Gene: ANXA6

309
ANX6|CBP68|CPB-II|p68|p70
annexin A6
protein-coding
5q33.1
Ensembl:ENSG00000197043 MIM:114070 Vega:OTTHUMG00000164179 UniprotKB:P08133
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.263e-1 (AD)  9.461e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15892650chr5:150524635ANXA66.620e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENO20.977
GOT10.977
NDRG30.975
MADD0.973
ATP1A10.973
MOAP10.971
KIFAP30.97
CD99L20.969
C1orf2160.966
SV2A0.965

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.549
RAI14-0.512
REST-0.51
YES1-0.506
OR4F29-0.505
WWTR1-0.49
HEY2-0.468
TFPI2-0.464
ASB4-0.463
RNF135-0.456

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0166141-nitronaphthalene1-nitronaphthalene metabolite binds to ANXA6 protein16453347
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ANXA6 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ANXA6 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ANXA6 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ANXA6 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ANXA6 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ANXA6 mRNA19770486
D000447AldehydesAldehydes results in increased expression of ANXA6 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ANXA6 mRNA16483693
C015001arsenitearsenite results in decreased expression of ANXA6 mRNA23974009
C015001arsenitearsenite results in increased methylation of ANXA6 promoter23974009
C547126AZM551248AZM551248 results in increased expression of ANXA6 mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of ANXA6 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANXA6 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANXA6 mRNA19770486|2071347
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ANXA6 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of ANXA6 protein28279065
C006780bisphenol Abisphenol A affects the expression of ANXA6 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ANXA6 mRNA25181051
D001761BleomycinBleomycin results in decreased expression of ANXA6 protein25933445
C018475butyraldehydebutyraldehyde results in increased expression of ANXA6 mRNA26079696
D002737ChloropreneChloroprene results in decreased expression of ANXA6 mRNA23125180
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of ANXA6 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of ANXA6 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ANXA6 mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in decreased expression of ANXA6 mRNA24921660
D003561CytarabineCytarabine results in decreased expression of ANXA6 mRNA21198554
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of ANXA6 mRNA17330099
D003907DexamethasoneDexamethasone results in increased expression of ANXA6 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ANXA6 mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ANXA6 mRNA16054899
D002945CisplatinCisplatin results in increased expression of ANXA6 mRNA27594783
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ANXA6 mRNA26924002
D004237DiuronDiuron results in increased expression of ANXA6 mRNA21551480
C013525ENNG[ENNG co-treated with Isoflavones] results in increased expression of ANXA6 protein22248470
C013525ENNGENNG results in increased expression of ANXA6 protein22248470
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ANXA6 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANXA6 mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of ANXA6 mRNA18035473
C069837fullerene C60fullerene C60 results in increased expression of ANXA6 mRNA19167457
D005839GentamicinsGentamicins results in increased expression of ANXA6 mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ANXA6 mRNA22634610
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of ANXA6 mRNA22634610
D006118GriseofulvinGriseofulvin results in increased expression of ANXA6 mRNA12735108
D006493HeparinHeparin results in increased expression of ANXA6 protein17488504
D017313FenretinideFenretinide results in decreased expression of ANXA6 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ANXA6 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANXA6 mRNA25613284
C051890irinotecanirinotecan metabolite results in increased expression of ANXA6 mRNA15956246
C051890irinotecanirinotecan results in increased expression of ANXA6 mRNA15956246
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ANXA6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ANXA6 mRNA16054899
D007529Isoflavones[ENNG co-treated with Isoflavones] results in increased expression of ANXA6 protein22248470
C544151jinfukangjinfukang results in increased expression of ANXA6 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of ANXA6 protein10768784
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ANXA6 mRNA23086925
C410337K 7174K 7174 results in decreased expression of ANXA6 mRNA24086573
D048628KetolidesKetolides analog results in increased expression of ANXA6 mRNA24967691
C045463leflunomideleflunomide results in increased expression of ANXA6 mRNA24136188
D008012LidocaineLidocaine results in increased expression of ANXA6 mRNA27018092
D008012LidocaineLidocaine results in increased expression of ANXA6 protein27018092
C002950methylformamidemethylformamide analog results in decreased expression of ANXA6 mRNA17040096
C002950methylformamidemethylformamide results in decreased expression of ANXA6 mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ANXA6 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ANXA6 mRNA23179753|2718838
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of ANXA6 mRNA16966085
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ANXA6 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ANXA6 protein26558463
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ANXA6 mRNA26924002
D009020MorphineMorphine results in decreased expression of ANXA6 protein23056601
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ANXA6 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ANXA6 mRNA"25620056
C031721naphthalenenaphthalene metabolite binds to ANXA6 protein16453347
C028007nickel monoxidenickel monoxide results in increased expression of ANXA6 mRNA19167457
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of ANXA6 protein19716841
D052638Particulate MatterParticulate Matter results in increased expression of ANXA6 protein17922515
C046012pentanalpentanal results in increased expression of ANXA6 mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ANXA6 protein26178269
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of ANXA6 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of ANXA6 mRNA23091169
D010936Plant ExtractsPlant Extracts results in increased expression of ANXA6 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of ANXA6 mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of ANXA6 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of ANXA6 mRNA26079696
D011794QuercetinQuercetin results in decreased expression of ANXA6 mRNA21632981
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ANXA6 mRNA16054899
D012822Silicon DioxideSilicon Dioxide results in increased expression of ANXA6 mRNA25351596
D012906SmokeSmoke results in increased expression of ANXA6 mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased expression of ANXA6 protein24866292
C016104sodium bichromatesodium bichromate affects the expression of ANXA6 mRNA22110744
D012969Sodium FluorideSodium Fluoride results in decreased expression of ANXA6 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ANXA6 mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ANXA6 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANXA6 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ANXA6 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ANXA6 mRNA26232522
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANXA6 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ANXA6 mRNA28065790
C012589trichostatin Atrichostatin A results in decreased expression of ANXA6 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ANXA6 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of ANXA6 mRNA17127020
D014520UrethaneUrethane results in decreased expression of ANXA6 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA6 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ANXA6 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ANXA6 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased expression of ANXA6 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased expression of ANXA6 protein17922515
C025643vinclozolinvinclozolin results in increased expression of ANXA6 mRNA22570695
D014810Vitamin EVitamin E results in increased expression of ANXA6 mRNA19244175
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of ANXA6 mRNA17330099
C111237vorinostatvorinostat results in increased expression of ANXA6 protein20543569

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI15576473  
GO:0005525GTP binding-IMP16605264  
GO:0005544calcium-dependent phospholipid binding-IDA2138016  
GO:0008289lipid binding-IMP16605264  
GO:0015276ligand-gated ion channel activity-IMP16605264  
GO:0015485cholesterol binding-IDA23360953  
GO:0042803protein homodimerization activity-IMP16605264  
GO:0048306calcium-dependent protein binding-IPI15226301  
GO ID GO Term Qualifier Evidence PubMed
GO:0006816calcium ion transport-IEA-  
GO:0006937regulation of muscle contraction-IEA-  
GO:0034220ion transmembrane transport-IMP16605264  
GO:0051260protein homooligomerization-IMP16605264  
GO:0051560mitochondrial calcium ion homeostasis-IEA-  
GO:0097190apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005765lysosomal membrane-IDA23360953  
GO:0005925focal adhesion-HDA21423176  
GO:0016020membrane-HDA19946888  
GO:0031902late endosome membrane-IDA23360953  
GO:0042470melanosome-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA19056867  20458337  21362503  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionIEA
R-HSA-445355Smooth Muscle ContractionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23541940TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis. (2013 May)Yin XYJ Dermatol Sci