Gene info: ID 3131

Gene: HLF

GENE ID: 3131

Synonyms: -

Description: HLF, PAR bZIP transcription factor

Gene type: protein-coding

Location: 17q22

dbXrefs: Ensembl:ENSG00000108924 MIM:142385 Vega:OTTHUMG00000177840 UniprotKB:Q16534

RefSeq: NG_046944.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.782e-1 (AD) 4.300e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PRKCB	0.968
RBFOX1	0.964
DLGAP1	0.963
CREG2	0.959
ITPR1	0.958
KIAA1549L	0.958
ADD2	0.956
THRB	0.956
RIMS3	0.955
NLK	0.955

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZNF114	-0.535
MYL3	-0.532
RAB13	-0.52
TFPI2	-0.519
WWTR1	-0.509
SNHG18	-0.506
C9orf135	-0.506
HEY2	-0.505
CMTM3	-0.498
HAS2	-0.495

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of HLF mRNA"	26377693
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of HLF mRNA	19933214
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HLF mRNA]"	19467301
D000082	Acetaminophen	Acetaminophen results in increased expression of HLF mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of HLF mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of HLF protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HLF mRNA	22100608\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of HLF gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HLF mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HLF mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of HLF mRNA	24449571
D001104	Arbutin	Arbutin results in decreased expression of HLF mRNA	17103032
D001280	Atrazine	Atrazine results in decreased expression of HLF mRNA	25929836
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of HLF mRNA	26377693
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of HLF mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of HLF mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of HLF mRNA	26377693
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of HLF mRNA	27858113
D004958	Estradiol	Estradiol results in decreased expression of HLF mRNA	20106945
C006780	bisphenol A	bisphenol A affects the methylation of HLF promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of HLF mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of HLF mRNA	22079614
C018475	butyraldehyde	butyraldehyde results in decreased expression of HLF mRNA	26079696
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of HLF mRNA	17484886
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HLF gene	20938992
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of HLF mRNA	27858113
D002922	Ciguatoxins	Ciguatoxins affects the expression of HLF mRNA	18353800
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of HLF mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of HLF mRNA	20106945\|2556210
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of HLF mRNA	23640034
D003703	Demecolcine	Demecolcine results in increased expression of HLF mRNA	23649840
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of HLF mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of HLF mRNA	27392435
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HLF mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in decreased expression of HLF mRNA	18457598
D004041	Dietary Fats	Dietary Fats results in increased expression of HLF mRNA	18042831\|1946730
D002117	Calcitriol	Calcitriol results in decreased expression of HLF mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of HLF mRNA	21592394
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of HLF mRNA	23649840
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HLF gene	20938992
D004397	Fonofos	Fonofos results in increased methylation of HLF promoter	22847954
D005557	Formaldehyde	Formaldehyde results in increased expression of HLF mRNA	23649840
D017313	Fenretinide	Fenretinide results in increased expression of HLF mRNA	28973697
D007545	Isoproterenol	Isoproterenol results in decreased expression of HLF mRNA	20003209
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of HLF mRNA	27392435
C011890	kojic acid	kojic acid results in decreased expression of HLF mRNA	16595896
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HLF gene	20938992
D008752	Methylene Chloride	Methylene Chloride results in increased expression of HLF mRNA	28392392
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of HLF mRNA	23649840
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of HLF mRNA"	24389112
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of HLF mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of HLF mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of HLF mRNA	24768652
D000073878	Palm Oil	Palm Oil results in increased expression of HLF mRNA	18042831
D010278	Parathion	Parathion results in increased methylation of HLF promoter	22847954
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in increased expression of HLF mRNA	19095052
D010634	Phenobarbital	Phenobarbital affects the expression of HLF mRNA	19159669
D010634	Phenobarbital	Phenobarbital affects the expression of HLF mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in decreased expression of HLF mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in increased expression of HLF mRNA	17426115
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of HLF mRNA	22714537
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of HLF mRNA	23608068
C045950	propiconazole	propiconazole results in decreased expression of HLF mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of HLF mRNA	24780913
D011794	Quercetin	Quercetin results in decreased expression of HLF mRNA	21632981
D012643	Selenium	Selenium results in decreased expression of HLF mRNA	19244175
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of HLF mRNA"	21514415
D017632	Asbestos, Serpentine	"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of HLF mRNA]"	21514415
D012834	Silver	Silver results in decreased expression of HLF mRNA	26014281
C017947	sodium arsenite	sodium arsenite results in decreased expression of HLF mRNA	18812580
D053260	Soot	Soot affects the expression of HLF mRNA	26551751
D020058	Styrene	Styrene results in increased expression of HLF mRNA	28951217
C012568	terbufos	terbufos results in increased methylation of HLF promoter	22847954
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of HLF mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of HLF mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HLF mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HLF mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HLF mRNA	19465110\|1977048
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HLF mRNA	19933214
C009495	titanium dioxide	titanium dioxide affects the expression of HLF mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in increased expression of HLF mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of HLF mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HLF mRNA	28111298
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of HLF mRNA	19042947
D014520	Urethane	Urethane results in decreased expression of HLF mRNA	28818685
D014527	Uric Acid	HLF gene SNP affects the abundance of Uric Acid	23263486
D014635	Valproic Acid	Valproic Acid affects the expression of HLF mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of HLF mRNA	28001369\|2915479
D014638	Vanadates	Vanadates results in increased expression of HLF mRNA	22714537
D014640	Vancomycin	Vancomycin results in increased expression of HLF mRNA	18930951
D014750	Vincristine	Vincristine results in increased expression of HLF mRNA	23649840
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of HLF mRNA	26682919
C088658	zoledronic acid	zoledronic acid results in decreased expression of HLF mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IBA	21873635
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IBA	21873635
GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	-	IDA	8065331
GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	-	IMP	8065331
GO:0003677	DNA binding	-	TAS	8639829
GO:0003690	double-stranded DNA binding	-	TAS	1386162
GO:0043565	sequence-specific DNA binding	-	IMP	8065331

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006366	transcription by RNA polymerase II	-	TAS	8639829
GO:0007275	multicellular organism development	-	TAS	1386162
GO:0035914	skeletal muscle cell differentiation	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	8065331
GO:0048511	rhythmic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28315337	p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD. (2017 Jul)	Mizuno S	Chest
6428285	Demonstration of a free elastolytic metalloenzyme in human lung lavage fluid and its relationship to alpha 1-antiprotease. (1984 Jun)	Niederman MS	Am Rev Respir Dis