Gene: HLA-DRB1

3123
DRB1|HLA-DR1B|HLA-DRB|SS1
major histocompatibility complex, class II, DR beta 1
protein-coding
6p21.32
Ensembl:ENSG00000196126 MIM:142857 Vega:OTTHUMG00000031196 UniprotKB:P01911
NG_029921.1
PubMed
ND
140   
9.137e-1 (AD)  6.334e-1 (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HLA-DPA10.913
HLA-DRA0.91
CD740.903
HLA-DPB10.868
HLA-DMA0.864
HLA-DQA10.847
FCGR3A0.845
ITGB20.845
ABI30.843
MYO1F0.842

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ST6GAL2-0.385
HES5-0.383
MARCH4-0.381
ZSCAN1-0.377
ATP2C2-0.373
ADRA1D-0.372
FRMPD2-0.366
ANKRD55-0.358
CYP1A1-0.356
TPBGL-0.347

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of HLA-DRB1 mRNA"20206263
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of HLA-DRB1 protein26194647
D000082AcetaminophenAcetaminophen results in decreased expression of HLA-DRB1 mRNA29067470
D000806Angiotensin-Converting Enzyme InhibitorsAngiotensin-Converting Enzyme Inhibitors affects the expression of HLA-DRB1 mRNA25811541
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HLA-DRB1 mRNA24449571|2533912
D001151ArsenicArsenic affects the expression of HLA-DRB1 mRNA18414638|2879323
D001241AspirinHLA-DRB1 gene SNP affects the susceptibility to Aspirin20485159
D001310AuranofinHLA-DRB1 gene polymorphism results in increased susceptibility to Auranofin11436868
D001379AzathioprineHLA-DRB1 gene polymorphism affects the susceptibility to Azathioprine25217962
C547126AZM551248AZM551248 results in increased expression of HLA-DRB1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HLA-DRB1 mRNA20106945
C020711beryllium sulfateberyllium sulfate results in increased expression of HLA-DRB1 mRNA16314022
C020711beryllium sulfateHLA-DRB1 protein mutant form results in increased susceptibility to beryllium sulfate16272364
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in increased expression of HLA-DRB1 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of HLA-DRB1 mRNA20660070
D004958EstradiolEstradiol results in increased expression of HLA-DRB1 mRNA24758408
C006780bisphenol Abisphenol A results in decreased expression of HLA-DRB1 mRNA25181051
C043266cefepimecefepime affects the expression of HLA-DRB1 mRNA25811541
D000068579CelecoxibCelecoxib affects the expression of HLA-DRB1 mRNA25811541
D002939CiprofloxacinCiprofloxacin affects the expression of HLA-DRB1 mRNA25811541
D002981ClindamycinClindamycin affects the expression of HLA-DRB1 mRNA25811541
D016572CyclosporineCyclosporine results in decreased expression of HLA-DRB1 mRNA20106945|2798913
D004008DiclofenacDiclofenac affects the expression of HLA-DRB1 mRNA25811541
D004110DiltiazemDiltiazem affects the expression of HLA-DRB1 mRNA25811541
C419708gefitinibgefitinib affects the expression of HLA-DRB1 mRNA25811541
D006852HydrochlorothiazideHydrochlorothiazide affects the expression of HLA-DRB1 mRNA25811541
C051890irinotecanirinotecan analog results in increased expression of HLA-DRB1 mRNA18927307
D007854LeadLead affects the expression of HLA-DRB1 mRNA28903495
D007854LeadLead results in decreased expression of HLA-DRB1 mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of HLA-DRB1 mRNA"24972896
C473384lumiracoxibHLA-DRB1 gene SNP affects the susceptibility to lumiracoxib20639878
D015122MercaptopurineHLA-DRB1 gene polymorphism affects the susceptibility to Mercaptopurine25217962
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of HLA-DRB1 mRNA12634122
D008795MetronidazoleMetronidazole affects the expression of HLA-DRB1 mRNA25811541
D009569Nitric OxideHLA-DRB1 protein results in increased abundance of Nitric Oxide17075829
D010165PalladiumHLA-DRB1 gene polymorphism affects the susceptibility to Palladium8725357
D010396PenicillamineHLA-DRB1 gene polymorphism results in increased susceptibility to Penicillamine6420562
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of HLA-DRB1 mRNA20660070
D011794QuercetinQuercetin results in increased expression of HLA-DRB1 mRNA16455785
D012906SmokeSmoke results in increased expression of HLA-DRB1 mRNA21095227
D013629TamoxifenTamoxifen affects the expression of HLA-DRB1 mRNA25811541
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HLA-DRB1 mRNA20055451
D014635Valproic AcidValproic Acid affects the expression of HLA-DRB1 mRNA25979313
C088658zoledronic acidzoledronic acid results in increased expression of HLA-DRB1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0023026MHC class II protein complex binding-HDA20458337  
GO:0042605peptide antigen binding-IDA21502329  
GO ID GO Term Qualifier Evidence PubMed
GO:0002506polysaccharide assembly with MHC class II protein complex-IDA21502329  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005765lysosomal membrane-IDA18305173  
GO:0005765lysosomal membrane-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IDA21502329  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030658transport vesicle membrane-TAS-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
GO:0031902late endosome membrane-IDA18305173  
GO:0032588trans-Golgi network membrane-TAS-  
GO:0042613MHC class II protein complex-IDA21502329  
GO:0070062extracellular exosome-HDA12519789  20458337  
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane-TAS-  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04514Cell adhesion molecules (CAMs)
hsa04612Antigen processing and presentation
hsa04640Hematopoietic cell lineage
hsa04672Intestinal immune network for IgA production
hsa04940Type I diabetes mellitus
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05150Staphylococcus aureus infection
hsa05310Asthma
hsa05320Autoimmune thyroid disease
hsa05322Systemic lupus erythematosus
hsa05323Rheumatoid arthritis
hsa05330Allograft rejection
hsa05332Graft-versus-host disease
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-202427Phosphorylation of CD3 and TCR zeta chainsTAS
R-HSA-202430Translocation of ZAP-70 to Immunological synapseTAS
R-HSA-202433Generation of second messenger moleculesTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389948PD-1 signalingTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26961744Autoantibodies to human citrullinated fibrinogen and their subfamilies to the alpha36-50Cit and beta60-74Cit fibrin peptides similarly predict radiographic damages: a prospective study in the French ESPOIR cohort of very early arthritides. (2016 Mar 8)Cornillet MRheumatology (Oxford)
19252239[Recent advances in the pathogenesis of rheumatoid arthritis]. (2009 Mar)Kawabata KClin Calcium
19151010Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis. (2010 Jan)Karlson EWAnn Rheum Dis
28336519Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-up. (2017 Sep)Manivel VAAnn Rheum Dis
20646949Rheumatoid arthritis and periodontal disease. (2010 Dec)Berthelot JMJoint Bone Spine
17530703Interaction between smoking, the shared epitope, and anti-cyclic citrullinated peptide: a mixed picture in three large North American rheumatoid arthritis cohorts. (2007 Jun)Lee HSArthritis Rheum
22440825Relationship between area-level socio-economic deprivation and autoantibody status in patients with rheumatoid arthritis: multicentre cross-sectional study. (2012 Oct)Mackie SLAnn Rheum Dis
16279844Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease. (2005 Oct)Kurylowicz AThyroid
17009227Influence of male sex on disease phenotype in familial rheumatoid arthritis. (2006 Oct)Jawaheer DArthritis Rheum
26339134HLA Haplotypes and Genotypes Frequencies in Brazilian Chronic Periodontitis Patients. (2015)Sippert EAMediators Inflamm
16973114Recent advances in the genetics of rheumatoid arthritis. (2006 Oct)Deighton CCurr Rheumatol Rep
25324153Interaction between passive smoking and two HLA genes with regard to multiple sclerosis risk. (2014 Dec)Hedstrom AKInt J Epidemiol
28855411Epstein-Barr virus, cytomegalovirus, and multiple sclerosis susceptibility: A multiethnic study. (2017 Sep 26)Langer-Gould ANeurology
25916813Associations with smoking and shared epitope differ between IgA- and IgG-class antibodies to cyclic citrullinated peptides in early rheumatoid arthritis. (2015 May)Svard AArthritis Rheumatol
18535114Alcohol consumption is associated with decreased risk of rheumatoid arthritis: results from two Scandinavian case-control studies. (2009 Feb)Kallberg HAnn Rheum Dis
21802972Does brachydactyly have a protective effect on the erosive changes in rheumatoid arthritis? (2012 May)Bang SYJoint Bone Spine
27339331T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis. (2016 Aug)Ockinger JClin Immunol
28708862Anti-citrullinated protein antibody positive rheumatoid arthritis is primarily determined by rheumatoid factor titre and the shared epitope rather than smoking per se. (2017)Murphy DPLoS One
16887863Smoking interacts with genetic risk factors in the development of rheumatoid arthritis among older Caucasian women. (2006 Sep)Criswell LAAnn Rheum Dis
23288628Genetics of rheumatoid arthritis - a comprehensive review. (2013 Oct)Kurko JClin Rev Allergy Immunol
15476204A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. (2004 Oct)Padyukov LArthritis Rheum
24942650Effects of smoking and shared epitope on the production of anti-citrullinated peptide antibody in a Japanese adult population. (2014 Dec)Terao CArthritis Care Res (Hoboken)
17023727Sex-specific manifestations of Lofgren's syndrome. (2007 Jan 1)Grunewald JAm J Respir Crit Care Med
21557256Correlation between HLA-DRB1, HLA-DQB1 polymorphism and autoantibodies against angiotensin AT(1) receptors in Chinese patients with essential hypertension. (2011 May)Zhu FClin Cardiol
24276366Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins. (2015 Feb)Hensvold AHAnn Rheum Dis
12209487Relationship among the HLA-DRB1 shared epitope, smoking, and rheumatoid factor production in rheumatoid arthritis. (2002 Aug)Mattey DLArthritis Rheum
28982023Soluble HLA-DR serum levels are associated with smoking but not with acute coronary syndrome. (2017 Nov)Tolva JAtherosclerosis
16702830Epidemiology and natural history of multiple sclerosis: new insights. (2006 Jun)Kantarci OCurr Opin Neurol
23407388An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes. (2013 Jul)Shimane KRheumatology (Oxford)
27602574Cigarette Smoke Induces Immune Responses to Vimentin in both, Arthritis-Susceptible and -Resistant Humanized Mice. (2016)Bidkar MPLoS One
18466580Evidence of linkage to chromosome 1 for early age of onset of rheumatoid arthritis and HLA marker DRB1 genotype in NARAC data. (2007)Xu WBMC Proc
28962582Low levels of antibodies against common viruses associate with anti-citrullinated protein antibody-positive rheumatoid arthritis; implications for disease aetiology. (2017 Sep 30)Sherina NArthritis Res Ther
18240242Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis. (2008 Feb)Farragher TMArthritis Rheum
22661643Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile. (2013 May)Lundberg KAnn Rheum Dis
21367760Antibodies to citrullinated alpha-enolase peptide 1 and clinical and radiological outcomes in rheumatoid arthritis. (2011 Jun)Fisher BAAnn Rheum Dis
29532745Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis. (2018 Mar 1)Graetz CMult Scler
17265477The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide. (2007 Feb)van der Helm-van Mil AHArthritis Rheum
19233045The preclinical stages of RA: lessons from human studies and animal models. (2009 Feb)El-Gabalawy HBest Pract Res Clin Rheumatol
24577137Adverse socioeconomic position during the life course is associated with multiple sclerosis. (2014 Jul)Briggs FBJ Epidemiol Community Health
24293566Associations of smoking and alcohol consumption with disease activity and functional status in rheumatoid arthritis. (2014 Jan)Lu BJ Rheumatol
12415586Nodular disease in rheumatoid arthritis: association with cigarette smoking and HLA-DRB1/TNF gene interaction. (2002 Nov)Mattey DLJ Rheumatol
23613482Thyroxin substitution and the risk of developing rheumatoid arthritis; results from the Swedish population-based EIRA study. (2014 Jun)Bengtsson CAnn Rheum Dis
21445357Effects of GSTM1 in rheumatoid arthritis; results from the Swedish EIRA study. (2011 Mar 22)Lundstrom EPLoS One
27652346Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. (2016 Oct)Rhead BNeurol Genet
22186711Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: a European-wide case study. (2012 Jun)Chinoy HAnn Rheum Dis
23908443Prevalence of anti-peptidylarginine deiminase type 4 antibodies in rheumatoid arthritis and unaffected first-degree relatives in indigenous North American Populations. (2013 Sep)Ferucci EDJ Rheumatol
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget
20722010Associations of cigarette smoking with rheumatoid arthritis in African Americans. (2010 Dec)Mikuls TRArthritis Rheum
20439292Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)van der Helm-van Mil AHAnn Rheum Dis
12373032Evidence for human leukocyte antigen-related susceptibility in idiopathic childhood ischemic stroke. (2002)Zou LPEur Neurol
19944780The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis. (2010 Mar)Tobon GJAutoimmun Rev
27859022Immunoglobulin (Ig)G1 and IgG4 anti-cyclic citrullinated peptide (CCP) associate with shared epitope, whereas IgG2 anti-CCP associates with smoking in patients with recent-onset rheumatoid arthritis (the Swedish TIRA project). (2017 Apr)Martinsson KClin Exp Immunol
16258907The interaction of smoking and the HLA-DRB1 shared epitope in rheumatoid factor-positive rheumatoid arthritis: comment on the article by Padyukov et al. (2005 Nov)de Vries NArthritis Rheum
28981958Pooled analysis of the HLA-DRB1 by smoking interaction in Parkinson disease. (2017 Nov)Chuang YHAnn Neurol
24297382Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles. (2015 Mar)Wagner CAAnn Rheum Dis
20375311Combined effects of smoking, anti-EBNA antibodies, and HLA-DRB1*1501 on multiple sclerosis risk. (2010 Apr 27)Simon KCNeurology
19585495Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population--a candidate gene approach. (2009 Oct 15)Castro FAInt J Cancer
20560812Influence of female hormonal factors, in relation to autoantibodies and genetic markers, on the development of rheumatoid arthritis in northern Sweden: a case-control study. (2010 Nov)Berglin EScand J Rheumatol
23495093Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis. (2013 Jul)Karlson EWArthritis Care Res (Hoboken)
23637323Interaction of HLA-DRB1*09:01 and *04:05 with smoking suggests distinctive mechanisms of rheumatoid arthritis susceptibility beyond the shared epitope. (2013 Jul)Bang SYJ Rheumatol
20112396Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status. (2010 Feb)Bang SYArthritis Rheum
19714585Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population. (2009 Sep)Morgan AWArthritis Rheum
19898480Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis. (2009 Dec)Mahdi HNat Genet
16947780Association of HLA-C3 and smoking with vasculitis in patients with rheumatoid arthritis. (2006 Sep)Turesson CArthritis Rheum
19427413Anti-citrullinated protein/peptide autoantibodies in association with genetic and environmental factors as indicators of disease outcome in rheumatoid arthritis. (2010 Jan)Szodoray PAutoimmun Rev
26255186Clinical and laboratory factors associated with interstitial lung disease in rheumatoid arthritis. (2015 Sep)Restrepo JFClin Rheumatol
22912672Interaction between smoking and HLA-DRB1*04 gene is associated with a high cardiovascular risk in Brazilian Amazon patients with rheumatoid arthritis. (2012)Boechat Nde OPLoS One
22867979Different risk factors between interstitial lung disease and airway disease in rheumatoid arthritis. (2012 Nov)Mori SRespir Med
29343473Smoking affects the interferon beta treatment response in multiple sclerosis. (2018 Feb 13)Petersen ERNeurology
