Gene: HELLS

3070
ICF4|LSH|Nbla10143|PASG|SMARCA6
helicase, lymphoid specific
protein-coding
10q23.33
Ensembl:ENSG00000119969 MIM:603946 Vega:OTTHUMG00000018793 UniprotKB:Q9NRZ9
NG_047057.1
PubMed
0   ANCO-SNPs
ND
2   
7.734e-1 (AD)  4.421e-1 (ND)   (Frontal_Cortex)
4.511e-1 (AD)  6.933e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC660.771
ZNF3330.767
TUBE10.758
RAPGEF60.754
CCDC140.753
ZNF5660.752
GOLGA8A0.75
NFE2L30.75
ZNF5290.745
RLF0.744

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLA2G5-0.379
WNT7B-0.316
TNNT1-0.31
HPR-0.3
S100A1-0.3
NWD1-0.291
FOLR1-0.287
BTBD17-0.286
ENHO-0.285
ADAMTSL5-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HELLS mRNA"28903501
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of HELLS mRNA"22101062
C0252231,4-dioxane"1,4-dioxane results in increased expression of HELLS protein"20025956
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of HELLS mRNA"19167446
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of HELLS mRNA"23829299
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HELLS mRNA"25380136
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of HELLS mRNA19191707
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of HELLS mRNA"19936915
D000082AcetaminophenAcetaminophen results in increased expression of HELLS mRNA22230336
D000082AcetaminophenAcetaminophen results in increased expression of HELLS protein20025956
D020106AcrylamideAcrylamide results in increased expression of HELLS protein20025956
D020106AcrylamideAcrylamide results in increased expression of HELLS mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HELLS protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HELLS mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HELLS mRNA19770486
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of HELLS mRNA"22863853
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HELLS mRNA26424790
D001379AzathioprineAzathioprine results in decreased expression of HELLS mRNA22623647
C447119bazedoxifenebazedoxifene results in decreased expression of HELLS mRNA19914376
D001507BeclomethasoneBeclomethasone results in decreased expression of HELLS mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HELLS mRNA20504355
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HELLS mRNA"20018196|2038263
D004958EstradiolEstradiol results in increased expression of HELLS mRNA19167446
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of HELLS mRNA]25210133
D004958EstradiolEstradiol results in increased expression of HELLS mRNA25210133
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HELLS mRNA26424790
C006780bisphenol Abisphenol A affects the expression of HELLS mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of HELLS mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of HELLS mRNA25181051
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of HELLS mRNA19000923
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of HELLS mRNA19000923
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HELLS mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of HELLS promoter22457795
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA]"20230807
D002110CaffeineCaffeine results in increased expression of HELLS protein20025956
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of HELLS mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HELLS mRNA27339419
D002509CephaloridineCephaloridine results in increased expression of HELLS mRNA18500788
D004390ChlorpyrifosChlorpyrifos results in decreased expression of HELLS mRNA20350560
D019826Cholic AcidCholic Acid results in increased expression of HELLS protein20025956
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of HELLS mRNA28472532
D002994ClofibrateClofibrate results in increased expression of HELLS protein20025956
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of HELLS mRNA20971185
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of HELLS mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of HELLS mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of HELLS mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of HELLS mRNA20106945|2214713
D000069439DasatinibDasatinib results in decreased expression of HELLS mRNA20579391
D003703DemecolcineDemecolcine results in decreased expression of HELLS mRNA23649840
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HELLS mRNA26424790
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HELLS mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of HELLS mRNA27594783
D002945CisplatinCisplatin results in increased expression of HELLS mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of HELLS mRNA28302478
D004026DieldrinDieldrin results in decreased expression of HELLS mRNA28385952
D000875AnthralinAnthralin results in increased expression of HELLS protein20025956
D002117CalcitriolCalcitriol results in decreased expression of HELLS mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of HELLS mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of HELLS protein"20025956
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of HELLS mRNA25380136
D004147DioxinsDioxins affects the expression of HELLS mRNA20463971
D004221DisulfiramDisulfiram results in decreased expression of HELLS mRNA20530235
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HELLS mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HELLS mRNA17942748
C024555ferric chlorideferric chloride results in increased expression of HELLS protein20025956
C029451ferrous chlorideferrous chloride results in increased expression of HELLS protein20025956
D005480FlurbiprofenFlurbiprofen results in increased expression of HELLS mRNA16949054
D005485FlutamideFlutamide results in decreased expression of HELLS mRNA21126777
D005557FormaldehydeFormaldehyde results in increased expression of HELLS mRNA23649840
D005897GlafenineGlafenine results in decreased expression of HELLS mRNA24136188
C492448ICG 001ICG 001 results in decreased expression of HELLS mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of HELLS mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of HELLS mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of HELLS mRNA18927307
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of HELLS mRNA24435446
C410337K 7174K 7174 results in decreased expression of HELLS mRNA24086573
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HELLS mRNA21641980
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HELLS mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HELLS mRNA23649840
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA]"20230807
C011309mezereinmezerein results in increased expression of HELLS mRNA19000923
C059539midostaurinmidostaurin results in decreased expression of HELLS mRNA20980353
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HELLS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HELLS mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of HELLS mRNA25380136
D009532NickelNickel results in increased expression of HELLS mRNA25583101
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA"20230807
D009538Nicotine"Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA]"20230807
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of HELLS mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of HELLS mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of HELLS mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of HELLS mRNA26516004
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of HELLS mRNA25658374
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of HELLS mRNA]19555225
C010272palytoxinpalytoxin results in increased expression of HELLS protein20025956
D010416PentachlorophenolPentachlorophenol results in decreased expression of HELLS mRNA24642059
D010416PentachlorophenolPentachlorophenol results in increased expression of HELLS mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HELLS protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HELLS protein20025956
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of HELLS mRNA26678675
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of HELLS mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of HELLS mRNA19136022
D010634PhenobarbitalPhenobarbital results in increased expression of HELLS mRNA19482888|2309116
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HELLS mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of HELLS mRNA19136022
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of HELLS mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of HELLS mRNA20813756
D011374ProgesteroneProgesterone results in decreased expression of HELLS mRNA21795739
D011374ProgesteroneProgesterone results in decreased expression of HELLS mRNA16966611|2223828
D011441PropylthiouracilPropylthiouracil results in increased expression of HELLS mRNA24780913
D011794QuercetinQuercetin affects the expression of HELLS mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of HELLS mRNA19167446
C059514resveratrolresveratrol results in decreased expression of HELLS mRNA15767336
C059514resveratrolresveratrol results in decreased expression of HELLS mRNA25905778
D012439SaccharinSaccharin results in increased expression of HELLS mRNA19000923
D012906SmokeSmoke results in decreased expression of HELLS mRNA21095227
D012977Sodium NitriteSodium Nitrite results in increased expression of HELLS protein20025956
D053260SootSoot results in increased expression of HELLS mRNA26551751
C013690styrene oxidestyrene oxide results in increased expression of HELLS protein20025956
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HELLS mRNA21641980
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of HELLS mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of HELLS mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HELLS mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HELLS mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HELLS mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HELLS mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HELLS mRNA21215274
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of HELLS mRNA19000923
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of HELLS mRNA25613284
D013849ThimerosalThimerosal results in increased expression of HELLS mRNA27188386
D013893ThiramThiram results in decreased expression of HELLS mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of HELLS mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of HELLS mRNA25729387
D019772TopotecanTopotecan results in decreased expression of HELLS mRNA25729387
D014212TretinoinTretinoin results in increased expression of HELLS protein20025956
D014241TrichloroethyleneTrichloroethylene results in increased methylation of HELLS gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of HELLS mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HELLS mRNA"26179874
D014520UrethaneUrethane results in decreased expression of HELLS mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of HELLS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HELLS mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of HELLS mRNA23179753|2915479
D014638VanadatesVanadates results in increased expression of HELLS mRNA19000923
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HELLS gene25560391
C025643vinclozolinvinclozolin results in increased expression of HELLS mRNA23555832
D014750VincristineVincristine results in decreased expression of HELLS mRNA23649840
C111237vorinostatvorinostat results in increased expression of HELLS mRNA27188386
C016837zinc chloridezinc chloride results in increased expression of HELLS mRNA19000923

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004386helicase activity-IEA-  
GO:0005515protein binding-IPI17314511  17353931  22157815  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006346methylation-dependent chromatin silencing-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007049cell cycle-IEA-  
GO:0007275multicellular organism development-ISS-  
GO:0010216maintenance of DNA methylation-ISS-  
GO:0031508pericentric heterochromatin assembly-ISS-  
GO:0046651lymphocyte proliferation-ISS-  
GO:0051301cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000775chromosome, centromeric region-ISS-  
GO:0005634nucleus-IEA-  
GO:0005721pericentric heterochromatin-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19287496FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. (2009)Gemenetzidis EPLoS One
22109759Linking expression of FOXM1, CEP55 and HELLS to tumorigenesis in oropharyngeal squamous cell carcinoma. (2011 Dec)Janus JRLaryngoscope