Gene: HLA-DQA1

3117
CELIAC1|DQ-A1|HLA-DQA
major histocompatibility complex, class II, DQ alpha 1
protein-coding
6p21.32
Ensembl:ENSG00000196735 MIM:146880 Vega:OTTHUMG00000031106 UniprotKB:P01909
NG_032876.1
PubMed
0   ANCO-SNPs
ND
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HLA-DOA0.931
PTPRC0.905
CD370.901
HLA-DPB10.897
RASGRP40.895
HLA-DPA10.894
CLEC7A0.891
TLR10.89
HLA-DMB0.889
SYK0.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP46A1-0.46
BDH1-0.459
KCNIP3-0.457
ZNF835-0.457
NEUROD6-0.448
MAGIX-0.448
ASPDH-0.447
MARCH4-0.443
WNT7A-0.44
CHRNA4-0.434

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of HLA-DQA1 mRNA"20638727
D000082AcetaminophenAcetaminophen results in increased expression of HLA-DQA1 mRNA26690555
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of HLA-DQA1 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HLA-DQA1 mRNA24449571
D001151ArsenicArsenic affects the expression of HLA-DQA1 mRNA18414638
D001151Arsenic[Arsenic results in increased abundance of Arsenicals] which affects the expression of HLA-DQA1 mRNA28793237
D001151ArsenicArsenic results in increased methylation of HLA-DQA1 gene27838757
D001152ArsenicalsArsenicals results in decreased expression of HLA-DQA1 mRNA28625800
D001152Arsenicals[Arsenic results in increased abundance of Arsenicals] which affects the expression of HLA-DQA1 mRNA28793237
D001310AuranofinHLA-DQA1 gene polymorphism results in increased susceptibility to Auranofin11436868
D001379AzathioprineHLA-DQA1 gene polymorphism affects the susceptibility to Azathioprine25217962
C547126AZM551248AZM551248 results in increased expression of HLA-DQA1 mRNA22323515
D001554BenzeneBenzene results in decreased expression of HLA-DQA1 mRNA16188091
C006780bisphenol Abisphenol A results in decreased expression of HLA-DQA1 mRNA25181051
D003907DexamethasoneDexamethasone results in increased expression of HLA-DQA1 mRNA12732289
D003907DexamethasoneDexamethasone results in increased expression of HLA-DQA1 protein12732289
D002117CalcitriolCalcitriol results in decreased expression of HLA-DQA1 mRNA26485663
C065180fluvastatinfluvastatin affects the expression of HLA-DQA1 mRNA25811541
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HLA-DQA1 mRNA22235868
C473384lumiracoxibHLA-DQA1 gene SNP affects the susceptibility to lumiracoxib20639878
D015122MercaptopurineHLA-DQA1 gene polymorphism affects the susceptibility to Mercaptopurine25217962
D008628MercuryMercury results in decreased expression of HLA-DQA1 mRNA16823088|1993728
D010165PalladiumHLA-DQA1 gene polymorphism affects the susceptibility to Palladium8725357
D011374ProgesteroneProgesterone results in decreased expression of HLA-DQA1 mRNA19690047
C005556propionaldehydepropionaldehyde results in decreased expression of HLA-DQA1 mRNA26079696
D011794QuercetinQuercetin results in increased expression of HLA-DQA1 mRNA16455785
C012526quercitrinquercitrin affects the expression of HLA-DQA1 mRNA25193878
D012834SilverSilver results in decreased expression of HLA-DQA1 mRNA26551752
C004648testosterone enanthatetestosterone enanthate affects the expression of HLA-DQA1 mRNA17440010
D024483Vitamin K 3Vitamin K 3 affects the expression of HLA-DQA1 mRNA20829426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11376336  14769912  16242130  25241761  
GO:0032395MHC class II receptor activity-NAS3584986  6415485  
GO:0032395MHC class II receptor activity-TAS2300572  
GO:0042605peptide antigen binding-ISS20356827  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-NAS3584986  6415485  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005765lysosomal membrane-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS3584986  6415485  
GO:0010008endosome membrane-IEA-  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030658transport vesicle membrane-TAS-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
GO:0032588trans-Golgi network membrane-TAS-  
GO:0042613MHC class II protein complex-ISS20356827  
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane-TAS-  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04514Cell adhesion molecules (CAMs)
hsa04612Antigen processing and presentation
hsa04672Intestinal immune network for IgA production
hsa04940Type I diabetes mellitus
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05150Staphylococcus aureus infection
hsa05310Asthma
hsa05320Autoimmune thyroid disease
hsa05322Systemic lupus erythematosus
hsa05323Rheumatoid arthritis
hsa05330Allograft rejection
hsa05332Graft-versus-host disease
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-202427Phosphorylation of CD3 and TCR zeta chainsTAS
R-HSA-202430Translocation of ZAP-70 to Immunological synapseTAS
R-HSA-202433Generation of second messenger moleculesTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389948PD-1 signalingTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26272072An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis. (2016 Jan)Jiang XRheumatology (Oxford)
16911023Interactions between fetal HLA-DQ alleles and maternal smoking influence birthweight. (2006 Sep)Taylor GMPaediatr Perinat Epidemiol
20061363Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes. (2010 May)Kohno TCarcinogenesis
16733891[Association of polymorphisms of human leucocyte antigen -DRB1 and -DQA1 allele with outcomes of hepatitis B virus infection in Han population of north China]. (2006 Apr)Lu LPZhongguo Yi Xue Ke Xue Yuan Xue Bao
15691311Association of Helicobacter pylori-related distal gastric cancer with the HLA class II gene DQB10602 and cagA strains in a southern European population. (2005 Feb)Quintero EHelicobacter
15346196Association between alcohol, smoking and HLA-DQA1*0201 genotype in psoriasis. (2004 Sep)Zheng GYActa Biochim Biophys Sin (Shanghai)
21777217Smoking and pathogenesis of psoriasis: a review of oxidative, inflammatory and genetic mechanisms. (2011 Dec)Armstrong AWBr J Dermatol
29030599Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. (2017 Oct 13)Joshi PKNat Commun