Gene: HEXA

3073
TSD
hexosaminidase subunit alpha
protein-coding
15q23
Ensembl:ENSG00000213614 MIM:606869 Vega:OTTHUMG00000133445 UniprotKB:P06865
NG_009017.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.551e-1 (AD)  9.414e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFATC2IP0.881
NUP1330.87
GPR1070.867
TMED40.867
C6orf890.865
MRPS160.864
RPA10.861
SLC11A20.861
TK20.859
SNRNP2000.858

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.65
OR4F29-0.603
MTRNR2L6-0.329
MTRNR2L9-0.298
SERPINC1-0.294
MTRNR2L10-0.263
RAX2-0.248
C7orf61-0.243
EPPIN-0.23
MIA-0.228

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HEXA mRNA"21354444|2527062
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of HEXA mRNA"20702594
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HEXA mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HEXA mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEXA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEXA mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of HEXA mRNA25064622
D000082AcetaminophenAcetaminophen affects the expression of HEXA mRNA15030884|1756273
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of HEXA mRNA28522335
D000638AmiodaroneAmiodarone affects the expression of HEXA mRNA25064622
C547126AZM551248AZM551248 results in increased expression of HEXA mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to HEXA promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HEXA mRNA15034205
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HEXA mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of HEXA mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of HEXA mRNA28628672
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HEXA mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of HEXA mRNA25270620
D002746ChlorpromazineChlorpromazine affects the expression of HEXA mRNA25064622
D002994ClofibrateClofibrate results in decreased expression of HEXA mRNA23811191
D002994ClofibrateClofibrate results in increased expression of HEXA mRNA25270620
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of HEXA mRNA15467011
D016572CyclosporineCyclosporine affects the expression of HEXA mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of HEXA mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HEXA mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of HEXA mRNA28628672
D004041Dietary FatsDietary Fats results in increased expression of HEXA mRNA28031460
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased secretion of [HEXA protein binds to HEXB protein]20082445
D004051Diethylhexyl PhthalatePlant Extracts inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of [HEXA protein binds to HEXB protein]]20082445
D004147DioxinsDioxins affects the expression of HEXA mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HEXA mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HEXA mRNA16174780|1755557
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HEXA mRNA16174780
D005444FlunarizineFlunarizine inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of [HEXB protein binds to HEXA protein]]19546254
D005485FlutamideFlutamide analog results in increased expression of HEXA mRNA17702527
D005485FlutamideFlutamide results in increased expression of HEXA mRNA17702527
D005485FlutamideFlutamide results in decreased expression of HEXA mRNA24136188
D005839GentamicinsGentamicins results in increased expression of HEXA mRNA22061828
D005897GlafenineGlafenine results in decreased expression of HEXA mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HEXA mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of HEXA mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HEXA mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HEXA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] affects the expression of HEXA mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of HEXA mRNA20003209
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of HEXA mRNA25613284
C042720mercuric bromidemercuric bromide results in increased expression of HEXA mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEXA mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HEXA mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HEXA mRNA23649840
D020748MibefradilMibefradil inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of [HEXB protein binds to HEXA protein]]19546254
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HEXA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HEXA mRNA"25554681|2562005
C051752nefazodonenefazodone results in decreased expression of HEXA mRNA24136188
C028007nickel monoxidenickel monoxide results in increased expression of HEXA mRNA19167457
D010269ParaquatParaquat affects the expression of HEXA mRNA25064622
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HEXA mRNA23427857
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of HEXA mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of HEXA mRNA19482888
D010758PhosphorusHEXA protein affects the metabolism of Phosphorus11392526
D010936Plant ExtractsPlant Extracts inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of [HEXA protein binds to HEXB protein]]20082445
D010936Plant ExtractsPlant Extracts results in increased expression of HEXA mRNA23557933
D012402RotenoneRotenone results in increased expression of HEXA mRNA17702527
C017947sodium arsenitesodium arsenite affects the expression of HEXA mRNA20816728
D012969Sodium FluorideSodium Fluoride results in decreased expression of HEXA protein28918527
D012999SomanSoman results in increased expression of HEXA mRNA19281266
D016559TacrolimusTacrolimus results in increased expression of HEXA mRNA25270620
D013629TamoxifenTamoxifen affects the expression of HEXA mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HEXA mRNA20702594|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of HEXA mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HEXA mRNA18796159
D013749TetrachlorodibenzodioxinFlunarizine inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of [HEXB protein binds to HEXA protein]]19546254
D013749TetrachlorodibenzodioxinMibefradil inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of [HEXB protein binds to HEXA protein]]19546254
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased secretion of [HEXB protein binds to HEXA protein]19546254
D013752TetracyclineTetracycline affects the expression of HEXA mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HEXA mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of HEXA mRNA25064622
C009495titanium dioxidetitanium dioxide results in decreased expression of HEXA mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of HEXA mRNA20133372
D014635Valproic AcidValproic Acid affects the expression of HEXA mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of HEXA mRNA25979313
C066075vanadium pentoxidevanadium pentoxide affects the expression of HEXA mRNA26210822
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of HEXA mRNA19165385
C025643vinclozolinvinclozolin results in decreased expression of HEXA mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of HEXA mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004563beta-N-acetylhexosaminidase activity-TAS-  
GO:0005515protein binding-IPI16698036  
GO:0008375acetylglucosaminyltransferase activity-IDA25645918  
GO:0046982protein heterodimerization activity-IDA6230359  
GO:0102148N-acetyl-beta-D-galactosaminidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006024glycosaminoglycan biosynthetic process-IDA25645918  
GO:0006687glycosphingolipid metabolic process-TAS-  
GO:0030207chondroitin sulfate catabolic process-TAS-  
GO:0030214hyaluronan catabolic process-TAS-  
GO:0042340keratan sulfate catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016020membrane-HDA19946888  
GO:0042582azurophil granule-IDA25645918  
GO:0043202lysosomal lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00511Other glycan degradation
hsa00520Amino sugar and nucleotide sugar metabolism
hsa00531Glycosaminoglycan degradation
hsa00603Glycosphingolipid biosynthesis - globo series
hsa00604Glycosphingolipid biosynthesis - ganglio series
hsa01100Metabolic pathways
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638074Keratan sulfate/keratin metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-1660662Glycosphingolipid metabolismTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-2022857Keratan sulfate degradationTAS
R-HSA-2024101CS/DS degradationTAS
R-HSA-2142845Hyaluronan metabolismTAS
R-HSA-2160916Hyaluronan uptake and degradationTAS
R-HSA-3560782Diseases associated with glycosaminoglycan metabolismTAS
R-HSA-3656234Defective HEXA causes GM2G1TAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19661247Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. (2009 Nov 1)Deshmukh HSAm J Respir Crit Care Med
17509640Congener-specific approach to human PCB concentrations by serum analysis. (2007 Aug)Park HChemosphere
23724965Prenatal exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) may influence birth weight among infants in a Swedish cohort with background exposure: a cross-sectional study. (2013 May 31)Lignell SEnviron Health