Gene: HMGB1

3146
HMG-1|HMG1|HMG3|SBP-1
high mobility group box 1
protein-coding
13q12.3
Ensembl:ENSG00000189403 MIM:163905 Vega:OTTHUMG00000016670 UniprotKB:P09429
NC_000013.11
PubMed
0   ANCO-SNPs
ND|AD
26   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.457e-1 (AD)  1.875e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C18orf320.938
SBDS0.928
C4orf30.923
UBE2E10.922
RPL220.921
DCTN60.919
PPP2CB0.919
RAC10.917
RPL150.915
SAP180.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.837
OR4F5-0.811
EPPIN-0.182
SDIM1-0.164
IQCJ-0.141
SLC22A13-0.133
PRDM14-0.13
IFNK-0.13
FAM71C-0.124
OR10K1-0.123

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05869Ethyl pyruvateSmall Molecule617-35-6InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of HMGB1 mRNA"19162173
C0006039621-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [HMGB1 protein binds to LY96 protein binds to TLR4 protein]]"29111459
C0006039621-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein binds to HMGB1 protein]]"28063877
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HMGB1 mRNA"19114083
C492600(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate"(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate affects the expression of HMGB1 mRNA"19176366
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of HMGB1 mRNA"19167446
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]27616297
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]"25929181
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HMGB1 mRNA"21346803
C0038982-anisidine2-anisidine results in increased expression of HMGB1 protein28089782
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]22014880
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of HMGB1 mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of HMGB1 mRNA"21346803
C0729564-nitrososulfamethoxazole4-nitrososulfamethoxazole results in increased secretion of HMGB1 protein28444390
C4664205,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of HMGB1 protein]"21113057
C1217077,3'-dihydroxy-4'-methoxyisoflavone"7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of HMGB1 protein"24455688
D000082AcetaminophenAcetaminophen results in increased secretion of HMGB1 protein21513726
D000082Acetaminophenethyl pyruvate inhibits the reaction [Acetaminophen results in increased secretion of HMGB1 protein]21513726
C056165acetovanilloneacetovanillone inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]26079697
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]26079697
D000171AcroleinAcrolein results in increased expression of HMGB1 mRNA18515264
D000255Adenosine TriphosphateHMGB1 protein affects the chemical synthesis of Adenosine Triphosphate21641551
C016601afimoxifeneafimoxifene results in decreased expression of HMGB1 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HMGB1 mRNA27153756
D019386AlendronateAlendronate affects the expression of HMGB1 mRNA16079270
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of HMGB1 protein]"25651848
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HMGB1 mRNA16483693
D000667AmpicillinAmpicillin results in increased expression of HMGB1 protein24747151
C044613angelicae sinensis extract"angelicae sinensis extract inhibits the reaction [endotoxin, Escherichia coli affects the localization of and results in increased secretion of HMGB1 protein]"16424112
C044613angelicae sinensis extract"angelicae sinensis extract inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased secretion of HMGB1 protein]"16424112
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HMGB1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of HMGB1 protein25258189
C006632arsenic trioxidearsenic trioxide results in increased secretion of HMGB1 protein27807322
C006632arsenic trioxideHMGB1 protein results in decreased susceptibility to arsenic trioxide27807322
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the localization of and results in increased secretion of HMGB1 protein"20616036
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of HMGB1 mRNA"20616036
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased secretion of HMGB1 protein"23937860|2416032
D017638Asbestos, Crocidolite"Interleukin 1 Receptor Antagonist Protein inhibits the reaction [Asbestos, Crocidolite results in increased secretion of HMGB1 protein]"23937860
D017638Asbestos, Crocidolite"NLRP3 protein promotes the reaction [Asbestos, Crocidolite results in increased secretion of HMGB1 protein]"23937860
D017638Asbestos, Crocidolite"TNF protein inhibits the reaction [Asbestos, Crocidolite results in increased secretion of HMGB1 protein]"23937860
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of HMGB1 protein"26678224
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased secretion of HMGB1 protein"20616036|2416032
D017638Asbestos, Crocidolite"Lignans inhibits the reaction [Asbestos, Crocidolite results in increased expression of HMGB1 protein]"26678224
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HMGB1 mRNA26424790
C005948astaxanthineastaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]16964424
D001280AtrazineAtrazine results in decreased expression of HMGB1 mRNA25929836
D001280AtrazineAtrazine results in increased expression of HMGB1 mRNA22982499
D001379AzathioprineAzathioprine results in increased expression of HMGB1 protein24184165
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HMGB1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HMGB1 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HMGB1 mRNA27858113
D004958EstradiolEstradiol results in decreased expression of HMGB1 mRNA23373633
D004958EstradiolEstradiol results in increased expression of HMGB1 mRNA16514628
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HMGB1 mRNA26424790
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of HMGB1 mRNA"20162321
C006780bisphenol Abisphenol A results in decreased expression of HMGB1 mRNA29275510
C006780bisphenol ABECN1 protein promotes the reaction [bisphenol A affects the localization of HMGB1 protein]26139607
C006780bisphenol Abisphenol A affects the expression of HMGB1 mRNA25181051
C006780bisphenol Abisphenol A promotes the reaction [Sirolimus affects the localization of HMGB1 protein]26139607
C006780bisphenol Abisphenol A results in increased expression of and affects the localization of HMGB1 protein26139607
C006780bisphenol Abisphenol A results in increased expression of HMGB1 mRNA26139607
C006780bisphenol Abisphenol A results in increased expression of HMGB1 protein26139607
C006780bisphenol Awortmannin inhibits the reaction [bisphenol A affects the localization of HMGB1 protein]26139607
D001761BleomycinBleomycin results in increased expression of HMGB1 protein25582705
D001761Bleomycinprotocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of HMGB1 protein]25582705
D001786Blood Glucose"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of HMGB1 protein]"21113057
D001786Blood Glucosemanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of HMGB1 protein]21113057
D001786Blood Glucose[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of HMGB1 protein21113057
D019328Buthionine Sulfoximine[Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein23986454
D019328Buthionine Sulfoximine[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein26177832
D019328Buthionine Sulfoximinegadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein]26177832
D020122tert-Butylhydroperoxide"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [HMGB1 protein binds to LY96 protein binds to TLR4 protein]]"29111459
D020122tert-Butylhydroperoxide"1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein binds to HMGB1 protein]]"28063877
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide promotes the reaction [HMGB1 protein binds to LY96 protein binds to TLR4 protein]29111459
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide promotes the reaction [LY96 protein binds to TLR4 protein binds to HMGB1 protein]28063877
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of HMGB1 protein28063877|2911145
D002104CadmiumCadmium results in decreased expression of HMGB1 mRNA24084258
D002104CadmiumCadmium results in increased expression of HMGB126051590
D002220CarbamazepineCarbamazepine affects the expression of HMGB1 mRNA24752500
D002220CarbamazepineCarbamazepine results in increased expression of HMGB1 protein22790970
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of and affects the localization of HMGB1 protein27601294
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HMGB1 mRNA27601294
D002251Carbon TetrachlorideQuercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of and affects the localization of HMGB1 protein]27601294
D002251Carbon TetrachlorideQuercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 mRNA]27601294
D002251Carbon TetrachlorideCarbon Tetrachloride affects the localization of and affects the secretion of HMGB1 protein22683883
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HMGB1 mRNA22683883
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HMGB1 protein22683883
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride affects the localization of and affects the secretion of HMGB1 protein]22683883
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 mRNA]22683883
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]22683883
C099555CD 437CD 437 results in decreased expression of HMGB1 mRNA12958071
D004390ChlorpyrifosChlorpyrifos results in increased expression of and affects the localization of HMGB1 protein26524701
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of HMGB1 mRNA28472532
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HMGB1 mRNA27858113
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of HMGB1 mRNA28219650
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of and results in increased localization of and results in increased secretion of HMGB1 protein]20110250
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of HMGB1 mRNA]20110250
C007095cobaltiprotoporphyrinHMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of and results in increased localization of and results in increased secretion of HMGB1 protein]]20110250
C007095cobaltiprotoporphyrinHMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of HMGB1 mRNA]]20110250
C018021cobaltous chloridecobaltous chloride results in decreased expression of HMGB1 mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of HMGB1 mRNA20971185
D003300CopperCopper results in decreased expression of HMGB1 mRNA25646894
D019327Copper SulfateCopper Sulfate results in decreased expression of HMGB1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of HMGB1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of HMGB1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of HMGB1 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of HMGB1 mRNA21878529
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride affects the localization of and affects the secretion of HMGB1 protein]22683883
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 mRNA]22683883
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]22683883
D016572CyclosporineCyclosporine results in decreased expression of HMGB1 mRNA25562108
D016572CyclosporineCyclosporine results in increased secretion of HMGB1 protein27585667
C403944cynandione Acynandione A results in decreased expression of HMGB1 protein22309483
D003561CytarabineCytarabine results in increased secretion of HMGB1 protein27807322
D003561CytarabineHMGB1 protein results in decreased susceptibility to Cytarabine27807322
C014347decitabinedecitabine affects the expression of HMGB1 mRNA23300844
C014347decitabinedecitabine results in decreased expression of HMGB1 mRNA19363521
C014347decitabineTP53 protein affects the reaction [decitabine results in decreased expression of HMGB1 mRNA]19363521
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HMGB1 mRNA26424790
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of HMGB1 mRNA"25908611
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HMGB1 mRNA17379624
D002945CisplatinCisplatin affects the expression of HMGB1 mRNA23300844
D004008DiclofenacDiclofenac affects the expression of HMGB1 mRNA24752500
D004008DiclofenacDiclofenac results in increased expression of HMGB1 mRNA26934552
D004008DiclofenacDiclofenac results in increased expression of HMGB1 protein24747151
D004008Diclofenac"Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein]"23939143
D004009DicloxacillinDicloxacillin results in increased expression of HMGB1 protein24747151
C000944dicrotophosdicrotophos results in decreased expression of HMGB1 mRNA28302478
C023635dienogestdienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein]22014880
C023635dienogestdienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]22014880
C023635dienogestdienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein]22014880
C023635dienogestdienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]22014880
D004041Dietary FatsDietary Fats results in increased expression of HMGB1 protein26293846
D004041Dietary FatsNLRP3 gene mutant form inhibits the reaction [Dietary Fats results in increased expression of HMGB1 protein]26293846
D004041Dietary Fats[Dietary Fats co-treated with Cholecalciferol] results in increased expression of HMGB1 mRNA20519084
D004041Dietary FatsSimvastatin inhibits the reaction [[Dietary Fats co-treated with Cholecalciferol] results in increased expression of HMGB1 mRNA]20519084
D002117CalcitriolCalcitriol results in decreased expression of HMGB1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of HMGB1 mRNA21592394
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of HMGB1 mRNA20886546
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of HMGB1 mRNA"27840820
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of HMGB1 mRNA28219650
C019357dioscindioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein]28082111
C109695dong quai"dong quai inhibits the reaction [endotoxin, Escherichia coli affects the localization of and results in increased secretion of HMGB1 protein]"16424112
C109695dong quai"dong quai inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased secretion of HMGB1 protein]"16424112
D004317DoxorubicinDoxorubicin results in increased secretion of HMGB1 protein27807322
D004317DoxorubicinHMGB1 protein results in decreased susceptibility to Doxorubicin27807322
D004317Doxorubicindioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein]28082111
D004317DoxorubicinDoxorubicin results in increased expression of HMGB1 protein28082111
C583240emodin-6-O-glucosideemodin-6-O-glucoside inhibits the reaction [HMGB1 protein results in increased activity of RELA protein modified form]23146691
C583240emodin-6-O-glucosideemodin-6-O-glucoside inhibits the reaction [HMGB1 protein results in increased expression of TNF protein]23146691
C583240emodin-6-O-glucoside"emodin-6-O-glucoside inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of HMGB1 protein]"23146691
C583240emodin-6-O-glucosideemodin-6-O-glucoside results in decreased secretion of HMGB1 protein23146691
D004656Enalapril"Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of HMGB1 protein]"19114890
D004656Enalapril"Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein]"19114890
C044101endotoxin, Escherichia coli"angelicae sinensis extract inhibits the reaction [endotoxin, Escherichia coli affects the localization of and results in increased secretion of HMGB1 protein]"16424112
C044101endotoxin, Escherichia coli"dong quai inhibits the reaction [endotoxin, Escherichia coli affects the localization of and results in increased secretion of HMGB1 protein]"16424112
C044101endotoxin, Escherichia coli"Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of HMGB1 protein]"19114890
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli affects the localization of and results in increased secretion of HMGB1 protein"16424112
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in increased secretion of HMGB1 protein"19114890
C044101endotoxin, Escherichia coli"Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein]"19114890
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in increased expression of HMGB1 protein"19114890
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HMGB1 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HMGB1 mRNA22079256
C083174erioniteerionite results in increased secretion of HMGB1 protein23937860
D000431Ethanolacetovanillone inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]26079697
D000431EthanolAcetylcysteine inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]26079697
D000431EthanolEthanol results in increased expression of and results in increased secretion of HMGB1 protein26079697
D000431Ethanoltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]26079697
D000431EthanolEthanol results in increased secretion of HMGB1 protein26079697
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HMGB1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGB1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HMGB1 mRNA16079270
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of HMGB1 mRNA23649840
C046522ethyl pyruvateethyl pyruvate inhibits the reaction [Acetaminophen results in increased secretion of HMGB1 protein]21513726
D005047EtoposideEtoposide results in increased secretion of HMGB1 protein27807322
D005047EtoposideHMGB1 protein results in decreased susceptibility to Etoposide27807322
D005436FloxacillinFloxacillin results in increased secretion of HMGB1 protein28444390
D005485FlutamideFlutamide results in increased expression of HMGB1 protein24747151
C070081fulvestrantfulvestrant results in decreased expression of HMGB1 mRNA16514628
C038958gadolinium chloridegadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein]26177832
D005839GentamicinsGentamicins results in increased expression of HMGB1 protein22061828
D005947GlucoseGLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to HMGB1 promoter]]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose results in increased expression of and results in increased secretion of HMGB1 protein]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose results in increased expression of HMGB1 mRNA]19833897
D005947GlucoseGlucose promotes the reaction [JUN protein binds to HMGB1 promoter]19833897
D005947GlucoseGlucose results in increased expression of and results in increased secretion of HMGB1 protein19833897
D005947GlucoseGlucose results in increased expression of HMGB1 mRNA19833897
D005947GlucoseJUN promotes the reaction [Glucose results in increased expression of HMGB1 mRNA]19833897
D005947GlucoseSOD2 inhibits the reaction [Glucose results in increased expression of and results in increased secretion of HMGB1 protein]19833897
D005947GlucoseSOD2 inhibits the reaction [Glucose results in increased expression of HMGB1 mRNA]19833897
D005947GlucoseUCP1 inhibits the reaction [Glucose results in increased expression of and results in increased secretion of HMGB1 protein]19833897
D005947GlucoseUCP1 inhibits the reaction [Glucose results in increased expression of HMGB1 mRNA]19833897
D005947GlucoseGlucose results in increased secretion of HMGB1 protein27783111
D005947GlucoseNLRP3 protein promotes the reaction [Glucose results in increased secretion of HMGB1 protein]27783111
D019695Glycyrrhizic AcidGlycyrrhizic Acid results in decreased activity of HMGB1 protein27689324|2778311
D019695Glycyrrhizic AcidGlycyrrhizic Acid results in decreased secretion of HMGB1 protein27585667
D006221HalothaneHalothane results in increased expression of HMGB1 protein21245496|2474715
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of HMGB1 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of HMGB1 protein20616036
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]17513788
D006861Hydrogen PeroxideHSPA1A protein inhibits the reaction [Hydrogen Peroxide affects the localization of HMGB1 protein]17513788
D006861Hydrogen PeroxideHSPA1A protein inhibits the reaction [Hydrogen Peroxide results in increased secretion of HMGB1 protein]17513788
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of HMGB1 protein17513788
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]17513788
D006861Hydrogen PeroxideHydrogen Peroxide results in increased secretion of HMGB1 protein17513788
D006861Hydrogen PeroxideQuercetin inhibits the reaction [Hydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]]17513788
D006861Hydrogen PeroxideHSF1 protein inhibits the reaction [Hydrogen Peroxide affects the localization of HMGB1 protein]22246807
D006861Hydrogen PeroxideHSF1 protein inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased secretion of HMGB1 protein]22246807
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of HMGB1 protein22246807|2741311
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of and results in increased secretion of HMGB1 protein22246807
D007052IbuprofenIbuprofen results in increased expression of HMGB1 protein24747151
C492448ICG 001ICG 001 results in decreased expression of HMGB1 mRNA26191083
D053590Interleukin 1 Receptor Antagonist Protein"Interleukin 1 Receptor Antagonist Protein inhibits the reaction [Asbestos, Crocidolite results in increased secretion of HMGB1 protein]"23937860
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HMGB1 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HMGB1 mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HMGB1 mRNA25613284
D007530IsofluraneIsoflurane results in increased expression of HMGB1 protein24747151
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of HMGB1 protein10768784
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of HMGB1 mRNA15618438
C410337K 7174K 7174 results in decreased expression of HMGB1 mRNA24086573
C064309kaempferol 3-O-sophorosidekaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]22178603
C064309kaempferol 3-O-sophorosidekaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]22178603
C064309kaempferol 3-O-sophorosidekaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]22178603
C064309kaempferol 3-O-sophorosidekaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein]22178603
C064309kaempferol 3-O-sophorosidekaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]22178603
C064309kaempferol 3-O-sophorosidekaempferol 3-O-sophoroside inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]22178603
C064309kaempferol 3-O-sophorosidekaempferol 3-O-sophoroside results in decreased susceptibility to HMGB1 protein22178603
D008012LidocaineLidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased localization of HMGB1 protein]21288974
D008012LidocaineLidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 mRNA]21288974
D017705Lignans"Lignans inhibits the reaction [Asbestos, Crocidolite results in increased expression of HMGB1 protein]"26678224
D017705LignansLignans results in decreased expression of HMGB1 mRNA26678224
C482199lipopolysaccharide, E coli O55-B5"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of HMGB1 protein]"25651848
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 affects the localization of HMGB1 protein"25651848
C482199lipopolysaccharide, E coli O55-B5"prolinedithiocarbamate inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of HMGB1 protein]"25651848
C482199lipopolysaccharide, E coli O55-B5"resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of HMGB1 protein]"25651848
C482199lipopolysaccharide, E coli O55-B5"Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein]"23939143
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein"23939143
C440499lipopolysaccharide, Escherichia coli O111 B4"emodin-6-O-glucoside inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of HMGB1 protein]"23146691
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of HMGB1 protein"23146691
C440499lipopolysaccharide, Escherichia coli O111 B4"angelicae sinensis extract inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased secretion of HMGB1 protein]"16424112
