Gene: HMGB2

3148
HMG2
high mobility group box 2
protein-coding
4q34.1
Ensembl:ENSG00000164104 MIM:163906 Vega:OTTHUMG00000160799 UniprotKB:P26583
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.147e-1 (AD)  3.801e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLN50.822
CALCOCO20.803
PPIL40.802
ZNF2740.792
MTA20.789
ASCC10.789
TMCO10.776
TMEM179B0.773
H3F3B0.772
SSR30.769

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.508
OR4F29-0.498
CYP1A1-0.278
ABCC12-0.241
OPRD1-0.239
LRRC38-0.238
PHOSPHO1-0.238
AGMAT-0.237
CACNA1S-0.235
WNT7A-0.228

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of HMGB2 mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of HMGB2 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HMGB2 mRNA"22698814|2890350
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HMGB2 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of HMGB2 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HMGB2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HMGB2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HMGB2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HMGB2 mRNA"25510870
C0194992-nitrofluorene2-nitrofluorene results in increased expression of HMGB2 mRNA15890375
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HMGB2 mRNA"23196670
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of HMGB2 mRNA15890375
D000082AcetaminophenAcetaminophen results in increased expression of HMGB2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of HMGB2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of HMGB2 mRNA17942131
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of HMGB2 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HMGB2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HMGB2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HMGB2 mRNA15890375
D000393Air PollutantsAir Pollutants analog results in decreased expression of HMGB2 mRNA21757418
C000188alachloralachlor results in increased expression of HMGB2 mRNA12419858
D000616AminoglutethimideAminoglutethimide results in decreased expression of HMGB2 protein26102013
D000638AmiodaroneAmiodarone affects the expression of HMGB2 mRNA18355885
D000639AmitriptylineAmitriptyline affects the expression of HMGB2 mRNA18355885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HMGB2 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of HMGB2 mRNA"22863853
D001151ArsenicArsenic affects the methylation of HMGB2 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of HMGB2 mRNA14703492
C015001arsenitearsenite results in decreased expression of HMGB2 mRNA18929588
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HMGB2 mRNA26424790
D001280AtrazineAtrazine results in increased expression of HMGB2 mRNA25929836
D001379AzathioprineAzathioprine results in decreased expression of HMGB2 mRNA22623647
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of HMGB2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HMGB2 mRNA21632981|2180250
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of HMGB2 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HMGB2 mRNA17942131
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HMGB2 mRNA15034205
D004958EstradiolEstradiol results in decreased expression of HMGB2 mRNA23019147
D004958EstradiolEstradiol results in increased expression of HMGB2 mRNA16474171|1916744
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HMGB2 mRNA26424790
D001622BetaineBetaine results in decreased expression of HMGB2 mRNA26391144
C095105bexarotenebexarotene results in decreased expression of HMGB2 mRNA16648578
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of HMGB2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of HMGB2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of HMGB2 mRNA16474171
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HMGB2 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of HMGB2 mRNA17942131
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased phosphorylation of HMGB2 protein22174045
D002065BuspironeBuspirone results in decreased expression of HMGB2 mRNA24136188
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of HMGB2 mRNA15707499
D002087ButyratesButyrates results in decreased expression of HMGB2 mRNA14674679
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HMGB2 mRNA18636176
D002211CapsaicinCapsaicin results in increased expression of HMGB2 mRNA16278290
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of HMGB2 mRNA19395590
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HMGB2 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of HMGB2 mRNA28472532
D002997ClomipramineClomipramine affects the expression of HMGB2 mRNA18355885
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of HMGB2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of HMGB2 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of HMGB2 mRNA15755911
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of HMGB2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with ESR1 protein] results in increased expression of HMGB2 mRNA18310284
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of HMGB2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of HMGB2 mRNA19167446
D003375CoumestrolESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of HMGB2 mRNA]18310284
C030973cupric oxidecupric oxide results in decreased expression of HMGB2 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of HMGB2 mRNA26577399
D016572CyclosporineCyclosporine affects the expression of HMGB2 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of HMGB2 mRNA21632981|2556210
D016572CyclosporineCyclosporine results in increased expression of HMGB2 mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of HMGB2 mRNA17942131|1977048
D000069439DasatinibDasatinib results in decreased expression of HMGB2 mRNA20579391
C014347decitabinedecitabine affects the expression of HMGB2 mRNA23300844
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HMGB2 mRNA26424790
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of HMGB2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HMGB2 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of HMGB2 mRNA14618091
D002945CisplatinCisplatin affects the expression of HMGB2 mRNA23300844
C000944dicrotophosdicrotophos results in decreased expression of HMGB2 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HMGB2 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HMGB2 mRNA]17854601
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HMGB2 mRNA19041683|1963824
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HMGB2 protein19041683
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of HMGB2 mRNA22129741
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of HMGB2 mRNA15890375
D002117CalcitriolCalcitriol results in decreased expression of HMGB2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of HMGB2 mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of HMGB2 mRNA15890375
D004317DoxorubicinHMGB2 protein affects the susceptibility to Doxorubicin16217747
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of HMGB2 mRNA12655031
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HMGB2 protein23301498
D000431EthanolEthanol results in decreased expression of HMGB2 mRNA15353170
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HMGB2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HMGB2 mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGB2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HMGB2 mRNA15834898
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HMGB2 mRNA16174780
D018120FinasterideFinasteride results in increased expression of HMGB2 mRNA24136188
D005419FlavonoidsFlavonoids results in increased expression of HMGB2 mRNA18035473
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of HMGB2 mRNA24657277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HMGB2 mRNA20938992
C039281furanfuran results in increased expression of HMGB2 mRNA20124500
D019833GenisteinGenistein results in increased expression of HMGB2 mRNA16474171
D019833GenisteinGenistein results in decreased expression of HMGB2 mRNA12075121
D005839GentamicinsGentamicins results in increased expression of HMGB2 mRNA22061828
D006046GoldGold results in decreased expression of HMGB2 mRNA25523186
D017313FenretinideFenretinide results in increased expression of HMGB2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of HMGB2 mRNA21179406
C031927hydroquinonehydroquinone results in decreased expression of HMGB2 mRNA23416264
D007099ImipramineImipramine affects the expression of HMGB2 mRNA18355885
C016517indole-3-carbinolindole-3-carbinol affects the expression of HMGB2 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of HMGB2 mRNA22129741
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of HMGB2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HMGB2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of HMGB2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of HMGB2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of HMGB2 mRNA28628672
C544151jinfukangjinfukang results in increased expression of HMGB2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HMGB2 mRNA23086925
C410337K 7174K 7174 results in decreased expression of HMGB2 mRNA24086573
D007654KetoconazoleKetoconazole affects the expression of HMGB2 mRNA18355885
C045463leflunomideleflunomide results in decreased expression of HMGB2 mRNA24136188
D064704LevofloxacinLevofloxacin results in decreased expression of HMGB2 mRNA24136188
D008154LucanthoneLucanthone results in decreased expression of HMGB2 mRNA21148553
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in increased expression of HMGB2 mRNA24525745
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HMGB2 mRNA21641980
D008701MethapyrileneMethapyrilene results in increased expression of HMGB2 mRNA15890375
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HMGB2 mRNA20938992
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of HMGB2 mRNA24657277
C005219methyl cellosolvemethyl cellosolve results in decreased expression of HMGB2 mRNA19643169
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of HMGB2 mRNA12634122
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of HMGB2 mRNA16525678
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of HMGB2 mRNA16026605
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of HMGB2 protein20553848
D009151Mustard GasMustard Gas results in decreased expression of HMGB2 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of HMGB2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HMGB2 mRNA"25554681
C012655nimesulidenimesulide results in decreased expression of HMGB2 mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of HMGB2 mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of HMGB2 mRNA22124623
D010126OzoneOzone results in increased expression of HMGB2 mRNA12763052
C500026palbociclibpalbociclib results in decreased expression of HMGB2 mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HMGB2 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HMGB2 protein26879310
D010634PhenobarbitalPhenobarbital results in increased expression of HMGB2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of HMGB2 mRNA19162173
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of HMGB2 mRNA15890375
C014153pirimiphos methylpirimiphos methyl results in increased expression of HMGB2 mRNA27845199
C006253pirinixic acidpirinixic acid results in increased expression of HMGB2 mRNA18301758|1844570
C006253pirinixic acidpirinixic acid results in increased expression of HMGB2 mRNA12832660|1589037
D010936Plant ExtractsPlant Extracts results in increased expression of HMGB2 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of HMGB2 mRNA16474171
C023844potassium nitratepotassium nitrate results in increased expression of HMGB2 mRNA15878651
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of HMGB2 mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of HMGB2 mRNA18070364
D011374ProgesteroneProgesterone results in decreased expression of HMGB2 mRNA20726854
C005556propionaldehydepropionaldehyde results in decreased expression of HMGB2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of HMGB2 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of HMGB2 mRNA21632981
C012526quercitrinquercitrin results in decreased expression of HMGB2 mRNA25193878
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of HMGB2 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of HMGB2 mRNA15767336
D012402RotenoneRotenone results in increased expression of HMGB2 mRNA19013527
C017947sodium arsenitesodium arsenite results in increased expression of HMGB2 protein20050688
C016104sodium bichromatesodium bichromate results in decreased expression of HMGB2 mRNA22561333
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HMGB2 mRNA21641980
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of HMGB2 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of HMGB2 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of HMGB2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of HMGB2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HMGB2 mRNA21802500
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of HMGB2 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HMGB2 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of HMGB2 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGB2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HMGB2 mRNA15034205|1946511
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HMGB2 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of HMGB2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of HMGB2 mRNA23557971
D019772TopotecanHMGB2 protein affects the susceptibility to Topotecan16217747
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of HMGB2 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of HMGB2 mRNA16249480
C012589trichostatin Atrichostatin A affects the expression of HMGB2 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of HMGB2 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of HMGB2 mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of HMGB2 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of HMGB2 mRNA29154799
D014640VancomycinVancomycin results in decreased expression of HMGB2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HMGB2 gene25560391
D014747VinblastineHMGB2 protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin affects the expression of HMGB2 mRNA19015723
D014800VitalliumVitallium analog results in decreased expression of HMGB2 mRNA23825117
D015032ZincZinc deficiency results in increased expression of HMGB2 mRNA16140947
D015032ZincZinc deficiency results in increased expression of HMGB2 protein16140947
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of HMGB2 mRNA]16140947
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of HMGB2 protein]16140947

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000400four-way junction DNA binding-ISS-  
GO:0001158enhancer sequence-specific DNA binding-ISS-  
GO:0003677DNA binding-IMP11909973  
GO:0003682chromatin binding-IBA21873635  
GO:0003684damaged DNA binding-IDA8226934  
GO:0003690double-stranded DNA binding-ISS-  
GO:0003697single-stranded DNA binding-ISS-  
GO:0003700DNA-binding transcription factor activity-IDA19223331  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI9636147  11909973  25416956  
GO:0008134transcription factor binding-ISS-  
GO:0008144drug binding-ISS-  
GO:0008301DNA binding, bending-IDA8339930  11909973  
GO:0019904protein domain specific binding-IEA-  
GO:0042056chemoattractant activity-IDA19811285  
GO:0044212transcription regulatory region DNA binding-IDA19965638  
GO:0044378non-sequence-specific DNA binding, bending-ISS-  
GO:0050786RAGE receptor binding-IGI19811285  
GO:0097100supercoiled DNA binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001938positive regulation of endothelial cell proliferation-IDA19811285  
GO:0002437inflammatory response to antigenic stimulus-ISS-  
GO:0006265DNA topological change-ISS-  
GO:0006309apoptotic DNA fragmentation-TAS-  
GO:0006325chromatin organization-NAS11909973  
GO:0006334nucleosome assembly-NAS11909973  
GO:0006338chromatin remodeling-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IDA7797075  
GO:0007289spermatid nucleus differentiation-IEA-  
GO:0008584male gonad development-IEA-  
GO:0032075positive regulation of nuclease activity-IDA978439  
GO:0032392DNA geometric change-ISS-  
GO:0032496response to lipopolysaccharide-ISS-  
GO:0032728positive regulation of interferon-beta production-IEA-  
GO:0033151V(D)J recombination-ISS-  
GO:0042493response to drug-ISS-  
GO:0043388positive regulation of DNA binding-IDA19965638  
GO:0045087innate immune response-IEA-  
GO:0045089positive regulation of innate immune response-IEA-  
GO:0045648positive regulation of erythrocyte differentiation-IMP19965638  
GO:0045654positive regulation of megakaryocyte differentiation-IMP19965638  
GO:0045892negative regulation of transcription, DNA-templated-IDA9636147  
GO:0045893positive regulation of transcription, DNA-templated-IDA19965638  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA19223331  19965638  
GO:0048545response to steroid hormone-IEA-  
GO:0050767regulation of neurogenesis-ISS-  
GO:0050829defense response to Gram-negative bacterium-IDA23877675  
GO:0050830defense response to Gram-positive bacterium-IDA23877675  
GO:0050918positive chemotaxis-IEA-  
GO:0051103DNA ligation involved in DNA repair-ISS-  
GO:0060326cell chemotaxis-IDA19811285  
GO:0071222cellular response to lipopolysaccharide-IEP19811285  
GO:0072091regulation of stem cell proliferation-ISS-  
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-ISS-  
GO:0000793condensed chromosome-IDA12925773  
GO:0005615extracellular space-IDA19811285  
GO:0005623cell-IDA15496585  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA8339930  11909973  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IDA11909973  
GO:0032991protein-containing complex-IDA11909973  
GO:0048471perinuclear region of cytoplasm-IDA9010268  11909973  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-140342Apoptosis induced DNA fragmentationTAS
R-HSA-211227Activation of DNA fragmentation factorTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-75153Apoptotic execution phaseTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19706323A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference. (2010 Feb)Wixted WEToxicol In Vitro