Gene: DNTTIP2

30836
ERBP|FCF2|HSU15552|LPTS-RP2|TdIF2
deoxynucleotidyltransferase terminal interacting protein 2
protein-coding
1p22.1
Ensembl:ENSG00000067334 MIM:611199 Vega:OTTHUMG00000010268 UniprotKB:Q5QJE6
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.836e-1 (AD)  6.296e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WTAP0.886
TRA2B0.881
NOP580.874
EIF2S20.871
BRIX10.871
ETF10.869
CCT6A0.864
PDIA30.861
KDELR20.858
RBM220.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.646
OR4F29-0.629
HES5-0.267
NXNL1-0.243
GH1-0.182
C16orf97-0.18
SPRR2A-0.174
LYZL2-0.171
REN-0.171
BTBD17-0.156

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of DNTTIP2 mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DNTTIP2 mRNA"25614096
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DNTTIP2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DNTTIP2 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of DNTTIP2 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of DNTTIP2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DNTTIP2 mRNA]17585979
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DNTTIP2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DNTTIP2 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of DNTTIP2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of DNTTIP2 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of DNTTIP2 mRNA25181051
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of DNTTIP2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DNTTIP2 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of DNTTIP2 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of DNTTIP2 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of DNTTIP2 mRNA20106945|2556210
D013759DronabinolDronabinol results in decreased expression of DNTTIP2 mRNA11015613
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DNTTIP2 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DNTTIP2 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of DNTTIP2 mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of DNTTIP2 mRNA27614199
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DNTTIP2 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DNTTIP2 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of DNTTIP2 mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of DNTTIP2 mRNA28329830
D005485FlutamideFlutamide results in increased expression of DNTTIP2 mRNA21126777
D005485FlutamideFlutamide results in increased expression of DNTTIP2 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of DNTTIP2 mRNA22634610
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of DNTTIP2 mRNA19376150
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DNTTIP2 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of DNTTIP2 mRNA20003209
C544151jinfukangjinfukang results in decreased expression of DNTTIP2 mRNA27392435
C410337K 7174K 7174 results in increased expression of DNTTIP2 mRNA24086573
C011890kojic acidkojic acid results in decreased expression of DNTTIP2 mRNA16595896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DNTTIP2 mRNA26011545
C568376MT19c compoundMT19c compound results in increased expression of DNTTIP2 mRNA21781307
C006253pirinixic acidpirinixic acid results in increased expression of DNTTIP2 mRNA23811191
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DNTTIP2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of DNTTIP2 mRNA22079256
D011794QuercetinQuercetin results in increased expression of DNTTIP2 mRNA21632981
D012834SilverSilver results in increased expression of DNTTIP2 mRNA26014281
C016104sodium bichromatesodium bichromate results in increased expression of DNTTIP2 mRNA24612858
C016104sodium bichromatesodium bichromate results in increased expression of DNTTIP2 mRNA25993096
D018038Sodium SeleniteSodium Selenite results in increased expression of DNTTIP2 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DNTTIP2 mRNA18762178
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DNTTIP2 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DNTTIP2 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DNTTIP2 mRNA28065790
D014635Valproic AcidValproic Acid results in decreased methylation of DNTTIP2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DNTTIP2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20887155Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. (2010 Dec)Edmiston JSBiomarkers