Gene: EHD4

30844
PAST4
EH domain containing 4
protein-coding
15q15.1
Ensembl:ENSG00000103966 MIM:605892 Vega:OTTHUMG00000130370 UniprotKB:Q9H223
NC_000015.10
SNP Mapped
2   ANCO-SNPs
CD|ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.686e-1 (AD)  9.262e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1648811chr15:41930192 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs12441018chr15:41901373 (GRCh38.p7)T>Gcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22451412chr15:42227210EHD49.730e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPP1R180.789
CXCL160.789
TRIM50.786
SLC15A30.779
TAP10.776
IFI300.776
LHFPL20.775
VASP0.774
MYD880.772
STAT30.771

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.368
MARCH4-0.342
KCNB2-0.333
ABCC12-0.315
PIP5KL1-0.314
DLK2-0.313
HAS1-0.31
SMIM18-0.309
TMEM179-0.309
SPEF1-0.309

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of EHD4 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EHD4 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EHD4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EHD4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EHD4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EHD4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of EHD4 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of EHD4 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of EHD4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EHD4 mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of EHD4 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EHD4 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of EHD4 mRNA24449571
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of EHD4 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EHD4 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EHD4 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of EHD4 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EHD4 mRNA18164116
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EHD4 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EHD4 mRNA19770486
D004958EstradiolEstradiol results in increased expression of EHD4 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of EHD4 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of EHD4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EHD4 gene28505145
C025703bleomycetinbleomycetin results in increased expression of EHD4 mRNA21040473
C018475butyraldehydebutyraldehyde results in increased expression of EHD4 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of EHD4 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of EHD4 mRNA23650126
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EHD4 mRNA27858113
C031180chrysenechrysene results in increased expression of EHD4 mRNA26377693
D002994ClofibrateClofibrate results in increased expression of EHD4 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of EHD4 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of EHD4 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of EHD4 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of EHD4 mRNA20106945|2556210
D003703DemecolcineDemecolcine results in increased expression of EHD4 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EHD4 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EHD4 mRNA21266533
D002945CisplatinCisplatin results in increased expression of EHD4 mRNA21151649
D004041Dietary FatsDietary Fats results in decreased expression of EHD4 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of EHD4 mRNA22609946
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EHD4 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of EHD4 mRNA17005392
D002117CalcitriolCalcitriol results in increased expression of EHD4 mRNA16002434
C118739entinostatentinostat results in increased expression of EHD4 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EHD4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EHD4 mRNA17942748
C540355fenamidonefenamidone results in increased expression of EHD4 mRNA27029645
C039281furanfuran results in decreased methylation of EHD4 gene27387713
C039281furanfuran results in increased expression of EHD4 mRNA27387713
C000625835HFPO2 compoundHFPO2 compound results in increased expression of EHD4 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of EHD4 mRNA27553808
D017313FenretinideFenretinide results in increased expression of EHD4 mRNA28973697
D007854LeadLead results in decreased expression of EHD4 mRNA19921347
D008727MethotrexateMethotrexate results in decreased expression of EHD4 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EHD4 mRNA27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EHD4 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EHD4 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of EHD4 protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EHD4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EHD4 mRNA"25554681
C031721naphthalene[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of EHD4 protein19438287
D009532NickelNickel results in increased expression of EHD4 mRNA24768652|2558310
C025589ochratoxin Aochratoxin A results in decreased expression of EHD4 mRNA22124623
D000073878Palm OilPalm Oil results in decreased expression of EHD4 mRNA18042831
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of EHD4 protein26879310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EHD4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of EHD4 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of EHD4 mRNA18301758|2081375
C513428pyrachlostrobinpyrachlostrobin results in increased expression of EHD4 mRNA27029645
C541923sandostatinLARsandostatinLAR results in decreased expression of EHD4 mRNA17210224
D012999SomanSoman results in increased expression of EHD4 mRNA19281266
D053260SootSoot results in decreased expression of EHD4 mRNA22461453
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EHD4 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EHD4 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EHD4 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of EHD4 mRNA25975270
D013849ThimerosalThimerosal results in decreased expression of EHD4 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of EHD4 mRNA23411599
D014212TretinoinTretinoin results in increased expression of EHD4 mRNA21934132
D014520UrethaneUrethane results in increased expression of EHD4 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EHD4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EHD4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EHD4 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of EHD4 gene29154799
D014640VancomycinVancomycin results in decreased expression of EHD4 mRNA18930951
C025643vinclozolinvinclozolin affects the expression of EHD4 mRNA19015723
C111237vorinostatvorinostat results in increased expression of EHD4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-TAS10673336  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI17233914  
GO:0005524ATP binding-IEA-  
GO:0005525GTP binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0006907pinocytosis-IEA-  
GO:0030100regulation of endocytosis-IEA-  
GO:0032456endocytic recycling-IGI17233914  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0051260protein homooligomerization-IPI17233914  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS10673336  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005886plasma membrane-IEA-  
GO:0016020membrane-HDA19946888  
GO:0031901early endosome membrane-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0055038recycling endosome membrane-IDA17233914  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
KEGG ID KEGG Term
hsa04144Endocytosis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal