Gene: CFHR1

3078
CFHL|CFHL1|CFHL1P|CFHR1P|FHR1|H36-1|H36-2|HFL1|HFL2
complement factor H related 1
protein-coding
1q31.3
Ensembl:ENSG00000244414 MIM:134371 Vega:OTTHUMG00000036276 UniprotKB:Q03591
NG_013060.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.052e-1 (AD)  9.045e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SKAP10.389
GPRIN20.378
RASSF60.373
AKAP140.372
ARHGAP360.364
TSPAN20.363
C10orf820.361
GPC30.359
LECT20.358
LOXL10.357

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPIPB6-0.254
AOC2-0.253
KRTAP5-9-0.234
ABCC2-0.233
THSD1-0.221
SPINK13-0.219
MROH6-0.216
ZNF695-0.214
DDIT4L-0.211
DCAF4L1-0.21

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CFHR1 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CFHR1 mRNA]"19467301
D000082AcetaminophenAcetaminophen affects the expression of CFHR1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CFHR1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CFHR1 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of CFHR1 mRNA21757418
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CFHR1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CFHR1 mRNA19770486
D004958EstradiolEstradiol affects the expression of CFHR1 mRNA15598610
C006780bisphenol Abisphenol A results in decreased expression of CFHR1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CFHR1 mRNA27339419
D002945CisplatinCisplatin results in increased expression of CFHR1 protein16803524
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CFHR1 mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of CFHR1 mRNA22609946|2501614
D004041Dietary FatsDietary Fats results in increased expression of CFHR1 mRNA19467301
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CFHR1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CFHR1 mRNA19638242
D005485FlutamideFlutamide results in decreased expression of CFHR1 mRNA24136188
C039281furanfuran results in decreased expression of CFHR1 mRNA25539665
C008261lead acetatelead acetate results in decreased expression of CFHR1 mRNA22609695
D064704LevofloxacinLevofloxacin results in increased expression of CFHR1 mRNA24136188
D008727MethotrexateMethotrexate affects the expression of CFHR1 mRNA18502557
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of CFHR1 mRNA22108045
C051752nefazodonenefazodone results in decreased expression of CFHR1 mRNA24136188
C006253pirinixic acidpirinixic acid results in decreased expression of CFHR1 mRNA23811191
D011374ProgesteroneProgesterone results in increased expression of CFHR1 mRNA20864642
C017947sodium arsenitesodium arsenite affects the expression of CFHR1 mRNA19590694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CFHR1 mRNA19770486
D014635Valproic AcidValproic Acid results in decreased methylation of CFHR1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23487775  
GO:0042803protein homodimerization activity-IDA23487775  
GO:0046982protein heterodimerization activity-IDA23487775  
GO ID GO Term Qualifier Evidence PubMed
GO:0006956complement activation-TAS1711047  
GO:0030449regulation of complement activation-TAS-  
GO:0032091negative regulation of protein binding-IMP23487775  
GO:0045919positive regulation of cytolysis-IMP23487775  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-TAS1711047  
GO:0032991protein-containing complex-IDA23487775  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18084039Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration. (2008 Apr 1)Spencer KLHum Mol Genet
23103884Age-related macular degeneration and coronary heart disease: evaluation of genetic and environmental associations. (2013 Feb)Keilhauer CNEur J Med Genet
27668132Novel Mechanistic Interplay between Products of Oxidative Stress and Components of the Complement System in AMD Pathogenesis. (2016 Feb)Du HOpen J Ophthalmol