Gene: HLA-DQA2

3118
DX-ALPHA|HLA-DXA|HLADQA2
major histocompatibility complex, class II, DQ alpha 2
protein-coding
6p21.32
Ensembl:ENSG00000237541 MIM:613503 Vega:OTTHUMG00000031108 UniprotKB:P01906
NC_000006.12
PubMed
0   ANCO-SNPs
ND
2   
8.925e-1 (AD)  9.117e-1 (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFEC0.704
SNX200.702
SP1400.7
IL150.693
HLA-DOA0.688
RHOH0.687
BTK0.686
FAM3B0.684
SAMSN10.684
SP140L0.681

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.362
WNT7A-0.347
CPLX3-0.347
MYADML2-0.33
SCRT1-0.327
CHRNA4-0.318
ATOH7-0.317
KCNK4-0.316
ZNF835-0.313
MAGIX-0.31

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00071Insulin PorkBiotechDrug12584-58-6ApprovedTarget
ID Drug Name Action PubMed
D001151ArsenicArsenic results in decreased expression of HLA-DQA2 mRNA27838757
C517284monomethyl phthalatemonomethyl phthalate affects the expression of HLA-DQA2 mRNA26924002
C005556propionaldehydepropionaldehyde results in increased expression of HLA-DQA2 mRNA26079696
D012967Sodium Dodecyl SulfateHLA-DQA2 SNP affects the susceptibility to Sodium Dodecyl Sulfate27258892

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0032395MHC class II receptor activity-NAS3036828  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-NAS3036828  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005765lysosomal membrane-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS3036828  
GO:0010008endosome membrane-IEA-  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0030658transport vesicle membrane-TAS-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
GO:0032588trans-Golgi network membrane-TAS-  
GO:0042613MHC class II protein complex-IEA-  
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane-TAS-  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04514Cell adhesion molecules (CAMs)
hsa04612Antigen processing and presentation
hsa04672Intestinal immune network for IgA production
hsa04940Type I diabetes mellitus
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05150Staphylococcus aureus infection
hsa05310Asthma
hsa05320Autoimmune thyroid disease
hsa05322Systemic lupus erythematosus
hsa05323Rheumatoid arthritis
hsa05330Allograft rejection
hsa05332Graft-versus-host disease
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-202427Phosphorylation of CD3 and TCR zeta chainsTAS
R-HSA-202430Translocation of ZAP-70 to Immunological synapseTAS
R-HSA-202433Generation of second messenger moleculesTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389948PD-1 signalingTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26423011Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. (2015 Oct)Wain LVLancet Respir Med
23284291Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (2012)Hancock DBPLoS Genet