Gene: HINT1

3094
HINT|NMAN|PKCI-1|PRKCNH1
histidine triad nucleotide binding protein 1
protein-coding
5q23.3
Ensembl:ENSG00000169567 MIM:601314 Vega:OTTHUMG00000128995 UniprotKB:P49773
NG_032998.1
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.475e-1 (AD)  7.212e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UQCRH0.976
BEX10.969
PITHD10.969
NDUFAB10.966
NDUFA40.964
UQCRFS10.963
PSMB70.963
ATP6V1E10.963
CLTA0.963
MORF4L10.963

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.768
OR4F29-0.751
MTRNR2L6-0.323
MAGEA12-0.321
CXCR2-0.3
MTRNR2L9-0.298
MTRNR2L10-0.291
KCNJ15-0.289
VNN3-0.28
P2RY14-0.276

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00131Adenosine monophosphateSmall Molecule61-19-8Approved|Investigational|NutraceuticalTarget
DB01972Guanosine-5'-MonophosphateSmall Molecule85-32-5ExperimentalTarget
DB021625'-O-(N-Ethyl-Sulfamoyl)AdenosineSmall MoleculeExperimentalTarget
DB02183Adenosine-5'-DitungstateSmall MoleculeExperimentalTarget
DB033498-Bromo-Adenosine-5'-MonophosphateSmall MoleculeExperimentalTarget
DB08934SofosbuvirSmall Molecule1190307-88-0ApprovedEnzyme
ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HINT1 mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HINT1 mRNA"18648102
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of HINT1 mRNA12419474
D000082AcetaminophenAcetaminophen results in decreased expression of HINT1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of HINT1 mRNA17562736
D000661AmphetamineHINT1 protein affects the susceptibility to Amphetamine17203012
C023650anilineaniline results in increased expression of HINT1 mRNA22016648
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of HINT1 mRNA18585445
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of HINT1 mRNA18585445
D001554BenzeneBenzene results in increased expression of HINT1 mRNA15120971|1512265
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HINT1 mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HINT1 mRNA21839799
C423844BL 11282BL 11282 results in decreased expression of HINT1 protein17458497
D002104CadmiumCadmium results in increased oxidation of HINT1 protein24077948
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA]"20230807
C100187chloropicrinchloropicrin results in decreased expression of HINT1 mRNA26352163
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of HINT1 mRNA23914054
D003703DemecolcineDemecolcine results in decreased expression of HINT1 mRNA23649840
C007262deoxynivalenoldeoxynivalenol results in decreased expression of HINT1 mRNA15371230
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of HINT1 mRNA]27941970
C542282dibutyldi(4-chlorobenzohydroxamato)tin(IV)dibutyldi(4-chlorobenzohydroxamato)tin(IV) results in increased expression of HINT1 protein22732634
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of HINT1 mRNA26924002
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of HINT1 mRNA15766595
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of HINT1 mRNA27638505
D004317DoxorubicinDoxorubicin results in increased expression of HINT1 mRNA22016648
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HINT1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HINT1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HINT1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HINT1 mRNA17942748
D005472FluorouracilFluorouracil results in increased expression of HINT1 protein15585135|1680352
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of HINT1 mRNA22634610
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of HINT1 mRNA17183730
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of HINT1 protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of HINT1 mRNA12419474
C492448ICG 001ICG 001 results in increased expression of HINT1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HINT1 mRNA25613284
D008148LovastatinLovastatin results in increased expression of HINT1 mRNA20493250
D008464MecamylamineMecamylamine inhibits the reaction [Nicotine results in increased expression of HINT1 protein]20514075
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA]"20230807
C517284monomethyl phthalatemonomethyl phthalate affects the expression of HINT1 mRNA26924002
D009020MorphineHINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]21235400
D009020MorphineHINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]21235400
D009020MorphineHINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]21235400
D009020MorphineHINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]18652891
D009020MorphineHINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]18652891
D009020MorphineHINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]18652891
D009020MorphineHINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]18652891
D009020MorphineHINT1 gene mutant form results in increased susceptibility to Morphine18652891
D009020MorphineMorphine promotes the reaction [HINT1 protein binds to PRKCG protein]21235400
D009538NicotineNicotine results in increased expression of HINT1 mRNA20514075
D009538NicotineMecamylamine inhibits the reaction [Nicotine results in increased expression of HINT1 protein]20514075
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA]"20230807
D009538NicotineNicotine results in increased expression of HINT1 protein20514075
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of HINT1 protein26178269
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HINT1 protein26879310
D011748PyrogallolPyrogallol results in increased expression of HINT1 mRNA20362636
D012402RotenoneRotenone results in increased expression of HINT1 mRNA22016648
D012524SarinSarin results in decreased expression of HINT1 protein28973502
C017947sodium arsenitesodium arsenite results in increased expression of HINT1 protein19294697
D012969Sodium FluorideSodium Fluoride results in increased expression of HINT1 protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of HINT1 mRNA18175754
D012460SulfasalazineSulfasalazine results in increased expression of HINT1 mRNA22016648
C025463sulindac sulfonesulindac sulfone results in increased expression of HINT1 mRNA18593937
C025463sulindac sulfonesulindac sulfone results in increased expression of HINT1 protein18593937
D013629TamoxifenTamoxifen affects the expression of HINT1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HINT1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HINT1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HINT1 protein15822908
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HINT1 mRNA25613284
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of HINT1 protein18951874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of HINT1 mRNA29024780
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of HINT1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of HINT1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HINT1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of HINT1 mRNA23034163
D014750VincristineVincristine results in decreased expression of HINT1 mRNA23649840
D014859WarfarinWarfarin results in increased expression of HINT1 mRNA20493250
D015032ZincZinc promotes the reaction [RAF1 protein binds to PRKCG protein binds to HINT1 protein]21235400

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-IEA-  
GO:0005080protein kinase C binding-TAS9770345  
GO:0016787hydrolase activity-IDA16835243  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IMP16835243  
GO:0007165signal transduction-TAS8812426  
GO:0009154purine ribonucleotide catabolic process-IDA16835243  
GO:0050850positive regulation of calcium-mediated signaling-IEA-  
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator-IMP16835243  
GO ID GO Term Qualifier Evidence PubMed
GO:0000118histone deacetylase complex-IDA16835243  
GO:0005634nucleus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005856cytoskeleton-TAS8812426  
GO:0005886plasma membrane-IDA-  
GO:0070062extracellular exosome-HDA19056867  20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20514075Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence. (2011 Aug)Jackson KJPharmacogenomics J
17978999Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trial. (2007 Nov)Ray RNicotine Tob Res
27563403Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1. (2016 Aug 11)Shah RACS Med Chem Lett
24447405Association between common genetic variants in the opioid pathway and smoking behaviors in Chinese men. (2014 Jan 21)Fang JBehav Brain Funct
22827509Acute behavioral effects of nicotine in male and female HINT1 knockout mice. (2012 Nov)Jackson KJGenes Brain Behav
23810802The histidine triad nucleotide binding 1 protein is involved in nicotine reward and physical nicotine withdrawal in mice. (2013 Aug 29)Jackson KJNeurosci Lett