Gene info: ID 3156

Gene: HMGCR

GENE ID: 3156

Synonyms: LDLCQ3

Description: 3-hydroxy-3-methylglutaryl-CoA reductase

Gene type: protein-coding

Location: 5q13.3

dbXrefs: Ensembl:ENSG00000113161 MIM:142910 Vega:OTTHUMG00000102069 UniprotKB:P04035

RefSeq: NG_011449.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.690e-1 (AD) 8.404e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DYNC1LI1	0.931
ATP6V1A	0.92
KIF3A	0.917
MTMR9	0.915
ITFG1	0.914
NECAP1	0.914
DHCR24	0.913
KIFAP3	0.913
WDR47	0.912
RNMT	0.909

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.485
CSAG1	-0.457
OR4F29	-0.441
MTRNR2L10	-0.428
ASB4	-0.425
MTRNR2L9	-0.421
MTRNR2L6	-0.415
MTRNR2L8	-0.412
NFE2	-0.412
RNF135	-0.411

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB00175	Pravastatin	Small Molecule	81093-37-0	Approved	Target
DB00227	Lovastatin	Small Molecule	75330-75-5	Approved\|Investigational	Target
DB00439	Cerivastatin	Small Molecule	145599-86-6	Approved\|Withdrawn	Target
DB00641	Simvastatin	Small Molecule	79902-63-9	Approved	Target
DB01076	Atorvastatin	Small Molecule	134523-00-5	Approved	Target
DB01095	Fluvastatin	Small Molecule	93957-54-1	Approved	Target
DB01098	Rosuvastatin	Small Molecule	287714-41-4	Approved	Target
DB01992	Coenzyme A	Small Molecule	85-61-0	Investigational\|Nutraceutical	Target
DB03169	(S)-Hmg-Coa	Small Molecule		Experimental	Target
DB03461	2'-Monophosphoadenosine 5'-Diphosphoribose	Small Molecule		Experimental	Target
DB04377	3-Hydroxy-3-Methyl-Glutaric Acid	Small Molecule		Experimental	Target
DB04447	1,4-Dithiothreitol	Small Molecule	3483-12-3	Experimental	Target
DB05317	TAK-475	Small Molecule	-	Investigational	Target
DB06693	Mevastatin	Small Molecule	73573-88-3	Experimental	Target
DB08860	Pitavastatin	Small Molecule	147511-69-1	Approved	Target
DB09061	Cannabidiol	Small Molecule	13956-29-1	Approved\|Investigational	Enzyme
DB09270	Ubidecarenone	Small Molecule	303-98-0	Approved\|Investigational\|Nutraceutical	Enzyme

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of HMGCR mRNA"	16269432
C026486	1,2,5,6-dibenzanthracene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of HMGCR mRNA"	17690111
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of HMGCR mRNA"	27071940
C472829	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of HMGCR mRNA]"	27071940
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of HMGCR mRNA"	19162173
C033489	1,3-dichloro-2-propanol	"1,3-dichloro-2-propanol results in increased expression of HMGCR protein"	24333398
C018406	1-(3-trifluoromethylphenyl)piperazine	1-(3-trifluoromethylphenyl)piperazine results in increased expression of HMGCR mRNA	26821219
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HMGCR mRNA"	22698814\|2890350
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HMGCR mRNA]"	22698814
C490166	1-(4-methoxyphenyl)piperazine	1-(4-methoxyphenyl)piperazine results in increased expression of HMGCR mRNA	26821219
C062078	1-(carboxymethylthio)tetradecane	1-(carboxymethylthio)tetradecane promotes the reaction [olanzapine results in decreased expression of HMGCR mRNA]	23226405
C062078	1-(carboxymethylthio)tetradecane	1-(carboxymethylthio)tetradecane results in decreased expression of HMGCR mRNA	23226405
C062078	1-(carboxymethylthio)tetradecane	olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of HMGCR mRNA]	23226405
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in decreased expression of HMGCR mRNA	28329830
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of HMGCR mRNA"	27291303
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of HMGCR mRNA"	21920950
C060080	2,2-bis(bromomethyl)-1,3-propanediol	"2,2-bis(bromomethyl)-1,3-propanediol results in decreased expression of HMGCR mRNA"	24273086
C003585	22-hydroxycholesterol	22-hydroxycholesterol results in decreased expression of HMGCR mRNA	19426978
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HMGCR mRNA"	19114083
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of HMGCR mRNA"	20005886
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in decreased expression of HMGCR mRNA]"	23756648
C013930	2,4-dibromophenol	"2,4-dibromophenol results in increased expression of HMGCR mRNA"	17447562
C044563	24-hydroxycholesterol	24-hydroxycholesterol results in decreased activity of HMGCR protein	7751816
C007997	25-hydroxycholesterol	[25-hydroxycholesterol co-treated with Mevalonic Acid] results in increased ubiquitination of HMGCR protein	21944868
C007997	25-hydroxycholesterol	25-hydroxycholesterol metabolite results in decreased activity of HMGCR protein	9059514
C007997	25-hydroxycholesterol	25-hydroxycholesterol results in decreased activity of HMGCR protein	18024962\|7749852
C007997	25-hydroxycholesterol	Dehydroepiandrosterone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]	9059514
C007997	25-hydroxycholesterol	Pregnenolone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]	9059514
C007997	25-hydroxycholesterol	25-hydroxycholesterol results in decreased expression of HMGCR mRNA	19260826
C007997	25-hydroxycholesterol	25-hydroxycholesterol results in decreased expression of HMGCR protein	19260826
C007997	25-hydroxycholesterol	25-hydroxycholesterol results in decreased activity of HMGCR protein	7749852
C058194	26-aminocholesterol	26-aminocholesterol results in decreased activity of HMGCR protein	7749852
C058194	26-aminocholesterol	26-aminocholesterol results in decreased activity of HMGCR protein	7749852
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of HMGCR mRNA"	20406850
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of HMGCR mRNA"	21346803
C486873	27-hydroxy-4-cholesten-3-one	27-hydroxy-4-cholesten-3-one results in decreased activity of HMGCR protein	7751816
C076996	27-hydroxycholesterol	27-hydroxycholesterol metabolite results in decreased activity of HMGCR protein	9059514
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in decreased activity of HMGCR protein	18024962\|7749852
C076996	27-hydroxycholesterol	[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein	11408283
C076996	27-hydroxycholesterol	Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]	9059514
C076996	27-hydroxycholesterol	Pregnenolone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]	9059514
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in decreased activity of HMGCR protein	14614521
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in decreased activity of HMGCR protein	7749852\|7788503
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in decreased expression of HMGCR mRNA	28167099
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in decreased expression of HMGCR protein	28167099
C050483	32-hydroxy-24,25-dihydrolanosterol	"32-hydroxy-24,25-dihydrolanosterol results in decreased activity of HMGCR protein"	12617470
C050483	32-hydroxy-24,25-dihydrolanosterol	"32-hydroxy-24,25-dihydrolanosterol results in decreased activity of HMGCR protein"	12617470
C032790	3,3',4,4',5,5'-hexabromobiphenyl	"3,3',4,4',5,5'-hexabromobiphenyl results in increased expression of HMGCR mRNA"	17447562
C036685	3,3',4,4'-tetrabromobiphenyl	"3,3',4,4'-tetrabromobiphenyl results in increased expression of HMGCR mRNA"	17447562
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HMGCR mRNA"	20574914
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HMGCR mRNA"	23196670
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of HMGCR mRNA	16788091
C008047	3-hydroxy-3-methylglutaryl-coenzyme A	HMGCR protein results in increased metabolism of 3-hydroxy-3-methylglutaryl-coenzyme A	19254925
C031285	3-xylene	3-xylene results in decreased expression of HMGCR mRNA	12815608
C482648	4-(1-(4-tert-butylphenyl)-2-oxo-4-pyrrolidinyl)methoxybenzoic acid	4-(1-(4-tert-butylphenyl)-2-oxo-4-pyrrolidinyl)methoxybenzoic acid metabolite results in decreased activity of HMGCR protein	12809954
C575631	4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile	"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of HMGCR mRNA"	21218783
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of HMGCR mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HMGCR mRNA"	27188386
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of HMGCR mRNA"	21346803
C573233	5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one	"[Dietary Fats co-treated with 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one] results in decreased expression of HMGCR mRNA"	24646949
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HMGCR mRNA"	27188386
C550547	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	"[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]"	21212096
C031477	7-hydroxycoumarin	7-hydroxycoumarin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]	26995004
C003001	7-ketocholesterol	[7-ketocholesterol co-treated with KNG1 protein modified form] results in decreased expression of HMGCR mRNA	23454145
C003001	7-ketocholesterol	[7-ketocholesterol co-treated with Oligomycins] results in decreased expression of HMGCR mRNA	23454145
C003001	7-ketocholesterol	[7-ketocholesterol co-treated with Rotenone] results in decreased expression of HMGCR mRNA	23454145
C003001	7-ketocholesterol	7-ketocholesterol results in decreased activity of HMGCR protein	7751816
C003001	7-ketocholesterol	7-ketocholesterol results in increased expression of HMGCR mRNA	23454145
D000082	Acetaminophen	Acetaminophen results in decreased expression of HMGCR mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of HMGCR mRNA	15030884\|1756273
D000082	Acetaminophen	Acetaminophen results in decreased expression of HMGCR mRNA	18246545
D000082	Acetaminophen	Acetaminophen results in increased expression of HMGCR mRNA	17202762
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]	19931295
D020106	Acrylamide	Acrylamide results in increased expression of HMGCR mRNA	28959563
C096064	actein	actein affects the expression of HMGCR mRNA	19527300
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HMGCR mRNA	21641981\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of HMGCR gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HMGCR mRNA	19770486
C006453	alliin	alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]	16640830
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]	19931295
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein]	19931295
D024502	alpha-Tocopherol	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in increased activity of HMGCR protein]	21535577
D024502	alpha-Tocopherol	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]	19595682
D000638	Amiodarone	Amiodarone results in increased expression of HMGCR mRNA	24489787
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HMGCR mRNA	16483693
C101036	ammonium metavanadate	[Ascorbic Acid co-treated with ammonium metavanadate] affects the activity of HMGCR protein	1669016
D000924	Anticholesteremic Agents	Anticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of HMGCR mRNA]	28275691
D000924	Anticholesteremic Agents	Anticholesteremic Agents results in increased expression of HMGCR mRNA	28275691
D016718	Arachidonic Acid	Arachidonic Acid results in decreased expression of HMGCR mRNA	16704987
C519728	archazolid B	archazolid B results in increased expression of HMGCR mRNA	25218289
C047721	artemisic acid	[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA	23063590
C047721	artemisic acid	[[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol	23063590
C047721	artemisic acid	artemisic acid results in decreased expression of HMGCR mRNA	23063590
C047721	artemisic acid	artemisic acid results in decreased expression of HMGCR protein	23063590
C047721	artemisic acid	[artemisic acid results in decreased expression of HMGCR protein] which results in decreased chemical synthesis of Cholesterol	23063590
C047721	artemisic acid	CEBPA protein inhibits the reaction [artemisic acid results in decreased expression of HMGCR mRNA]	23063590
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased activity of HMGCR protein"	21257924
D017638	Asbestos, Crocidolite	"manganese protoporphyrin inhibits the reaction [Asbestos, Crocidolite results in decreased activity of HMGCR protein]"	21257924
D017638	Asbestos, Crocidolite	"tempol inhibits the reaction [Asbestos, Crocidolite results in decreased activity of HMGCR protein]"	21257924
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with ammonium metavanadate] affects the activity of HMGCR protein	1669016
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in decreased activity of HMGCR protein	10652993
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of HMGCR mRNA	10652993
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of and results in increased activity of HMGCR protein	9512650
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of HMGCR mRNA	10357840\|1261214
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased activity of HMGCR protein	9653895
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased activity of HMGCR protein	12056585\|1206572
