Gene: MR1

3140
HLALS
major histocompatibility complex, class I-related
protein-coding
1q25.3
Ensembl:ENSG00000153029 MIM:600764 Vega:OTTHUMG00000035175 UniprotKB:Q95460
NG_042221.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.335e-1 (AD)  3.648e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITPR20.829
TEP10.805
DSC20.803
MTM10.802
SLC2A120.79
ATP10D0.787
CD1090.78
TBC1D2B0.778
CD3020.777
TGFBR30.777

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.365
ABCC12-0.352
GALNT14-0.344
NANOS3-0.343
KCNIP3-0.338
MAGIX-0.332
ADRA1D-0.331
NPAS1-0.329
CREB3L1-0.325
VGF-0.323

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00098Antithymocyte immunoglobulin (rabbit)BiotechDrugApprovedTarget
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of MR1 mRNA22230336
D000212AcyclovirAcyclovir affects the expression of MR1 mRNA25811541
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MR1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MR1 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MR1 protein21527772
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MR1 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of MR1 mRNA21757418
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of MR1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MR1 mRNA16483693
D000806Angiotensin-Converting Enzyme InhibitorsAngiotensin-Converting Enzyme Inhibitors affects the expression of MR1 mRNA25811541
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MR1 mRNA24449571
D001151ArsenicArsenic results in increased methylation of MR1 gene24525453
C006632arsenic trioxidearsenic trioxide results in increased expression of MR1 mRNA22521957
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MR1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MR1 mRNA22228805|2719552
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MR1 mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of MR1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of MR1 mRNA25181051
D016642BupropionBupropion affects the expression of MR1 mRNA25811541
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MR1 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride affects the expression of MR1 mRNA18804290
D002220CarbamazepineCarbamazepine affects the expression of MR1 mRNA25811541
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MR1 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MR1 mRNA18804290
D003024ClozapineClozapine affects the expression of MR1 mRNA25811541
D003042CocaineCocaine results in increased expression of MR1 mRNA17898221
D003520CyclophosphamideCyclophosphamide results in increased expression of MR1 mRNA21527772
D016572CyclosporineCyclosporine results in decreased expression of MR1 mRNA20106945
D003703DemecolcineDemecolcine results in increased expression of MR1 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MR1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MR1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of MR1 mRNA27392435|2759478
D004008DiclofenacDiclofenac affects the expression of MR1 mRNA25811541
C000944dicrotophosdicrotophos results in decreased expression of MR1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of MR1 mRNA18042831
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of MR1 mRNA"21527772
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MR1 mRNA23649840
D005047EtoposideEtoposide affects the expression of MR1 mRNA25811541
D005047EtoposideEtoposide results in increased expression of MR1 mRNA21527772
D005472FluorouracilFluorouracil results in increased expression of MR1 mRNA16101138
D005557FormaldehydeFormaldehyde results in increased expression of MR1 mRNA23649840
C419708gefitinibgefitinib affects the expression of MR1 mRNA25811541
D006852HydrochlorothiazideHydrochlorothiazide affects the expression of MR1 mRNA25811541
D007069IfosfamideIfosfamide affects the expression of MR1 mRNA25811541
C038192iopromideiopromide affects the expression of MR1 mRNA25811541
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MR1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MR1 mRNA24796395
D048628KetolidesKetolides analog results in increased expression of MR1 mRNA24967691
D007840LatexLatex analog results in increased expression of MR1 mRNA24768652
D008034LincomycinLincomycin affects the expression of MR1 mRNA25811541
D008528Mefenamic AcidMefenamic Acid affects the expression of MR1 mRNA25811541
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MR1 mRNA21527772|2364984
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MR1 mRNA"26251327
D008911MinocyclineMinocycline affects the expression of MR1 mRNA25811541
D009151Mustard GasMustard Gas results in increased expression of MR1 mRNA25102026
D009151Mustard GasMustard Gas results in increased expression of MR1 mRNA15674844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of MR1 mRNA"29244179
D009532NickelNickel results in increased expression of MR1 mRNA25583101
D009643NorfloxacinNorfloxacin affects the expression of MR1 mRNA25811541
D010126OzoneOzone results in decreased expression of MR1 mRNA12763052
D000073878Palm OilPalm Oil results in increased expression of MR1 mRNA18042831
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of MR1 mRNA28973697
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of MR1 mRNA18804290
D010634PhenobarbitalPhenobarbital results in increased expression of MR1 mRNA19270015
D010878PiperacillinPiperacillin affects the expression of MR1 mRNA25811541
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of MR1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of MR1 mRNA20813756
D010894PiroxicamPiroxicam affects the expression of MR1 mRNA25811541
C005556propionaldehydepropionaldehyde results in increased expression of MR1 mRNA26079696
D011794QuercetinQuercetin results in increased expression of MR1 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of MR1 mRNA19429434
C072379repagliniderepaglinide affects the expression of MR1 mRNA25811541
C059514resveratrolresveratrol results in increased expression of MR1 mRNA25888808
D012293RifampinRifampin affects the expression of MR1 mRNA25811541
C116926rofecoxibrofecoxib affects the expression of MR1 mRNA25811541
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MR1 mRNA25895662
D012460SulfasalazineSulfasalazine affects the expression of MR1 mRNA25811541
D013629TamoxifenTamoxifen results in increased expression of MR1 mRNA19429434
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MR1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MR1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MR1 mRNA25975270
D014520UrethaneUrethane results in decreased expression of MR1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of MR1 mRNA29154799
D014638VanadatesVanadates results in increased expression of MR1 mRNA22714537
D014640VancomycinVancomycin affects the expression of MR1 mRNA25811541
D014750VincristineVincristine results in increased expression of MR1 mRNA23649840
D014810Vitamin EVitamin E results in decreased expression of MR1 mRNA19244175
D015215ZidovudineZidovudine affects the expression of MR1 mRNA25811541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0032393MHC class I receptor activity-TAS7624800  
GO ID GO Term Qualifier Evidence PubMed
GO:0002367cytokine production involved in immune response-IEA-  
GO:0002474antigen processing and presentation of peptide antigen via MHC class I-IEA-  
GO:0006955immune response-IBA21873635  
GO:0006955immune response-TAS7624800  
GO:0007165signal transduction-IEA-  
GO:0032611interleukin-1 beta production-IEA-  
GO:0032620interleukin-17 production-IEA-  
GO:0045087innate immune response-IEA-  
GO:0050829defense response to Gram-negative bacterium-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005783endoplasmic reticulum-IDA21190736  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA-  
GO:0016021integral component of membrane-IEA-  
GO:0042612MHC class I protein complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22969204Adalimumab in prevention of postoperative recurrence of Crohn's disease in high-risk patients. (2012 Aug 28)Aguas MWorld J Gastroenterol
27694276Dynamic contrast-enhanced MRI measurement of renal function in healthy participants. (2017 Jun)Eikefjord EActa Radiol