Gene: HLA-DQB1

3119
CELIAC1|HLA-DQB|IDDM1
major histocompatibility complex, class II, DQ beta 1
protein-coding
6p21.32
Ensembl:ENSG00000179344 MIM:604305 Vega:OTTHUMG00000031124 UniprotKB:P01920
NG_029922.1
PubMed
0   ANCO-SNPs
ND
11   
6.931e-1 (AD)  9.022e-1 (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HLA-DRB10.68
HLA-DQA10.657
CSF2RA0.606
WAS0.604
CD740.601
CD370.6
C1QB0.598
HLA-DRA0.597
C1QA0.597
ADAM280.595

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REN-0.374
HES5-0.333
HPDL-0.325
BTBD17-0.304
ZSCAN1-0.295
SLC13A5-0.294
FAM180B-0.289
ARSF-0.288
AKR7A3-0.272
CRH-0.27

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00071Insulin PorkBiotechDrug12584-58-6ApprovedTarget
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HLA-DQB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HLA-DQB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HLA-DQB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HLA-DQB1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of HLA-DQB1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HLA-DQB1 mRNA22100608
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of HLA-DQB1 mRNA"23195993
D000658AmoxicillinAmoxicillin affects the expression of HLA-DQB1 mRNA25811541
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HLA-DQB1 mRNA24449571
D001151ArsenicArsenic affects the expression of HLA-DQB1 mRNA18414638
D001151ArsenicHLA-DQB1 mRNA results in decreased susceptibility to Arsenic17976673
C547126AZM551248AZM551248 results in increased expression of HLA-DQB1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of HLA-DQB1 mRNA22342234
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of HLA-DQB1 mRNA18192240
D002220CarbamazepineCarbamazepine affects the expression of HLA-DQB1 mRNA25811541
D002444CefuroximeCefuroxime affects the expression of HLA-DQB1 mRNA25811541
D003907DexamethasoneDexamethasone affects the expression of HLA-DQB1 mRNA12732289
D004317DoxorubicinDoxorubicin results in decreased expression of HLA-DQB1 mRNA16404146
D004317DoxorubicinHLA-DQB1 mRNA results in decreased susceptibility to Doxorubicin16322897
C118739entinostatentinostat results in increased expression of HLA-DQB1 mRNA27188386
D005279FenoprofenFenoprofen affects the expression of HLA-DQB1 mRNA25811541
D017313FenretinideFenretinide results in decreased expression of HLA-DQB1 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HLA-DQB1 mRNA23086925
D007660KetoprofenKetoprofen affects the expression of HLA-DQB1 mRNA25811541
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HLA-DQB1 mRNA22235868
C473384lumiracoxibHLA-DQB1 gene SNP affects the susceptibility to lumiracoxib20639878
D008628MercuryMercury results in decreased expression of HLA-DQB1 mRNA16823088
D008628MercuryMercury results in increased expression of HLA-DQB1 mRNA19937285
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HLA-DQB1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HLA-DQB1 mRNA23649840
D008795MetronidazoleMetronidazole affects the expression of HLA-DQB1 mRNA25811541
D009532NickelNickel results in increased expression of HLA-DQB1 mRNA23195993|2476865
D009543NifedipineNifedipine affects the expression of HLA-DQB1 mRNA25811541
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of HLA-DQB1 mRNA19074003
C507134ON 01910ON 01910 affects the expression of HLA-DQB1 mRNA22351695
C008729oxaprozinoxaprozin affects the expression of HLA-DQB1 mRNA25811541
D010165PalladiumHLA-DQB1 gene polymorphism affects the susceptibility to Palladium8725357
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HLA-DQB1 mRNA"27188386
D010419PentamidinePentamidine affects the expression of HLA-DQB1 mRNA25811541
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside results in increased expression of HLA-DQB1 mRNA19194470
D011794QuercetinQuercetin results in increased expression of HLA-DQB1 mRNA16455785
D015474IsotretinoinIsotretinoin results in increased expression of HLA-DQB1 mRNA20436886
D012293RifampinRifampin affects the expression of HLA-DQB1 mRNA25811541
D012643SeleniumSelenium results in increased expression of HLA-DQB1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of HLA-DQB1 mRNA25351596
D019821SimvastatinSimvastatin affects the expression of HLA-DQB1 mRNA25811541
C061133tamibarotenetamibarotene results in increased expression of HLA-DQB1 mRNA17229644
C004648testosterone enanthatetestosterone enanthate affects the expression of HLA-DQB1 mRNA17440010
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of HLA-DQB1 mRNA19074003
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of HLA-DQB1 mRNA28111298
D014046TolmetinTolmetin affects the expression of HLA-DQB1 mRNA25811541
D014051Toluene 2,4-Diisocyanate"HLA-DQB1 gene polymorphism affects the susceptibility to Toluene 2,4-Diisocyanate"18447907
D014212TretinoinTretinoin results in increased expression of HLA-DQB1 mRNA23830798
C012589trichostatin Atrichostatin A results in increased expression of HLA-DQB1 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HLA-DQB1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HLA-DQB1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HLA-DQB1 mRNA23179753|2438349
D014810Vitamin EVitamin E results in increased expression of HLA-DQB1 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of HLA-DQB1 mRNA20829426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11376336  14769912  
GO:0032395MHC class II receptor activity-NAS2998758  
GO:0042605peptide antigen binding-ISS20356827  
GO ID GO Term Qualifier Evidence PubMed
GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response-IDA17050030  
GO:0002455humoral immune response mediated by circulating immunoglobulin-IDA17050030  
GO:0006955immune response-NAS2998758  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005765lysosomal membrane-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0010008endosome membrane-IEA-  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-NAS2998758  
GO:0030658transport vesicle membrane-TAS-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
GO:0032588trans-Golgi network membrane-TAS-  
GO:0042613MHC class II protein complex-ISS20356827  
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane-TAS-  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04514Cell adhesion molecules (CAMs)
hsa04612Antigen processing and presentation
hsa04672Intestinal immune network for IgA production
hsa04940Type I diabetes mellitus
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05150Staphylococcus aureus infection
hsa05310Asthma
hsa05320Autoimmune thyroid disease
hsa05322Systemic lupus erythematosus
hsa05323Rheumatoid arthritis
hsa05330Allograft rejection
hsa05332Graft-versus-host disease
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-202427Phosphorylation of CD3 and TCR zeta chainsTAS
R-HSA-202430Translocation of ZAP-70 to Immunological synapseTAS
R-HSA-202433Generation of second messenger moleculesTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389948PD-1 signalingTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16862049A prospective study of upper aerodigestive tract manifestations of mucous membrane pemphigoid. (2006 Jul)Alexandre MMedicine (Baltimore)
16188098[Relationship between pneumoconiosis and the polymorphisms of HLA-DRB1*, DQB1* genes]. (2005 Aug)Fan XYZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
15691311Association of Helicobacter pylori-related distal gastric cancer with the HLA class II gene DQB10602 and cagA strains in a southern European population. (2005 Feb)Quintero EHelicobacter
22443520Individual composition of human leukocyte antigens and periodontopathogens in the background of periodontitis. (2013 Jan)Reichert SJ Periodontol
23284291Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (2012)Hancock DBPLoS Genet
19039244Active and passive smoking and risk of narcolepsy in people with HLA DQB1*0602: a population-based case-control study. (2009)Ton TGNeuroepidemiology
20221267IgG abnormality in narcolepsy and idiopathic hypersomnia. (2010 Mar 5)Tanaka SPLoS One
24148080Human papillomavirus promotes esophageal squamous cell carcinoma by regulating DNA methylation and expression of HLA-DQB1. (2014 Mar)Feng BAsia Pac J Clin Oncol
26423011Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. (2015 Oct)Wain LVLancet Respir Med
17370149Association of HLA-DQB1 gene polymorphisms with outcomes of HBV infection in Chinese Han population. (2007 Feb 24)Zhu XLSwiss Med Wkly
21557256Correlation between HLA-DRB1, HLA-DQB1 polymorphism and autoantibodies against angiotensin AT(1) receptors in Chinese patients with essential hypertension. (2011 May)Zhu FClin Cardiol