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of and results in increased activity of HMGCR protein	9512650
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of HMGCR mRNA	12056585\|1206572
D000069059	Atorvastatin Calcium	Mevalonic Acid inhibits the reaction [Atorvastatin Calcium results in increased activity of HMGCR protein]	12056585
D000069059	Atorvastatin Calcium	Mevalonic Acid inhibits the reaction [Atorvastatin Calcium results in increased expression of HMGCR mRNA]	12056585
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in decreased activity of HMGCR protein	15616150\|1580238
C406592	azaspiracid	azaspiracid results in increased expression of HMGCR mRNA	28939011
D001379	Azathioprine	Azathioprine results in decreased expression of HMGCR mRNA	22623647
D001548	Benzalkonium Compounds	Benzalkonium Compounds results in increased expression of HMGCR mRNA	26919959
D001554	Benzene	Benzene results in increased expression of HMGCR mRNA	19162166
D001554	Benzene	Benzene affects the expression of HMGCR mRNA	15878777
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of HMGCR mRNA	17690111
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of HMGCR mRNA	16269432
D019324	beta-Naphthoflavone	AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HMGCR mRNA]	22234961
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of HMGCR mRNA	22234961
D019324	beta-Naphthoflavone	AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HMGCR mRNA]	22234961
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of HMGCR mRNA	22234961
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HMGCR mRNA	18164116
D001572	Benzofurans	Benzofurans results in increased expression of HMGCR mRNA	17447562
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of HMGCR mRNA"	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of HMGCR mRNA	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HMGCR mRNA	16269432\|2006483
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HMGCR mRNA	19770486\|2156981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HMGCR mRNA	22300585
D001564	Benzo(a)pyrene	Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]	19931295
D001564	Benzo(a)pyrene	AHR mutant form inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]	19931295
D001564	Benzo(a)pyrene	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]	19931295
D001564	Benzo(a)pyrene	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein]	19931295
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HMGCR mRNA	19931295
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HMGCR protein	19931295
D001564	Benzo(a)pyrene	Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]	19931295
D001564	Benzo(a)pyrene	Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein]	19931295
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HMGCR mRNA"	19150397
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid affects the expression of HMGCR mRNA	18192240
D001629	Bezafibrate	Bezafibrate results in increased activity of HMGCR protein	2044640
D001629	Bezafibrate	Bezafibrate results in decreased activity of HMGCR protein	2044640\|2907502
D001647	Bile Acids and Salts	[CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] which results in increased expression of and results in increased activity of HMGCR protein	16477808
D001663	Bilirubin	[Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein	12700418
C006780	bisphenol A	bisphenol A affects the methylation of HMGCR promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased methylation of HMGCR promoter	27502578
C006780	bisphenol A	bisphenol A results in increased expression of HMGCR mRNA	21932408\|2516818
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in decreased expression of HMGCR mRNA]"	23756648
C006780	bisphenol A	bisphenol A results in increased expression of HMGCR mRNA	24768697
C006780	bisphenol A	bisphenol A results in increased methylation of HMGCR gene	28505145
D001973	Bromodeoxyuridine	[Bromodeoxyuridine co-treated with furan] affects the expression of HMGCR mRNA	24910943
D001973	Bromodeoxyuridine	Bromodeoxyuridine results in increased expression of HMGCR mRNA	24910943
D002079	Butter	Butter results in decreased expression of HMGCR mRNA	16631440
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in increased activity of HMGCR protein	9199277
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of HMGCR mRNA	12414654
C584509	C646 compound	C646 compound results in decreased expression of HMGCR mRNA	26191083
D002104	Cadmium	Cadmium results in increased activity of HMGCR protein	21535577
D002104	Cadmium	Cadmium results in increased expression of HMGCR mRNA	17066326
D002104	Cadmium	myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased activity of HMGCR protein]	25240712
D002104	Cadmium	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in increased activity of HMGCR protein]	21535577
D002104	Cadmium	[Streptozocin co-treated with Cadmium] results in increased activity of HMGCR protein	25240712
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of HMGCR mRNA	24527689
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HMGCR mRNA	23741332
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HMGCR mRNA	17066326\|1901038
C037123	cadmium sulfate	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of HMGCR mRNA	18654764
C040048	caffeic acid	caffeic acid results in decreased expression of HMGCR mRNA	21870829
D000074262	Canola Oil	Canola Oil results in decreased expression of HMGCR mRNA	16631440
D002220	Carbamazepine	Carbamazepine results in decreased expression of HMGCR mRNA	19566492
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of HMGCR mRNA	27339419
C086276	cerivastatin	cerivastatin results in decreased activity of HMGCR protein	11950701\|1580238
D002635	Chenodeoxycholic Acid	HMGCR protein results in decreased susceptibility to Chenodeoxycholic Acid	7461467
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in decreased activity of HMGCR protein	6832710
D048271	Chitosan	Chitosan inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]	28987369
D048271	Chitosan	[Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]	28987369
C035377	chlorendic acid	chlorendic acid results in decreased expression of HMGCR mRNA	24273086
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of HMGCR mRNA	23650126
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of HMGCR mRNA	18178546
D002726	Chlorogenic Acid	Chlorogenic Acid results in decreased expression of HMGCR mRNA	21870829
D002726	Chlorogenic Acid	Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]	20696151
D002726	Chlorogenic Acid	[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]	20696151
D002746	Chlorpromazine	Chlorpromazine results in increased expression of HMGCR mRNA	17052361
C011724	cholest-5-en-3 beta,7 alpha-diol	"cholest-5-en-3 beta,7 alpha-diol results in decreased activity of HMGCR protein"	9199277
C015073	cholest-8(14)-en-3-ol-15-one	cholest-8(14)-en-3-ol-15-one results in decreased activity of HMGCR protein	7751816
D002784	Cholesterol	Cholesterol results in decreased activity of HMGCR protein	10561571
D002784	Cholesterol	[[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol	23063590
D002784	Cholesterol	[artemisic acid results in decreased expression of HMGCR protein] which results in decreased chemical synthesis of Cholesterol	23063590
D002784	Cholesterol	Cholesterol results in decreased activity of HMGCR protein	18024962
D002784	Cholesterol	Cholesterol results in decreased expression of HMGCR mRNA	17516993
D002784	Cholesterol	[Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol	16027736
D002784	Cholesterol	[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein	11408283
D002784	Cholesterol	[Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol	16027736
D002784	Cholesterol	Cholesterol results in decreased expression of HMGCR mRNA	16581047
D002784	Cholesterol	Selenium promotes the reaction [Cholesterol results in decreased expression of HMGCR mRNA]	16581047
D002784	Cholesterol	[turmeric extract co-treated with Cholesterol] results in decreased expression of HMGCR mRNA	21535835
D002784	Cholesterol	HMGCR protein results in increased chemical synthesis of Cholesterol	12700418
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of HMGCR mRNA"	23900008
D002791	Cholesterol, Dietary	"Plant Preparations inhibits the reaction [Cholesterol, Dietary results in increased expression of HMGCR mRNA]"	23900008
D008078	Cholesterol, LDL	"HMGCR polymorphism affects the abundance of Cholesterol, LDL"	18332269
D015243	Cholesterol, VLDL	"HMGCR intron polymorphism results in increased abundance of Cholesterol, VLDL"	17870053
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HMGCR mRNA	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of HMGCR mRNA	18952117
D002794	Choline	RXRA gene mutant form promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of HMGCR mRNA]	18952117
D002857	Chromium	Chromium results in decreased expression of HMGCR mRNA	17547211
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of HMGCR mRNA	28472532
D002922	Ciguatoxins	Ciguatoxins affects the expression of HMGCR mRNA	18353800
C029010	cinnamic acid	cinnamic acid results in decreased expression of HMGCR mRNA	21870829
D002994	Clofibrate	Clofibrate results in decreased expression of HMGCR mRNA	17495091
D002994	Clofibrate	Clofibrate results in decreased expression of HMGCR	16502264
D002994	Clofibrate	Clofibrate results in decreased activity of HMGCR protein	18611391
D002994	Clofibrate	Clofibrate results in decreased expression of HMGCR mRNA	23811191
D002994	Clofibrate	Clofibrate results in decreased expression of HMGCR protein	20573577
D002994	Clofibrate	[Clofibrate co-treated with Diethylhexyl Phthalate] results in decreased expression of HMGCR mRNA	9207284
D002994	Clofibrate	Clofibrate results in decreased activity of HMGCR protein	1327145
D002994	Clofibrate	Clofibrate results in decreased expression of HMGCR mRNA	12518023\|1712630
D002994	Clofibrate	Mevalonic Acid inhibits the reaction [Clofibrate results in decreased expression of HMGCR mRNA]	12518023
D003024	Clozapine	Clozapine results in increased activity of HMGCR protein	16027736
D003024	Clozapine	[Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol	16027736
D003024	Clozapine	[Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides	16027736
D003024	Clozapine	Clozapine results in increased expression of HMGCR mRNA	16027736\|1705236
C018021	cobaltous chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of HMGCR mRNA	18654764
C018021	cobaltous chloride	cobaltous chloride results in increased expression of HMGCR mRNA	19376846
D000069472	Colesevelam Hydrochloride	Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA]	22120639
D000069472	Colesevelam Hydrochloride	Colesevelam Hydrochloride results in increased expression of HMGCR mRNA	22120639
D005576	Colforsin	AR protein promotes the reaction [Colforsin results in increased expression of HMGCR protein]	16751804
D005576	Colforsin	Colforsin affects the expression of HMGCR mRNA	20726872
D005576	Colforsin	[Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA	16935330
D005576	Colforsin	Colforsin results in increased expression of HMGCR mRNA	16751804\|1693533
D005576	Colforsin	Valproic Acid affects the reaction [Colforsin affects the expression of HMGCR mRNA]	20726872
D003300	Copper	Copper results in decreased expression of HMGCR mRNA	20020678
D003300	Copper	Copper results in decreased expression of HMGCR mRNA	17205981
D003300	Copper	Copper results in increased expression of HMGCR mRNA	22465980
C098468	copper histidine	copper histidine results in increased expression of HMGCR mRNA	24170205
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of HMGCR mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in increased expression of HMGCR mRNA	12860252
D003314	Corn Oil	Corn Oil affects the expression of HMGCR mRNA	16360708
C030123	coumarin	coumarin results in increased expression of HMGCR mRNA	18480146
C551994	crizotinib	crizotinib results in increased expression of HMGCR mRNA	23707608
D003474	Curcumin	Curcumin results in increased expression of HMGCR mRNA	16713233
D003474	Curcumin	Curcumin affects the expression of HMGCR mRNA	27208389
D003474	Curcumin	Curcumin affects the expression of HMGCR protein	27208389
D003474	Curcumin	Curcumin results in decreased expression of HMGCR mRNA	27208389
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of HMGCR mRNA	25497113
C009160	cyclonite	cyclonite results in increased expression of HMGCR mRNA	25559034
D016572	Cyclosporine	Cyclosporine results in decreased expression of HMGCR mRNA	20106945\|2163298
D016572	Cyclosporine	Cyclosporine results in increased expression of HMGCR mRNA	17516993
D016572	Cyclosporine	Cyclosporine results in decreased expression of HMGCR mRNA	19224547
C093628	cyproconazole	cyproconazole affects the expression of HMGCR mRNA	22045034
