Gene: HLA-DRB4

3126
DR4|DRB4|HLA-DR4B
major histocompatibility complex, class II, DR beta 4
protein-coding
6p21.3
Ensembl:ENSG00000227357 UniprotKB:P13762
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HLA-DRB4 mRNA24449571
D001151ArsenicHLA-DRB4 mRNA results in decreased susceptibility to Arsenic17976673
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HLA-DRB4 mRNA22316170
C018475butyraldehydebutyraldehyde results in increased expression of HLA-DRB4 mRNA26079696
D002273CarcinogensCarcinogens results in decreased expression of HLA-DRB4 mRNA22269147
D003703DemecolcineDemecolcine results in decreased expression of HLA-DRB4 mRNA23649840
D004317DoxorubicinHLA-DRB4 mRNA results in decreased susceptibility to Doxorubicin16322897
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of HLA-DRB4 mRNA23649840
C051890irinotecanirinotecan analog results in increased expression of HLA-DRB4 mRNA18927307
D008345ManganeseManganese results in increased expression of HLA-DRB4 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of HLA-DRB4 mRNA17175027
D008727MethotrexateMethotrexate results in decreased expression of HLA-DRB4 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HLA-DRB4 mRNA23649840
D009153MutagensMutagens results in decreased expression of HLA-DRB4 mRNA22269147
D009532NickelHLA-DRB4 gene polymorphism affects the susceptibility to Nickel8725357
D010165PalladiumHLA-DRB4 gene polymorphism affects the susceptibility to Palladium8725357
C012526quercitrinquercitrin affects the expression of HLA-DRB4 mRNA25193878
C016766sulforafansulforafan results in decreased expression of HLA-DRB4 mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HLA-DRB4 mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HLA-DRB4 mRNA21296121
D014750VincristineVincristine results in decreased expression of HLA-DRB4 mRNA23649840
C088658zoledronic acidzoledronic acid results in increased expression of HLA-DRB4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005765lysosomal membrane-IDA18305173  
GO:0005765lysosomal membrane-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0030658transport vesicle membrane-TAS-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
GO:0031902late endosome membrane-IDA18305173  19117940  
GO:0032588trans-Golgi network membrane-TAS-  
GO:0042613MHC class II protein complex-IEA-  
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane-TAS-  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04514Cell adhesion molecules (CAMs)
hsa04612Antigen processing and presentation
hsa04640Hematopoietic cell lineage
hsa04672Intestinal immune network for IgA production
hsa04940Type I diabetes mellitus
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05150Staphylococcus aureus infection
hsa05310Asthma
hsa05320Autoimmune thyroid disease
hsa05322Systemic lupus erythematosus
hsa05323Rheumatoid arthritis
hsa05330Allograft rejection
hsa05332Graft-versus-host disease
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-202427Phosphorylation of CD3 and TCR zeta chainsTAS
R-HSA-202430Translocation of ZAP-70 to Immunological synapseTAS
R-HSA-202433Generation of second messenger moleculesTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389948PD-1 signalingTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget