Gene: HLA-DOB

3112
DOB|HLA_DOB
major histocompatibility complex, class II, DO beta
protein-coding
6p21.32
Ensembl:ENSG00000241106 MIM:600629 Vega:OTTHUMG00000031213 UniprotKB:P13765
NG_012008.1
PubMed
0   ANCO-SNPs
ND
1   
6.665e-2 (AD)  9.127e-1 (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RUFY40.619
TIMD40.607
KRTAP20-10.593
CCL70.589
IDO10.589
CYP19A10.588
IL270.587
SIGLEC120.581
ZBP10.574
SIGLEC10.572

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLB-0.204
WNT7A-0.199
ATP6V1E2-0.197
NPY2R-0.191
KLRG1-0.188
CYP1A1-0.186
ARSE-0.185
UPK1A-0.18
VIT-0.18
COX8C-0.178

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000447AldehydesAldehydes results in increased expression of HLA-DOB mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of HLA-DOB mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HLA-DOB mRNA24449571
D001280AtrazineAtrazine results in increased expression of HLA-DOB mRNA25929836
D001548Benzalkonium CompoundsHLA-DOB SNP affects the susceptibility to Benzalkonium Compounds27258892
C006780bisphenol Abisphenol A results in increased expression of HLA-DOB mRNA25181051
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of HLA-DOB mRNA17183730
C059500meropenemmeropenem affects the expression of HLA-DOB mRNA25811541
D015735MifepristoneMifepristone results in decreased expression of HLA-DOB mRNA17584828
D009532NickelNickel results in increased expression of HLA-DOB mRNA24768652|2558310
D014295TrimethoprimTrimethoprim affects the expression of HLA-DOB mRNA25811541
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of HLA-DOB mRNA17183730

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0023026MHC class II protein complex binding-IDA22733780  
GO:0032395MHC class II receptor activity-TAS2998758  
GO ID GO Term Qualifier Evidence PubMed
GO:0002587negative regulation of antigen processing and presentation of peptide antigen via MHC class II-IDA22733780  
GO:0006955immune response-IEA-  
GO:0007165signal transduction-IEA-  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IDA8890155  
GO:0005765lysosomal membrane-TAS-  
GO:0010008endosome membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0042613MHC class II protein complex-IDA22733780  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04514Cell adhesion molecules (CAMs)
hsa04612Antigen processing and presentation
hsa04672Intestinal immune network for IgA production
hsa04940Type I diabetes mellitus
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05150Staphylococcus aureus infection
hsa05310Asthma
hsa05320Autoimmune thyroid disease
hsa05322Systemic lupus erythematosus
hsa05323Rheumatoid arthritis
hsa05330Allograft rejection
hsa05332Graft-versus-host disease
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2132295MHC class II antigen presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26272072An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis. (2016 Jan)Jiang XRheumatology (Oxford)