Gene: HGF

3082
DFNB39|F-TCF|HGFB|HPTA|SF
hepatocyte growth factor
protein-coding
7q21.11
Ensembl:ENSG00000019991 MIM:142409 Vega:OTTHUMG00000023804 UniprotKB:P14210
NG_016274.2
PubMed
ND
40   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.612e-1 (AD)  2.607e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06055763chr7:81399308HGF2.460e-8Maternal smoking in pregnancy27040690
cg06055763chr7:81399308HGF7.130e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH3BP20.728
SYPL20.727
C4orf190.726
NEK60.722
TGFB20.721
TNFRSF11B0.719
GLIS30.708
FGF110.706
PTAR10.703
F30.703

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BFSP1-0.516
SLC7A4-0.495
NUDT18-0.462
ADTRP-0.446
MYCNOS-0.443
TMEFF2-0.442
E2F1-0.441
TPBGL-0.439
NRG1-0.439
PPEF1-0.437

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01109HeparinSmall Molecule9005-49-6Approved|InvestigationalTarget
DB02264O2-Sulfo-Glucuronic AcidSmall MoleculeExperimentalTarget
DB03959N,O6-Disulfo-GlucosamineSmall MoleculeExperimentalTarget
DB05434ABT-510Small Molecule251579-55-2InvestigationalTarget
DB12307ForetinibSmall Molecule849217-64-7InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of HGF mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[IL6 protein co-treated with HGF protein co-treated with TGFA protein] affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B1 mRNA]"27530964
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HGF mRNA"28903501
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"15-hydroxy-5,8,11,13-eicosatetraenoic acid promotes the reaction [HGF protein affects the localization of PRKCA protein]"15613483
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HGF protein results in increased phosphorylation of MAPK1 protein]12639917
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HGF protein results in increased phosphorylation of MAPK3 protein]12639917
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HGF protein affects the localization of PRKCA protein]15613483
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HGF results in increased expression of MMP9]11981761
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HGF results in increased phosphorylation of MAPK1 protein]11981761
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HGF results in increased phosphorylation of MAPK3 protein]11981761
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HGF protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]]16109756|1808389
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of HGF mRNA"21703328
C478479((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)"((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]"21812414
C478479((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)"((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]"18632630
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of HGF mRNA"11223164
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased secretion of HGF protein"11223164
C1191304-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [HGF protein results in increased phosphorylation of MAPK1 protein]11891194
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HGF mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HGF mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HGF mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of HGF mRNA12419474
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF mRNA]28844859
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF protein]28844859
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Thapsigargin results in decreased expression of HGF mRNA]28844859
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Tunicamycin results in decreased expression of HGF mRNA]28844859
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Tunicamycin results in decreased expression of HGF protein]28844859
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of HGF mRNA28844859
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of HGF protein28844859
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one inhibits the reaction [HGF protein results in increased phosphorylation of and results in increased activity of MET protein]"20661229
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]"21812414
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HGF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HGF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HGF mRNA"27188386
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [TGFB1 protein results in increased expression of HGF protein]"16757516
C000603579A-1155463A-1155463 inhibits the reaction [[MET protein affects the susceptibility to HGF protein] affects the reaction [BRAF protein mutant form results in increased susceptibility to vemurafenib]]27689874
C501332ABT-737ABT-737 inhibits the reaction [[MET protein affects the susceptibility to HGF protein] affects the reaction [BRAF protein mutant form results in increased susceptibility to vemurafenib]]27689874
D000082AcetaminophenAcetaminophen affects the expression of HGF mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of HGF mRNA21135413
D000082AcetaminophenFLT1 protein affects the reaction [Acetaminophen results in increased expression of HGF mRNA]21135413
D000082Acetaminophen[EGF protein co-treated with HGF protein] promotes the reaction [Acetaminophen results in decreased expression of CYP1A2 mRNA]12969438
D019342Acetic AcidAcetic Acid results in increased expression of HGF11891194
D000111AcetylcysteineAcetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of HGF protein]16757516
C103303alitretinoinalitretinoin results in decreased expression of HGF mRNA11223164
C103303alitretinoinalitretinoin results in decreased secretion of HGF protein11223164
C103303alitretinoinalitretinoin results in increased expression of HGF mRNA16192631
C103303alitretinoinalitretinoin results in increased secretion of HGF protein16192631
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in increased expression of HGF protein1370768
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HGF mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HGF mRNA24449571
D001151ArsenicArsenic affects the methylation of HGF gene25304211
D001151ArsenicArsenic results in increased expression of HGF mRNA11134558
C006632arsenic trioxidearsenic trioxide results in decreased expression of HGF mRNA15761015
C006632arsenic trioxidearsenic trioxide results in increased expression of HGF mRNA18414637
D001194AsbestosAsbestos results in increased expression of HGF protein25162674
D001241AspirinAspirin inhibits the reaction [HGF results in increased activity of MAPK1 protein]11981761
D001241AspirinAspirin inhibits the reaction [HGF results in increased activity of MAPK3 protein]11981761
D001241AspirinAspirin inhibits the reaction [HGF results in increased expression of MMP9]11981761
D001374AzacitidineAzacitidine results in increased expression of HGF mRNA19194470
C044946benazeprilbenazepril results in increased expression of HGF mRNA16696918
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HGF mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HGF protein21467743
C048081beraprostberaprost results in decreased expression of HGF mRNA28887131
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of HGF mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of HGF mRNA17404688
D004958EstradiolEstradiol results in decreased expression of HGF mRNA25210133
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of HGF mRNA26496021
D004958EstradiolEstradiol affects the expression of HGF mRNA15364205
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA]12745093
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of HGF mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of HGF mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HGF gene28505145
C006780bisphenol Abisphenol A affects the expression of HGF mRNA15364205
C035760bis(sulfosuccinimidyl)suberateHGF protein promotes the reaction [bis(sulfosuccinimidyl)suberate promotes the reaction [MET protein binds to MET protein]]25971889
C035760bis(sulfosuccinimidyl)suberateQuercetin inhibits the reaction [HGF protein promotes the reaction [bis(sulfosuccinimidyl)suberate promotes the reaction [MET protein binds to MET protein]]]25971889
D001761BleomycinBleomycin results in increased expression of HGF mRNA22687607
D001761BleomycinBleomycin results in increased secretion of HGF protein22687607
D001761BleomycinBleomycin results in decreased expression of HGF mRNA16115399
D001761BleomycinBleomycin results in decreased expression of HGF protein16115399
D001761BleomycinValsartan inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]16115399
D001761BleomycinValsartan inhibits the reaction [Bleomycin results in decreased expression of HGF protein]16115399
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of HGF protein9763232
D002104CadmiumCadmium results in decreased expression of HGF mRNA22666406
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HGF mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of HGF promoter22457795
D002118CalciumHGF protein results in increased abundance of Calcium10963052
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of HGF mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride inhibits the reaction [HGF protein affects the localization of LGALS7 protein]18395096
D002251Carbon TetrachlorideCarbon Tetrachloride inhibits the reaction [HGF protein affects the localization of SMAD3 protein]18395096
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HGF mRNA20227401|2220675
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HGF protein25445725
D002251Carbon TetrachlorideHGF protein affects the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]17976157
D002251Carbon TetrachlorideHGF protein affects the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]17976157
D002251Carbon TetrachlorideHGF protein affects the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]17976157
D002251Carbon TetrachlorideHGF protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]18395096
D002251Carbon TetrachlorideLipids inhibits the reaction [Carbon Tetrachloride results in increased expression of HGF protein]25445725
D002251Carbon TetrachloridePhycocyanin inhibits the reaction [Carbon Tetrachloride results in increased expression of HGF mRNA]20227401
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of HGF mRNA]22206755
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HGF mRNA17468546
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HGF mRNA12445174|1609704
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HGF protein17166617
D002251Carbon TetrachlorideDalteparin promotes the reaction [Carbon Tetrachloride results in increased expression of HGF protein]17166617
D002251Carbon TetrachlorideHGF protein affects the reaction [Carbon Tetrachloride results in increased expression of ANXA3 mRNA]18182385
D002251Carbon TetrachlorideIFNA1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of HGF mRNA]12445174
D002251Carbon TetrachlorideIFNG protein inhibits the reaction [Carbon Tetrachloride results in increased expression of HGF mRNA]12445174
D002251Carbon TetrachlorideIL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of HGF mRNA]16097045
D002251Carbon TetrachlorideIL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of HGF protein]16097045
D002251Carbon TetrachloridePLAU protein promotes the reaction [Carbon Tetrachloride results in increased expression of HGF mRNA]18481824
D002251Carbon TetrachlorideTNF protein inhibits the reaction [Carbon Tetrachloride results in increased expression of HGF mRNA]12445174
C031662CB 3717CB 3717 results in increased expression of HGF mRNA11139396|1737128
D002108CeruletideCeruletide promotes the reaction [HGF protein results in increased expression of PTGS2 mRNA]14751415
D002108CeruletideCeruletide promotes the reaction [HGF protein results in increased expression of PTGS2 protein]14751415
D002108CeruletideHGF protein inhibits the reaction [Ceruletide results in increased expression of IL1B protein]14751415
D002108CeruletideHGF protein promotes the reaction [Ceruletide results in increased expression of PTGS2 mRNA]14751415
D002108CeruletideHGF protein promotes the reaction [Ceruletide results in increased expression of PTGS2 protein]14751415
D002635Chenodeoxycholic AcidChenodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D002772Cholera ToxinChenodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D002772Cholera ToxinCholera Toxin results in increased expression of HGF mRNA15802798
D002772Cholera ToxinCholera Toxin results in increased expression of HGF protein15802798
D002772Cholera ToxinDeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D002772Cholera ToxinDexamethasone inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D002772Cholera ToxinGlycochenodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D002772Cholera ToxinTaurochenodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D002772Cholera ToxinTGFB1 inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D002772Cholera ToxinUrsodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF mRNA]15802798
D002772Cholera ToxinUrsodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HGF mRNA20938992
C019304ciprofibrateciprofibrate results in increased expression of HGF protein1370768
D002953CitrininCitrinin results in increased expression of HGF mRNA23856526
D003300CopperCopper affects the expression of HGF mRNA23825565
C551994crizotinib[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein22683780
C551994crizotinib[[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of CRKL protein22683780
C551994crizotinib[[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK1 protein22683780
C551994crizotinib[[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of MAPK3 protein22683780
C551994crizotinib[[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein] which results in increased phosphorylation of STAT3 protein22683780
C551994crizotinib[PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein]22683780
C029892cupric chloridecupric chloride inhibits the reaction [HGF protein binds to MET protein]15161915
C029892cupric chloridecupric chloride inhibits the reaction [HGF protein results in increased activity of MET protein]15161915
C029892cupric chlorideDiethyl Pyrocarbonate inhibits the reaction [cupric chloride inhibits the reaction [HGF protein binds to MET protein]]15161915
D003474CurcuminCurcumin results in decreased expression of HGF protein23555722
D003474CurcuminCurcumin results in increased expression of HGF protein23555722
D003474CurcuminCurcumin results in decreased expression of HGF18462866
D016572CyclosporineCyclosporine results in decreased expression of HGF mRNA15250830
D016572CyclosporineCyclosporine results in decreased expression of HGF protein15250830
D016572CyclosporineCyclosporine results in increased expression of HGF mRNA15250830
D016572CyclosporineCyclosporine results in increased expression of HGF protein15250830
D017985DalteparinDalteparin promotes the reaction [Carbon Tetrachloride results in increased expression of HGF protein]17166617
D003634DDTDDT results in decreased expression of HGF mRNA25014179
D003840Deoxycholic AcidDeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D003907DexamethasoneDexamethasone inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D003907DexamethasoneDexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HGF protein]15802798
D003907DexamethasoneDexamethasone results in decreased expression of HGF mRNA1459995
D003907DexamethasoneDexamethasone results in decreased expression of HGF protein1459995
C051715dibromoacetonitriledibromoacetonitrile results in increased expression of HGF mRNA21986297
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of HGF mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of HGF mRNA18503570
C058705diethyl malatediethyl malate affects the expression of HGF mRNA24814887
D004052DiethylnitrosamineCTNNB1 protein promotes the reaction [Diethylnitrosamine results in decreased expression of HGF protein]20583210
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of HGF protein20583210
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HGF mRNA18691550
D004052DiethylnitrosamineMAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HGF mRNA]18691550
D004047Diethyl PyrocarbonateDiethyl Pyrocarbonate inhibits the reaction [cupric chloride inhibits the reaction [HGF protein binds to MET protein]]15161915
D004128DimethylnitrosamineDimethylnitrosamine affects the expression of HGF mRNA16596271
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of HGF mRNA15086199
D004128DimethylnitrosamineHGF protein inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]18637143
D004128DimethylnitrosamineHGF protein inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 protein]18637143
C024629dimethyl phthalatedimethyl phthalate results in increased expression of HGF mRNA26924002
D004317DoxorubicinHGF protein results in decreased susceptibility to Doxorubicin15688034
D004317DoxorubicinHGF protein results in decreased susceptibility to Doxorubicin15688034|1610975
D004317Doxorubicin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HGF protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]]16109756|1808389
D004317DoxorubicinHGF protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]16109756|1808389
D004317DoxorubicinHGF protein inhibits the reaction [Doxorubicin results in decreased expression of MET protein]16109756|1808389
D004317DoxorubicinHGF protein inhibits the reaction [Doxorubicin results in decreased expression of MYH6 protein]16109756
D004317DoxorubicinHGF protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]18083897
D004317DoxorubicinHGF protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]18083897
D004317DoxorubicinHGF protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MAPK1 protein]16109756
D004317DoxorubicinHGF protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MAPK3 protein]16109756
D004317DoxorubicinDoxorubicin results in increased expression of HGF mRNA24742701
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of HGF mRNA"17881167
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of HGF mRNA"16696918
C479799(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in decreased expression of HGF mRNA15528975
C098320efavirenzefavirenz results in increased secretion of HGF protein21619898
C118739entinostatentinostat results in increased expression of HGF mRNA27188386
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]19244381
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [HGF protein results in increased phosphorylation of MAPK1 protein]19244381
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [HGF protein results in increased phosphorylation of MAPK3 protein]19244381
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]19244381
C010452estradiol-17 beta-benzoateestradiol-17 beta-benzoate affects the expression of HGF mRNA15059950
C025483estradiol-17 beta-glucuronide[HGF protein results in increased expression of SLCO1A1 protein] which results in increased uptake of estradiol-17 beta-glucuronide18031729
C025483estradiol-17 beta-glucuronideHGF protein results in increased uptake of estradiol-17 beta-glucuronide18031729
C025483estradiol-17 beta-glucuronideochratoxin A inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]18031729
C025483estradiol-17 beta-glucuronideOuabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]18031729
C025483estradiol-17 beta-glucuronideSLCO1A1 protein affects the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]18031729
C025483estradiol-17 beta-glucuronideSulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]18031729
D000431EthanolEthanol results in increased expression of HGF protein19397965
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HGF mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HGF mRNA17942748
D017308EtodolacEtodolac results in decreased expression of HGF mRNA10807402
D005492Folic AcidFolic Acid results in increased expression of HGF mRNA11139396
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HGF mRNA20938992
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of HGF mRNA20846436
D005688Galactosamine4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF mRNA]28844859
D005688Galactosamine4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF protein]28844859
D005688Galactosamine[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF mRNA28844859
D005688Galactosamine[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF protein28844859
D019833GenisteinGenistein results in decreased expression of HGF mRNA22228119
D005978GlutathioneHGF protein results in increased abundance of Glutathione10544272
D005978Glutathione[HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione10544272
D005999Glycochenodeoxycholic AcidGlycochenodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D006025GlycosaminoglycansGlycosaminoglycans affects the reaction [HGF protein binds to and results in increased activity of MET protein]20807638
D006493HeparinHeparin promotes the reaction [HGF protein binds to and results in increased activity of MET protein]9083085
D006493HeparinHeparin results in increased expression of HGF protein18243369
D006493HeparinHGF protein binds to Heparin9083085
D006493HeparinHeparin results in increased secretion of HGF protein15367830
D006497Heparitin SulfateHeparitin Sulfate analog binds to HGF protein14707131
D017313FenretinideFenretinide results in decreased expression of HGF mRNA28973697
D006854HydrocortisoneHydrocortisone results in decreased expression of HGF protein1459995
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of HGF mRNA12419474
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid binds to and results in increased activity of TBXA2R protein] which results in increased expression of HGF mRNA"22206755
D007538IsoniazidHGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased abundance of Reactive Oxygen Species]23764483
D007538IsoniazidHGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]23764483
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of HGF mRNA15618438
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HGF mRNA24435446
C006552kaempferolkaempferol inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]19244381
C006552kaempferolkaempferol inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]19244381
D008055LipidsLipids inhibits the reaction [Carbon Tetrachloride results in increased expression of HGF protein]25445725
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HGF mRNA12057914
D008070Lipopolysaccharides4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF mRNA]28844859
D008070Lipopolysaccharides4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF protein]28844859
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF mRNA28844859
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of HGF protein28844859
D015636Magnesium ChlorideMagnesium Chloride inhibits the reaction [HGF protein binds to MET protein]15161915
C025340manganese chloridemanganese chloride inhibits the reaction [HGF protein binds to MET protein]15161915
D008558MelphalanMelphalan results in decreased expression of HGF mRNA22363485
D008627Mercuric ChlorideMercuric Chloride results in increased activity of HGF protein8342615
D008627Mercuric ChlorideMercuric Chloride results in increased expression of HGF mRNA8342615
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HGF mRNA20938992
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HGF mRNA23519560
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of HGF mRNA18675455
D008770MethylnitrosoureaQuercetin inhibits the reaction [Methylnitrosourea results in decreased expression of HGF mRNA]18675455
D008777MethyltestosteroneMethyltestosterone results in increased expression of HGF mRNA29191790
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of HGF mRNA26924002
C040015myricetinmyricetin inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]19244381
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [HGF results in increased activity of MAPK1 protein]11981761
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [HGF results in increased activity of MAPK3 protein]11981761
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [HGF results in increased expression of MMP9]11981761
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of HGF mRNA10807402
C548173N-(2-fluoro-4-((2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)carbonylaminopyridin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide"N-(2-fluoro-4-((2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)carbonylaminopyridin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide inhibits the reaction [HGF protein results in decreased susceptibility to NVP-TAE684]"22553343
C558744N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo(d)thiazol-2-yl)acetamideN-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo(d)thiazol-2-yl)acetamide inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]21332118
D019829NevirapineNevirapine results in decreased secretion of HGF protein21619898
D009543NifedipineNifedipine results in increased expression of HGF protein15071489
C007350nitrofennitrofen results in decreased expression of HGF mRNA27480986
C007350nitrofennitrofen results in decreased expression of HGF protein27480986
C025256nonylphenolnonylphenol affects the expression of HGF mRNA15364205
C100284norgestometnorgestomet results in decreased expression of HGF mRNA10954858
C516714NVP-TAE684GAB1 protein promotes the reaction [HGF protein results in decreased susceptibility to NVP-TAE684]22553343
C516714NVP-TAE684HGF protein inhibits the reaction [NVP-TAE684 results in decreased phosphorylation of AKT1 protein]22553343
C516714NVP-TAE684HGF protein inhibits the reaction [NVP-TAE684 results in decreased phosphorylation of ALK protein]22553343
C516714NVP-TAE684HGF protein inhibits the reaction [NVP-TAE684 results in decreased phosphorylation of GAB1 protein]22553343
C516714NVP-TAE684HGF protein inhibits the reaction [NVP-TAE684 results in decreased phosphorylation of MAPK1 protein]22553343
C516714NVP-TAE684HGF protein inhibits the reaction [NVP-TAE684 results in decreased phosphorylation of MAPK3 protein]22553343
C516714NVP-TAE684HGF protein results in decreased susceptibility to NVP-TAE68422553343
C516714NVP-TAE684MET protein promotes the reaction [HGF protein results in decreased susceptibility to NVP-TAE684]22553343
C516714NVP-TAE684"N-(2-fluoro-4-((2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)carbonylaminopyridin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide inhibits the reaction [HGF protein results in decreased susceptibility to NVP-TAE684]"22553343
C025589ochratoxin Aochratoxin A inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]18031729
D009966OrphenadrineOrphenadrine affects the expression of HGF mRNA23665939
C026055oxilofrineoxilofrine inhibits the reaction [VEGFA protein results in increased expression of HGF protein]20643105
D010100OxygenOxygen deficiency results in decreased expression of HGF mRNA26516004
D010100OxygenOxygen deficiency results in decreased expression of HGF mRNA20880076
D010269ParaquatParaquat results in increased expression of HGF mRNA16324872
D052638Particulate MatterParticulate Matter results in increased expression of HGF mRNA17450221
C410127PCB 180PCB 180 results in decreased expression of HGF mRNA26238599
C115711PD 173074[PD 173074 results in decreased activity of FGFR1 protein] inhibits the reaction [[crizotinib results in decreased phosphorylation of MET protein] which results in increased expression of HGF protein]22683780
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of HGF mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HGF protein22414604
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HGF protein20118188
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [sodium arsenite results in increased expression of HGF mRNA]19349368
D015232DinoprostoneHGF protein results in increased abundance of Dinoprostone14751415
D015232Dinoprostonerofecoxib inhibits the reaction [HGF protein results in increased abundance of Dinoprostone]14751415
D015232Dinoprostone[rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [HGF protein results in increased abundance of Dinoprostone]14751415
D010634Phenobarbital[MYC gene co-treated with HGF gene] results in decreased susceptibility to Phenobarbital8807143
D010634PhenobarbitalPhenobarbital affects the expression of HGF mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of HGF mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of HGF protein1370768
D010798PhycocyaninPhycocyanin inhibits the reaction [Carbon Tetrachloride results in increased expression of HGF mRNA]20227401
C014153pirimiphos methylpirimiphos methyl results in increased expression of HGF mRNA27845199
C006253pirinixic acidpirinixic acid results in decreased expression of HGF mRNA20813756|2381119
C006253pirinixic acidpirinixic acid results in increased expression of HGF mRNA12832660
D010972Platelet Activating FactorPlatelet Activating Factor results in decreased expression of HGF mRNA15307983
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of HGF mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of HGF mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of HGF mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of HGF mRNA22238285
D011441PropylthiouracilPropylthiouracil results in decreased expression of HGF mRNA24780913
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of HGF mRNA23274088
C008704pyrithione[Zinc co-treated with pyrithione] promotes the reaction [HGF protein results in increased expression of PCNA mRNA]22374166
D011794QuercetinQuercetin inhibits the reaction [HGF protein promotes the reaction [bis(sulfosuccinimidyl)suberate promotes the reaction [MET protein binds to MET protein]]]25971889
D011794QuercetinQuercetin inhibits the reaction [HGF protein results in increased expression of and results in increased phosphorylation of MET protein]25971889
D011794QuercetinQuercetin inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]19244381
D011794QuercetinQuercetin inhibits the reaction [HGF protein results in increased phosphorylation of GAB1 protein]25971889
D011794QuercetinQuercetin inhibits the reaction [HGF protein results in increased phosphorylation of MET protein]19244381
D011794QuercetinQuercetin inhibits the reaction [HGF protein results in increased phosphorylation of PTK2 protein]25971889
D011794QuercetinQuercetin results in decreased expression of HGF mRNA25971889
D011794QuercetinQuercetin inhibits the reaction [Methylnitrosourea results in decreased expression of HGF mRNA]18675455
C012526quercitrinquercitrin results in increased expression of HGF mRNA25193878
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of HGF mRNA16497877
D017382Reactive Oxygen SpeciesHGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased abundance of Reactive Oxygen Species]23764483
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of HGF mRNA15672869
D017382Reactive Oxygen Speciesresveratrol inhibits the reaction [Reactive Oxygen Species results in increased expression of HGF mRNA]15672869
D012110ReserpineReserpine results in increased expression of HGF protein16081063
C059514resveratrolresveratrol results in decreased expression of HGF mRNA15280659
C059514resveratrolresveratrol results in increased expression of HGF mRNA22086758
C059514resveratrolresveratrol results in increased expression of HGF protein22086758
C059514resveratrolresveratrol inhibits the reaction [Reactive Oxygen Species results in increased expression of HGF mRNA]15672869
D015474IsotretinoinIsotretinoin results in decreased expression of HGF mRNA11223164
D015474IsotretinoinIsotretinoin results in decreased secretion of HGF protein11223164
C013672riddelliineriddelliine results in increased expression of HGF mRNA18047727
D012293RifampinHGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased abundance of Reactive Oxygen Species]23764483
D012293RifampinHGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]23764483
C116926rofecoxibrofecoxib results in decreased expression of HGF mRNA17070997
C116926rofecoxibrofecoxib inhibits the reaction [HGF protein results in increased abundance of Dinoprostone]14751415
C116926rofecoxibrofecoxib inhibits the reaction [HGF protein results in increased expression of IL10 protein]14751415
C116926rofecoxib[rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [HGF protein results in increased abundance of Dinoprostone]14751415
C116926rofecoxib[rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [HGF protein results in increased expression of IL10 protein]14751415
C116926rofecoxibrofecoxib results in decreased susceptibility to HGF protein14751415
D012406RoxarsoneRoxarsone results in increased expression of HGF mRNA18414637
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of HGF mRNA"16678137
C496827salubrinalsalubrinal inhibits the reaction [Thapsigargin results in decreased expression of HGF mRNA]28844859
C496827salubrinalsalubrinal inhibits the reaction [Thapsigargin results in decreased expression of HGF protein]28844859
C496827salubrinalsalubrinal inhibits the reaction [Tunicamycin results in decreased expression of HGF mRNA]28844859
C496827salubrinalsalubrinal inhibits the reaction [Tunicamycin results in decreased expression of HGF protein]28844859
D012834SilverSilver results in decreased expression of HGF mRNA26551752
D012906SmokeSmoke results in decreased nitrosation of HGF protein21652289
C017947sodium arsenitePertussis Toxin inhibits the reaction [sodium arsenite results in increased expression of HGF mRNA]19349368
C017947sodium arseniteS1PR1 protein affects the reaction [sodium arsenite results in increased expression of HGF mRNA]19349368
C017947sodium arsenitesodium arsenite results in increased expression of HGF mRNA19349368
C017947sodium arsenitesodium arsenite results in increased expression of HGF mRNA16876216
C016104sodium bichromatesodium bichromate results in increased expression of HGF mRNA25993096
D018038Sodium SeleniteSodium Selenite inhibits the reaction [TGFB1 protein results in increased expression of HGF protein]16757516
D018038Sodium SeleniteSodium Selenite results in decreased expression of HGF mRNA18175754
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of HGF mRNA23274088
C060506sphingosine 1-phosphatesphingosine 1-phosphate results in increased expression of HGF mRNA19349368
D010042OuabainOuabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]18031729
D012460SulfasalazineSulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA]12745093
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]18031729
C025462sulindac sulfidesulindac sulfide results in decreased expression of HGF mRNA10807402
C112689TAC 101TAC 101 inhibits the reaction [HGF protein results in increased expression of MET protein]9932610
D013619TacrineTacrine results in increased expression of HGF mRNA12832660
D013629TamoxifenTamoxifen affects the expression of HGF mRNA17555576
D013655Taurochenodeoxycholic AcidTaurochenodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D013656Taurocholic AcidHGF protein results in increased uptake of Taurocholic Acid18031729
C084178telmisartantelmisartan results in increased expression of HGF mRNA21479465
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HGF mRNA22298810
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HGF mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HGF mRNA22666406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HGF mRNA12167310|1566782
D013755Tetradecanoylphorbol AcetateDexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HGF protein]15802798
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of HGF mRNA15802798
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of HGF protein15802798
D013755Tetradecanoylphorbol AcetateTGFB1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HGF protein]15802798
D013755Tetradecanoylphorbol AcetateUrsodeoxycholic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HGF mRNA]15802798
D013755Tetradecanoylphorbol AcetateUrsodeoxycholic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HGF protein]15802798
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HGF mRNA23519560
D013792ThalidomideThalidomide affects the expression of HGF mRNA15939924
D013792ThalidomideThalidomide affects the expression of HGF protein15939924
D013792ThalidomideThalidomide affects the secretion of HGF protein15939924
D013792ThalidomideThalidomide results in decreased activity of HGF protein17557286
D019284Thapsigargin4-phenylbutyric acid inhibits the reaction [Thapsigargin results in decreased expression of HGF mRNA]28844859
D019284Thapsigarginsalubrinal inhibits the reaction [Thapsigargin results in decreased expression of HGF mRNA]28844859
D019284Thapsigarginsalubrinal inhibits the reaction [Thapsigargin results in decreased expression of HGF protein]28844859
D019284ThapsigarginThapsigargin results in decreased expression of HGF mRNA28844859
D019284ThapsigarginThapsigargin results in decreased expression of HGF protein28844859
D013853ThioacetamideHGF protein results in decreased susceptibility to Thioacetamide12479984
D013853ThioacetamideHGF protein inhibits the reaction [Thioacetamide results in increased expression of COL1A2 mRNA]10677585
D013853ThioacetamideHGF protein inhibits the reaction [Thioacetamide results in increased expression of COL4A1 mRNA]10677585
D013853ThioacetamideHGF protein inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]10677585
C009495titanium dioxidetitanium dioxide results in decreased expression of HGF mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of HGF mRNA18087596
D014212TretinoinTretinoin inhibits the reaction [HGF protein results in increased expression of MET protein]9932610
D014212TretinoinTretinoin results in decreased expression of HGF mRNA11223164
D014212TretinoinTretinoin results in decreased secretion of HGF protein11223164
D014212TretinoinTretinoin results in increased expression of HGF mRNA16051641
D014212TretinoinTretinoin results in increased secretion of HGF protein17170094
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HGF mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of HGF mRNA24935251|2623859
D014415Tunicamycin4-phenylbutyric acid inhibits the reaction [Tunicamycin results in decreased expression of HGF mRNA]28844859
D014415Tunicamycin4-phenylbutyric acid inhibits the reaction [Tunicamycin results in decreased expression of HGF protein]28844859
D014415Tunicamycinsalubrinal inhibits the reaction [Tunicamycin results in decreased expression of HGF mRNA]28844859
D014415Tunicamycinsalubrinal inhibits the reaction [Tunicamycin results in decreased expression of HGF protein]28844859
D014415TunicamycinTunicamycin results in decreased expression of HGF mRNA28844859
D014415TunicamycinTunicamycin results in decreased expression of HGF protein28844859
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF mRNA]15802798
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]15802798
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HGF mRNA]15802798
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HGF protein]15802798
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of HGF mRNA11983124
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HGF mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HGF mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HGF mRNA23179753|2438349
D000068756ValsartanValsartan inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]16115399
D000068756ValsartanValsartan inhibits the reaction [Bleomycin results in decreased expression of HGF protein]16115399
D014638VanadatesVanadates promotes the reaction [HGF protein results in increased expression of PCNA mRNA]22374166
D014639VanadiumVanadium results in decreased expression of HGF mRNA19000753
C066075vanadium pentoxidevanadium pentoxide results in increased expression of HGF mRNA17459161
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HGF gene25560391
C551177vemurafenibA-1155463 inhibits the reaction [[MET protein affects the susceptibility to HGF protein] affects the reaction [BRAF protein mutant form results in increased susceptibility to vemurafenib]]27689874
C551177vemurafenibABT-737 inhibits the reaction [[MET protein affects the susceptibility to HGF protein] affects the reaction [BRAF protein mutant form results in increased susceptibility to vemurafenib]]27689874
C551177vemurafenib[MET protein affects the susceptibility to HGF protein] affects the reaction [BRAF protein mutant form results in increased susceptibility to vemurafenib]27689874
C551177vemurafenib[MET protein affects the susceptibility to HGF protein] affects the reaction [[BRAF protein mutant form results in increased susceptibility to vemurafenib] which results in increased expression of BBC3 protein]27689874
C551177vemurafenib[MET protein affects the susceptibility to HGF protein] affects the reaction [[BRAF protein mutant form results in increased susceptibility to vemurafenib] which results in increased expression of BCL2L11 protein]27689874
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HGF mRNA"27188386
D015032Zinc[Zinc co-treated with pyrithione] promotes the reaction [HGF protein results in increased expression of PCNA mRNA]22374166
C016837zinc chloridezinc chloride inhibits the reaction [HGF protein binds to MET protein]15161915
D015034Zinc OxideZinc Oxide affects the expression of HGF mRNA28648595
D019287Zinc Sulfate[Zinc Sulfate co-treated with HGF protein] results in increased phosphorylation of MAPK1 protein22374166
D019287Zinc Sulfate[Zinc Sulfate co-treated with HGF protein] results in increased phosphorylation of MAPK3 protein22374166
D019287Zinc Sulfate[Zinc Sulfate co-treated with HGF protein] results in increased phosphorylation of MET protein22374166

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IBA21873635  
GO:0004252serine-type endopeptidase activityNOTNAS2531289  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI1846706  12694198  15167892  16537482  17804794  17981115  
18585357  25416956  
GO:0008083growth factor activity-NAS2531289  
GO:0042056chemoattractant activity-IDA21245381  
GO:0042802identical protein binding-IPI17804794  20624990  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0000187activation of MAPK activity-IEA-  
GO:0000278mitotic cell cycle-NAS2531289  
GO:0000902cell morphogenesis-IEA-  
GO:0001837epithelial to mesenchymal transition-TAS14679171  
GO:0001889liver development-IEA-  
GO:0001934positive regulation of protein phosphorylation-IBA21873635  
GO:0002576platelet degranulation-TAS-  
GO:0006508proteolysisNOTNAS2531289  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010507negative regulation of autophagy-NAS24743740  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IDA20655899  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030212hyaluronan metabolic process-IEA-  
GO:0030335positive regulation of cell migration-IBA21873635  
GO:0030335positive regulation of cell migration-IDA21245381  
GO:0031100animal organ regeneration-IEA-  
GO:0031643positive regulation of myelination-IEA-  
GO:0032715negative regulation of interleukin-6 production-IEA-  
GO:0032733positive regulation of interleukin-10 production-IEA-  
GO:0033137negative regulation of peptidyl-serine phosphorylation-IEA-  
GO:0035729cellular response to hepatocyte growth factor stimulus-IBA21873635  
GO:0035729cellular response to hepatocyte growth factor stimulus-IDA21245381  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA20655899  
GO:0045669positive regulation of osteoblast differentiation-NAS22521434  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-NAS22521434  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048012hepatocyte growth factor receptor signaling pathway-IBA21873635  
GO:0048012hepatocyte growth factor receptor signaling pathway-IDA21245381  
GO:0050728negative regulation of inflammatory response-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA21245381  
GO:0050918positive chemotaxis-IEA-  
GO:0051450myoblast proliferation-IEA-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0060326cell chemotaxis-IDA21245381  
GO:0060665regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling-IDA14517989  
GO:0070572positive regulation of neuron projection regeneration-IEA-  
GO:0090201negative regulation of release of cytochrome c from mitochondria-IDA20655899  
GO:1900744regulation of p38MAPK cascade-IEA-  
GO:1901299negative regulation of hydrogen peroxide-mediated programmed cell death-IDA20655899  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-IEA-  
GO:1902947regulation of tau-protein kinase activity-IEA-  
GO:2000573positive regulation of DNA biosynthetic process-IDA2531289  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0016020membrane-HDA19946888  
GO:0031093platelet alpha granule lumen-TAS-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04510Focal adhesion
hsa05144Malaria
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266695Interleukin-7 signalingIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-6806834Signaling by METTAS
R-HSA-6806942MET Receptor ActivationTAS
R-HSA-6807004Negative regulation of MET activityTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-8851805MET activates RAS signalingTAS
R-HSA-8851907MET activates PI3K/AKT signalingTAS
R-HSA-8865999MET activates PTPN11TAS
R-HSA-8874081MET activates PTK2 signalingTAS
R-HSA-8875513MET interacts with TNS proteinsTAS
R-HSA-8875555MET activates RAP1 and RAC1TAS
R-HSA-8875656MET receptor recyclingTAS
R-HSA-8875791MET activates STAT3TAS
R-HSA-8875878MET promotes cell motilityTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29558956MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner. (2018 Mar 20)Andriani FJ Hematol Oncol
18638565Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk. (2008 Aug-Sep)Amati MMutat Res
27071409Associations of Insulin and IGFBP-3 with Lung Cancer Susceptibility in Current Smokers. (2016 Jul)Ho GYFJ Natl Cancer Inst
26667487Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment. (2016 Apr 1)Delitto DClin Cancer Res
19223316Vascular endothelial growth factor, its soluble receptor, and hepatocyte growth factor: clinical and genetic correlates and association with vascular function. (2009 May)Lieb WEur Heart J
18990973Systemic impairment in relation to disease burden in patients with moderate COPD eligible for a lifestyle program. Findings from the INTERCOM trial. (2008)van Wetering CRInt J Chron Obstruct Pulmon Dis
27684606Effects of cigarette smoking on cardiovascular-related protein profiles in two community-based cohort studies. (2016 Nov)Huang BAtherosclerosis
27033561Urinary biomarkers are associated with incident cardiovascular disease, all-cause mortality and deterioration of kidney function in type 2 diabetic patients with microalbuminuria. (2016 Jul)von Scholten BJDiabetologia
28572400Hepatocyte growth factor demonstrates racial heterogeneity as a biomarker for coronary heart disease. (2017 Aug)Bielinski SJHeart
15071489Effect of nifedipine on endothelial function in normotensive smokers: potential contribution of increase in circulating hepatocyte growth factor. (2004 Oct)Yamasaki KJ Hum Hypertens
11917058Serum hepatocyte growth factor is associated with viral hepatitis, cardiovascular disease, erythropoietin treatment, and type of heparin in haemodialysis patients. (2002 Apr)Borawski JNephrol Dial Transplant
25581751The effect of nicotine and cotinine on human gingival fibroblasts attachment to root surfaces. (2015 Sep)Esfahrood ZRJ Basic Clin Physiol Pharmacol
11677362Association between carotid arterial remodeling and plasma concentration of circulating hepatocyte growth factor. (2001 Nov)Yamamoto YJ Hypertens
26870265Nicotine enhances hepatocyte growth factor-mediated lung cancer cell migration by activating the alpha7 nicotine acetylcholine receptor and phosphoinositide kinase-3-dependent pathway. (2016 Jan)Yoneyama ROncol Lett
24140093Higher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome. (2013 Dec)Dalamaga MMetabolism
21142980Effects of cigarette smoke condensate and nicotine on human gingival fibroblast-mediated collagen degradation. (2011 Jul)Zhang WJ Periodontol
23216133Contact lens wearing and chronic cigarette smoking positively correlate with TGF-beta1 and VEGF tear levels and impaired corneal wound healing after photorefractive keratectomy. (2013 Mar)Roszkowska AMCurr Eye Res
20636139Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells. (2010 Nov)San Miguel SMJ Periodontol
19396864CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma -A miRNA microarray analysis. (2009 Jul)Guled MGenes Chromosomes Cancer
10522774The effects of nicotine and age on replication and viability of human gingival fibroblasts in vitro. (1999 Oct)Checchi LJ Clin Periodontol
16539839Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts. (2006 Apr)Ho YCActa Pharmacol Sin
25249428A phase II study of erlotinib monotherapy in pre-treated non-small cell lung cancer without EGFR gene mutation who have never/light smoking history: re-evaluation of EGFR gene status (NEJ006/TCOG0903). (2014 Nov)Matsumoto YLung Cancer
15064106Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population. (2004 Apr)Takiuchi SAtherosclerosis
19097356Pathology of renal tumors in adults. Molecular biology, histopathological diagnosis and prognosis. (2008)Okon KPol J Pathol
26138771Angiogenesis Biomarkers May Be Useful in the Management of Patients With Indeterminate Pulmonary Nodules. (2015 Aug)Seder CWAnn Thorac Surg
22687639Blood biomarkers and measures of pulmonary function--a study from the Swedish twin registry. (2012 Sep)Engstrom GRespir Med
26631852Current therapies and investigational drugs for peripheral arterial disease. (2016 Apr)Suzuki JHypertens Res
23148928An investigation of the resolution of inflammation (catabasis) in COPD. (2012 Nov 13)Noguera ARespir Res
15775199[Division of endocrinology and metabolism, strategy for treatment of diabetic vascular complications for physicians]. (2003 Sep)Egawa KClin Calcium
16254251Cigarette smoking induces overexpression of hepatocyte growth factor in type II pneumocytes and lung cancer cells. (2006 Mar)Chen JTAm J Respir Cell Mol Biol
11325063Microtubules and vimentin associated filaments (VIFs) in cultured human gingival fibroblasts (HGFs) after exposure to acrolein and acetaldehyde. (2001 Mar)Poggi PAnn Anat
22672958Serum hepatocyte growth factor and cancer mortality in an apparently healthy Japanese population. (2012)Otsuka MJ Epidemiol
29193859Comparative evaluation of salivary hepatocyte growth factor in smokers and non-smokers with chronic periodontitis. (2018 May)Guru SJ Investig Clin Dent
29634978Clinical implication of programmed death-ligand 1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition. (2018 Apr 7)Kwon MJHum Pathol
29589872Cigarette Smoking Impairs Adipose Stromal Cell Vasculogenic Activity and Abrogates Potency to Ameliorate Ischemia. (2018 Mar 28)Barwinska DStem Cells
17545521Nuclear factor-kappaB-related serum factors as longitudinal biomarkers of response and survival in advanced oropharyngeal carcinoma. (2007 Jun 1)Allen CClin Cancer Res
26892517Circulating level of hepatocyte growth factor predicts incidence of type 2 diabetes mellitus: The Multi-Ethnic Study of Atherosclerosis (MESA). (2016 Mar)Bancks MPMetabolism
23398210Hepatocyte growth factor and interferon-gamma inducible protein-10 are related to visceral adiposity. (2013 Apr)Faber DREur J Clin Invest
19756735Mina53, a novel c-Myc target gene, is frequently expressed in lung cancers and exerts oncogenic property in NIH/3T3 cells. (2010 Mar)Komiya KJ Cancer Res Clin Oncol
11525435Regulation of cytokine production in human gingival fibroblasts following treatment with nicotine and lipopolysaccharide. (2001 Aug)Wendell KJJ Periodontol