Gene: HLA-DPB1

3115
DPB1|HLA-DP|HLA-DP1B|HLA-DPB
major histocompatibility complex, class II, DP beta 1
protein-coding
6p21.32
Ensembl:ENSG00000223865 MIM:142858 Vega:OTTHUMG00000031076 UniprotKB:P04440
NG_033242.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HLA-DPA10.923
CD740.905
HLA-DRA0.902
HLA-DMA0.901
HLA-DQA10.897
HLA-DOA0.892
PTPRC0.885
LST10.88
CMTM70.878
TBXAS10.874

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.399
NEUROD6-0.39
ST6GAL2-0.387
ZNF835-0.385
KCNIP3-0.377
LRTM2-0.373
MYADML2-0.371
BCL11A-0.367
CYP46A1-0.367
ADRA1D-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of HLA-DPB1 mRNA26690555
D000447AldehydesAldehydes results in increased expression of HLA-DPB1 mRNA25014914
D000638AmiodaroneAmiodarone results in increased expression of HLA-DPB1 mRNA19774075
D018501Antirheumatic Agents[Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of HLA-DPB1 mRNA16817978
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HLA-DPB1 mRNA24449571
D001151ArsenicArsenic results in decreased expression of HLA-DPB1 mRNA27838757
D001548Benzalkonium CompoundsHLA-DPB1 SNP affects the susceptibility to Benzalkonium Compounds27258892
D001554BenzeneBenzene results in decreased expression of HLA-DPB1 mRNA16188091
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HLA-DPB1 mRNA15034205
D001608BerylliumHLA-DPB1 gene polymorphism results in increased susceptibility to Beryllium11551429
D001608BerylliumHLA-DPB1 gene SNP results in increased susceptibility to Beryllium17956852
D001608BerylliumHLA-DPB1 protein mutant form binds to Beryllium17956852
D001608BerylliumHLA-DPB1 protein mutant form results in increased susceptibility to Beryllium15273960
C020711beryllium sulfateberyllium sulfate binds to HLA-DPB1 protein11423174
D000069286BortezomibBortezomib results in decreased expression of HLA-DPB1 mRNA20977926
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of HLA-DPB1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of HLA-DPB1 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of HLA-DPB1 mRNA25979313
D003907DexamethasoneDexamethasone results in increased expression of HLA-DPB1 mRNA12732289
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of HLA-DPB1 mRNA17572062
D008727Methotrexate[Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of HLA-DPB1 mRNA16817978
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HLA-DPB1 mRNA23649840
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of HLA-DPB1 mRNA"12756304
C046012pentanalpentanal results in increased expression of HLA-DPB1 mRNA26079696
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of HLA-DPB1 mRNA22714537
C005556propionaldehydepropionaldehyde results in increased expression of HLA-DPB1 mRNA26079696
D015474IsotretinoinIsotretinoin results in increased expression of HLA-DPB1 mRNA20436886
C016766sulforafansulforafan results in decreased expression of HLA-DPB1 mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HLA-DPB1 mRNA15034205
D013849ThimerosalThimerosal results in decreased expression of HLA-DPB1 mRNA27188386
D014635Valproic AcidValproic Acid affects the expression of HLA-DPB1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HLA-DPB1 mRNA19101580
D019287Zinc SulfateZinc Sulfate results in decreased expression of HLA-DPB1 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042605peptide antigen binding-IDA20356827  
GO ID GO Term Qualifier Evidence PubMed
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-IMP20356827  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0032729positive regulation of interferon-gamma production-IMP20356827  
GO:0042102positive regulation of T cell proliferation-IMP20356827  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0050870positive regulation of T cell activation-IMP20356827  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005765lysosomal membrane-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IMP20356827  
GO:0010008endosome membrane-IEA-  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030658transport vesicle membrane-TAS-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
GO:0032588trans-Golgi network membrane-TAS-  
GO:0042613MHC class II protein complex-IDA20356827  
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane-TAS-  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04514Cell adhesion molecules (CAMs)
hsa04612Antigen processing and presentation
hsa04672Intestinal immune network for IgA production
hsa04940Type I diabetes mellitus
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05150Staphylococcus aureus infection
hsa05310Asthma
hsa05320Autoimmune thyroid disease
hsa05322Systemic lupus erythematosus
hsa05323Rheumatoid arthritis
hsa05330Allograft rejection
hsa05332Graft-versus-host disease
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-202427Phosphorylation of CD3 and TCR zeta chainsTAS
R-HSA-202430Translocation of ZAP-70 to Immunological synapseTAS
R-HSA-202433Generation of second messenger moleculesTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389948PD-1 signalingTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17653770Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease. (2007 Nov)Chen ZHum Genet
28025329Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. (2017 Jan 15)Seow WJHum Mol Genet