29070529Anticitrullinated protein/peptide antibody multiplexing defines an extended group of ACPA-positive rheumatoid arthritis patients with distinct genetic and environmental determinants. (2018 Feb)Ronnelid JAnn Rheum Dis
20537173Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study. (2010)Bang SYArthritis Res Ther
18173373Immunity to citrullinated proteins in rheumatoid arthritis. (2008)Klareskog LAnnu Rev Immunol
26718593Epidemiology of multiple sclerosis. (2016 Jan)Leray ERev Neurol (Paris)
26554752Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology. (2016 Mar)Kharlamova NArthritis Rheumatol
23577190PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. (2013)Suzuki TPLoS One
23505239Smoking, the HLA-DRB1 shared epitope and ACPA fine-specificity in Koreans with rheumatoid arthritis: evidence for more than one pathogenic pathway linking smoking to disease. (2014 Apr)Fisher BAAnn Rheum Dis
17763436Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles. (2007 Sep)Verpoort KNArthritis Rheum
16868893Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a Polish population study. (2006 Jun)Kurylowicz AExp Clin Endocrinol Diabetes
23320113Environmental factors associated with disease progression after the first demyelinating event: results from the multi-center SET study. (2013)Horakova DPLoS One
23483715Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis. (2013 Mar)Pierrot-Deseilligny CTher Adv Neurol Disord
25274070Environmental exposures and the risk of multiple sclerosis investigated in a Norwegian case-control study. (2014 Oct 3)Gustavsen MWBMC Neurol
20061955The rheumatoid arthritis HLA-DRB1 shared epitope. (2010 May)Holoshitz JCurr Opin Rheumatol
17983708Rheumatoid arthritis in smokers could be linked to Proteus urinary tract infections. (2008)Rashid TMed Hypotheses
24067379Entering a new phase of immunogenetics in the idiopathic inflammatory myopathies. (2013 Nov)Rothwell SCurr Opin Rheumatol
28674691Influence of Cigarette Smoking on Rheumatoid Arthritis Risk in the Han Chinese Population. (2017)Yin JFront Med (Lausanne)
26106958The role of KIR2DL3/HLA-C*0802 in Brazilian patients with rheumatoid vasculitis. (2015 Jun)Nishimura WEClinics (Sao Paulo)
19479873Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important. (2009 Jun)Lundstrom EArthritis Rheum
17436241Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. (2007 May)Kallberg HAm J Hum Genet
17370149Association of HLA-DQB1 gene polymorphisms with outcomes of HBV infection in Chinese Han population. (2007 Feb 24)Zhu XLSwiss Med Wkly
27215344Circulating secretory IgA antibodies against cyclic citrullinated peptides in early rheumatoid arthritis associate with inflammatory activity and smoking. (2016 May 23)Roos KArthritis Res Ther
28369180Possible Interaction Between Cigarette Smoking and HLA-DRB1 Variation in the Risk of Follicular Lymphoma. (2017 Apr 15)Baecklund FAm J Epidemiol
25182674Strategies for evaluating idiopathic inflammatory myopathy disease susceptibility genes. (2014 Oct)Rothwell SCurr Rheumatol Rep
12110146Epidemiology and genetics of rheumatoid arthritis. (2002)Silman AJArthritis Res
16014670Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles. (2006 Mar)Linn-Rasker SPAnn Rheum Dis
22835281New insights into the genetics of immune responses in rheumatoid arthritis. (2012 Aug)Ruyssen-Witrand ATissue Antigens
20046016[Is rheumatoid arthritis without anti-citrullinated peptide antibody a genetically distinct subset?]. (2009 Dec)Ohmura KNihon Rinsho Meneki Gakkai Kaishi
20733153Combined effects of smoking, anti-EBNA antibodies, and HLA-DRB1 1501 on multiple sclerosis risk. (2010 Aug 24)Exley CNeurology
24489016Association of rheumatoid arthritis susceptibility gene with lipid profiles in patients with rheumatoid arthritis. (2014 Jun)Davis LARheumatology (Oxford)
21532235Rheumatoid arthritis following a treatment with IFN-alpha/ribavirin against HCV infection. (2011)Izumi YIntern Med
24569640Rheumatoid arthritis in the Women's Health Initiative: methods and baseline evaluation. (2014 Apr 1)Kuller LHAm J Epidemiol
27036319HLA-DRB1*03 as a risk factor for microalbuminuria in same duration of type 1 diabetes: a case control study. (2016 Mar 31)Razanskaite-Virbickiene DBMC Nephrol
20192991Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. (2010 Jan)Wegner NImmunol Rev
17469097Association of DRB1 shared epitope genotypes with early mortality in rheumatoid arthritis: results of eighteen years of followup from the early rheumatoid arthritis study. (2007 May)Mattey DLArthritis Rheum
28457683[Epidemiology and natural history of giant cell arteritis]. (2017 Oct)Mahr ARev Med Interne
20888281Anti-CCP antibodies are associated with early age at onset in patients with rheumatoid arthritis. (2011 Mar)Diaz FJJoint Bone Spine
22443520Individual composition of human leukocyte antigens and periodontopathogens in the background of periodontitis. (2013 Jan)Reichert SJ Periodontol
11358413What is the natural history of rheumatoid arthritis? (2001 Mar)Ollier WEBest Pract Res Clin Rheumatol
17653770Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease. (2007 Nov)Chen ZHum Genet
24812286Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies. (2014 Oct)Jiang XAnn Rheum Dis
26901036Alleles of HLA-DRB1*04 Associated with Pulmonary Tuberculosis in Amazon Brazilian Population. (2016)Souza de Lima DPLoS One
17212707Human MHC region harbors both susceptibility and protective haplotypes for coronary artery disease. (2007 Jan)Palikhe ATissue Antigens
25182207Anti-citrullinated peptides as autoantigens in rheumatoid arthritis-relevance to treatment. (2014 Nov)Sakkas LIAutoimmun Rev
26272072An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis. (2016 Jan)Jiang XRheumatology (Oxford)
24068971Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking. (2013)Scott ICPLoS Genet
16188098[Relationship between pneumoconiosis and the polymorphisms of HLA-DRB1*, DQB1* genes]. (2005 Aug)Fan XYZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
28597127The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement. (2017 Oct)Hedstrom AKEur J Epidemiol
21496252Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers. (2011 Apr 15)Saevarsdottir SArthritis Res Ther
25135760Smoking induces overexpression of immediate early genes in active Graves' ophthalmopathy. (2014 Oct)Planck TThyroid
20436074Antibodies to porphyromonas gingivalis are associated with anticitrullinated protein antibodies in patients with rheumatoid arthritis and their relatives. (2010 Jun)Hitchon CAJ Rheumatol
21149499Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke. (2011 Mar)Kallberg HAnn Rheum Dis
22968483Genotypes in relation to phenotypic appearance and exposure to environmental factors in Graves' hyperthyroidism. (2012 Dec)Vos XGEur J Endocrinol
23836776Association of tobacco exposure and reduction of radiographic progression in early rheumatoid arthritis: results from a French multicenter cohort. (2013 Dec)Vesperini VArthritis Care Res (Hoboken)
16142711An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility. (2005 Sep)van der Helm-van Mil AHArthritis Rheum
21339219Genetics of ACPA-positive rheumatoid arthritis: the beginning of the end? (2011 Mar)de Vries RRAnn Rheum Dis
20080387The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis. (2010 Aug)Tobon GJJ Autoimmun
20234359Ethnogenetic heterogeneity of rheumatoid arthritis-implications for pathogenesis. (2010 May)Kochi YNat Rev Rheumatol
26866831Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis. (2016 Aug)Sparks JAArthritis Rheumatol
16255018Relative contribution of cardiovascular risk factors and rheumatoid arthritis clinical manifestations to atherosclerosis. (2005 Nov)del Rincon IArthritis Rheum
16733891[Association of polymorphisms of human leucocyte antigen -DRB1 and -DQA1 allele with outcomes of hepatitis B virus infection in Han population of north China]. (2006 Apr)Lu LPZhongguo Yi Xue Ke Xue Yuan Xue Bao
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