Gene: KCNIP1

30820
KCHIP1|VABP
potassium voltage-gated channel interacting protein 1
protein-coding
5q35.1
Ensembl:ENSG00000182132 MIM:604660 Vega:OTTHUMG00000130442 UniprotKB:Q9NZI2
NG_011538.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.741e-4 (AD)  5.191e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11134638chr5:170580499 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs888936chr5:170496899 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC24A30.695
SDC30.693
TIMM8B0.688
RND20.684
BAALC0.678
COX200.67
PARL0.667
MORN20.664
C18orf320.661
IDNK0.651

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.58
OR4F29-0.525
NPC1L1-0.284
NEUROG3-0.266
NPIPB6-0.264
REP15-0.264
RAX2-0.259
CCNA2-0.258
HSD11B2-0.256
BNIPL-0.254

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of KCNIP1 mRNA"27291303
C0179063-dinitrobenzene3-dinitrobenzene affects the expression of KCNIP1 mRNA24140754
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of KCNIP1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of KCNIP1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of KCNIP1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of KCNIP1 mRNA21298039
D005680gamma-Aminobutyric AcidKCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased abundance of gamma-Aminobutyric Acid]25917026
D0157614-Aminopyridine4-Aminopyridine results in decreased expression of KCNIP1 mRNA24378259
D0157614-Aminopyridine4-Aminopyridine results in increased expression of KCNIP1 mRNA25917026
D0157614-AminopyridineKCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased abundance of gamma-Aminobutyric Acid]25917026
D0157614-AminopyridineKCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA]25917026
D0157614-AminopyridineKCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA]25917026
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNIP1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of KCNIP1 mRNA25929836
C006780bisphenol Abisphenol A affects the expression of KCNIP1 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of KCNIP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KCNIP1 gene28505145
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of KCNIP1 mRNA23640034
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of KCNIP1 mRNA20170705
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of KCNIP1 mRNA18936297
C039281furanfuran results in decreased expression of KCNIP1 mRNA25539665|2619464
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of KCNIP1 mRNA24810058
D011192Potassium DichromatePotassium Dichromate results in increased expression of KCNIP1 mRNA23608068
C017947sodium arsenitesodium arsenite affects the methylation of KCNIP1 gene28589171
D012969Sodium FluorideSodium Fluoride results in increased expression of KCNIP1 mRNA27862939
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KCNIP1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005244voltage-gated ion channel activity-IEA-  
GO:0005267potassium channel activity-IEA-  
GO:0005509calcium ion binding-IDA17187064  
GO:0005515protein binding-IPI15358149  17057713  17187064  
GO:0015459potassium channel regulator activity-IDA10676964  17187064  
GO ID GO Term Qualifier Evidence PubMed
GO:0071805potassium ion transmembrane transport-IEA-  
GO:1901379regulation of potassium ion transmembrane transport-IDA10676964  17187064  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA10676964  
GO:0005886plasma membrane-TAS-  
GO:0008076voltage-gated potassium channel complex-IDA10676964  17187064  
GO:0030425dendrite-IEA-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IDA10676964  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576894Phase 1 - inactivation of fast Na+ channelsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal