Gene: ANXA4

307
ANX4|HEL-S-274|P32.5|PAP-II|PIG28|PP4-X|ZAP36
annexin A4
protein-coding
2p13.3
Ensembl:ENSG00000196975 MIM:106491 Vega:OTTHUMG00000129649 UniprotKB:P09525
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.249e-1 (AD)  6.010e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06635952chr2:70025869ANXA4Gene body5.683e-4Alcohol use disorders26763658
cg06635952chr2:70025869ANXA41.170e-8Maternal smoking in pregnancy27040690
cg06635952chr2:70025869ANXA41.350e-8Maternal smoking in pregnancy27040690
cg06635952chr2:70025869ANXA41.050e-9Maternal smoking in pregnancy27040690
cg06635952chr2:70025869ANXA47.600e-17Smoking27651444
cg06635952chr2:70025869ANXA41.260e-11Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNX60.874
VAMP30.871
FGF10.858
RDX0.857
NEK70.851
LRRCC10.849
PLA2G160.847
FCHSD20.841
KTN10.841
SOS20.84

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HCN4-0.506
KCNG1-0.497
OPRD1-0.468
CHRNA2-0.465
OR4F29-0.464
KCNK3-0.462
GPR26-0.452
CDH22-0.45
KCNK12-0.448
TCERG1L-0.445

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ANXA4 mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ANXA4 mRNA"25614096
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of ANXA4 mRNA"18343893
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ANXA4 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ANXA4 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ANXA4 mRNA"28973690
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ANXA4 mRNA"23994337
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ANXA4 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ANXA4 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ANXA4 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased expression of ANXA4 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of ANXA4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ANXA4 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of ANXA4 mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of ANXA4 mRNA"23195993
D000638AmiodaroneAmiodarone results in increased expression of ANXA4 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ANXA4 mRNA16483693
D001151ArsenicArsenic affects the methylation of ANXA4 gene25304211
C487081belinostatbelinostat results in decreased expression of ANXA4 mRNA27188386
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of ANXA4 mRNA23994337
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ANXA4 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANXA4 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ANXA4 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of ANXA4 mRNA25047013
C006780bisphenol Abisphenol A results in increased expression of ANXA4 mRNA25181051
D001761BleomycinBleomycin results in decreased expression of ANXA4 protein25933445
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ANXA4 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of ANXA4 mRNA26079696
D002166CamptothecinCamptothecin results in increased expression of ANXA4 mRNA17374387
D002220CarbamazepineCarbamazepine affects the expression of ANXA4 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ANXA4 mRNA15240111
D002273CarcinogensCarcinogens results in increased expression of ANXA4 mRNA16316942
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of ANXA4 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ANXA4 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in decreased expression of ANXA4 mRNA24386269
D003300CopperANXA4 protein binds to Copper14534351|1535973
D019327Copper SulfateCopper Sulfate results in decreased expression of ANXA4 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of ANXA4 mRNA19789285
D019327Copper SulfateCopper Sulfate results in decreased expression of ANXA4 mRNA19549813
C057862cyanoginosin LRcyanoginosin LR results in increased expression of ANXA4 protein19822598
C057862cyanoginosin LRcyanoginosin LR results in increased expression of ANXA4 mRNA17654400
D016572CyclosporineCyclosporine results in decreased expression of ANXA4 mRNA25562108|2798913
D003630DaunorubicinDaunorubicin results in increased expression of ANXA4 mRNA17374387
C526360dechlorane plusdechlorane plus results in decreased expression of ANXA4 protein24463492
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of ANXA4 mRNA17330099
D003907DexamethasoneDexamethasone results in increased expression of ANXA4 mRNA25047013
D003907DexamethasoneDexamethasone results in increased expression of ANXA4 mRNA22733784
D016190CarboplatinANXA4 protein results in decreased susceptibility to Carboplatin24150977
D016190CarboplatinATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Carboplatin]24150977
D016190CarboplatinCarboplatin affects the localization of ANXA4 protein24150977
D002945CisplatinATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Cisplatin]24150977
D002945CisplatinCisplatin affects the localization of ANXA4 protein24150977
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ANXA4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ANXA4 mRNA27392435
D002945CisplatinANXA4 results in decreased susceptibility to Cisplatin21636539
C000944dicrotophosdicrotophos results in decreased expression of ANXA4 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of ANXA4 mRNA18042831
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of ANXA4 mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ANXA4 mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ANXA4 mRNA25380136
D004237DiuronDiuron results in decreased expression of ANXA4 mRNA21551480
C118739entinostatentinostat results in increased expression of ANXA4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ANXA4 protein20227414
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ANXA4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ANXA4 mRNA17557909
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ANXA4 mRNA23649840
D005047EtoposideEtoposide results in increased expression of ANXA4 mRNA17374387
D005419FlavonoidsFlavonoids results in decreased expression of ANXA4 mRNA18035473
D016650Fluorescein-5-isothiocyanateFluorescein-5-isothiocyanate binds to ANXA4 protein27129696
D005472FluorouracilFluorouracil results in decreased expression of ANXA4 mRNA15109396
D005485FlutamideFlutamide results in decreased expression of ANXA4 mRNA24793618
D005557FormaldehydeFormaldehyde results in increased expression of ANXA4 mRNA23649840
C039281furanfuran results in increased expression of ANXA4 mRNA26194646
D005839GentamicinsGentamicins results in decreased expression of ANXA4 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of ANXA4 mRNA24136188
C010176halofuginonehalofuginone results in increased expression of ANXA4 mRNA17180598
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ANXA4 protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ANXA4 mRNA20044591
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ANXA4 protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ANXA4 protein23178681
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANXA4 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ANXA4 mRNA27392435
C410337K 7174K 7174 results in decreased expression of ANXA4 mRNA24086573
D007649KetamineKetamine results in increased expression of ANXA4 mRNA20080153
D007854LeadLead results in decreased expression of ANXA4 mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ANXA4 mRNA"11578593
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of ANXA4 mRNA26667767
D008070LipopolysaccharidesLipopolysaccharides results in decreased methylation of ANXA4 gene21212295
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ANXA4 mRNA25613284
D008094LithiumLithium results in increased expression of ANXA4 protein18296634
D008095Lithocholic AcidLithocholic Acid results in increased expression of ANXA4 mRNA20359477
D008095Lithocholic AcidPregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA4 mRNA]20359477
D008148LovastatinLovastatin results in decreased expression of ANXA4 mRNA20493250
C005095malachite greenmalachite green results in decreased expression of ANXA4 protein22446826
C042720mercuric bromidemercuric bromide results in increased expression of ANXA4 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of ANXA4 mRNA20353558
D008627Mercuric ChlorideMercuric Chloride affects the expression of ANXA4 protein21458406
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ANXA4 mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ANXA4 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ANXA4 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ANXA4 protein26558463
D015741MetriboloneMetribolone results in increased expression of ANXA4 protein17152098
C523799MRK 003MRK 003 results in decreased expression of ANXA4 mRNA21169257
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ANXA4 mRNA25380136
D009532NickelNickel results in decreased expression of ANXA4 mRNA23195993
C012655nimesulidenimesulide results in increased expression of ANXA4 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of ANXA4 mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of ANXA4 protein19716841
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ANXA4 mRNA25729387
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of ANXA4 mRNA18636392
D017239PaclitaxelANXA4 results in decreased susceptibility to Paclitaxel21636539
D000073878Palm OilPalm Oil results in decreased expression of ANXA4 mRNA18042831
D010396PenicillaminePenicillamine results in decreased expression of ANXA4 mRNA19575532
D010396PenicillaminePenicillamine results in increased expression of ANXA4 mRNA19575532
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ANXA4 protein19474218
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ANXA4 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ANXA4 protein26879310
D010634PhenobarbitalPhenobarbital results in decreased methylation of ANXA4 gene19233941
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ANXA4 mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of ANXA4 mRNA14741686
D010936Plant ExtractsPlant Extracts results in increased expression of ANXA4 mRNA23557933
D010984PlatinumANXA4 protein results in decreased abundance of Platinum24150977
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA4 mRNA]20359477
C045362prochlorazprochloraz results in decreased expression of ANXA4 mRNA21470553
D011441PropylthiouracilPropylthiouracil affects the expression of ANXA4 mRNA24780913
D015237DinoprostDinoprost results in increased expression of ANXA4 mRNA11517196
D011794QuercetinQuercetin results in increased expression of ANXA4 protein14750173
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of ANXA4 mRNA26667767
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ANXA4 mRNA25895662
D012834SilverSilver results in increased expression of ANXA4 mRNA27131904
D012999SomanSoman results in increased expression of ANXA4 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ANXA4 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ANXA4 mRNA18343893|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ANXA4 mRNA23994337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ANXA4 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANXA4 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of ANXA4 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ANXA4 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ANXA4 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ANXA4 mRNA21934132
C011559tributyltintributyltin results in increased expression of ANXA4 mRNA21683754
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ANXA4 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ANXA4 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of ANXA4 mRNA17127020
D014520UrethaneUrethane results in decreased expression of ANXA4 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA4 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ANXA4 mRNA28001369|2915479
D014635Valproic AcidValproic Acid results in increased expression of ANXA4 mRNA23179753|2352703
C025643vinclozolinvinclozolin affects the expression of ANXA4 mRNA19015723
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of ANXA4 mRNA17330099
D014859WarfarinWarfarin results in decreased expression of ANXA4 mRNA20493250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004859phospholipase inhibitor activity-NAS2970257  
GO:0005509calcium ion binding-IDA20237821  
GO:0005515protein binding-IPI21044950  
GO:0005544calcium-dependent phospholipid binding-IDA2138016  
GO:0005544calcium-dependent phospholipid binding-NAS2970257  
GO:0042802identical protein binding-IPI16687573  
GO:0048306calcium-dependent protein binding-IPI15226301  20237821  
GO:0051059NF-kappaB binding-IPI20237821  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IDA20237821  
GO:0007165signal transduction-TAS16130169  
GO:0007219Notch signaling pathway-IEA-  
GO:0030855epithelial cell differentiation-IEP21492153  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IDA20237821  
GO:0043066negative regulation of apoptotic process-TAS16130169  
GO:0043086negative regulation of catalytic activity-IEA-  
GO:2000483negative regulation of interleukin-8 secretion-IMP22056994  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16687573  20237821  
GO:0005737cytoplasm-IDA20237821  
GO:0005737cytoplasm-TAS16130169  
GO:0005886plasma membrane-IDA16687573  
GO:0009986cell surface-IDA22056994  
GO:0012506vesicle membrane-IDA16687573  
GO:0031965nuclear membrane-IDA16687573  
GO:0048471perinuclear region of cytoplasm-IDA16687573  
GO:0070062extracellular exosome-HDA19056867  19199708  20458337  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22847161Potential association between ANXA4 polymorphisms and aspirin-exacerbated respiratory disease. (2012 Sep)Park TJDiagn Mol Pathol