C440499lipopolysaccharide, Escherichia coli O111 B4"BECN1 protein affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of HMGB1 protein]"19265175
C440499lipopolysaccharide, Escherichia coli O111 B4"dong quai inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased secretion of HMGB1 protein]"16424112
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased secretion of HMGB1 protein"16424112
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMGB1 mRNA"24802390
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMGB1 protein"19265175|2184334
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of and affects the localization of HMGB1 protein"19265175
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of and results in increased expression of HMGB1 protein"21843347
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of HMGB1 protein"21767162
C440499lipopolysaccharide, Escherichia coli O111 B4"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of HMGB1 protein]"21843347
C440499lipopolysaccharide, Escherichia coli O111 B4"Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of HMGB1 protein]"19265175
C440499lipopolysaccharide, Escherichia coli O111 B4"Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMGB1 protein]"19265175
C440499lipopolysaccharide, Escherichia coli O111 B4"Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of and affects the localization of HMGB1 protein]"19265175
C440499lipopolysaccharide, Escherichia coli O111 B4"resveratrol affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMGB1 mRNA]"24802390
C440499lipopolysaccharide, Escherichia coli O111 B4"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMGB1 protein]"24802390
C440499lipopolysaccharide, Escherichia coli O111 B4"wortmannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of and affects the localization of HMGB1 protein]"19265175
C440499lipopolysaccharide, Escherichia coli O111 B4"SOD2 protein inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of HMGB1 protein]"21767162
D008070Lipopolysaccharides3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]22014880
D008070Lipopolysaccharidesdienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein]22014880
D008070Lipopolysaccharidesdienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]22014880
D008070Lipopolysaccharidesdienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein]22014880
D008070Lipopolysaccharidesdienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]22014880
D008070Lipopolysaccharideskaempferol 3-O-sophoroside inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]22178603
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein22014880
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein22014880
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein22014880
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA22014880
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HMGB1 mRNA21617575
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HMGB1 protein20699433|2161757
D008070LipopolysaccharidesLipopolysaccharides results in increased secretion of HMGB1 protein22178603|2238681
D008070Lipopolysaccharideslycopene inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]22429818
D008070LipopolysaccharidesOleanolic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]22386814
D008070LipopolysaccharidesPolymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]22014880
D008070LipopolysaccharidesPolymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]22014880
D008070LipopolysaccharidesProgesterone inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein]22014880
D008070LipopolysaccharidesProgesterone inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]22014880
D008070LipopolysaccharidesProgesterone inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein]22014880
D008070LipopolysaccharidesProgesterone inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]22014880
D008070LipopolysaccharidesTLR4 mutant form inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]22014880
D008070Lipopolysaccharides[troglitazone results in increased activity of PPARG protein] inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 mRNA]21617575
D008070Lipopolysaccharides[troglitazone results in increased activity of PPARG protein] inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]21617575
D008070LipopolysaccharidesLidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased localization of HMGB1 protein]21288974
D008070LipopolysaccharidesLidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 mRNA]21288974
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of and results in increased localization of HMGB1 protein21288974
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HMGB1 mRNA21288974
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]22429818
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of and results in increased secretion of PLA2G2A protein]22429818
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of and results in increased secretion of TNF protein]22429818
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 mRNA]22429818
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]22429818
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of SELE mRNA]22429818
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]22429818
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]22429818
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein]22429818
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 mRNA]22429818
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]22429818
C015329lycopenelycopene inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]22429818
C015329lycopenelycopene results in decreased susceptibility to HMGB1 protein22429818
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [HMGB1 protein results in decreased expression of CDH5 protein]25979658
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [HMGB1 protein results in decreased expression of TJP1 protein]25979658
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Streptozocin results in increased expression of HMGB1 mRNA]19833897
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of HMGB1 protein]21113057
D008550MelatoninMelatonin inhibits the reaction [tetrachlorobenzoquinone affects the localization of HMGB1 protein]27413111
D008550MelatoninMelatonin inhibits the reaction [tetrachlorobenzoquinone results in increased acetylation of and results in increased phosphorylation of HMGB1 protein]27413111
D008550MelatoninMelatonin inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of HMGB1 protein]27413111
D008627Mercuric ChlorideMercuric Chloride affects the expression of HMGB1 mRNA20353558
D008713Methimazole[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein26177832
D008713Methimazolegadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein]26177832
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HMGB1 mRNA23649840
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of HMGB1 mRNA12634122
D015741MetriboloneMetribolone results in decreased expression of HMGB1 protein17152098
C517469MK615 extractMK615 extract inhibits the reaction [HMGB1 protein results in increased expression of CCL5 mRNA]27415824
C517469MK615 extractMK615 extract inhibits the reaction [HMGB1 protein results in increased expression of IL1B mRNA]27415824
C517469MK615 extractMK615 extract inhibits the reaction [HMGB1 protein results in increased expression of IL6 mRNA]27415824
C517469MK615 extractMK615 extract inhibits the reaction [HMGB1 protein results in increased expression of IL6 protein]27415824
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of HMGB1 protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HMGB1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HMGB1 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of HMGB1 protein21399660
C045863neo-gambogic acidneo-gambogic acid inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]27616297
C045863neo-gambogic acidneo-gambogic acid inhibits the reaction [[Silicon Dioxide results in increased expression of HMGB1 protein] which results in increased expression of ACTA2 protein]27616297
C045863neo-gambogic acidneo-gambogic acid inhibits the reaction [[Silicon Dioxide results in increased expression of HMGB1 protein] which results in increased expression of COL1A2 protein]27616297
C045863neo-gambogic acidneo-gambogic acid inhibits the reaction [[Silicon Dioxide results in increased expression of HMGB1 protein] which results in increased expression of COL3A1 protein]27616297
C045863neo-gambogic acidneo-gambogic acid inhibits the reaction [[Silicon Dioxide results in increased expression of HMGB1 protein] which results in increased expression of ZC3H12A protein]27616297
D009532NickelNickel results in decreased expression of HMGB1 mRNA24084258
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of HMGB1 protein]"21843347
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of HMGB1 mRNA20971185
D009828Oleanolic AcidOleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]22386814
D009828Oleanolic AcidOleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]22386814
D009828Oleanolic AcidOleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]22386814
D009828Oleanolic AcidOleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of TNF protein]22386814
D009828Oleanolic AcidOleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]22386814
D009828Oleanolic AcidOleanolic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]22386814
D009828Oleanolic AcidOleanolic Acid results in decreased expression of HMGB1 protein22386814
D009828Oleanolic AcidOleanolic Acid results in decreased susceptibility to HMGB1 protein22386814
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of HMGB1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of and results in increased secretion of HMGB1 protein28294475
D010100OxygenOxygen deficiency results in increased expression of HMGB1 mRNA28294475
D010100Oxygen[Oxygen deficiency results in increased secretion of HMGB1 protein] which results in increased expression of ICAM1 protein28294475
D010100Oxygen[Oxygen deficiency results in increased secretion of HMGB1 protein] which results in increased expression of VCAM1 protein28294475
D010100Oxygentanshinone II A sodium sulfonate inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of HMGB1 protein]28294475
D010100Oxygentanshinone II A sodium sulfonate inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 mRNA]28294475
D010100Oxygentanshinone II A sodium sulfonate inhibits the reaction [[Oxygen deficiency results in increased secretion of HMGB1 protein] which results in increased expression of ICAM1 protein]28294475
D010100Oxygentanshinone II A sodium sulfonate inhibits the reaction [[Oxygen deficiency results in increased secretion of HMGB1 protein] which results in increased expression of VCAM1 protein]28294475
D010100Oxygen"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of HMGB1 protein]"21113057
D010100Oxygenmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of HMGB1 protein]21113057
D010100Oxygen[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of HMGB1 protein21113057
D010126Ozone[Ozone co-treated with Vehicle Emissions] results in increased expression of HMGB1 mRNA20980218
D017239PaclitaxelHMGB1 protein affects the susceptibility to Paclitaxel16217747
D017239PaclitaxelPaclitaxel results in decreased expression of HMGB1 protein27474498
D019308Palmitic AcidPalmitic Acid results in increased secretion of HMGB1 protein27689324
D010269ParaquatParaquat results in increased expression of HMGB1 mRNA19497220
D052638Particulate MatterParticulate Matter results in increased expression of and affects the localization of HMGB1 protein29233668
D052638Particulate MatterParticulate Matter results in increased expression of HMGB1 mRNA29233668
D010672Phenytoin[Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein23986454
D010936Plant ExtractsPlant Extracts results in decreased expression of HMGB1 mRNA21920417
D010936Plant ExtractsPlant Extracts results in increased expression of HMGB1 mRNA23557933
D011112Polymyxin BPolymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]22014880
D011112Polymyxin BPolymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]22014880
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HMGB1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of HMGB1 mRNA22079256
C023844potassium nitratepotassium nitrate results in increased expression of HMGB1 mRNA15878651
D011374ProgesteroneProgesterone inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein]22014880
D011374ProgesteroneProgesterone inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]22014880
D011374ProgesteroneProgesterone inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein]22014880
D011374ProgesteroneProgesterone inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA]22014880
C066229prolinedithiocarbamate"prolinedithiocarbamate inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of HMGB1 protein]"25651848
C045950propiconazolepropiconazole results in decreased expression of HMGB1 mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of HMGB1 mRNA24780913
C005581protocatechualdehydeprotocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein]25582705
C005581protocatechualdehydeprotocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of HMGB1 protein]25582705
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]27616297
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HMGB1 mRNA]15477007
D011794QuercetinQuercetin results in increased expression of HMGB1 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of and affects the localization of HMGB1 protein]27601294
D011794QuercetinQuercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 mRNA]27601294
D011794QuercetinQuercetin inhibits the reaction [HMGB1 protein results in increased activity of and affects the localization of RELA protein]19265175
D011794QuercetinQuercetin inhibits the reaction [HMGB1 protein results in increased degradation of NFKBIA protein]19265175
D011794QuercetinQuercetin inhibits the reaction [HMGB1 protein results in increased expression of IL1B mRNA]19265175
D011794QuercetinQuercetin inhibits the reaction [HMGB1 protein results in increased expression of TNF mRNA]19265175
D011794QuercetinQuercetin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein]19265175
D011794QuercetinQuercetin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein]19265175
D011794QuercetinQuercetin inhibits the reaction [HMGB1 protein results in increased secretion of IL1B protein]19265175
D011794QuercetinQuercetin inhibits the reaction [HMGB1 protein results in increased secretion of TNF protein]19265175
D011794QuercetinQuercetin inhibits the reaction [Hydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]]17513788
D011794Quercetin"Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of HMGB1 protein]"19265175
D011794Quercetin"Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMGB1 protein]"19265175
D011794Quercetin"Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of and affects the localization of HMGB1 protein]"19265175
D011794QuercetinQuercetin inhibits the reaction [TNF protein results in increased secretion of and affects the localization of HMGB1 protein]19265175
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of HMGB1 mRNA16514628
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of HMGB1 mRNA16079270
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of HMGB1 mRNA19167446
C059514resveratrolNFE2L2 protein affects the reaction [resveratrol inhibits the reaction [HMGB1 protein results in decreased expression of CDH5 protein]]25979658
C059514resveratrol"resveratrol affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMGB1 mRNA]"24802390
C059514resveratrol[resveratrol co-treated with HMGB1 protein] affects the localization of NFE2L2 protein25979658
C059514resveratrol[resveratrol co-treated with HMGB1 protein] results in increased expression of ABCC5 mRNA25979658
C059514resveratrol[resveratrol co-treated with HMGB1 protein] results in increased expression of AKR1B10 mRNA25979658
C059514resveratrol[resveratrol co-treated with HMGB1 protein] results in increased expression of HMOX1 mRNA25979658
C059514resveratrol[resveratrol co-treated with HMGB1 protein] results in increased expression of NQO1 mRNA25979658
C059514resveratrolresveratrol inhibits the reaction [HMGB1 protein results in decreased expression of CDH5 protein]25979658
C059514resveratrolresveratrol inhibits the reaction [HMGB1 protein results in decreased expression of NFE2L2 mRNA]25979658
C059514resveratrolresveratrol inhibits the reaction [HMGB1 protein results in decreased expression of NFE2L2 protein]25979658
C059514resveratrolresveratrol inhibits the reaction [HMGB1 protein results in decreased expression of TJP1 protein]25979658
C059514resveratrol"resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of HMGB1 protein]"25651848
C059514resveratrol"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMGB1 protein]"24802390
C041376rosmarinic acidrosmarinic acid results in decreased expression of HMGB1 protein28789951
C093642SB 203580SB 203580 inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]27616297
C477523SC 514SC 514 inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]27616297
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of HMGB1 mRNA19244175
C097256semapimodsemapimod results in decreased expression of HMGB1 protein15947118
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased secretion of HMGB1 protein"24160326
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased secretion of HMGB1 protein"24160326
D012822Silicon Dioxide2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]27616297
D012822Silicon DioxideHMGB1 protein promotes the reaction [Silicon Dioxide results in decreased expression of BCL2L1 protein]27616297
D012822Silicon DioxideHMGB1 protein promotes the reaction [Silicon Dioxide results in increased cleavage of CASP3 protein]27616297
D012822Silicon DioxideHMGB1 protein promotes the reaction [Silicon Dioxide results in increased secretion of HMGB1 protein]27616297
D012822Silicon DioxideHMGB1 protein promotes the reaction [[Silicon Dioxide results in increased secretion of HMGB1 protein] which results in increased expression of ACTA2 protein]27616297
D012822Silicon DioxideHMGB1 protein promotes the reaction [[Silicon Dioxide results in increased secretion of HMGB1 protein] which results in increased expression of COL1A2 protein]27616297
D012822Silicon DioxideHMGB1 protein promotes the reaction [[Silicon Dioxide results in increased secretion of HMGB1 protein] which results in increased expression of COL3A1 protein]27616297
D012822Silicon DioxideHMGB1 protein promotes the reaction [[Silicon Dioxide results in increased secretion of HMGB1 protein] which results in increased expression of ZC3H12A protein]27616297
D012822Silicon Dioxideneo-gambogic acid inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]27616297
D012822Silicon Dioxideneo-gambogic acid inhibits the reaction [[Silicon Dioxide results in increased expression of HMGB1 protein] which results in increased expression of ACTA2 protein]27616297
D012822Silicon Dioxideneo-gambogic acid inhibits the reaction [[Silicon Dioxide results in increased expression of HMGB1 protein] which results in increased expression of COL1A2 protein]27616297
D012822Silicon Dioxideneo-gambogic acid inhibits the reaction [[Silicon Dioxide results in increased expression of HMGB1 protein] which results in increased expression of COL3A1 protein]27616297
D012822Silicon Dioxideneo-gambogic acid inhibits the reaction [[Silicon Dioxide results in increased expression of HMGB1 protein] which results in increased expression of ZC3H12A protein]27616297
D012822Silicon Dioxidepyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]27616297
D012822Silicon DioxideSB 203580 inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]27616297
D012822Silicon DioxideSC 514 inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]27616297
D012822Silicon DioxideSilicon Dioxide results in increased expression of HMGB1 protein27616297
D012822Silicon DioxideSilicon Dioxide results in increased secretion of HMGB1 protein27616297
D012822Silicon Dioxide[Silicon Dioxide results in increased secretion of HMGB1 protein] which results in increased expression of ACTA2 protein27616297
D012822Silicon Dioxide[Silicon Dioxide results in increased secretion of HMGB1 protein] which results in increased expression of COL1A2 protein27616297
D012822Silicon Dioxide[Silicon Dioxide results in increased secretion of HMGB1 protein] which results in increased expression of COL3A1 protein27616297
D012822Silicon Dioxide[Silicon Dioxide results in increased secretion of HMGB1 protein] which results in increased expression of ZC3H12A protein27616297
D012822Silicon DioxideU 0126 inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]27616297
D019821SimvastatinSimvastatin inhibits the reaction [[Dietary Fats co-treated with Cholecalciferol] results in increased expression of HMGB1 mRNA]20519084
D020123Sirolimusbisphenol A promotes the reaction [Sirolimus affects the localization of HMGB1 protein]26139607
D020123SirolimusSirolimus affects the localization of HMGB1 protein26139607
C009277sodium arsenatesodium arsenate results in increased expression of HMGB1 mRNA21795629
D013311Streptozocinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Streptozocin results in increased expression of HMGB1 mRNA]19833897
D013311StreptozocinStreptozocin results in increased expression of HMGB1 mRNA19833897
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of HMGB1 mRNA16214533
D012460SulfasalazineSulfasalazine results in increased expression of HMGB1 mRNA16141653
C024894tanshinone II A sodium sulfonatetanshinone II A sodium sulfonate inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of HMGB1 protein]28294475
C024894tanshinone II A sodium sulfonatetanshinone II A sodium sulfonate inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 mRNA]28294475
C024894tanshinone II A sodium sulfonatetanshinone II A sodium sulfonate inhibits the reaction [[Oxygen deficiency results in increased secretion of HMGB1 protein] which results in increased expression of ICAM1 protein]28294475
C024894tanshinone II A sodium sulfonatetanshinone II A sodium sulfonate inhibits the reaction [[Oxygen deficiency results in increased secretion of HMGB1 protein] which results in increased expression of VCAM1 protein]28294475
D013654TaurineTaurine results in decreased expression of HMGB1 mRNA16579726
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of HMGB1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of HMGB1 mRNA21592394
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide affects the expression of HMGB1 protein24430359
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased expression of HMGB1 mRNA27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased expression of HMGB1 protein27413111
C000591600tetrachlorobenzoquinoneTLR4 gene mutant form inhibits the reaction [tetrachlorobenzoquinone affects the localization of HMGB1 protein]27413111
C000591600tetrachlorobenzoquinoneTLR4 gene mutant form inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HMGB1 mRNA]27413111
C000591600tetrachlorobenzoquinoneHMGB1 affects the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of IL1B protein]27413111
C000591600tetrachlorobenzoquinoneHMGB1 affects the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of IL6 protein]27413111
C000591600tetrachlorobenzoquinoneHMGB1 affects the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of TNF protein]27413111
C000591600tetrachlorobenzoquinoneHMGB1 affects the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 protein]27413111
C000591600tetrachlorobenzoquinoneMelatonin inhibits the reaction [tetrachlorobenzoquinone affects the localization of HMGB1 protein]27413111
C000591600tetrachlorobenzoquinoneMelatonin inhibits the reaction [tetrachlorobenzoquinone results in increased acetylation of and results in increased phosphorylation of HMGB1 protein]27413111
C000591600tetrachlorobenzoquinoneMelatonin inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of HMGB1 protein]27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone affects the localization of HMGB1 protein27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone promotes the reaction [HMGB1 protein binds to AGER protein]27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone promotes the reaction [HMGB1 protein binds to TLR2 protein]27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone promotes the reaction [HMGB1 protein binds to TLR4 protein]27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone promotes the reaction [HMGB1 protein binds to TLR9 protein]27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased acetylation of and results in increased phosphorylation of HMGB1 protein27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased secretion of HMGB1 protein27413111
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGB1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HMGB1 mRNA24058054
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HMGB1 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HMGB1 mRNA15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HMGB1 mRNA25613284
D013849ThimerosalThimerosal results in increased expression of HMGB1 mRNA27188386
D013974ThyroxineThyroxine affects the expression of HMGB1 mRNA17403546
D014051Toluene 2,4-Diisocyanate"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]"25929181
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein"25929181|2832985
D014051Toluene 2,4-Diisocyanate"TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]"28329851
D019772TopotecanHMGB1 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of HMGB1 mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of HMGB1 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HMGB1 mRNA"26179874
C057693troglitazone[troglitazone results in increased activity of PPARG protein] inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 mRNA]21617575
C057693troglitazone[troglitazone results in increased activity of PPARG protein] inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]21617575
C057693troglitazone[troglitazone results in increased activity of PPARG protein] which results in decreased expression of HMGB1 mRNA21617575
C057693troglitazone[troglitazone results in increased activity of PPARG protein] which results in decreased expression of HMGB1 protein21617575
C425776tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketonetyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]26079697
C113580U 0126U 0126 inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]27616297
D014501UraniumUranium affects the expression of HMGB1 mRNA15672453
D014501UraniumUranium affects the expression of HMGB1 protein15672453
D017974Uranium CompoundsUranium Compounds results in decreased expression of HMGB1 mRNA19654044
C005460uranyl acetateuranyl acetate affects the expression of HMGB1 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of HMGB1 protein15672453
D014635Valproic AcidValproic Acid results in decreased expression of HMGB1 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of HMGB1 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased methylation of HMGB1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of HMGB1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HMGB1 gene25560391
D001335Vehicle Emissions[Ozone co-treated with Vehicle Emissions] results in increased expression of HMGB1 mRNA20980218
D014747VinblastineHMGB1 protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin results in decreased expression of HMGB1 mRNA22570695
D014750VincristineHMGB1 protein results in decreased susceptibility to Vincristine27807322
D014750VincristineVincristine results in increased secretion of HMGB1 protein27807322
D014750VincristineVincristine results in decreased expression of HMGB1 protein27474498
D002762Cholecalciferol[Dietary Fats co-treated with Cholecalciferol] results in increased expression of HMGB1 mRNA20519084
D002762CholecalciferolSimvastatin inhibits the reaction [[Dietary Fats co-treated with Cholecalciferol] results in increased expression of HMGB1 mRNA]20519084
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of HMGB1 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of HMGB1 mRNA19244175
C009687wortmannin"wortmannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of and affects the localization of HMGB1 protein]"19265175
C009687wortmanninwortmannin inhibits the reaction [bisphenol A affects the localization of HMGB1 protein]26139607

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000400four-way junction DNA binding-ISS-  
GO:0000405bubble DNA binding-ISS-  
GO:0001530lipopolysaccharide binding-IDA21660935  
GO:0001786phosphatidylserine binding-IDA18768881  
GO:0003682chromatin binding-IBA21873635  
GO:0003684damaged DNA binding-IDA17803946  
GO:0003684damaged DNA binding-ISS-  
GO:0003690double-stranded DNA binding-ISS-  
GO:0003697single-stranded DNA binding-ISS-  
GO:0003700DNA-binding transcription factor activity-IDA19223331  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003725double-stranded RNA binding-IEA-  
GO:0003727single-stranded RNA binding-IEA-  
GO:0005125cytokine activity-ISS-  
GO:0005178integrin binding-IDA20826760  
GO:0005515protein binding-IPI8006019  9472015  11748232  15014079  19505873  20819940  
23063560  23303669  24474694  25416956  
GO:0008134transcription factor binding-IPI19223331  
GO:0008301DNA binding, bending-IMP19223331  
GO:0008301DNA binding, bending-ISS-  
GO:0010858calcium-dependent protein kinase regulator activity-IEA-  
GO:0016829lyase activity-IDA17803946  
GO:0019958C-X-C chemokine binding-IDA22370717  
GO:0030295protein kinase activator activity-IEA-  
GO:0042056chemoattractant activity-ISS-  
GO:0050786RAGE receptor binding-ISS-  
GO:0070182DNA polymerase binding-IDA17803946  
GO:0070491repressing transcription factor binding-IPI19223331  
GO:0097100supercoiled DNA binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP19158276  
GO:0001654eye development-IEA-  
GO:0001773myeloid dendritic cell activation-ISS-  
GO:0001935endothelial cell proliferation-IEA-  
GO:0002218activation of innate immune response-IDA24971542  
GO:0002224toll-like receptor signaling pathway-TAS-  
GO:0002270plasmacytoid dendritic cell activation-IEA-  
GO:0002281macrophage activation involved in immune response-IEA-  
GO:0002407dendritic cell chemotaxis-ISS-  
GO:0002437inflammatory response to antigenic stimulus-IEP19841752  
GO:0002643regulation of tolerance induction-IDA18631454  
GO:0002840regulation of T cell mediated immune response to tumor cell-ISS-  
GO:0006265DNA topological change-ISS-  
GO:0006284base-excision repair-IEA-  
GO:0006309apoptotic DNA fragmentation-TAS-  
GO:0006310DNA recombination-ISS-  
GO:0006338chromatin remodeling-IBA21873635  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IDA11748232  
GO:0006914autophagy-IEA-  
GO:0006954inflammatory response-IDA23146691  
GO:0007204positive regulation of cytosolic calcium ion concentration-IDA22370717  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010506regulation of autophagy-IMP20819940  
GO:0017055negative regulation of RNA polymerase II transcriptional preinitiation complex assembly-IDA8006019  
GO:0030324lung development-IEA-  
GO:0031175neuron projection development-ISS-  
GO:0031497chromatin assembly-IEA-  
GO:0032072regulation of restriction endodeoxyribonuclease activity-IDA17803946  
GO:0032147activation of protein kinase activity-IEA-  
GO:0032392DNA geometric change-ISS-  
GO:0032425positive regulation of mismatch repair-IDA15014079  
GO:0032689negative regulation of interferon-gamma production-IDA22473704  
