Gene: HMBS

3145
PBG-D|PBGD|PORC|UPS
hydroxymethylbilane synthase
protein-coding
11q23.3
Ensembl:ENSG00000256269 MIM:609806 Vega:OTTHUMG00000168295 UniprotKB:P08397
NG_008093.1
PubMed
0   ANCO-SNPs
ND
1   
6.032e-1 (AD)  2.605e-1 (ND)   (Frontal_Cortex)
7.232e-1 (AD)  6.792e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MRPL280.82
COMMD50.817
SSNA10.816
MRPL120.814
TMEM2080.805
SPAG70.8
MRPS340.795
OXLD10.795
MCRS10.793
SURF20.792

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.582
OR4F29-0.526
MTRNR2L9-0.371
MTRNR2L6-0.367
MTRNR2L10-0.345
ADH1B-0.342
EBF1-0.315
P2RY14-0.307
TBX18-0.305
CES1-0.3

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HMBS mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HMBS mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of HMBS mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of HMBS mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of HMBS mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]10656287
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]10656287
D015250AclarubicinAcetylcysteine inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]10656287
D015250AclarubicinAclarubicin results in increased expression of HMBS mRNA10656287
D015250Aclarubicinpyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]10656287
D015250AclarubicinQuercetin inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]10656287
D012435S-Adenosylhomocysteinecatechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA]24141029
D012435S-Adenosylhomocysteine[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA24141029
D012436S-Adenosylmethioninecatechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA]24141029
D012436S-Adenosylmethionine[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA24141029
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HMBS mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of HMBS mRNA25258189
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HMBS mRNA20064835
D004958EstradiolEstradiol affects the expression of HMBS mRNA16684588
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HMBS mRNA28628672
D020148Butyric AcidAcetylcysteine inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]10656287
D020148Butyric AcidButyric Acid results in increased expression of HMBS mRNA10656287|1475731
D020148Butyric Acidchebulinic acid inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]14769215
D020148Butyric Acidpyrrolidine dithiocarbamic acid inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]10656287
D020148Butyric AcidQuercetin inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]10656287
D020148Butyric Acidtellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]14757314
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HMBS mRNA23741332
D002220CarbamazepineCarbamazepine results in decreased activity of HMBS protein6132132
C034221catechol[catechol co-treated with Hemin] results in increased expression of HMBS mRNA24141029
C034221catecholcatechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA]24141029
C034221catecholcatechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA]24141029
C034221catecholcatechol promotes the reaction [Hemin results in increased expression of HMBS mRNA]28552822
C034221catecholcatechol results in decreased methylation of HMBS promoter23022512
C034221catecholcatechol results in increased expression of HMBS mRNA23022512|2855282
C034221catecholcatechol results in increased methylation of HMBS exon28552822
C034221catecholCOMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA]24141029
C034221catecholHemin promotes the reaction [catechol results in increased expression of HMBS mRNA]28552822
C103481chebulinic acidchebulinic acid inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]14769215
C103481chebulinic acidchebulinic acid results in decreased expression of HMBS mRNA14769215
D002738ChloroquineHMBS mutant form results in increased susceptibility to Chloroquine8772850
C018021cobaltous chloridecobaltous chloride results in decreased expression of HMBS mRNA19376846
D003300CopperCopper results in decreased activity of HMBS protein19888908
D019327Copper SulfateCopper Sulfate results in decreased expression of HMBS mRNA19549813
C014347decitabinedecitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]23973255
C014347decitabinedecitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]23973255
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HMBS mRNA28628672
D003976DiazinonDiazinon results in increased methylation of HMBS gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HMBS mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HMBS mRNA21266533
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HMBS protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HMBS mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased activity of HMBS protein10416826
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HMBS mRNA16940010
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of HMBS mRNA23649840
D018120FinasterideFinasteride results in increased expression of HMBS mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of HMBS mRNA18035473
D005485FlutamideFlutamide results in increased expression of HMBS mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of HMBS mRNA17285311
D006427Hemin[catechol co-treated with Hemin] results in increased expression of HMBS mRNA24141029
D006427Hemincatechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA]24141029
D006427Hemincatechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA]24141029
D006427Hemincatechol promotes the reaction [Hemin results in increased expression of HMBS mRNA]28552822
D006427HeminCOMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA]24141029
D006427Hemindecitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]23973255
D006427Hemindecitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]23973255
D006427HeminHemin promotes the reaction [catechol results in increased expression of HMBS mRNA]28552822
D006427HeminHemin results in increased expression of HMBS mRNA21414390|2855282
D006427Heminhydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]21414390|2397325
D006427Heminhydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]21414390
D006427HeminPhenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA]21414390|2397325
D006427Hemin[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA24141029
D006427Hemin[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA24141029
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of HMBS mRNA15159207
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMBS protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of HMBS protein23178681
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMBS protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of HMBS protein23178681
C031927hydroquinonedecitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]23973255
C031927hydroquinonehydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]21414390|2397325
C013038hydroxyhydroquinonehydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]21414390
C024393hydroxymethylbilaneHMBS protein results in increased abundance of hydroxymethylbilane23973255
D007099ImipramineImipramine results in decreased activity of HMBS protein10416826
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HMBS mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HMBS mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HMBS mRNA28628672
C544151jinfukangjinfukang results in increased expression of HMBS mRNA27392435
C008261lead acetatelead acetate results in increased activity of HMBS protein10416826
C029891lead chloridelead chloride results in decreased activity of HMBS protein10416826
D008694MethamphetamineMethamphetamine results in decreased expression of HMBS mRNA24042092
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HMBS mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of HMBS mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HMBS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HMBS mRNA"25554681
C051752nefazodonenefazodone results in increased expression of HMBS mRNA24136188
D009532NickelNickel results in increased expression of HMBS mRNA24768652|2558310
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of HMBS mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of HMBS mRNA25729387
D017239PaclitaxelPaclitaxel results in decreased expression of HMBS mRNA15585946
D010416PentachlorophenolPentachlorophenol results in increased expression of HMBS mRNA23892564
D019800Phenoldecitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]23973255
D019800PhenolPhenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA]21414390|2397325
C006253pirinixic acidpirinixic acid results in increased expression of HMBS mRNA19162173
D010936Plant ExtractsPlant Extracts results in increased expression of HMBS mRNA23557933
D010938Plant OilsPlant Oils results in decreased expression of HMBS mRNA23370395
C010313pseudocumenepseudocumene results in decreased expression of HMBS protein17337753
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]10656287
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]10656287
D011794QuercetinQuercetin inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]10656287
D011794QuercetinQuercetin inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]10656287
D012643SeleniumSelenium results in increased expression of HMBS mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of HMBS mRNA29191790
C016104sodium bichromatesodium bichromate results in increased expression of HMBS mRNA12325037
D012969Sodium FluorideSodium Fluoride results in increased expression of HMBS protein28918527
D013629TamoxifenTamoxifen results in decreased expression of HMBS mRNA15849065
C087926tellimagrandin Itellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]14757314
C087926tellimagrandin Itellimagrandin I results in decreased expression of HMBS mRNA14757314
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HMBS mRNA18163543|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HMBS mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HMBS mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HMBS mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of HMBS protein24648495
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of HMBS mRNA25729387
D019772TopotecanTopotecan results in decreased expression of HMBS mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of HMBS mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of HMBS mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of HMBS mRNA19042947
D014303TrinitrotolueneTrinitrotoluene affects the expression of HMBS mRNA21346803
D014520UrethaneUrethane results in decreased expression of HMBS mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of HMBS mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HMBS gene25560391
C025643vinclozolinvinclozolin results in decreased expression of HMBS mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004418hydroxymethylbilane synthase activity-IBA21873635  
GO:0004418hydroxymethylbilane synthase activity-IDA18004775  
GO:0004418hydroxymethylbilane synthase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006782protoporphyrinogen IX biosynthetic process-IEA-  
GO:0006783heme biosynthetic process-IBA21873635  
GO:0006783heme biosynthetic process-IC18004775  
GO:0006783heme biosynthetic process-TAS-  
GO:0018160peptidyl-pyrromethane cofactor linkage-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00860Porphyrin and chlorophyll metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-189445Metabolism of porphyrinsTAS
R-HSA-189451Heme biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301372Acute Intermittent Porphyria (1993)Whatley SD-