Gene info: ID 3107

Gene: HLA-C

GENE ID: 3107

Description: major histocompatibility complex, class I, C

Gene type: protein-coding

Location: 6p21.33

dbXrefs: Ensembl:ENSG00000204525 MIM:142840 Vega:OTTHUMG00000031154 UniprotKB:P04222

RefSeq: NG_029422.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : 9.749e-3 (AD) 3.517e-1 (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HLA-A	0.862
HLA-E	0.861
HLA-B	0.852
B2M	0.84
PSME1	0.813
SERPING1	0.811
PSMB8	0.794
MYL12A	0.792
ECE1	0.792
TAGLN2	0.79

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.55
OR4F5	-0.529
MARCH4	-0.273
CYP1A1	-0.263
PRLHR	-0.254
KIT	-0.252
GPR52	-0.252
PPEF1	-0.244
CRH	-0.243
ADRA1D	-0.242

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of HLA-C mRNA"	20206263
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HLA-C mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HLA-C mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HLA-C mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HLA-C mRNA"	27188386
C106538	abacavir	abacavir binds to HLA-C protein	19629158
D000082	Acetaminophen	Acetaminophen results in increased expression of HLA-C mRNA	26690555
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of HLA-C mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of HLA-C gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of HLA-C mRNA	15725085\|1576101
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HLA-C mRNA	20458559
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of HLA-C mRNA	22342234
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HLA-C mRNA"	19150397
C020711	beryllium sulfate	beryllium sulfate results in increased expression of HLA-C mRNA	16314022
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HLA-C mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of HLA-C mRNA	19619570
C006780	bisphenol A	bisphenol A results in increased expression of HLA-C mRNA	28079927
C006780	bisphenol A	bisphenol A affects the expression of HLA-C mRNA	25181051
C025703	bleomycetin	bleomycetin results in decreased expression of HLA-C mRNA	21040473
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of HLA-C mRNA	12419474\|1533650
C099555	CD 437	CD 437 results in decreased expression of HLA-C mRNA	12958071
C018021	cobaltous chloride	cobaltous chloride results in increased expression of HLA-C mRNA	19320972\|1937684
D016572	Cyclosporine	Cyclosporine results in increased expression of HLA-C mRNA	22147139
D003907	Dexamethasone	Dexamethasone results in decreased expression of HLA-C mRNA	25047013
D002945	Cisplatin	[Piroxicam co-treated with Cisplatin] results in increased expression of HLA-C mRNA	21858171
C118739	entinostat	entinostat results in increased expression of HLA-C mRNA	27188386
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of HLA-C mRNA	12419474
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of HLA-C mRNA	8196671
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of HLA-C mRNA	28001369
D016685	Mitomycin	Mitomycin results in decreased expression of HLA-C mRNA	12760830
C523799	MRK 003	MRK 003 results in decreased expression of HLA-C mRNA	21169257
C025589	ochratoxin A	ochratoxin A results in increased acetylation of HLA-C promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in increased acetylation of HLA-C promoter] which results in increased expression of HLA-C mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in increased expression of HLA-C mRNA	29098329
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HLA-C mRNA	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of HLA-C mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of HLA-C mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HLA-C mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HLA-C mRNA]	17655762
D052638	Particulate Matter	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of HLA-C mRNA]	17655762
D052638	Particulate Matter	Particulate Matter affects the expression of HLA-C mRNA	17655762
D052638	Particulate Matter	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HLA-C mRNA]	17655762
D052638	Particulate Matter	Particulate Matter results in decreased expression of HLA-C mRNA	24769257
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HLA-C mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of HLA-C mRNA	26272509
D010894	Piroxicam	[Piroxicam co-treated with Cisplatin] results in increased expression of HLA-C mRNA	21858171
D012643	Selenium	Selenium results in increased expression of HLA-C mRNA	19244175
C017947	sodium arsenite	sodium arsenite results in decreased expression of HLA-C protein	20050688
D013449	Sulfonamides	Sulfonamides binds to HLA-C protein	19629158
C061133	tamibarotene	tamibarotene results in increased expression of HLA-C mRNA	15498508
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HLA-C mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HLA-C mRNA	19619570
D014212	Tretinoin	Tretinoin results in increased expression of HLA-C mRNA	15498508\|1721838
C012589	trichostatin A	trichostatin A results in increased expression of HLA-C mRNA	24935251
D017974	Uranium Compounds	Uranium Compounds results in decreased expression of HLA-C mRNA	19654044
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HLA-C mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of HLA-C mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of HLA-C mRNA	19101580\|2317975
D001335	Vehicle Emissions	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of HLA-C mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of HLA-C mRNA	17655762
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of HLA-C mRNA]	17655762
D014810	Vitamin E	Vitamin E results in increased expression of HLA-C mRNA	19244175
D024483	Vitamin K 3	Vitamin K 3 affects the expression of HLA-C mRNA	20044591
D024483	Vitamin K 3	Vitamin K 3 affects the expression of HLA-C mRNA	20829426
C111237	vorinostat	vorinostat results in increased expression of HLA-C mRNA	27188386
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of HLA-C mRNA	12756304

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	18322206 19858347 28685972
GO:0042605	peptide antigen binding	-	IBA	21873635
GO:0042605	peptide antigen binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001916	positive regulation of T cell mediated cytotoxicity	-	IBA	21873635
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	-	IBA	21873635
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	-	TAS	-
GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	-	IBA	21873635
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	-
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	-	TAS	-
GO:0006955	immune response	-	IBA	21873635
GO:0016032	viral process	-	IEA	-
GO:0050776	regulation of immune response	-	TAS	-
GO:0060333	interferon-gamma-mediated signaling pathway	-	TAS	-
GO:0060337	type I interferon signaling pathway	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	TAS	-
GO:0005783	endoplasmic reticulum	-	ISS	-
GO:0005794	Golgi apparatus	-	ISS	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0009986	cell surface	-	ISS	-
GO:0012507	ER to Golgi transport vesicle membrane	-	TAS	-
GO:0030670	phagocytic vesicle membrane	-	TAS	-
GO:0031901	early endosome membrane	-	TAS	-
GO:0042612	MHC class I protein complex	-	ISS	-
GO:0055038	recycling endosome membrane	-	TAS	-
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04144	Endocytosis
hsa04145	Phagosome
hsa04514	Cell adhesion molecules (CAMs)
hsa04612	Antigen processing and presentation
hsa04650	Natural killer cell mediated cytotoxicity
hsa04940	Type I diabetes mellitus
hsa05320	Autoimmune thyroid disease
hsa05330	Allograft rejection
hsa05332	Graft-versus-host disease
hsa05416	Viral myocarditis

Reactome ID	Reactome Term	Evidence
R-HSA-1236974	ER-Phagosome pathway	TAS
R-HSA-1236974	ER-Phagosome pathway	IEA
R-HSA-1236975	Antigen processing-Cross presentation	TAS
R-HSA-1236975	Antigen processing-Cross presentation	IEA
R-HSA-1236977	Endosomal/Vacuolar pathway	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-877300	Interferon gamma signaling	TAS
R-HSA-909733	Interferon alpha/beta signaling	TAS
R-HSA-913531	Interferon Signaling	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	IEA
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	IEA
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16947780	Association of HLA-C3 and smoking with vasculitis in patients with rheumatoid arthritis. (2006 Sep)	Turesson C	Arthritis Rheum
26106958	The role of KIR2DL3/HLA-C*0802 in Brazilian patients with rheumatoid vasculitis. (2015 Jun)	Nishimura WE	Clinics (Sao Paulo)
21953342	The association between smoking and the development of psoriatic arthritis among psoriasis patients. (2012 Feb)	Eder L	Ann Rheum Dis
27539526	[DNA damage associated genetic variants contribute to lung cancer susceptibility in a Han Chinese population]. (2016 Aug 6)	Li ZH	Zhonghua Yu Fang Yi Xue Za Zhi