Gene: CXXC1

30827
2410002I16Rik|5830420C16Rik|CFP1|CGBP|HsT2645|PCCX1|PHF18|SPP1|ZCGPC1|hCGBP
CXXC finger protein 1
protein-coding
18q21.1
Ensembl:ENSG00000154832 MIM:609150 Vega:OTTHUMG00000132670 UniprotKB:Q9P0U4
NC_000018.10
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.100e-1 (AD)  1.434e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRRT0.927
SNRNP700.927
RBM100.926
TRMT10.925
RING10.922
ACIN10.918
GAK0.914
CTTN0.911
GGA10.91
DMPK0.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.716
OR4F29-0.712
TRDN-0.257
MTRNR2L9-0.228
GSDMC-0.22
TTLL10-AS1-0.218
MYL1-0.215
ARHGEF35-0.204
AGTR1-0.203
MYH2-0.203

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CXXC1 mRNA"21346803
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of CXXC1 mRNA20829426
D000082AcetaminophenAcetaminophen affects the expression of CXXC1 mRNA17562736
D001151ArsenicArsenic affects the methylation of CXXC1 gene25304211
D001194AsbestosAsbestos results in increased expression of CXXC1 mRNA22076105
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CXXC1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of CXXC1 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of CXXC1 promoter27334623
C006780bisphenol Abisphenol A affects the expression of CXXC1 mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of CXXC1 mRNA19549813
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CXXC1 mRNA28628672
D004147DioxinsDioxins affects the expression of CXXC1 mRNA20463971
D005485FlutamideFlutamide results in increased expression of CXXC1 mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CXXC1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CXXC1 mRNA28628672
C025340manganese chloridemanganese chloride results in decreased expression of CXXC1 mRNA27913844
C025340manganese chloridemanganese chloride results in increased methylation of CXXC1 gene27913844
D008731MethoxychlorMethoxychlor affects the expression of CXXC1 mRNA20829426
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CXXC1 mRNA"22076105
D012643SeleniumSelenium results in increased expression of CXXC1 mRNA19244175
C009277sodium arsenatesodium arsenate results in increased expression of CXXC1 mRNA23922661
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CXXC1 mRNA21570461
D014635Valproic AcidValproic Acid affects the expression of CXXC1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CXXC1 mRNA23179753
C025643vinclozolinvinclozolin results in decreased expression of CXXC1 mRNA23034163
D015032ZincZinc deficiency results in increased expression of CXXC1 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000987proximal promoter sequence-specific DNA binding-IEA-  
GO:0005515protein binding-IPI17998332  23870121  25416956  26496610  
GO:0008270zinc ion binding-IEA-  
GO:0042800histone methyltransferase activity (H3-K4 specific)contributes_toIDA17355966  
GO:0045322unmethylated CpG binding-IDA10688657  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IDA10688657  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0036498IRE1-mediated unfolded protein response-TAS-  
GO:0045893positive regulation of transcription, DNA-templated-IBA21873635  
GO:0045893positive regulation of transcription, DNA-templated-IDA10688657  
GO:0051568histone H3-K4 methylation-IDA17355966  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10688657  
GO:0005654nucleoplasm-TAS-  
GO:0005669transcription factor TFIID complex-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0016363nuclear matrix-IEA-  
GO:0016607nuclear speck-IDA-  
GO:0035097histone methyltransferase complex-IDA17355966  
GO:0048188Set1C/COMPASS complex-IDA17998332  18838538  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-381038XBP1(S) activates chaperone genesTAS
R-HSA-381070IRE1alpha activates chaperonesTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal