Gene: AOAH

313
-
acyloxyacyl hydrolase
protein-coding
7p14.2
Ensembl:ENSG00000136250 MIM:102593 Vega:OTTHUMG00000023566 UniprotKB:P28039
NC_000007.14
SNP Mapped
1   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.641e-1 (AD)  8.453e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6959295chr7:36659079 (GRCh38.p7)C>Tcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPVL0.902
HLA-DOA0.899
TLR70.898
SIRPB20.892
ADAM280.891
SYK0.889
CD370.887
MILR10.886
TRAF3IP30.885
TLR60.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WFDC1-0.344
CPLX3-0.333
NANOS3-0.322
SOHLH1-0.321
CHRNA4-0.321
ARSF-0.319
C9orf24-0.316
SLC29A4-0.316
KCNIP3-0.315
HES6-0.314

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOAH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOAH mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of AOAH mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOAH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOAH mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of AOAH gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of AOAH mRNA24449571
D001151ArsenicArsenic affects the methylation of AOAH gene25304211
C006780bisphenol Abisphenol A results in increased expression of AOAH mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of AOAH mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AOAH mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AOAH mRNA20938992
C412815GW 4064GW 4064 results in increased expression of AOAH mRNA26655953
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in decreased expression of AOAH mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AOAH mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AOAH mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of AOAH mRNA]25890327
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of AOAH mRNA]25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of AOAH mRNA25890327
D008694MethamphetamineAOAH gene SNP affects the susceptibility to Methamphetamine18316681
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AOAH mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AOAH mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AOAH mRNA"25554681
D009532NickelNickel results in increased expression of AOAH mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of AOAH mRNA19167457
D010936Plant ExtractsPlant Extracts results in increased expression of AOAH mRNA23557933
C017947sodium arsenitesodium arsenite affects the methylation of AOAH gene28589171
D013752TetracyclineTetracycline results in increased expression of AOAH mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AOAH mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of AOAH mRNA20133372
D014212TretinoinTretinoin results in decreased expression of AOAH mRNA16604517
C012589trichostatin Atrichostatin A results in decreased expression of AOAH mRNA24935251
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in decreased expression of AOAH mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOAH mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of AOAH mRNA23179753|2627250
D014640VancomycinVancomycin results in increased expression of AOAH mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of AOAH gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of AOAH mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AOAH mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of AOAH mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IDA29343645  
GO:0050528acyloxyacyl hydrolase activity-IDA1883828  29343645  
GO ID GO Term Qualifier Evidence PubMed
GO:0006631fatty acid metabolic process-IDA1883828  29343645  
GO:0009104lipopolysaccharide catabolic process-IDA1883828  29343645  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0031410cytoplasmic vesicle-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal