Gene: UBE2K

3093
E2-25K|HIP2|HYPG|LIG|UBC1
ubiquitin conjugating enzyme E2 K
protein-coding
4p14
Ensembl:ENSG00000078140 MIM:602846 Vega:OTTHUMG00000160543 UniprotKB:P61086
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.388e-1 (AD)  1.003e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02407068chr4:39771851UBE2K1.710e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NAPG0.977
ATP6V1C10.976
NDFIP10.973
GSK3B0.972
TRAPPC6B0.972
CLTC0.972
SHOC20.971
REEP50.971
PPP2R5E0.97
NECAP10.969

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.608
OR4F29-0.57
CSAG1-0.43
HEY2-0.394
MYL3-0.374
MAGEA12-0.37
RAI14-0.366
MTRNR2L10-0.362
CNN2-0.36
RHOD-0.359

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of UBE2K mRNA"15375163
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of UBE2K mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of UBE2K mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of UBE2K mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of UBE2K mRNA21641981
D000616AminoglutethimideAminoglutethimide results in decreased expression of UBE2K protein26102013
D001151ArsenicArsenic affects the methylation of UBE2K gene25304211
D001241AspirinAspirin results in increased expression of UBE2K mRNA11906190
D001280AtrazineAtrazine results in decreased expression of UBE2K mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UBE2K mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UBE2K mRNA22228805|2719552
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of UBE2K mRNA"19150397|2623829
C044887beta-methylcholinebeta-methylcholine affects the expression of UBE2K mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of UBE2K mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of UBE2K mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of UBE2K protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of UBE2K mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased expression of UBE2K mRNA20061341
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of UBE2K mRNA23650126
D002994ClofibrateClofibrate results in increased expression of UBE2K mRNA23811191
C018021cobaltous chloridecobaltous chloride results in increased expression of UBE2K mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of UBE2K mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of UBE2K mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of UBE2K mRNA22147139
D002945CisplatinCisplatin results in decreased expression of UBE2K mRNA27594783
D004041Dietary FatsDietary Fats results in decreased expression of UBE2K mRNA25016146
D004147DioxinsDioxins affects the expression of UBE2K mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UBE2K mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBE2K mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of UBE2K mRNA23649840
D005485FlutamideFlutamide results in increased expression of UBE2K mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of UBE2K mRNA23649840
C039281furanfuran results in decreased expression of UBE2K mRNA25539665
C020758indium trichlorideindium trichloride results in increased expression of UBE2K protein19539025
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of UBE2K mRNA25613284
C544151jinfukangjinfukang results in decreased expression of UBE2K mRNA27392435
D007854LeadLead affects the splicing of UBE2K mRNA28903495
D008466MechlorethamineMechlorethamine results in increased expression of UBE2K mRNA17107856
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of UBE2K mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of UBE2K mRNA20061341
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of UBE2K mRNA26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of UBE2K mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of UBE2K protein26558463
C051752nefazodonenefazodone results in increased expression of UBE2K mRNA24136188
C012655nimesulidenimesulide results in increased expression of UBE2K mRNA24136188
D010416PentachlorophenolPentachlorophenol results in increased expression of UBE2K mRNA23892564
C006253pirinixic acidpirinixic acid results in increased expression of UBE2K mRNA15375163|2381119
D015474IsotretinoinIsotretinoin results in decreased expression of UBE2K mRNA20436886
C009277sodium arsenatesodium arsenate results in increased expression of UBE2K mRNA21795629
C017947sodium arseniteTP53 protein affects the reaction [sodium arsenite results in increased expression of UBE2K mRNA]16966095
C016104sodium bichromatesodium bichromate results in increased expression of UBE2K mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of UBE2K mRNA22561333
D013629TamoxifenTamoxifen affects the expression of UBE2K mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UBE2K mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UBE2K mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UBE2K mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of UBE2K mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of UBE2K mRNA18087596
D014635Valproic AcidValproic Acid affects the expression of UBE2K mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of UBE2K mRNA23179753|2718838
C111237vorinostatvorinostat results in decreased expression of UBE2K mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-IDA20061386  
GO:0005515protein binding-IPI17500595  19549727  20965177  23275563  24446487  25416956  
27107012  27173435  
GO:0005524ATP binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI16714285  17873885  
GO:0034450ubiquitin-ubiquitin ligase activity-IDA17873885  
GO:0061631ubiquitin conjugating enzyme activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IBA21873635  
GO:0006511ubiquitin-dependent protein catabolic process-TAS8702625  
GO:0010800positive regulation of peptidyl-threonine phosphorylation-IDA24882218  
GO:0010994free ubiquitin chain polymerization-IDA24882218  
GO:0016567protein ubiquitination-TAS-  
GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process-IEA-  
GO:0035458cellular response to interferon-beta-IMP24882218  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0060340positive regulation of type I interferon-mediated signaling pathway-IMP24882218  
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-IEA-  
GO:0070936protein K48-linked ubiquitination-IDA20061386  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0032433filopodium tip-IEA-  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8852135Protein ubiquitinationTAS
R-HSA-8866652Synthesis of active ubiquitin: roles of E1 and E2 enzymesTAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingIEA
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20552680Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood. (2010 Oct 5)Bousman CAAm J Med Genet B Neuropsychiatr Genet