Gene: CFH

3075
AHUS1|AMBP1|ARMD4|ARMS1|CFHL3|FH|FHL1|HF|HF1|HF2|HUS
complement factor H
protein-coding
1q31.3
Ensembl:ENSG00000000971 MIM:134370 Vega:OTTHUMG00000035607 UniprotKB:P08603
NG_007259.1
PubMed
ND
139   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.233e-1 (AD)  8.063e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CFI0.891
TGFBR20.881
MECOM0.874
MYOF0.866
ELOVL70.863
ITGA10.854
CYYR10.85
FLI10.85
ERG0.846
CP0.845

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.552
MAGIX-0.543
FLRT1-0.526
HAS1-0.525
ASPDH-0.513
CHRNA4-0.511
ADRA1D-0.508
MARCH4-0.508
KREMEN2-0.507
CORT-0.501

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0810141,2-bis(2,4,6-tribromophenoxy)ethane"1,2-bis(2,4,6-tribromophenoxy)ethane results in decreased expression of CFH mRNA"28249227
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of CFH mRNA"18281256
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CFH mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CFH mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CFH mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of CFH protein26194647
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CFH mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of CFH mRNA27761495
D000082AcetaminophenAcetaminophen results in increased expression of CFH mRNA26690555
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CFH mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CFH mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CFH mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CFH gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CFH mRNA23630614
D000393Air PollutantsAir Pollutants analog results in decreased expression of CFH mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CFH mRNA16483693
C015001arsenitearsenite results in decreased expression of CFH mRNA23974009
D016589AstemizoleAstemizole results in decreased expression of CFH mRNA20221588
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CFH mRNA19770486
D004958EstradiolEstradiol affects the expression of CFH mRNA15598610
D004958EstradiolEstradiol results in increased expression of CFH mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of CFH mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of CFH mRNA27104808
C006780bisphenol Abisphenol A results in decreased expression of CFH mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of CFH mRNA26794494
C018475butyraldehydebutyraldehyde results in decreased expression of CFH mRNA26079696
D002104CadmiumCFH protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride affects the expression of CFH mRNA22110744
D002734Chlorophyll"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in increased expression of CFH mRNA]"22079312
D002746Chlorpromazine[Chlorpromazine co-treated with Cholic Acids] affects the expression of CFH mRNA27344345
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of CFH mRNA27344345
D002793Cholic Acids[Chlorpromazine co-treated with Cholic Acids] affects the expression of CFH mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of CFH mRNA27344345
D002793Cholic Acids[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of CFH mRNA27344345
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CFH mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CFH mRNA]17585979
D002994ClofibrateClofibrate results in decreased expression of CFH mRNA12851107
D003010ClorgylineClorgyline results in increased expression of CFH mRNA19691856
C018021cobaltous chloridecobaltous chloride results in decreased expression of CFH mRNA24386269
D003042CocaineCocaine results in decreased expression of CFH mRNA17898221
D003300CopperCFH protein binds to Copper23896426
D003300CopperCopper results in decreased expression of CFH protein22480594
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of CFH mRNA27344345
D016572CyclosporineCyclosporine results in decreased expression of CFH mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of CFH mRNA19770486|2383089
C041517dibenzo(a,l)pyrene"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in increased expression of CFH mRNA]"22079312
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of CFH mRNA"22079312
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of CFH mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CFH mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of CFH mRNA26934552
D004026DieldrinDieldrin results in increased expression of CFH mRNA20438755|2304172
D004041Dietary FatsDietary Fats results in decreased expression of CFH mRNA18042831|2501614
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CFH mRNA19638242
D004237DiuronDiuron results in decreased expression of CFH mRNA21551480
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of CFH mRNA25198161
D004726EndosulfanEndosulfan results in decreased expression of CFH mRNA23208437
D000431EthanolEthanol results in increased expression of CFH protein19609968
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of CFH mRNA27344345
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CFH mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CFH mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CFH mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CFH mRNA17351261
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CFH mRNA15834898|1755790
D005485FlutamideFlutamide results in decreased expression of CFH mRNA24136188|2479361
C056933fumonisin B1fumonisin B1 results in decreased expression of CFH mRNA16221962
C039281furanfuran results in decreased expression of CFH mRNA25539665|2619464
D005839GentamicinsGentamicins results in increased expression of CFH mRNA21081137
D017313FenretinideFenretinide results in increased expression of CFH mRNA28973697
C082770IMM 125IMM 125 results in increased expression of CFH mRNA21081137
D007545IsoproterenolIsoproterenol results in increased expression of CFH mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CFH mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CFH mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CFH mRNA26752646
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CFH mRNA"24972896
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CFH mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CFH mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CFH mRNA"25620056
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of CFH mRNA27344345
C051752nefazodonenefazodone results in decreased expression of CFH mRNA24136188
D009532NickelCFH protein binds to Nickel23896426
D009532NickelNickel results in increased expression of CFH mRNA24084258
C012655nimesulidenimesulide results in decreased expression of CFH mRNA24136188
C076029olanzapineolanzapine results in decreased phosphorylation of CFH protein25821032
D000069463Olive OilOlive Oil analog affects the expression of CFH mRNA17349074
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CFH mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of CFH mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of CFH mRNA18042831
D052638Particulate MatterParticulate Matter results in increased expression of CFH protein17520064
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of CFH mRNA21984479
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of CFH mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of CFH mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of CFH mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CFH mRNA18467677|2093613
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of CFH mRNA]18467677
D010634PhenobarbitalPhenobarbital affects the expression of CFH mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of CFH mRNA23091169
D010795Phthalic AcidsPhthalic Acids results in increased expression of CFH mRNA21061450
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of CFH mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of CFH mRNA16221962|1846767
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of CFH mRNA]18467677
D028321Plant PreparationsPlant Preparations results in decreased expression of CFH protein28284660
D011374ProgesteroneProgesterone results in increased expression of CFH mRNA20864642|2179573
D011374ProgesteroneProgesterone results in decreased expression of CFH mRNA20726854
C045950propiconazolepropiconazole results in decreased expression of CFH mRNA21278054
C502851quinocetonequinocetone results in decreased expression of CFH mRNA27046791
C059514resveratrolresveratrol results in decreased expression of CFH mRNA25905778
C089730rosiglitazonerosiglitazone results in decreased expression of CFH mRNA25572481
C049705S-1,2-dichlorovinyl-N-acetylcysteine"S-1,2-dichlorovinyl-N-acetylcysteine results in increased expression of CFH mRNA"16844155
D012643SeleniumSelenium results in decreased expression of CFH mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CFH mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CFH mRNA19073995
C009277sodium arsenatesodium arsenate results in increased expression of CFH mRNA23922661
C016104sodium bichromatesodium bichromate affects the expression of CFH mRNA22110744
D013629TamoxifenTamoxifen affects the expression of CFH mRNA17555576
C004648testosterone enanthatetestosterone enanthate affects the expression of CFH mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CFH mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CFH mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CFH mRNA23864506|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CFH mRNA16267337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CFH mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CFH mRNA18465118|2121527
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CFH mRNA25729387
D019772TopotecanTopotecan results in increased expression of CFH mRNA25729387
D014204Trenbolone AcetateTrenbolone Acetate results in decreased expression of CFH mRNA25198161
C012589trichostatin Atrichostatin A results in increased expression of CFH mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CFH mRNA19042947
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CFH mRNA17982090
C057693troglitazonetroglitazone results in decreased expression of CFH mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of CFH mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of CFH mRNA17963808
D014640VancomycinVancomycin results in decreased expression of CFH mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CFH protein17520064
C025643vinclozolinvinclozolin results in decreased expression of CFH mRNA23034163
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of CFH mRNA"25198161
D015032ZincCFH protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16612335  18627465  19050261  19225461  19632990  21317894  
24835392  26538390  
GO:0008201heparin binding-IDA22471560  
GO:0043395heparan sulfate proteoglycan binding-IDA22471560  
GO ID GO Term Qualifier Evidence PubMed
GO:0006956complement activation-IDA24835392  
GO:0006957complement activation, alternative pathway-IEA-  
GO:0016032viral process-IEA-  
GO:0030449regulation of complement activation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-TAS9312129  
GO:0070062extracellular exosome-HDA23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22232432Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population. (2012 Feb 16)Nakata IInvest Ophthalmol Vis Sci
21197116Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study. (2010 Dec 17)Ryu EMol Vis
19168221Complement component C3 and risk of age-related macular degeneration. (2009 Mar)Despriet DDOphthalmology
21541267Complement factor B polymorphism 32W protects against age-related macular degeneration. (2011 Apr 20)Hughes AEMol Vis
29801032Association of Single-Nucleotide Polymorphisms in Age-Related Macular Degeneration With Pseudodrusen: Secondary Analysis of Data From the Comparison of AMD Treatments Trials. (2018 May 3)Lin LYJAMA Ophthalmol
16816528CFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degeneration. (2006)Seddon JMHum Hered
18084039Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration. (2008 Apr 1)Spencer KLHum Mol Genet
17558024Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3. (2007 Aug 3)Wu ZJ Biol Chem
21139980Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration. (2010 Nov 17)Seddon JMMol Vis
18599571Cataract surgery and the risk of aging macula disorder: the rotterdam study. (2008 Nov)Ho LInvest Ophthalmol Vis Sci
19661236Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. (2009 Dec)Reynolds RInvest Ophthalmol Vis Sci
20605213C-reactive protein levels and complement factor H polymorphism interaction in age-related macular degeneration and its progression. (2010 Oct)Robman LOphthalmology
24608419Elevated high-density lipoprotein cholesterol and age-related macular degeneration: the Alienor study. (2014)Cougnard-Gregoire APLoS One
28332910Association between Dietary Xanthophyll (Lutein and Zeaxanthin) Intake and Early Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study. (2017 Oct)Lin HOphthalmic Epidemiol
21825180Risk assessment model for development of advanced age-related macular degeneration. (2011 Dec)Klein MLArch Ophthalmol
25788651Risk Factors for Age-Related Macular Degeneration in an Elderly Japanese Population: The Hatoyama Study. (2015 Apr)Aoki AInvest Ophthalmol Vis Sci
21959373Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors. (2011 Nov)Seddon JMOphthalmology
26843839Complement factor H polymorphism rs1061170 and the effect of cigarette smoking on the risk of lung cancer. (2015)Ezzeldin NContemp Oncol (Pozn)
27239555Oxidative stress, innate immunity, and age-related macular degeneration. (2016)Shaw PXAIMS Mol Sci
22933840Association analysis of genetic and environmental risk factors in the cuticular drusen subtype of age-related macular degeneration. (2012)van de Ven JPMol Vis
29596588Incidence of and Risk Factors Associated With Age-Related Macular Degeneration: Four-Year Follow-up From the ALIENOR Study. (2018 May 1)Saunier VJAMA Ophthalmol
21642625Associations of complement factor H and smoking with early age-related macular degeneration: the ALIENOR study. (2011 Jul 29)Delcourt CInvest Ophthalmol Vis Sci
25695752Association of Smoking and CFH and ARMS2 Risk Variants With Younger Age at Onset of Neovascular Age-Related Macular Degeneration. (2015 May)Lechanteur YTJAMA Ophthalmol
25277308FPR1 interacts with CFH, HTRA1 and smoking in exudative age-related macular degeneration and polypoidal choroidal vasculopathy. (2014 Dec)Liang XYEye (Lond)
21558292CFH, VEGF and HTRA1 promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration. (2012 Feb)McKibbin MBr J Ophthalmol
21682878Identifying subtypes of patients with neovascular age-related macular degeneration by genotypic and cardiovascular risk characteristics. (2011 Jun 17)Feehan MBMC Med Genet
26896123Incidence of Age-Related Macular Degeneration in a Multi-Ethnic United States Population: The Multi-Ethnic Study of Atherosclerosis. (2016 Jun)Fisher DEOphthalmology
18316707HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH. (2008 Jun)Tam POInvest Ophthalmol Vis Sci
24953792Cigarette smoking and the natural history of age-related macular degeneration: the Beaver Dam Eye Study. (2014 Oct)Myers CEOphthalmology
24491417Risk factors associated with reticular pseudodrusen versus large soft drusen. (2014 May)Boddu SAm J Ophthalmol
17241667Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration. (2007 Jun)Scott WKOphthalmology
17962488Coding and noncoding variants in the CFH gene and cigarette smoking influence the risk of age-related macular degeneration in a Japanese population. (2007 Nov)Mori KInvest Ophthalmol Vis Sci
18097986Review of genetics in age related macular degeneration. (2007 Oct-Dec)Montezuma SRSemin Ophthalmol
25478207Age-related macular degeneration: insights into inflammatory genes. (2014)Cascella RJ Ophthalmol
23481534Dietary omega-3 fatty acids, other fat intake, genetic susceptibility, and progression to incident geographic atrophy. (2013 May)Reynolds ROphthalmology
18541031The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. (2008 Jun 9)Zhang HBMC Med Genet
25363549Early and exudative age-related macular degeneration is associated with increased plasma levels of soluble TNF receptor II. (2015 May)Faber CActa Ophthalmol
15728332Tobacco smoke dysregulates endothelial vasoregulatory transcripts in vivo. (2005 May 11)Maresh JGPhysiol Genomics
25838066Incidence, Progression, and Associated Risk Factors of Medium Drusen in Age-Related Macular Degeneration: Findings From the 15-Year Follow-up of an Australian Cohort. (2015 Jun)Joachim NDJAMA Ophthalmol
27668132Novel Mechanistic Interplay between Products of Oxidative Stress and Components of the Complement System in AMD Pathogenesis. (2016 Feb)Du HOpen J Ophthalmol
21402993Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors. (2011 Mar)Chen YArch Ophthalmol
18164066Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration. (2008 Jul)Deangelis MMOphthalmology
22197220Cigarette smoking strongly modifies the association of complement factor H variant and the risk of lung cancer. (2012 Apr)Zhang ZCancer Epidemiol
21169531Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility. (2011 Mar)Spencer KLInvest Ophthalmol Vis Sci
24557084Growth of geographic atrophy on fundus autofluorescence and polymorphisms of CFH, CFB, C3, FHR1-3, and ARMS2 in age-related macular degeneration. (2014 May)Caire JJAMA Ophthalmol
17210851Cigarette smoking, CFH, APOE, ELOVL4, and risk of neovascular age-related macular degeneration. (2007 Jan)DeAngelis MMArch Ophthalmol
17210852A prospective study of 2 major age-related macular degeneration susceptibility alleles and interactions with modifiable risk factors. (2007 Jan)Schaumberg DAArch Ophthalmol
23706948Incidence and progression of geographic atrophy: observations from a population-based cohort. (2013 Oct)Joachim NOphthalmology
23562165Age-related macular degeneration and modification of systemic complement factor H production through liver transplantation. (2013 Aug)Khandhadia SOphthalmology
29424826How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration? (2018 Mar)McCarty CAOptom Vis Sci
26654980Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration. (2016 Apr)Marazita MCRedox Biol
17472578The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors. (2007 Aug)Stark KClin Sci (Lond)
24576882Genetic and environmental risk factors for age-related macular degeneration in persons 90 years and older. (2014 Mar 25)Ersoy LInvest Ophthalmol Vis Sci
26154559The genetic variant rs4073 A-->T of the Interleukin-8 promoter region is associated with the earlier onset of exudative age-related macular degeneration. (2015 Dec)Hautamaki AActa Ophthalmol
26354764Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration. (2015 Nov)Meyers KJOphthalmology
16642439Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. (2006 May)Schmidt SAm J Hum Genet
20538655Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese. (2010 Sep)Yang XBr J Ophthalmol
18704199Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration. (2008 Aug 11)Kim IKMol Vis
23950155Association between the cholesteryl ester transfer protein gene and polypoidal choroidal vasculopathy. (2013 Sep 9)Nakata IInvest Ophthalmol Vis Sci
19048105Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration. (2008)Seitsonen SPPLoS One
17724217Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration. (2007 Sep)Spencer KLInvest Ophthalmol Vis Sci
24675670Impact of the common genetic associations of age-related macular degeneration upon systemic complement component C3d levels. (2014)Ristau TPLoS One
28912512Assessing individual risk for AMD with genetic counseling, family history, and genetic testing. (2018 Feb)Cascella REye (Lond)
19999660[Identification of susceptibility genes for age-related macular degeneration--a success story of molecular genetics]. (2009)Seitsonen SDuodecim
23577725Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. (2013 May)Naj ACAnn Hum Genet
16849663Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration. (2006 Jul 19)Despriet DDJAMA
19117936Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. (2009 May)Seddon JMInvest Ophthalmol Vis Sci
26312598Association between vitamin D status and age-related macular degeneration by genetic risk. (2015 Oct)Millen AEJAMA Ophthalmol
19899988Association of c3 gene polymorphisms with neovascular age-related macular degeneration in a chinese population. (2009 Aug)Pei XTCurr Eye Res
26383995The Incidence and Progression of Age-Related Macular Degeneration over 15 Years: The Blue Mountains Eye Study. (2015 Dec)Joachim NOphthalmology
29487693Uncovering genetic and non-genetic biomarkers specific for exudative age-related macular degeneration: significant association of twelve variants. (2018 Jan 30)Cascella ROncotarget
24332537Incidence and progression of reticular drusen in age-related macular degeneration: findings from an older Australian cohort. (2014 Apr)Joachim NOphthalmology
18627285Complement factor H variant p.Y402H in pseudoxanthoma elasticum patients. (2008 Sep)Gotting CGenet Test
16630992A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study. (2006 Apr 18)Kardys IJ Am Coll Cardiol
19074778Combined effects of complement factor H genotypes, fish consumption, and inflammatory markers on long-term risk for age-related macular degeneration in a cohort. (2009 Mar 1)Wang JJAm J Epidemiol
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