GO:0032727positive regulation of interferon-alpha production-IEA-  
GO:0032728positive regulation of interferon-beta production-IEA-  
GO:0032733positive regulation of interleukin-10 production-IDA22473704  
GO:0032735positive regulation of interleukin-12 production-IMP15944249  
GO:0032760positive regulation of tumor necrosis factor production-IEA-  
GO:0033151V(D)J recombination-IDA9166431  
GO:0034137positive regulation of toll-like receptor 2 signaling pathway-IEA-  
GO:0034145positive regulation of toll-like receptor 4 signaling pathway-IEA-  
GO:0034165positive regulation of toll-like receptor 9 signaling pathway-ISS-  
GO:0035711T-helper 1 cell activation-IDA22473704  
GO:0035767endothelial cell chemotaxis-IEA-  
GO:0042104positive regulation of activated T cell proliferation-IMP15944249  
GO:0043065positive regulation of apoptotic process-IDA19800306  
GO:0043277apoptotic cell clearance-IDA18768881  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA19800306  
GO:0043312neutrophil degranulation-TAS-  
GO:0043371negative regulation of CD4-positive, alpha-beta T cell differentiation-IDA22473704  
GO:0043388positive regulation of DNA binding-IDA11748232  19223331  
GO:0043410positive regulation of MAPK cascade-IDA12765338  
GO:0043536positive regulation of blood vessel endothelial cell migration-IMP28276476  
GO:0043537negative regulation of blood vessel endothelial cell migration-IDA23148224  
GO:0045063T-helper 1 cell differentiation-IMP15944249  
GO:0045087innate immune response-TAS-  
GO:0045639positive regulation of myeloid cell differentiation-IEA-  
GO:0045819positive regulation of glycogen catabolic process-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA19223331  
GO:0046330positive regulation of JNK cascade-IDA12765338  
GO:0050716positive regulation of interleukin-1 secretion-IDA12765338  
GO:0050718positive regulation of interleukin-1 beta secretion-IEA-  
GO:0050918positive chemotaxis-IEA-  
GO:0051103DNA ligation involved in DNA repair-ISS-  
GO:0051106positive regulation of DNA ligation-ISS-  
GO:0051384response to glucocorticoid-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA22370717  
GO:0071639positive regulation of monocyte chemotactic protein-1 production-IEA-  
GO:0090026positive regulation of monocyte chemotaxis-IDA22370717  
GO:0090303positive regulation of wound healing-IEA-  
GO:0097350neutrophil clearance-IDA18768881  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IEA-  
GO:1903672positive regulation of sprouting angiogenesis-IEA-  
GO:1905564positive regulation of vascular endothelial cell proliferation-IMP28276476  
GO:1990774tumor necrosis factor secretion-IDA12765338  
GO:2000426negative regulation of apoptotic cell clearance-IDA20826760  
GO:2000778positive regulation of interleukin-6 secretion-IDA12765338  
GO:2000819regulation of nucleotide-excision repair-IEA-  
GO:2001200positive regulation of dendritic cell differentiation-IMP15944249  
GO ID GO Term Qualifier Evidence PubMed
GO:0000793condensed chromosome-IDA12925773  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA19841752  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA8339930  19223331  
GO:0005654nucleoplasm-TAS-  
GO:0005769early endosome-IEA-  
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IEA-  
GO:0009986cell surface-IDA19841752  
GO:0017053transcriptional repressor complexcolocalizes_withIDA19158276  
GO:0034774secretory granule lumen-TAS-  
GO:0035868alphav-beta3 integrin-HMGB1 complex-IDA20826760  
GO:0043005neuron projection-IEA-  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-140342Apoptosis induced DNA fragmentationTAS
R-HSA-1606322ZBP1(DAI) mediated induction of type I IFNsTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-1810476RIP-mediated NFkB activation via ZBP1TAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-211227Activation of DNA fragmentation factorTAS
R-HSA-3134963DEx/H-box helicases activate type I IFN and inflammatory cytokines production TAS
R-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complexTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5686938Regulation of TLR by endogenous ligandTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-75153Apoptotic execution phaseTAS
R-HSA-879415Advanced glycosylation endproduct receptor signalingTAS
R-HSA-879415Advanced glycosylation endproduct receptor signalingIEA
R-HSA-9020702Interleukin-1 signalingTAS
R-HSA-933542TRAF6 mediated NF-kB activationTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28423715A functional variant at the miRNA binding site in HMGB1 gene is associated with risk of oral squamous cell carcinoma. (2017 May 23)Lin CWOncotarget
22333024[Levels of HMGB1 in induced sputum from patients with asthma and chronic obstructive pulmonary disease]. (2011 Nov 15)Cheng ZZhonghua Yi Xue Za Zhi
28287180Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. (2017 Mar 13)Morrow JDSci Rep
24587320The effects of smoking on levels of endothelial progenitor cells and microparticles in the blood of healthy volunteers. (2014)Mobarrez FPLoS One
26798204Association between HMGB1 and COPD: A Systematic Review. (2015)Gangemi SMediators Inflamm
21380479High mobility group protein B1 (HMGB1) in Asthma: comparison of patients with chronic obstructive pulmonary disease and healthy controls. (2011)Hou CMol Med
28159648The role of neuroimmune signaling in alcoholism. (2017 Aug 1)Crews FTNeuropharmacology
25175868Neuroimmune basis of alcoholic brain damage. (2014)Crews FTInt Rev Neurobiol
23895427The cytokine mRNA increase induced by withdrawal from chronic ethanol in the sterile environment of brain is mediated by CRF and HMGB1 release. (2013 Dec)Whitman BAAlcohol Clin Exp Res
25658530Acute pulmonary exacerbation and lung function decline in patients with cystic fibrosis: high-mobility group box 1 (HMGB1) between inflammation and infection. (2015 Apr)Chirico VClin Microbiol Infect
28187002A multicenter matched case-control analysis on seven polymorphisms from HMGB1 and RAGE genes in predicting hepatocellular carcinoma risk. (2017 Jul 25)Wang DOncotarget
19150066Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients. (2009 Aug)Yan XXAtherosclerosis
28118842Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7. (2017 Jan 25)Coleman LG JrJ Neuroinflammation
25787746Mechanisms of neuroimmune gene induction in alcoholism. (2016 May)Crews FTPsychopharmacology (Berl)
21643870Increased heat shock protein 70 levels in induced sputum and plasma correlate with severity of asthma patients. (2011 Nov)Hou CCell Stress Chaperones
29102800HMGB1/IL-1beta complexes regulate neuroimmune responses in alcoholism. (2017 Nov 2)Coleman LG JrBrain Behav Immun
28209360Levels of high-mobility group box-1 in gingival crevicular fluid in nonsmokers and smokers with chronic periodontitis. (2017 Dec)Lin YCJ Formos Med Assoc
27693003Electronic cigarettes increase endothelial progenitor cells in the blood of healthy volunteers. (2016 Dec)Antoniewicz LAtherosclerosis
22860230Autophagy in pancreatic cancer pathogenesis and treatment. (2012)Kang RAm J Cancer Res
23206318High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. (2013 Apr 1)Crews FTBiol Psychiatry
23867237Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking. (2013 Nov)Vetreno RPNeurobiol Dis
24976997Changes of HMGB1 and sRAGE during the recovery of COPD exacerbation. (2014 Jun)Zhang YJ Thorac Dis
24551070Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling. (2014)Zou JYPLoS One
25192219Cigarette smoke-induced damage-associated molecular pattern release from necrotic neutrophils triggers proinflammatory mediator release. (2015 May)Heijink IHAm J Respir Cell Mol Biol
22423653HMGB1: a smoking gun in lupus nephritis? (2012 Mar 14)Pisetsky DSArthritis Res Ther
22932142[Expressions and clinical significance of high mobility group box-1 mRNA and protein in laryngeal squamous cell carcinoma tissues and serum]. (2012 Jun)Guo YZhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi