Lead results in decreased expression of NOTCH2 protein]	29301062
D007854	Lead	Lead promotes the reaction [HDAC1 protein binds to HDAC2 protein]	29301062
D007854	Lead	Lead results in increased expression of HDAC2 mRNA	29301062
D007854	Lead	Lead results in increased expression of HDAC2 protein	29301062
D008466	Mechlorethamine	Mechlorethamine results in increased expression of HDAC2 protein	28184907
D008466	Mechlorethamine	Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of HDAC2 protein]	28184907
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HDAC2 gene	20938992
C013598	methoxyacetic acid	methoxyacetic acid results in decreased activity of HDAC2 protein	15103026
D015735	Mifepristone	Mifepristone results in increased expression of HDAC2 mRNA	17584828
C523184	mocetinostat	mocetinostat results in decreased expression of HDAC2 protein	26378038
C406082	monomethylarsonous acid	[vorinostat co-treated with monomethylarsonous acid] results in decreased expression of HDAC2 mRNA	23891734
C051752	nefazodone	nefazodone results in decreased expression of HDAC2 mRNA	24136188
C028007	nickel monoxide	nickel monoxide results in decreased expression of HDAC2 mRNA	19167457
C017557	nickel subsulfide	nickel subsulfide results in increased expression of HDAC2 mRNA	21086188
D009538	Nicotine	Nicotine results in increased expression of HDAC2 mRNA	24709674
D009538	Nicotine	Nicotine results in increased expression of HDAC2 mRNA	24709674
C012655	nimesulide	nimesulide results in decreased expression of HDAC2 mRNA	24136188
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HDAC2 protein	26879310
D010936	Plant Extracts	Plant Extracts results in increased expression of HDAC2 mRNA	23557933
C472086	polyphenon E	polyphenon E results in decreased expression of HDAC2 protein	23285096
C472086	polyphenon E	TP53 mutant form promotes the reaction [polyphenon E results in decreased expression of HDAC2 protein]	23285096
C059514	resveratrol	resveratrol results in increased metabolism of HDAC2 protein	23463510
C059514	resveratrol	resveratrol results in decreased expression of HDAC2 mRNA	25905778
C087123	romidepsin	romidepsin results in decreased activity of HDAC2 protein	25699604
D012906	Smoke	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein]	18421014
D012906	Smoke	Curcumin inhibits the reaction [Smoke results in decreased activity of HDAC2 protein]	18421014
D012906	Smoke	Curcumin inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein]	18421014
D012906	Smoke	Smoke results in decreased activity of HDAC2 protein	18421014
D012906	Smoke	Smoke results in increased degradation of and results in decreased expression of HDAC2 protein	18421014
C009277	sodium arsenate	Fluoxetine affects the reaction [sodium arsenate affects the expression of HDAC2 protein]	24952232
C009277	sodium arsenate	sodium arsenate affects the expression of HDAC2 protein	24952232
C009277	sodium arsenate	sodium arsenate results in decreased expression of HDAC2 mRNA	21795629
C009277	sodium arsenate	sodium arsenate results in increased expression of HDAC2 mRNA	21795629
C009277	sodium arsenate	sodium arsenate results in increased expression of HDAC2 protein	26193056
C017947	sodium arsenite	Estradiol inhibits the reaction [sodium arsenite results in increased expression of HDAC2 mRNA]	22952798
C017947	sodium arsenite	sodium arsenite results in increased expression of HDAC2 mRNA	22952798
C017947	sodium arsenite	sodium arsenite results in increased expression of HDAC2 mRNA	19822182
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in decreased expression of HDAC2 mRNA"	26680231
D013629	Tamoxifen	Tamoxifen promotes the reaction [HDAC2 protein binds to FOXM1 promoter]	20208560
D013629	Tamoxifen	Tamoxifen affects the expression of HDAC2 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HDAC2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDAC2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HDAC2 mRNA	19770486\|2405805
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HDAC2 mRNA	17942748
D013806	Theophylline	Theophylline results in increased expression of HDAC2 protein	15337792
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of HDAC2 mRNA	19969065
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution promotes the reaction [HDAC2 protein binds to ACTA2 promoter]	23967268
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution promotes the reaction [HDAC2 protein binds to MYH11 promoter]	23967268
C012589	trichostatin A	trichostatin A results in decreased activity of HDAC2 protein	15103026\|1842101
C012589	trichostatin A	trichostatin A results in decreased activity of HDAC2 protein	25699604
C000602704	UF010 compound	UF010 compound results in decreased activity of HDAC2 protein	25699604
C406224	valdecoxib	valdecoxib results in decreased expression of HDAC2 mRNA	24136188
D014635	Valproic Acid	Hydroxyurea promotes the reaction [Valproic Acid results in decreased expression of HDAC2 protein]	17653085
D014635	Valproic Acid	Valproic Acid results in decreased activity of HDAC2 protein	15103026
D014635	Valproic Acid	Valproic Acid results in decreased expression of HDAC2 mRNA	24200999
D014635	Valproic Acid	Valproic Acid results in decreased expression of HDAC2 protein	17653085\|2420099
D014635	Valproic Acid	Valproic Acid results in increased degradation of HDAC2 protein	16294345
D014635	Valproic Acid	Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of HDAC2 protein]	28184907
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of HDAC2 gene	25560391
D024483	Vitamin K 3	Vitamin K 3 affects the expression of HDAC2 mRNA	20044591
C111237	vorinostat	vorinostat binds to and results in decreased activity of HDAC2 protein	19084294
C111237	vorinostat	[vorinostat co-treated with monomethylarsonous acid] results in decreased expression of HDAC2 mRNA	23891734
C111237	vorinostat	vorinostat results in decreased expression of HDAC2 protein	18850582
C111237	vorinostat	vorinostat results in decreased activity of HDAC2 protein	17988634\|2485920

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	contributes_to	HDA	16217013
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	contributes_to	HDA	16217013
GO:0001103	RNA polymerase II repressing transcription factor binding	-	IPI	22926524
GO:0003682	chromatin binding	-	ISS	-
GO:0003723	RNA binding	-	HDA	22681889
GO:0004407	histone deacetylase activity	-	IDA	16642021
GO:0004407	histone deacetylase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	9150135 11062478 11259576 11641274 11739383 12140263 12176973 12670868 12711603 14752048 16254079 16464847 16595694 16919237 17245431 17314511 17318229 17827154 17956988 17984088 18451879 19182791 19343227 19497860 19505873 19703393 19805145 20195357 20398657 20651739 21258344 21549307 21914818 21965678 22416134 23752268 24970816 25150861 25241761 25314079 26028330 26496610
GO:0008134	transcription factor binding	-	IPI	17827154
GO:0019213	deacetylase activity	-	ISS	-
GO:0019899	enzyme binding	-	IPI	11062478 11641274
GO:0031072	heat shock protein binding	-	IEA	-
GO:0031492	nucleosomal DNA binding	contributes_to	HDA	16217013
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	-	IEA	-
GO:0033558	protein deacetylase activity	-	IMP	19041327
GO:0042826	histone deacetylase binding	-	IPI	28046085
GO:0043565	sequence-specific DNA binding	-	IDA	19276356
GO:0051059	NF-kappaB binding	-	IPI	17785205
GO:1990841	promoter-specific chromatin binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	19041327 19276356
GO:0001975	response to amphetamine	-	IEA	-
GO:0003300	cardiac muscle hypertrophy	-	IEA	-
GO:0006338	chromatin remodeling	-	IC	17827154
GO:0006344	maintenance of chromatin silencing	-	IMP	19372552
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007596	blood coagulation	-	TAS	-
GO:0008284	positive regulation of cell proliferation	-	IMP	18347167
GO:0009913	epidermal cell differentiation	-	ISS	21093383
GO:0010718	positive regulation of epithelial to mesenchymal transition	-	IEA	-
GO:0010870	positive regulation of receptor biosynthetic process	-	IMP	18316616
GO:0010977	negative regulation of neuron projection development	-	ISS	18754010
GO:0016358	dendrite development	-	ISS	-
