Gene: HIVEP1

3096
CIRIP|CRYBP1|GAAP|MBP-1|PRDII-BF1|Schnurri-1|ZAS1|ZNF40|ZNF40A
human immunodeficiency virus type I enhancer binding protein 1
protein-coding
6p24.1
Ensembl:ENSG00000095951 MIM:194540 Vega:OTTHUMG00000014265 UniprotKB:P15822
NC_000006.12
SNP Mapped
1   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.249e-2 (AD)  9.017e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1570989chr6:12048594 (GRCh38.p7)A>Galcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RASAL20.906
TUBGCP40.906
HIVEP20.905
FBXO110.904
MKL20.904
BOD1L10.901
TNPO30.901
SBNO10.9
POM1210.9
MAGI30.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCL7C-0.438
HEY2-0.435
ROM1-0.429
MYL3-0.426
COPZ2-0.421
RAB13-0.42
MDFI-0.411
SH2D1A-0.41
S100A1-0.404
APOA1-0.394

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HIVEP1 mRNA"25510870
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of HIVEP1 mRNA"19414516
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HIVEP1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HIVEP1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HIVEP1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HIVEP1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HIVEP1 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of HIVEP1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIVEP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIVEP1 mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of HIVEP1 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIVEP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIVEP1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of HIVEP1 mRNA25064622
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of HIVEP1 mRNA"23195993
D000638AmiodaroneAmiodarone affects the expression of HIVEP1 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of HIVEP1 mRNA12420312
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of HIVEP1 mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of HIVEP1 mRNA"18687144
D001564Benzo(a)pyreneBenzo(a)pyrene affects the splicing of HIVEP1 exon26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HIVEP1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HIVEP1 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of HIVEP1 mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of HIVEP1 mRNA19371625
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of HIVEP1 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of HIVEP1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of HIVEP1 mRNA15003993
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of HIVEP1 mRNA24763279
D002746ChlorpromazineChlorpromazine affects the expression of HIVEP1 mRNA25064622
D002994ClofibrateClofibrate results in increased expression of HIVEP1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of HIVEP1 mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of HIVEP1 mRNA20971185
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of HIVEP1 mRNA26033743
D003300CopperCopper deficiency results in increased expression of HIVEP1 mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of HIVEP1 mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of HIVEP1 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of HIVEP1 mRNA19167446
D003471CuprizoneCuprizone affects the expression of HIVEP1 mRNA27523638
D003471CuprizoneCuprizone results in increased expression of HIVEP1 mRNA26577399
D016572CyclosporineCyclosporine affects the expression of HIVEP1 mRNA25064622
D016572CyclosporineCyclosporine results in decreased methylation of HIVEP1 promoter27989131
D016572CyclosporineCyclosporine results in increased expression of HIVEP1 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HIVEP1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HIVEP1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of HIVEP1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of HIVEP1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of HIVEP1 mRNA28302478
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of HIVEP1 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of HIVEP1 mRNA26033743
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of HIVEP1 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HIVEP1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HIVEP1 mRNA25064622
D015025ZearalenoneZearalenone results in increased expression of HIVEP1 mRNA19371625
D005485FlutamideFlutamide results in decreased expression of HIVEP1 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of HIVEP1 mRNA20655997
C069837fullerene C60fullerene C60 results in increased expression of HIVEP1 mRNA19167457
D019833GenisteinGenistein results in increased expression of HIVEP1 mRNA19371625
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of HIVEP1 gene28505145
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of HIVEP1 mRNA24763279
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of HIVEP1 mRNA26846883
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HIVEP1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of HIVEP1 mRNA27392435
C045463leflunomideleflunomide results in increased expression of HIVEP1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of HIVEP1 mRNA"24972896
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HIVEP1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of HIVEP1 mRNA26378955
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIVEP1 mRNA"27188386
D009532NickelNickel results in increased expression of HIVEP1 mRNA23195993
C029938nickel sulfatenickel sulfate results in increased expression of HIVEP1 mRNA16780908|2271453
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of HIVEP1 mRNA20971185
C016340o,p'-DDT"o,p'-DDT results in increased expression of HIVEP1 mRNA"19371625
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of HIVEP1 mRNA25729387
D010269ParaquatParaquat affects the expression of HIVEP1 mRNA25064622
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HIVEP1 mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of HIVEP1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of HIVEP1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HIVEP1 mRNA26794494
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HIVEP1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of HIVEP1 mRNA22079256|2271453
D011441PropylthiouracilPropylthiouracil results in increased expression of HIVEP1 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of HIVEP1 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of HIVEP1 mRNA25905778
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of HIVEP1 mRNA16214533
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HIVEP1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of HIVEP1 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HIVEP1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of HIVEP1 mRNA25975270
D013752TetracyclineTetracycline affects the expression of HIVEP1 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HIVEP1 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of HIVEP1 mRNA25064622
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of HIVEP1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of HIVEP1 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of HIVEP1 mRNA"19682533
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HIVEP1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of HIVEP1 mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIVEP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HIVEP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HIVEP1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased methylation of HIVEP1 gene29154799
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased expression of HIVEP1 mRNA]19225232

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001206transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding-IBA21873635  
GO:0003677DNA binding-TAS2106471  
GO:0005515protein binding-IPI16713569  19732766  21078624  23414517  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19732766  
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IDA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal