Gene: HGD

3081
AKU|HGO
homogentisate 1,2-dioxygenase
protein-coding
3q13.33
Ensembl:ENSG00000113924 MIM:607474 Vega:OTTHUMG00000159441 UniprotKB:Q93099
NG_011957.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.346e-1 (AD)  5.787e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7613732chr3:120631658 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR550.559
LAMP50.543
ZNF1840.534
CCNO0.533
SH3RF20.531
MAN1C10.528
IFT1220.528
WIPF30.525
TMOD10.523
ROS10.521

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCKAP5-0.36
PDE11A-0.354
C5orf64-0.322
CTNNA3-0.32
KLRC3-0.302
MOBP-0.302
C10orf62-0.3
NEK7-0.294
BCHE-0.288
BCAS1-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HGD mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of HGD mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of HGD mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HGD protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HGD gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HGD mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of HGD mRNA21757418
D000638AmiodaroneAmiodarone affects the expression of HGD mRNA19483382
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HGD mRNA24449571
D001151ArsenicArsenic affects the methylation of HGD gene25304211
D001280AtrazineAtrazine results in increased expression of HGD mRNA22378314
D001374AzacitidineAzacitidine results in increased expression of HGD mRNA20823114
C547126AZM551248AZM551248 results in decreased expression of HGD mRNA22323515
C487081belinostatbelinostat results in decreased expression of HGD mRNA27188386
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of HGD mRNA23656968
D001553BenzbromaroneBenzbromarone affects the expression of HGD mRNA19483382
D001554BenzeneBenzene results in decreased expression of HGD mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HGD mRNA26001963
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of HGD mRNA21632023
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HGD mRNA22178795
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of HGD mRNA20660070
C006780bisphenol Abisphenol A results in increased expression of HGD mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of HGD mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HGD mRNA27339419
D002922CiguatoxinsCiguatoxins affects the expression of HGD mRNA18353800
D002994ClofibrateClofibrate results in increased expression of HGD mRNA22300585
D002994ClofibrateClofibrate affects the expression of HGD mRNA19483382
C018021cobaltous chloridecobaltous chloride results in increased expression of HGD protein24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of HGD mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of HGD protein22699969
D003471CuprizoneCuprizone results in decreased expression of HGD mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of HGD mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of HGD mRNA19770486
C000944dicrotophosdicrotophos results in decreased expression of HGD mRNA28302478
D005001EthionineEthionine affects the expression of HGD mRNA19483382
D005485FlutamideFlutamide results in decreased expression of HGD mRNA24793618
C039281furanfuran results in decreased expression of HGD mRNA26194646
D019833GenisteinGenistein affects the expression of HGD mRNA18214933
D005897GlafenineGlafenine results in decreased expression of HGD mRNA24136188
C412815GW 4064GW 4064 results in increased expression of HGD mRNA26655953
D017313FenretinideFenretinide results in increased expression of HGD mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HGD mRNA26752646
C008261lead acetatelead acetate results in decreased expression of HGD protein21247988
D008627Mercuric ChlorideMercuric Chloride affects the expression of HGD protein21458406
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HGD mRNA23458150
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of HGD mRNA16966085
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of HGD mRNA29162477
C051752nefazodonenefazodone results in decreased expression of HGD mRNA24136188
D009532NickelNickel results in decreased expression of HGD mRNA25583101
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of HGD protein19716841
D009853OmeprazoleOmeprazole affects the expression of HGD mRNA19483382
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in decreased expression of HGD mRNA24888373
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of HGD mRNA23602845
D010634PhenobarbitalPhenobarbital affects the expression of HGD mRNA23091169
C006253pirinixic acidpirinixic acid affects the expression of HGD mRNA19483382
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in decreased expression of HGD mRNA24888373
D011192Potassium DichromatePotassium Dichromate results in decreased expression of HGD mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of HGD mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of HGD mRNA21540246
C005556propionaldehydepropionaldehyde results in decreased expression of HGD mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of HGD mRNA19483382|2478091
D015474IsotretinoinIsotretinoin results in decreased expression of HGD mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HGD mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of HGD mRNA23922661
C016104sodium bichromatesodium bichromate results in decreased expression of HGD mRNA24612858
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of HGD mRNA21632023
C016104sodium bichromatesodium bichromate results in decreased expression of HGD mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HGD mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HGD mRNA21998131
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of HGD mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HGD mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HGD mRNA21215274
D013853ThioacetamideThioacetamide affects the expression of HGD mRNA19483382
D013853ThioacetamideThioacetamide results in decreased expression of HGD mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of HGD protein22609517
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of HGD protein22595367
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HGD mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of HGD mRNA17963808
D014640VancomycinVancomycin results in increased expression of HGD mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HGD gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of HGD mRNA26682919
C111237vorinostatvorinostat results in decreased expression of HGD mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of HGD mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004411homogentisate 1,2-dioxygenase activity-EXP8782815  
GO:0004411homogentisate 1,2-dioxygenase activity-IBA21873635  
GO:0005515protein binding-IPI21044950  
GO:0042802identical protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006520cellular amino acid metabolic process-IBA21873635  
GO:0006559L-phenylalanine catabolic process-IBA21873635  
GO:0006559L-phenylalanine catabolic process-IEA-  
GO:0006559L-phenylalanine catabolic process-TAS-  
GO:0006572tyrosine catabolic process-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-71182Phenylalanine and tyrosine catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14581353Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia. (2003 Oct 15)Miller CTClin Cancer Res
21467942Clinical parameters including serum pepsinogen level and management strategy in patients with premalignant gastric dysplasia. (2011 May)Chang YWEur J Gastroenterol Hepatol