Gene: HHEX

3087
HEX|HMPH|HOX11L-PEN|PRH|PRHX
hematopoietically expressed homeobox
protein-coding
10q23.33
Ensembl:ENSG00000152804 MIM:604420 Vega:OTTHUMG00000018762 UniprotKB:Q03014
NC_000010.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.590e-1 (AD)  8.054e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20180364chr10:94448532HHEXPromoter3.452e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GIMAP80.889
FLI10.868
GIMAP10.853
TGFBR20.85
MECOM0.845
TNFAIP80.843
FOXC10.84
GIMAP40.84
GIMAP60.839
ADPRH0.837

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.493
KCNK4-0.491
LRTM2-0.484
LRFN2-0.478
MYADML2-0.477
TMEM179-0.472
ASPDH-0.471
EXTL1-0.469
HAS1-0.469
KREMEN2-0.467

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of HHEX mRNA"26377693
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of HHEX mRNA"20453058
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of HHEX mRNA19933214
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of HHEX mRNA"21920950
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of HHEX mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHEX mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHEX mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HHEX mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHEX mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHEX mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HHEX mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of HHEX mRNA22634333
D000082AcetaminophenAcetaminophen affects the expression of HHEX mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HHEX mRNA27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of HHEX mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HHEX mRNA16483693
D001374AzacitidineAzacitidine results in increased expression of HHEX mRNA27590069
D001379AzathioprineAzathioprine results in decreased expression of HHEX mRNA22623647
C487081belinostatbelinostat results in increased expression of HHEX mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHEX mRNA"27188386
D001554BenzeneBenzene affects the expression of HHEX mRNA15878777
D001554BenzeneBenzene results in increased expression of HHEX mRNA17905399
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HHEX mRNA21632981
C006780bisphenol Abisphenol A affects the methylation of HHEX promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of HHEX mRNA25181051
D002065BuspironeBuspirone results in decreased expression of HHEX mRNA24136188
D002087ButyratesButyrates results in increased expression of and affects the localization of HHEX protein16854221
D002220CarbamazepineCarbamazepine affects the expression of HHEX mRNA22634333
D002635Chenodeoxycholic AcidChenodeoxycholic Acid promotes the reaction [NR1H4 binds to HHEX intron]19072826
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of HHEX mRNA19072826
D002635Chenodeoxycholic AcidNR1H4 affects the reaction [Chenodeoxycholic Acid results in increased expression of HHEX mRNA]19072826
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of HHEX mRNA19072826
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of HHEX protein19072826
D002635Chenodeoxycholic AcidNR1H4 mutant form inhibits the reaction [Chenodeoxycholic Acid results in increased expression of HHEX mRNA]19072826
D002635Chenodeoxycholic AcidNR1H4 mutant form inhibits the reaction [Chenodeoxycholic Acid results in increased expression of HHEX protein]19072826
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HHEX gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of HHEX mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of HHEX mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of HHEX mRNA20106945|2163298
D003976DiazinonDiazinon results in increased methylation of HHEX gene22964155
C016366dibenzothiophenedibenzothiophene results in increased expression of HHEX mRNA23656968
D002945CisplatinHHEX protein affects the susceptibility to Cisplatin16217747
D004008DiclofenacDiclofenac results in decreased expression of HHEX mRNA26934552
D004041Dietary FatsDietary Fats results in increased expression of HHEX mRNA18042831
C118739entinostatentinostat results in increased expression of HHEX mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HHEX mRNA"27188386
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of HHEX mRNA20064776
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HHEX mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HHEX mRNA20227414
C024565ethylene dichlorideethylene dichloride results in increased expression of HHEX mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of HHEX mRNA23649840
C061365flusilazoleflusilazole affects the expression of HHEX mRNA22634333
D005492Folic AcidFolic Acid inhibits the reaction [Lithium affects the expression of HHEX mRNA]19638421
D005492Folic AcidInositol promotes the reaction [Folic Acid inhibits the reaction [Lithium affects the expression of HHEX mRNA]]19638421
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HHEX gene20938992
C039281furanfuran results in decreased expression of HHEX mRNA25539665|2619464
C412815GW 4064GW 4064 results in increased expression of HHEX mRNA19072826
C412815GW 4064NR1H4 mutant form inhibits the reaction [GW 4064 results in increased expression of HHEX mRNA]19072826
D007294InositolInositol promotes the reaction [Folic Acid inhibits the reaction [Lithium affects the expression of HHEX mRNA]]19638421
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HHEX mRNA25613284
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of HHEX protein17337753
C410337K 7174K 7174 results in decreased expression of HHEX mRNA24086573
C045463leflunomideleflunomide results in decreased expression of HHEX mRNA28988120
D008094LithiumFolic Acid inhibits the reaction [Lithium affects the expression of HHEX mRNA]19638421
D008094LithiumInositol promotes the reaction [Folic Acid inhibits the reaction [Lithium affects the expression of HHEX mRNA]]19638421
D008094LithiumLithium affects the expression of HHEX mRNA19638421
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HHEX gene20938992
D008727MethotrexateMethotrexate affects the expression of HHEX mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HHEX mRNA23458150
C030957methylmercury IImethylmercury II results in increased expression of HHEX mRNA17905399
D016685MitomycinHHEX protein affects the susceptibility to Mitomycin16217747
C051752nefazodonenefazodone results in decreased expression of HHEX mRNA24136188
D009532NickelNickel results in decreased expression of HHEX mRNA23195993
C012655nimesulidenimesulide results in decreased expression of HHEX mRNA24136188
C570897NSC668394NSC668394 results in increased expression of HHEX mRNA27137931
C025589ochratoxin Aochratoxin A results in decreased expression of HHEX mRNA29274910
D000073878Palm OilPalm Oil results in increased expression of HHEX mRNA18042831
C086401pentabromodiphenyl etherpentabromodiphenyl ether affects the expression of HHEX mRNA22039834
C539348perfluorobutanesulfonic acidperfluorobutanesulfonic acid affects the expression of HHEX mRNA22071372
C033094perfluorobutyric acidperfluorobutyric acid results in decreased expression of HHEX mRNA22071372
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of HHEX mRNA22071372
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of HHEX mRNA22071372
C479228perfluorohexanoic acidperfluorohexanoic acid results in increased expression of HHEX mRNA22071372
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of HHEX mRNA22071372
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of HHEX mRNA21184528
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of HHEX mRNA18407306|2307402
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of HHEX mRNA22071372
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HHEX mRNA23399300
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HHEX mRNA22071372
C586085perfluoroundecanoic acidperfluoroundecanoic acid results in increased expression of HHEX mRNA22071372
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HHEX mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of HHEX mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of HHEX mRNA18445702
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HHEX mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of HHEX mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of HHEX mRNA28903501
D011794QuercetinQuercetin results in decreased expression of HHEX mRNA21632981
D011794QuercetinQuercetin results in increased expression of HHEX mRNA21565894
C009250sevofluranesevoflurane affects the expression of HHEX mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HHEX mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of HHEX mRNA19073995|2322117
D012834SilverSilver results in decreased expression of HHEX mRNA26014281
D012999SomanSoman results in increased expression of HHEX mRNA19281266
C105686SU 5402SU 5402 results in increased expression of HHEX mRNA16326079
C009361sulisobenzonesulisobenzone results in increased expression of HHEX mRNA20937294
D013739TestosteroneTestosterone results in increased expression of HHEX mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HHEX mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HHEX mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HHEX mRNA24058054
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of HHEX mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HHEX mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HHEX mRNA21215274|2172422
D013752TetracyclineTetracycline results in decreased expression of HHEX mRNA24469900
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HHEX mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of HHEX mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of HHEX mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of HHEX mRNA28065790
D014118Toxins, Biological"Toxins, Biological affects the expression of HHEX mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of HHEX mRNA15894607|1721838
D014212TretinoinTretinoin results in increased expression of and affects the localization of HHEX protein16854221
D014212TretinoinTretinoin results in increased expression of HHEX mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of and affects the localization of HHEX protein16854221
C012589trichostatin Atrichostatin A results in increased expression of HHEX mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HHEX mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of HHEX mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HHEX mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of HHEX mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of HHEX mRNA17963808
D014873Water PollutantsWater Pollutants results in increased expression of HHEX mRNA23591932

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15016828  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15016828  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0003682chromatin binding-IEA-  
GO:0005515protein binding-IPI10597310  12826010  19324893  25416956  
GO:0008134transcription factor binding-IPI15016828  
GO:0008190eukaryotic initiation factor 4E binding-IDA12554669  
GO:0008301DNA binding, bending-IDA18755198  
GO:0017025TBP-class protein binding-TAS19324893  
GO:0042803protein homodimerization activity-IPI16540119  
GO:0043565sequence-specific DNA binding-IDA10871399  
GO:0044212transcription regulatory region DNA binding-IDA18755198  
GO:0044212transcription regulatory region DNA binding-TAS19324893  
GO:0070491repressing transcription factor binding-IDA15187083  
GO:0071837HMG box domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IDA10871399  15016828  
GO:0001570vasculogenesis-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0002573myeloid leukocyte differentiation-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006406mRNA export from nucleus-IDA12554669  
GO:0007219Notch signaling pathway-IEA-  
GO:0007492endoderm development-IEA-  
GO:0008283cell proliferation-IDA12554669  
GO:0009611response to wounding-IEA-  
GO:0009952anterior/posterior pattern specification-ISS-  
GO:0010621negative regulation of transcription by transcription factor localization-IC18713067  
GO:0010944negative regulation of transcription by competitive promoter binding-TAS19324893  
GO:0016055Wnt signaling pathway-IEA-  
GO:0016525negative regulation of angiogenesis-ISS15016828  
GO:0016973poly(A)+ mRNA export from nucleus-IMP12554669  
GO:0022027interkinetic nuclear migration-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030154cell differentiation-IC10871399  
GO:0030177positive regulation of Wnt signaling pathway-ISS-  
GO:0030183B cell differentiation-ISS-  
GO:0030878thyroid gland development-IEA-  
GO:0030948negative regulation of vascular endothelial growth factor receptor signaling pathway-ISS15016828  
GO:0031016pancreas development-IEA-  
GO:0034504protein localization to nucleus-IDA18713067  
GO:0035050embryonic heart tube development-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0043434response to peptide hormone-IEA-  
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity-IDA12554669  
GO:0045892negative regulation of transcription, DNA-templated-IDA10871399  15016828  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12655000  
GO:0048853forebrain morphogenesis-IEA-  
GO:0060431primary lung bud formation-IEA-  
GO:0061010gall bladder development-IEA-  
GO:0061011hepatic duct development-IEA-  
GO:0061017hepatoblast differentiation-IEA-  
GO:0070365hepatocyte differentiation-IEA-  
GO:0071103DNA conformation change-IDA18755198  
GO:0090009primitive streak formation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA12554669  12588764  12826010  
GO:0005737cytoplasm-IDA12554669  12826010  
GO:0032993protein-DNA complex-IDA18755198  
KEGG ID KEGG Term
hsa04950Maturity onset diabetes of the young
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29720110Effect of smoking on the association of HHEX (rs5015480) with diabetes among Korean women and heavy smoking men. (2018 May 2)Sull JWBMC Med Genet
19020324Clinical risk factors, DNA variants, and the development of type 2 diabetes. (2008 Nov 20)Lyssenko VN Engl J Med