Gene: HIC1

3090
ZBTB29|ZNF901|hic-1
HIC ZBTB transcriptional repressor 1
protein-coding
17p13.3
Ensembl:ENSG00000177374 MIM:603825 Vega:OTTHUMG00000177635 UniprotKB:Q14526
NG_027689.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.776e-1 (AD)  1.639e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00138101chr17:1961109HIC11.800e-18Smoking27651444
cg00911794chr17:1962132HIC14.300e-14Smoking27651444
cg23621097chr17:1962236HIC12.400e-12Smoking27651444
cg24173182chr17:1961286HIC13.400e-11Smoking27651444
cg02376827chr17:1961510HIC15.400e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PGF0.74
SLC12A70.688
DLL40.686
GPER10.681
IFITM10.678
TOR4A0.653
ADM0.649
EVA1B0.646
ANKRD370.645
PLEKHG20.64

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FSTL5-0.414
PPEF1-0.401
SVOP-0.393
ANKRD55-0.386
KBTBD7-0.383
ROBO2-0.381
KCNB2-0.373
SPHKAP-0.373
GAD2-0.372
ST6GALNAC5-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of HIC1 mRNA"26377693
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HIC1 mRNA"27291303
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of HIC1 mRNA12958071
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of HIC1 mRNA16788091
D000082AcetaminophenAcetaminophen affects the expression of HIC1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of HIC1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HIC1 mRNA]17585979
D020106AcrylamideAcrylamide results in decreased expression of HIC1 mRNA28959563
C430898AGN 194204AGN 194204 results in increased expression of HIC1 mRNA16339527
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HIC1 mRNA24449571
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of HIC1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of HIC1 mRNA27858113
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of HIC1 mRNA26377693
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of HIC1 mRNA23117580
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HIC1 mRNA20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of HIC1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to HIC1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HIC1 mRNA22228805|2719552
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HIC1 mRNA"20382639
C006780bisphenol Abisphenol A affects the expression of HIC1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of HIC1 mRNA26363213
C006780bisphenol Abisphenol A affects the expression of HIC1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HIC1 mRNA28628672
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of HIC1 mRNA18654764
C099555CD 437CD 437 results in decreased expression of HIC1 mRNA12958071
D002737ChloropreneChloroprene results in decreased expression of HIC1 mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of HIC1 mRNA27858113
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of HIC1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HIC1 mRNA]17585979
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of HIC1 mRNA18654764
C014347decitabinedecitabine results in increased expression of HIC1 mRNA19440673
D003703DemecolcineDemecolcine results in decreased expression of HIC1 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HIC1 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of HIC1 mRNA27392435
D005047EtoposideE2F1 protein affects the reaction [Etoposide results in increased expression of HIC1 mRNA]19491197
D005047EtoposideEtoposide promotes the reaction [E2F1 protein binds to HIC1 promoter]19491197
D005047EtoposideEtoposide results in increased expression of HIC1 mRNA19491197
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HIC1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HIC1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of HIC1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HIC1 mRNA24796395
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of HIC1 mRNA18654764
D008777MethyltestosteroneMethyltestosterone results in increased expression of HIC1 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HIC1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HIC1 mRNA"25554681
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HIC1 mRNA19710929
D011374Progesterone[Progesterone co-treated with TGFB1 protein] results in increased expression of HIC1 mRNA21768398
D011374ProgesteroneProgesterone results in increased expression of HIC1 mRNA21768398
C005556propionaldehydepropionaldehyde results in decreased expression of HIC1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of HIC1 mRNA24780913
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in increased expression of HIC1 mRNA23274088
C043680ptaquilosideptaquiloside results in increased expression of HIC1 mRNA23274088
D012715Sesame OilSesame Oil results in decreased expression of HIC1 mRNA29191790
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in increased expression of HIC1 mRNA23274088
D018038Sodium SeleniteSodium Selenite results in increased expression of HIC1 mRNA23274088
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of HIC1 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HIC1 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HIC1 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HIC1 mRNA20159946|2791314
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HIC1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HIC1 mRNA27913140
C009495titanium dioxidetitanium dioxide results in decreased expression of HIC1 mRNA23409001
D014212TretinoinTretinoin results in increased expression of HIC1 mRNA17218384|2372400
D014520UrethaneUrethane results in increased expression of HIC1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of HIC1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of HIC1 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HIC1 gene25560391
D014750VincristineVincristine results in decreased expression of HIC1 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA15231840  
GO:0003700DNA-binding transcription factor activity-IDA15231840  
GO:0003700DNA-binding transcription factor activity-TAS7585125  
GO:0005515protein binding-IPI12052894  16724116  16762039  19486893  
GO:0042826histone deacetylase binding-IDA12052894  
GO:0043565sequence-specific DNA binding-IDA15231840  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA12052894  15231840  
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-TAS7585125  
GO:0006974cellular response to DNA damage stimulus-IBA21873635  
GO:0007275multicellular organism development-IEA-  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IDA16269335  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030178negative regulation of Wnt signaling pathway-IDA16724116  
GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-ISS-  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3232118SUMOylation of transcription factorsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23435205Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma. (2013 Apr 1)Brait MCell Cycle
21318053DNA hypermethylation markers of poor outcome in laryngeal cancer. (2010 Sep 1)Stephen JKClin Epigenetics