GO:0016575	histone deacetylation	-	IMP	19372552
GO:0031000	response to caffeine	-	IEA	-
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0032732	positive regulation of interleukin-1 production	-	IEA	-
GO:0032760	positive regulation of tumor necrosis factor production	-	IEA	-
GO:0032922	circadian regulation of gene expression	-	ISS	-
GO:0032967	positive regulation of collagen biosynthetic process	-	IC	19041327
GO:0034605	cellular response to heat	-	IEA	-
GO:0035094	response to nicotine	-	IEA	-
GO:0042220	response to cocaine	-	IEA	-
GO:0042475	odontogenesis of dentin-containing tooth	-	ISS	21093383
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	-	IEA	-
GO:0042733	embryonic digit morphogenesis	-	ISS	21093383
GO:0043044	ATP-dependent chromatin remodeling	-	HDA	16217013
GO:0043066	negative regulation of apoptotic process	-	ISS	21093383
GO:0043392	negative regulation of DNA binding	-	IEA	-
GO:0043433	negative regulation of DNA-binding transcription factor activity	-	IMP	19041327
GO:0045347	negative regulation of MHC class II biosynthetic process	-	IC	19041327
GO:0045862	positive regulation of proteolysis	-	IMP	19041327
GO:0045892	negative regulation of transcription, DNA-templated	-	IC	19041327
GO:0045892	negative regulation of transcription, DNA-templated	-	IMP	19276356
GO:0045893	positive regulation of transcription, DNA-templated	-	IC	19041327
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	19041327 19372552
GO:0048149	behavioral response to ethanol	-	IEA	-
GO:0048714	positive regulation of oligodendrocyte differentiation	-	IEA	-
GO:0055093	response to hyperoxia	-	IEA	-
GO:0060789	hair follicle placode formation	-	ISS	21093383
GO:0061000	negative regulation of dendritic spine development	-	IEA	-
GO:0061029	eyelid development in camera-type eye	-	ISS	21093383
GO:0061198	fungiform papilla formation	-	ISS	21093383
GO:0070301	cellular response to hydrogen peroxide	-	IEA	-
GO:0070932	histone H3 deacetylation	-	ISS	-
GO:0070933	histone H4 deacetylation	-	ISS	-
GO:0071300	cellular response to retinoic acid	-	IEA	-
GO:0071560	cellular response to transforming growth factor beta stimulus	-	IEA	-
GO:1903351	cellular response to dopamine	-	IEA	-
GO:2000757	negative regulation of peptidyl-lysine acetylation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000790	nuclear chromatin	-	HDA	16217013
GO:0005634	nucleus	-	IDA	18347167 24970816
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IDA	24970816
GO:0005737	cytoplasm	-	TAS	12711221
GO:0016580	Sin3 complex	-	IDA	14966270 17827154
GO:0016581	NuRD complex	-	IDA	17827154 19644445 22926524
GO:0032991	protein-containing complex	-	HDA	16217013
GO:0032991	protein-containing complex	-	IDA	28046085
GO:0035098	ESC/E(Z) complex	-	IDA	20075857

KEGG ID	KEGG Term
hsa04110	Cell cycle
hsa04330	Notch signaling pathway
hsa05016	Huntington's disease
hsa05200	Pathways in cancer
hsa05220	Chronic myeloid leukemia

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-1257604	PIP3 activates AKT signaling	IEA
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-157118	Signaling by NOTCH	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-193670	p75NTR negatively regulates cell cycle via SC1	IEA
R-HSA-193704	p75 NTR receptor-mediated signalling	IEA
R-HSA-1980143	Signaling by NOTCH1	IEA
R-HSA-212165	Epigenetic regulation of gene expression	IEA
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	TAS
R-HSA-2644603	Signaling by NOTCH1 in Cancer	TAS
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	TAS
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	TAS
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	TAS
R-HSA-2990846	SUMOylation	TAS
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	TAS
R-HSA-3214815	HDACs deacetylate histones	TAS
R-HSA-3247509	Chromatin modifying enzymes	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	IEA
R-HSA-427413	NoRC negatively regulates rRNA expression	IEA
R-HSA-4551638	SUMOylation of chromatin organization proteins	TAS
R-HSA-4839726	Chromatin organization	TAS
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	IEA
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	IEA
R-HSA-5633007	Regulation of TP53 Activity	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6804758	Regulation of TP53 Activity through Acetylation	TAS
R-HSA-6807070	PTEN Regulation	IEA
R-HSA-6807070	PTEN Regulation	TAS
R-HSA-73762	RNA Polymerase I Transcription Initiation	TAS
R-HSA-73854	RNA Polymerase I Promoter Clearance	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73864	RNA Polymerase I Transcription	TAS
R-HSA-73887	Death Receptor Signalling	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-8943724	Regulation of PTEN gene transcription	IEA
R-HSA-8943724	Regulation of PTEN gene transcription	TAS
R-HSA-9006925	Intracellular signaling by second messengers	IEA
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16574938	The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease. (2006 Jul 1)	Szulakowski P	Am J Respir Crit Care Med
27266347	[Relationship between expression of HDAC2, IL-8, TNF-alpha in lung adenocarcinoma tissues and smoking]. (2016 May 17)	Yao LK	Zhonghua Yi Xue Za Zhi
23717666	Changes in airway histone deacetylase2 in smokers and COPD with inhaled corticosteroids: a randomized controlled trial. (2013)	Sohal SS	PLoS One
22196881	The effects of cigarette smoke on airway inflammation in asthma and COPD: therapeutic implications. (2012 Mar)	Tamimi A	Respir Med
17720468	Epigenetic regulation of airway inflammation. (2007 Dec)	Adcock IM	Curr Opin Immunol
29782855	Role of statins and mevalonate pathway on impaired HDAC2 activity induced by oxidative stress in human airway epithelial cells. (2018 May 18)	Matera MG	Eur J Pharmacol
21147623	Tiotropium increases cytosolic muscarinic M3 receptors and acetylated H3 histone proteins in induced sputum cells of COPD patients. (2010 Nov 4)	Holownia A	Eur J Med Res
15738302	Histone acetylation and deacetylation: importance in inflammatory lung diseases. (2005 Mar)	Barnes PJ	Eur Respir J
25511602	[Effects of smoking on expressions of HIF-1alpha and HDAC2 in asthmatic mice]. (2014 Sep 16)	Xu H	Zhonghua Yi Xue Za Zhi
25814047	Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. (2015 Oct)	Pandey SC	Neurobiol Dis
22005302	Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. (2011 Nov)	Malhotra D	J Clin Invest
24368768	Down-regulated peroxisome proliferator-activated receptor gamma (PPARgamma) in lung epithelial cells promotes a PPARgamma agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD). (2014 Mar 7)	Lakshmi SP	J Biol Chem
24528596	Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. (2014 Aug)	Sakharkar AJ	Int J Neuropsychopharmacol
21228544	Patterns of inflammatory responses in large and small airways in smokers with and without chronic obstructive pulmonary disease. (2011)	Isajevs S	Respiration
15001333	Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. (2004 Feb 28)	Barnes PJ	Lancet
27328977	A mucoactive drug carbocisteine ameliorates steroid resistance in rat COPD model. (2016 Aug)	Song Y	Pulm Pharmacol Ther
22978694	Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. (2013 May 20)	Sundar IK	Antioxid Redox Signal
24030221	Passive smoking impairs histone deacetylase-2 in children with severe asthma. (2014 Feb)	Kobayashi Y	Chest
28174112	Epigenetic basis of the dark side of alcohol addiction. (2017 Aug 1)	Pandey SC	Neuropharmacology
18234319	The role of histone deacetylases in asthma and allergic diseases. (2008 Mar)	Bhavsar P	J Allergy Clin Immunol
17147010	Histone deacetylation: an important mechanism in inflammatory lung diseases. (2005 Dec)	Adcock IM	COPD
27959513	Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia. (2017 Mar 15)	Schroeder FA	ACS Chem Neurosci
18421014	Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. (2008 Sep)	Meja KK	Am J Respir Cell Mol Biol
25191382	Epigenetics and chromatin remodeling play a role in lung disease. (2011)	Mortaz E	Tanaffos
29520058	Histone deacetylases mediate GABAA receptor expression, physiology, and behavioral maladaptations in rat models of alcohol dependence. (2018 Jun)	Bohnsack JP	Neuropsychopharmacology