Gene: ZBTB48

3104
HKR3|TZAP|ZNF855|pp9964
zinc finger and BTB domain containing 48
protein-coding
1p36.31
Ensembl:ENSG00000204859 MIM:165270 Vega:OTTHUMG00000001438 UniprotKB:P10074
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.751e-1 (AD)  1.319e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs731024chr1:6584663 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRMT10.89
TRMT2A0.886
GMPPA0.885
DRG20.882
TELO20.881
SUGP10.88
DUS1L0.88
SPNS10.878
MFSD100.878
NAT90.874

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.672
OR4F29-0.637
KRT73-0.251
MTRNR2L6-0.251
MTRNR2L9-0.249
VNN2-0.235
TBX4-0.234
MROH9-0.231
KLRC2-0.231
OR10A7-0.227

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ZBTB48 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ZBTB48 mRNA19770486
C006780bisphenol Abisphenol A affects the methylation of ZBTB48 promoter27334623
C006780bisphenol Abisphenol A results in increased methylation of ZBTB48 gene28505145
C584509C646 compoundC646 compound results in increased expression of ZBTB48 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ZBTB48 promoter22457795
D002994ClofibrateClofibrate results in decreased expression of ZBTB48 mRNA23811191
D016572CyclosporineCyclosporine results in increased expression of ZBTB48 mRNA19770486
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZBTB48 mRNA17942748
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZBTB48 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ZBTB48 mRNA25613284
D008627Mercuric ChlorideMercuric Chloride affects the expression of ZBTB48 mRNA20353558
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ZBTB48 mRNA23649840
C044361M-VAC protocolZBTB48 protein results in decreased susceptibility to M-VAC protocol15814643
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ZBTB48 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of ZBTB48 mRNA19167457
D010047Ovalbumin[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of ZBTB48 mRNA19176365
D052638Particulate Matter[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of ZBTB48 mRNA19176365
C006253pirinixic acidpirinixic acid results in decreased expression of ZBTB48 mRNA23811191
C045950propiconazolepropiconazole results in decreased expression of ZBTB48 mRNA21278054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZBTB48 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZBTB48 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZBTB48 mRNA25613284
C057693troglitazonetroglitazone results in decreased expression of ZBTB48 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of ZBTB48 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003691double-stranded telomeric DNA binding-IDA28082411  
GO:0003700DNA-binding transcription factor activity-TAS8661141  
GO:0005515protein binding-IPI16189514  21516116  25416956  
GO:0042802identical protein binding-IPI25416956  
GO:0044212transcription regulatory region DNA binding-IDA28500257  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0010833telomere maintenance via telomere lengthening-IMP28082411  28500257  
GO:0045893positive regulation of transcription, DNA-templated-IMP28500257  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric region-IDA28082411  28500257  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal