Gene: CFHR2

3080
CFHL2|FHR2|HFL3
complement factor H related 2
protein-coding
1q31.3
Ensembl:ENSG00000080910 MIM:600889 Vega:OTTHUMG00000036518 UniprotKB:P36980
NG_042816.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.681e-2 (AD)  9.002e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PGA30.627
ATP4B0.55
OR1J10.544
KRTAP29-10.535
OR2G20.533
PRR90.521
OR6Q10.521
FOXE10.514
GKN20.504
IL370.502

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CADM1-0.24
PTCH1-0.235
RXRG-0.229
PCDHGA3-0.227
CHRDL1-0.224
PCDHGA2-0.221
DCHS2-0.218
PCDHB11-0.215
ACER1-0.215
TYW1B-0.215

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of CFHR2 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CFHR2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CFHR2 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CFHR2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CFHR2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CFHR2 mRNA19770486
C006780bisphenol Abisphenol A results in decreased methylation of CFHR2 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of CFHR2 mRNA25594700
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CFHR2 mRNA27339419
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of CFHR2 protein28596144
D016572CyclosporineCyclosporine results in decreased expression of CFHR2 mRNA20106945|2798913
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CFHR2 mRNA28085963
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CFHR2 mRNA26159488
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CFHR2 mRNA"25620056
D010416PentachlorophenolPentachlorophenol results in decreased expression of CFHR2 mRNA23892564
C006253pirinixic acidpirinixic acid results in decreased expression of CFHR2 mRNA23811191
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CFHR2 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CFHR2 mRNA20106945
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CFHR2 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of CFHR2 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CFHR2 gene25560391
D015032ZincZinc deficiency results in decreased expression of CFHR2 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23487775  
GO:0042803protein homodimerization activity-IDA23487775  
GO:0046982protein heterodimerization activity-IDA23487775  
GO ID GO Term Qualifier Evidence PubMed
GO:0030449regulation of complement activation-TAS-  
GO:0032091negative regulation of protein binding-IMP23487775  
GO:0045919positive regulation of cytolysis-IMP23487775  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0032991protein-containing complex-IDA23487775  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18541031The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. (2008 Jun 9)Zhang HBMC Med Genet