Gene: NRG1

3084
ARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDF
neuregulin 1
protein-coding
8p12
Ensembl:ENSG00000157168 MIM:142445 Vega:OTTHUMG00000163918 UniprotKB:Q02297
NG_012005.2
PubMed|SNP Mapped
OD|ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.141e-1 (AD)  8.836e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2466046chr8:32659643 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLSTN20.89
CNIH30.888
CORO2A0.881
GRM80.874
AHNAK20.869
CPNE40.865
ERC20.861
NELL10.86
SPHKAP0.857
VSTM50.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASB4-0.605
YES1-0.573
ITGB5-0.572
ACOX2-0.566
RHOD-0.554
PARD3B-0.554
MAML2-0.553
ARHGAP31-0.551
CDC14A-0.549
IMPA2-0.547

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of NRG1 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of NRG1 mRNA]"27071940
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of NRG1 mRNA"28903501
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in increased expression of NRG1 mRNA26821219
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of NRG1 mRNA28329830
C0326681-nitropyrene1-nitropyrene results in increased expression of NRG1 mRNA19041380
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"ERBB3 affects the reaction [NRG1 results in decreased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine]"19509167
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"NRG1 protein affects the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of AKT1 protein]"19509167
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"NRG1 protein promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased phosphorylation of ERBB3 protein]"19509167
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"NRG1 results in decreased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"19509167
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of NRG1 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl affects the expression of NRG1 mRNA"21703328
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of NRG1 mRNA"23146750
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of NRG1 mRNA"21920950
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-oneNRG1 protein alternative form inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]15231676
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-oneNRG1 protein alternative form inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]15231676
C4881852-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide"NRG1 protein alternative form inhibits the reaction [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]"15231676
C4881852-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide"NRG1 protein alternative form inhibits the reaction [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]"15231676
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of NRG1 mRNA"25710175
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of NRG1 mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NRG1 mRNA]"21851831
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NRG1 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHB protein results in decreased expression of NRG1 mRNA]23071612
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP10 protein]]19801490
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]]19801490
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]19801490
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP5 protein]]19801490
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP6 protein]]19801490
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]]19801490
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NRG1 mRNA"21346803
C0194992-nitrofluorene2-nitrofluorene results in increased expression of NRG1 mRNA14600272|1589037
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"NRG1 results in decreased susceptibility to 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"20701826
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NRG1 mRNA"19692669|2095900
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NRG1 mRNA14600272|1589037
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of NRG1 mRNA17562736
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NRG1 mRNA25607892
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NRG1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NRG1 mRNA14600272|1589037
D000393Air PollutantsAir Pollutants analog results in increased expression of NRG1 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NRG1 mRNA16483693
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NRG1 mRNA25607892
C081565arachidonyltrifluoromethanearachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK1 protein]15231676
C081565arachidonyltrifluoromethanearachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein]15231676
D001151ArsenicArsenic affects the expression of NRG1 protein24675094
D001151ArsenicArsenic affects the methylation of NRG1 gene25304211
D001151ArsenicArsenic results in increased expression of NRG1 mRNA19945496
D001151ArsenicArsenic results in decreased expression of NRG1 mRNA24019935
C006632arsenic trioxidearsenic trioxide results in increased expression of NRG1 mRNA22521957
C015001arsenitearsenite results in decreased expression of NRG1 mRNA23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of NRG1 mRNA"24160326
C547126AZM551248AZM551248 results in increased expression of NRG1 mRNA22323515
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NRG1 mRNA18164116
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NRG1 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NRG1 mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [KU-32 compound inhibits the reaction [NRG1 protein results in increased expression of and results in increased phosphorylation of JUN protein]]23240583
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NRG1 protein results in increased expression of and results in increased phosphorylation of JUN protein]23240583
D004958EstradiolESR1 protein affects the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]26502914
D004958Estradiolfulvestrant inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]26502914
D004958Estradiol[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein26502914
D004958EstradiolRaloxifene Hydrochloride inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]26502914
D004958EstradiolTamoxifen inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]26502914
D004958EstradiolEstradiol results in decreased expression of NRG1 mRNA20068009
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of NRG1 mRNA27685785
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK1 protein]15231676
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein]15231676
C006780bisphenol Abisphenol A results in increased methylation of NRG1 promoter27271280
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NRG1 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NRG1 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of NRG1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NRG1 gene28505145
C038091butylparaben[butylparaben co-treated with NRG1 protein] promotes the reaction [ESR1 protein binds to MYC enhancer]26502914
C038091butylparabenbutylparaben promotes the reaction [NRG1 protein results in increased expression of MYC mRNA]26502914
C038091butylparaben[NRG1 protein co-treated with butylparaben] results in increased expression of MYC protein26502914
C038091butylparabenNRG1 protein promotes the reaction [butylparaben results in increased expression of MYC mRNA]26502914
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NRG1 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NRG1 mRNA25607892
C018475butyraldehydebutyraldehyde results in increased expression of NRG1 mRNA26079696
D002101Cacodylic AcidCacodylic Acid results in increased expression of NRG1 mRNA17720352
D002104CadmiumCadmium results in increased expression of NRG1 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NRG1 mRNA12160620
D019256Cadmium ChlorideCadmium Chloride affects the expression of NRG1 mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of NRG1 promoter22457795
D002235CarbofuranCarbofuran results in decreased expression of NRG1 mRNA28982980
D000068579CelecoxibCelecoxib inhibits the reaction [IL1B protein results in increased expression of and results in increased secretion of NRG1 protein]16357062
D000068579CelecoxibCelecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]16357062
D000068579CelecoxibDinoprostone inhibits the reaction [Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]]16357062
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NRG1 mRNA20938992
D003024ClozapineClozapine results in increased expression of NRG1 mRNA19502011
D003024ClozapineNRG1 protein affects the susceptibility to Clozapine15706234
D003024ClozapineClozapine affects the expression of NRG1 protein18184445
C018021cobaltous chloridecobaltous chloride results in decreased expression of NRG1 mRNA19320972
D005576Colforsin[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NRG1 mRNA21047912
D005576ColforsinU 0126 inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NRG1 mRNA]21047912
D019327Copper SulfateCopper Sulfate results in increased expression of NRG1 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in increased expression of NRG1 mRNA21527772
D016572CyclosporineCyclosporine results in increased expression of NRG1 mRNA20106945|2214713
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of NRG1 mRNA23640034
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NRG1 mRNA23914054
D013759DronabinolNRG1 gene SNP affects the susceptibility to Dronabinol20582876
D013759DronabinolNRG1 affects the susceptibility to Dronabinol17333138|1790552
D013759Dronabinol[NRG1 affects the susceptibility to Dronabinol] which affects the expression of FOS protein17905522
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NRG1 mRNA]27941970
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NRG1 mRNA25607892
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRG1 mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NRG1 mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRG1 mRNA25607892
D004041Dietary FatsDietary Fats results in decreased expression of NRG1 mRNA25016146
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NRG1 mRNA25607892
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRG1 mRNA25607892
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NRG1 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NRG1 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of NRG1 mRNA15890375
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of NRG1 mRNA20886546
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of NRG1 mRNA14600272|1589037
C547156dimethylthioarsinic aciddimethylthioarsinic acid results in decreased expression of NRG1 mRNA19945496
D004237DiuronDiuron results in decreased expression of NRG1 mRNA25152437
D004317DoxorubicinDoxorubicin results in increased expression of NRG1 mRNA28940058
D004317DoxorubicinNRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of AKT1 protein]15833803
D004317DoxorubicinNRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of ERBB2 protein]15833803
D004317DoxorubicinNRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of MAPK1 protein]15833803
D004317DoxorubicinNRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of MAPK3 protein]15833803
D004317DoxorubicinNRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of RPS6KB1 protein]15833803
D004317DoxorubicinNRG1 protein affects the reaction [Doxorubicin results in decreased expression of TNNC1 protein]19801490
D004317DoxorubicinNRG1 protein affects the reaction [Doxorubicin results in decreased expression of TNNI3 protein]19801490
D004317DoxorubicinNRG1 protein affects the reaction [Doxorubicin results in decreased expression of TNNT2 protein]19801490
D004317DoxorubicinNRG1 protein affects the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]19801490
D004317DoxorubicinNRG1 protein affects the susceptibility to Doxorubicin19801490
D004317Doxorubicin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP10 protein]]19801490
D004317Doxorubicin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]]19801490
D004317Doxorubicin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]19801490
D004317Doxorubicin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP5 protein]]19801490
D004317Doxorubicin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP6 protein]]19801490
D004317Doxorubicin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]]19801490
D004317DoxorubicinAKT1 protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNI3 protein]]19801490
D004317DoxorubicinAKT1 protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]]19801490
D004317DoxorubicinDoxorubicin results in increased expression of NRG1 protein alternative form17308081
D004317DoxorubicinERBB2 protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNI3 protein]]19801490
D004317DoxorubicinERBB2 protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]]19801490
D004317DoxorubicinMTOR protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNI3 protein]]19801490
D004317DoxorubicinMTOR protein promotes the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]]19801490
D004317DoxorubicinNRG1 protein affects the reaction [Doxorubicin results in increased degradation of TNNI3 protein]19801490
D004317DoxorubicinNRG1 protein alternative form inhibits the reaction [Doxorubicin results in decreased expression of ATP2A2 protein]17005195
D004317DoxorubicinNRG1 protein alternative form inhibits the reaction [Doxorubicin results in decreased expression of GSR mRNA]17005195
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNI3 mRNA]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNI3 protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 mRNA]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of EIF4EBP1 protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of EIF4G1 protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of RPS6KB2 protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of RPS6 protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP10 protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP5 protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP6 protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in increased ubiquitination of TNNI3 protein]19801490
C118739entinostatentinostat results in decreased expression of NRG1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NRG1 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NRG1 mRNA25607892
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of NRG1 mRNA20346928
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NRG1 mRNA22079256
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NRG1 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRG1 mRNA25607892
C540355fenamidonefenamidone results in increased expression of NRG1 mRNA27029645
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of NRG1 mRNA28329830
D005472FluorouracilNRG1 protein affects the susceptibility to Fluorouracil16217747
D005485FlutamideFlutamide results in decreased expression of NRG1 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NRG1 mRNA20938992
D004397FonofosFonofos results in increased methylation of NRG1 promoter22847954
C070081fulvestrantfulvestrant inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]26502914
C039281furanfuran results in increased expression of NRG1 mRNA24183702
C039281furanfuran results in increased expression of NRG1 mRNA25539665|2619464
C056507gemcitabinegemcitabine results in increased expression of NRG1 mRNA17039268
D005947GlucoseMAPK1 protein promotes the reaction [NRG1 protein results in increased transport of Glucose]14711829
D005947GlucoseMAPK3 protein promotes the reaction [NRG1 protein results in increased transport of Glucose]14711829
D005947Glucose[NRG1 protein binds to ERBB3 protein] which results in increased transport of Glucose14711829
D005947GlucoseNRG1 protein results in increased transport of Glucose14711829
D005947GlucosePDK1 protein promotes the reaction [NRG1 protein results in increased transport of Glucose]14711829
D005947GlucosePRKCZ protein promotes the reaction [NRG1 protein results in increased transport of Glucose]14711829
D005947GlucoseTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [NRG1 protein results in increased transport of Glucose]14711829
D006220HaloperidolHaloperidol results in increased expression of NRG1 protein18184445|2696161
D006861Hydrogen PeroxideNRG1 protein alternative form inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein]17005195
C016517indole-3-carbinolindole-3-carbinol affects the expression of NRG1 mRNA21396975
