Gene: HLA-DRB3

3125
HLA-DPB1|HLA-DR1B|HLA-DR3B
major histocompatibility complex, class II, DR beta 3
protein-coding
6p21.3
Ensembl:ENSG00000196101 MIM:612735 UniprotKB:P79483
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of HLA-DRB3 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HLA-DRB3 mRNA25339124
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of HLA-DRB3 mRNA17404688
C030583ceric oxideceric oxide analog results in decreased expression of HLA-DRB3 mRNA24821434
C060728cobalt oxidecobalt oxide analog results in decreased expression of HLA-DRB3 mRNA24821434
C038192iopromideiopromide affects the expression of HLA-DRB3 mRNA25811541
D008148LovastatinLovastatin affects the expression of HLA-DRB3 mRNA25811541
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of HLA-DRB3 mRNA17404688
D012643SeleniumSelenium results in increased expression of HLA-DRB3 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of HLA-DRB3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0032395MHC class II receptor activity-NAS6414998  
GO:0042605peptide antigen binding-ISS20356827  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-NAS8775462  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005765lysosomal membrane-IDA18305173  
GO:0005765lysosomal membrane-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS6414998  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030658transport vesicle membrane-TAS-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
GO:0031902late endosome membrane-IDA18305173  
GO:0032588trans-Golgi network membrane-TAS-  
GO:0042613MHC class II protein complex-ISS20356827  
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane-TAS-  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04514Cell adhesion molecules (CAMs)
hsa04612Antigen processing and presentation
hsa04640Hematopoietic cell lineage
hsa04672Intestinal immune network for IgA production
hsa04940Type I diabetes mellitus
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05150Staphylococcus aureus infection
hsa05310Asthma
hsa05320Autoimmune thyroid disease
hsa05322Systemic lupus erythematosus
hsa05323Rheumatoid arthritis
hsa05330Allograft rejection
hsa05332Graft-versus-host disease
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-202427Phosphorylation of CD3 and TCR zeta chainsTAS
R-HSA-202430Translocation of ZAP-70 to Immunological synapseTAS
R-HSA-202433Generation of second messenger moleculesTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389948PD-1 signalingTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17509091Are there common human leucocyte antigen associations in juvenile idiopathic arthritis and periodontitis? (2007 Jun)Reichert SJ Clin Periodontol