D007213IndomethacinIndomethacin results in decreased expression of NRG1 mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NRG1 mRNA24796395|2675264
D007649KetamineKetamine results in decreased expression of NRG1 mRNA20000043
C581040KU-32 compoundbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [KU-32 compound inhibits the reaction [NRG1 protein results in increased expression of and results in increased phosphorylation of JUN protein]]23240583
C581040KU-32 compoundKU-32 compound inhibits the reaction [NRG1 protein results in decreased expression of MPZ protein]23240583
C581040KU-32 compoundKU-32 compound inhibits the reaction [NRG1 protein results in increased expression of and results in increased phosphorylation of JUN protein]23240583
C581040KU-32 compoundKU-32 compound inhibits the reaction [NRG1 protein results in decreased expression of MPZ protein]20711301
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NRG1 mRNA25607892
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRG1 mRNA25607892
D008344Maneb[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NRG1 mRNA23017109
D008694MethamphetamineNRG1 gene SNP affects the susceptibility to Methamphetamine18316681
D008701MethapyrileneMethapyrilene results in increased expression of NRG1 mRNA15890375
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NRG1 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of NRG1 mRNA21678067
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NRG1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NRG1 mRNA21527772
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of NRG1 mRNA22401849
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of NRG1 protein24625837
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of NRG1 mRNA"29244179
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of NRG1 mRNA28174063
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NRG1 mRNA"25554681
C031721naphthalenenaphthalene analog results in increased expression of NRG1 mRNA24976557
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of NRG1 mRNA25380136
C461488N-benzylpiperazineN-benzylpiperazine results in increased expression of NRG1 mRNA26821219
D009532NickelNickel results in increased expression of NRG1 mRNA24768652|2558310
C119536nickel acetatenickel acetate results in decreased expression of and results in decreased phosphorylation of NRG1 protein22210268
C119536nickel acetatenickel acetate results in decreased expression of NRG1 mRNA22210268
C022838nickel chloridenickel chloride results in increased expression of NRG1 mRNA17312168
C029938nickel sulfatenickel sulfate results in decreased expression of NRG1 mRNA22714537
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of NRG1 mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of NRG1 mRNA19716841
C025589ochratoxin Aochratoxin A results in decreased expression of NRG1 mRNA22124623
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NRG1 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of NRG1 mRNA25607892
D009966OrphenadrineOrphenadrine affects the expression of NRG1 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NRG1 mRNA25729387
D010126OzoneOzone results in increased expression of NRG1 mRNA16716893
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of NRG1 mRNA26272509
D010269Paraquat[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NRG1 mRNA23017109
D010278ParathionParathion results in increased methylation of NRG1 promoter22847954
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NRG1 mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of NRG1 mRNA19162173
D015232DinoprostoneDinoprostone inhibits the reaction [Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]]16357062
D015232DinoprostoneDinoprostone results in increased expression of NRG1 mRNA16357062
D010634PhenobarbitalPhenobarbital affects the expression of NRG1 mRNA19159669
D010656PhenylephrinePhenylephrine results in decreased expression of NRG1 mRNA16698793
D010656PhenylephrinePhenylephrine results in decreased expression of NRG1 protein16698793
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NRG1 mRNA26272509
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of NRG1 mRNA15890375
C006253pirinixic acidpirinixic acid results in decreased expression of NRG1 mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of NRG1 mRNA]17950772
C006253pirinixic acidpirinixic acid results in increased expression of NRG1 mRNA15890375|1916217
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NRG1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NRG1 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of NRG1 mRNA23608068
C045362prochlorazprochloraz results in increased expression of NRG1 mRNA21470553
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NRG1 mRNA25607892
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRG1 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NRG1 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRG1 mRNA25607892
D011374ProgesteroneNRG1 protein promotes the reaction [AREG protein results in increased abundance of Progesterone]21047912
C005556propionaldehydepropionaldehyde results in increased expression of NRG1 mRNA26079696
C006068propylparabenNRG1 protein promotes the reaction [propylparaben results in increased expression of MYC mRNA]26502914
C006068propylparabenpropylparaben promotes the reaction [NRG1 protein results in increased expression of MYC mRNA]26502914
D011441PropylthiouracilPropylthiouracil results in increased expression of NRG1 mRNA24780913
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in increased expression of NRG1 mRNA23274088
C107773pterostilbenepterostilbene inhibits the reaction [NRG1 protein alternative form results in increased expression of MMP9 mRNA]19617202
C107773pterostilbenepterostilbene inhibits the reaction [NRG1 protein alternative form results in increased expression of MMP9 protein]19617202
C107773pterostilbenepterostilbene results in decreased susceptibility to NRG1 protein alternative form19617202
C513428pyrachlostrobinpyrachlostrobin results in increased expression of NRG1 mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]26502914
C059514resveratrolresveratrol inhibits the reaction [NRG1 protein alternative form results in increased expression of MMP9 protein]17651959
C059514resveratrolresveratrol inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of MAPK1 protein]17651959
C059514resveratrolresveratrol inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of MAPK3 protein]17651959
C059514resveratrolresveratrol results in decreased expression of NRG1 mRNA12002526
D018967RisperidoneRisperidone results in increased expression of NRG1 protein26961615
C093642SB 203580SB 203580 results in decreased susceptibility to NRG1 protein alternative form19617202
C115461SC 560SC 560 results in decreased expression of NRG1 mRNA14633654
C410733scriptaidscriptaid affects the expression of NRG1 mRNA18813790
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the expression of NRG1 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NRG1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of NRG1 mRNA25351596
C017947sodium arsenitesodium arsenite affects the methylation of NRG1 gene28589171
C016104sodium bichromatesodium bichromate results in increased expression of NRG1 mRNA22561333|2599309
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in increased expression of NRG1 mRNA23274088
D018038Sodium SeleniteSodium Selenite results in increased expression of NRG1 mRNA23274088
D012999SomanSoman results in increased expression of NRG1 mRNA19281266
D013629TamoxifenTamoxifen inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]26502914
C012568terbufosterbufos results in increased methylation of NRG1 promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of NRG1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NRG1 mRNA23152189
D013749Tetrachlorodibenzodioxin"2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NRG1 mRNA]"21851831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NRG1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NRG1 mRNA19770486|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NRG1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NRG1 mRNA19692669|2095900
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of NRG1 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NRG1 mRNA21047912
D013755Tetradecanoylphorbol AcetateU 0126 inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NRG1 mRNA]21047912
D013853ThioacetamideThioacetamide results in increased expression of NRG1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of NRG1 gene26756918
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NRG1 mRNA25729387
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [NRG1 protein results in increased transport of Glucose]14711829
D014212TretinoinTretinoin results in decreased expression of NRG1 mRNA21934132
D014212TretinoinTretinoin results in increased expression of NRG1 mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased expression of NRG1 mRNA25549359
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of NRG1 mRNA24935251|2627250
D014303TrinitrotolueneTrinitrotoluene affects the expression of NRG1 mRNA21346803
C057693troglitazonetroglitazone results in increased expression of NRG1 mRNA19140230
C113580U 0126NRG1 protein alternative form inhibits the reaction [U 0126 results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]15231676
C113580U 0126NRG1 protein alternative form inhibits the reaction [U 0126 results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]15231676
C113580U 0126U 0126 inhibits the reaction [LHB protein results in decreased expression of NRG1 mRNA]23071612
C113580U 0126U 0126 inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NRG1 mRNA]21047912
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of NRG1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of NRG1 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of NRG1 gene29154799
D014638VanadatesVanadates results in increased expression of NRG1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NRG1 gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NRG1 mRNA25607892
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRG1 mRNA25607892
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NRG1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of NRG1 mRNA26272509
D019287Zinc SulfateZinc Sulfate affects the expression of and affects the splicing of NRG1 mRNA10878590
C088658zoledronic acidzoledronic acid results in decreased expression of NRG1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003712transcription coregulator activity-IDA15073182  
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005125cytokine activity-TAS10372964  
GO:0005176ErbB-2 class receptor binding-IEA-  
GO:0005178integrin binding-IDA20682778  
GO:0008083growth factor activity-NAS8096067  
GO:0030296protein tyrosine kinase activator activity-IBA21873635  
GO:0030297transmembrane receptor protein tyrosine kinase activator activity-NAS1348215  1350381  
GO:0030971receptor tyrosine kinase binding-NAS1348215  1350381  
GO:0043125ErbB-3 class receptor binding-IDA20682778  
GO:0045499chemorepellent activity-IEA-  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0000187activation of MAPK activity-IMP20682778  
GO:0000902cell morphogenesis-IEA-  
GO:0001964startle response-IEA-  
GO:0003161cardiac conduction system development-IEA-  
GO:0003222ventricular trabecula myocardium morphogenesis-IDA17336907  
GO:0007154cell communication-TAS17432114  
GO:0007171activation of transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0007171activation of transmembrane receptor protein tyrosine kinase activity-IEA-  
GO:0007399nervous system development-IBA21873635  
GO:0007399nervous system development-TAS17432114  
GO:0007416synapse assembly-IEA-  
GO:0007422peripheral nervous system development-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0008284positive regulation of cell proliferation-IMP20682778  
GO:0008366axon ensheathment-IEA-  
GO:0009790embryo development-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0014032neural crest cell development-TAS17432114  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0021781glial cell fate commitment-IEA-  
GO:0021842chemorepulsion involved in interneuron migration from the subpallium to the cortex-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030879mammary gland development-TAS17432114  
GO:0031643positive regulation of myelination-IEA-  
GO:0032148activation of protein kinase B activity-IMP20682778  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0038127ERBB signaling pathway-IDA11389077  
GO:0038127ERBB signaling pathway-IMP20682778  
GO:0038128ERBB2 signaling pathway-TAS-  
GO:0038129ERBB3 signaling pathway-IDA27353365  
GO:0042060wound healing-TAS16412517  
GO:0042177negative regulation of protein catabolic process-IEA-  
GO:0043496regulation of protein homodimerization activity-TAS16412517  
GO:0043497regulation of protein heterodimerization activity-IDA10559227  
GO:0045213neurotransmitter receptor metabolic process-IEA-  
GO:0045773positive regulation of axon extension-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA15073182  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0046579positive regulation of Ras protein signal transduction-IEA-  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048513animal organ development-IBA21873635  
GO:0048663neuron fate commitment-IEA-  
GO:0048709oligodendrocyte differentiation-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0051048negative regulation of secretion-IDA10559227  
GO:0051155positive regulation of striated muscle cell differentiation-ISS-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0055007cardiac muscle cell differentiation-ISS-  
GO:0060379cardiac muscle cell myoblast differentiation-IDA17336907  
GO:0060956endocardial cell differentiation-IDA17336907  
GO:0060999positive regulation of dendritic spine development-IEA-  
GO:0070886positive regulation of calcineurin-NFAT signaling cascade-IEA-  
GO:2000010positive regulation of protein localization to cell surface-IEA-  
GO:2000145regulation of cell motility-TAS-  
GO:2000727positive regulation of cardiac muscle cell differentiation-IEA-  
GO:2001223negative regulation of neuron migration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS1348215  1350381  8096067  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0009897external side of plasma membrane-IEA-  
GO:0016020membrane-NAS8096067  
GO:0030425dendrite-IEA-  
GO:0030673axolemma-IEA-  
GO:0031594neuromuscular junction-IEA-  
GO:0044297cell body-IEA-  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1227986Signaling by ERBB2TAS
R-HSA-1227986Signaling by ERBB2IEA
R-HSA-1236394Signaling by ERBB4TAS
R-HSA-1236394Signaling by ERBB4IEA
R-HSA-1250196SHC1 events in ERBB2 signalingIEA
R-HSA-1250196SHC1 events in ERBB2 signalingTAS
R-HSA-1250342PI3K events in ERBB4 signalingTAS
R-HSA-1250347SHC1 events in ERBB4 signalingTAS
R-HSA-1251985Nuclear signaling by ERBB4IEA
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1306955GRB7 events in ERBB2 signalingTAS
R-HSA-1358803Downregulation of ERBB2:ERBB3 signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1963640GRB2 events in ERBB2 signalingTAS
R-HSA-1963642PI3K events in ERBB2 signalingTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6785631ERBB2 Regulates Cell MotilityTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-8847993ERBB2 Activates PTK6 SignalingTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8863795Downregulation of ERBB2 signalingTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25870798Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer. (2015 Apr)Kohno TTransl Lung Cancer Res
27027665Gene aberrations for precision medicine against lung adenocarcinoma. (2016 Jun)Saito MCancer Sci
27353026A functional neuregulin-1 gene variant and stressful life events: Effect on drug use in a longitudinal population-representative cohort study. (2017 Jan)Vaht MJ Psychopharmacol
27784625Nicotine-induced neuroplasticity counteracts the effect of schizophrenia-linked neuregulin 1 signaling on NMDAR function in the rat hippocampus. (2017 Feb)Yamazaki YNeuropharmacology
28892072Neuregulin signaling pathway in smoking behavior. (2017 Aug 22)Gupta RTransl Psychiatry
26200269Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung. (2015 Aug)Shim HSJ Thorac Oncol
24795156A three-way parallel ICA approach to analyze links among genetics, brain structure and brain function. (2014 Sep)Vergara VMNeuroimage
22520967Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans. (2012 Oct 15)Han SBiol Psychiatry
29225331Elevated peripheral expression of neuregulin-1 (NRG1) mRNA isoforms in clozapine-treated schizophrenia patients. (2017 Dec 11)Mostaid MSTransl Psychiatry