C100330	cytosterone	cytosterone results in decreased activity of HMGCR protein	7751816
D015084	2,4-Dichlorophenoxyacetic Acid	"2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCR"	26838045
C014347	decitabine	decitabine affects the expression of HMGCR mRNA	23300844
D003897	Desmosterol	Desmosterol results in decreased expression of HMGCR protein	19260826
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]	9059514
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]	9059514
C007262	deoxynivalenol	deoxynivalenol results in decreased expression of HMGCR mRNA	22982764
C521776	Desmodium gangeticum extract	Desmodium gangeticum extract affects the activity of HMGCR protein	15740881
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of HMGCR mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of HMGCR mRNA	16962226
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in decreased expression of HMGCR mRNA"	16269432
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of HMGCR mRNA	17379624\|2126653
D002945	Cisplatin	Cisplatin affects the expression of HMGCR mRNA	23300844
D002945	Cisplatin	Cisplatin results in decreased expression of HMGCR mRNA	27594783
C000944	dicrotophos	dicrotophos results in decreased expression of HMGCR mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of HMGCR mRNA	26924002
D004041	Dietary Fats	"[Dietary Fats co-treated with 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one] results in decreased expression of HMGCR mRNA"	24646949
D004041	Dietary Fats	Dietary Fats results in increased activity of HMGCR protein	18166149
D004041	Dietary Fats	Dietary Fats results in increased expression of HMGCR mRNA	18166149\|2470957
D004041	Dietary Fats	resveratrol inhibits the reaction [Dietary Fats results in increased activity of HMGCR protein]	18166149
D004041	Dietary Fats	resveratrol inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]	18166149
D004041	Dietary Fats	zerumbone inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]	24709573
D004041	Dietary Fats	Anticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of HMGCR mRNA]	28275691
D004041	Dietary Fats	Dietary Fats affects the expression of HMGCR mRNA	19680557
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of HMGCR mRNA	28275691\|2843392
D004041	Dietary Fats	Dietary Fats results in decreased expression of HMGCR mRNA	23756648
D004041	Dietary Fats	Dietary Fats results in increased expression of HMGCR mRNA	18292748
D004041	Dietary Fats	[Sodium Cholate co-treated with Dietary Fats] results in decreased expression of HMGCR mRNA	23665937
D004041	Dietary Fats	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in decreased expression of HMGCR mRNA]"	23756648
D004041	Dietary Fats	Chitosan inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]	28987369
D004041	Dietary Fats	Dietary Fats results in decreased expression of HMGCR mRNA	23524313
D004041	Dietary Fats	Dietary Fats results in decreased expression of HMGCR protein	23524313
D004041	Dietary Fats	Dietary Fats results in increased expression of HMGCR mRNA	28987369
D004041	Dietary Fats	Dietary Fats results in increased expression of HMGCR protein	25087745
D004041	Dietary Fats	[Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]	28987369
D004041	Dietary Fats	Fish Oils inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]	28987369
D004041	Dietary Fats	orlistat inhibits the reaction [Dietary Fats results in increased expression of HMGCR protein]	25087745
D004041	Dietary Fats	piperine inhibits the reaction [Dietary Fats results in increased expression of HMGCR protein]	25087745
D019422	Dietary Sucrose	Anticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of HMGCR mRNA]	28275691
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of HMGCR mRNA	28275691\|2843392
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of HMGCR mRNA	25975992
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HMGCR mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of HMGCR mRNA]	19850644
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in decreased expression of HMGCR mRNA]"	23756648
D004051	Diethylhexyl Phthalate	[Clofibrate co-treated with Diethylhexyl Phthalate] results in decreased expression of HMGCR mRNA	9207284
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of HMGCR mRNA	24535843
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HMGCR mRNA	18164116
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of HMGCR mRNA	28943392
C115058	difenoconazole	difenoconazole results in increased expression of HMGCR mRNA	28263823
C025605	diisobutyl phthalate	diisobutyl phthalate results in decreased expression of HMGCR mRNA	28655647
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of HMGCR mRNA	17547211
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of HMGCR mRNA	25380136
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of HMGCR mRNA	26924002
C027387	di-n-hexyl phthalate	di-n-hexyl phthalate results in decreased expression of HMGCR mRNA	26934186
C051904	dinophysistoxin 1	dinophysistoxin 1 results in decreased expression of HMGCR mRNA	28939011
D004726	Endosulfan	Endosulfan results in decreased expression of HMGCR mRNA	12735107
C100264	enniatins	enniatins results in decreased expression of HMGCR mRNA	25625232
C118739	entinostat	entinostat results in decreased expression of HMGCR mRNA	27188386
C031365	epomediol	epomediol results in increased activity of HMGCR protein	10961725\|1147352
D000431	Ethanol	Ethanol results in decreased activity of HMGCR protein	22841563
D000431	Ethanol	Ethanol results in increased expression of HMGCR mRNA	19167417
D000431	Ethanol	Ethanol results in increased activity of HMGCR protein	28442378
D000431	Ethanol	zingerone inhibits the reaction [Ethanol results in increased activity of HMGCR protein]	28442378
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased activity of HMGCR protein	11473529
C002994	ethylene dimethanesulfonate	ethylene dimethanesulfonate results in decreased expression of HMGCR mRNA	22711419
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of HMGCR mRNA	23649840
C010087	eucalyptol	eucalyptol results in decreased expression of HMGCR protein	24613879
D005054	Eugenol	Eugenol results in decreased expression of HMGCR mRNA	21870829
D000069438	Ezetimibe	Ezetimibe results in increased activity of HMGCR protein	17980884
D000069438	Ezetimibe	[Simvastatin co-treated with Ezetimibe] results in increased expression of HMGCR mRNA	17980884
D000069438	Ezetimibe	Ezetimibe results in increased expression of HMGCR mRNA	17130282
D000069438	Ezetimibe	Simvastatin promotes the reaction [Ezetimibe results in increased expression of HMGCR mRNA]	17130282
C004808	farnesyl pyrophosphate	[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate	17208200
D005228	Fatty Acids, Essential	"Fatty Acids, Essential deficiency results in increased expression of HMGCR mRNA"	23333450
D005231	Fatty Acids, Unsaturated	"Fatty Acids, Unsaturated results in increased expression of HMGCR mRNA"	18356535
C033789	fenarimol	fenarimol results in increased expression of HMGCR mRNA	28970091
D011345	Fenofibrate	Fenofibrate results in increased expression of HMGCR mRNA	23063693
D011345	Fenofibrate	NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]	23063693
D011345	Fenofibrate	NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]	23063693
D011345	Fenofibrate	Fenofibrate results in decreased expression of HMGCR mRNA	16595124
C004999	ferulic acid	ferulic acid results in decreased expression of HMGCR mRNA	21870829
D000068876	Fingolimod Hydrochloride	Fingolimod Hydrochloride results in increased expression of HMGCR mRNA	24356939
D005395	Fish Oils	[Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]	28987369
D005395	Fish Oils	Fish Oils inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]	28987369
D005411	Flame Retardants	Flame Retardants results in decreased expression of HMGCR mRNA	17447562
D005411	Flame Retardants	Flame Retardants results in increased expression of HMGCR mRNA	17447562
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in decreased expression of HMGCR mRNA	28329830
C007738	fluoranthene	fluoranthene results in decreased expression of HMGCR mRNA	28329830
C061365	flusilazole	flusilazole affects the expression of HMGCR mRNA	22634333
D005485	Flutamide	Flutamide results in decreased expression of HMGCR mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of HMGCR mRNA	24136188
C065180	fluvastatin	[APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin	19773416
C065180	fluvastatin	fluvastatin results in decreased activity of HMGCR protein	8593127
C065180	fluvastatin	fluvastatin results in decreased activity of HMGCR protein	11335104\|1580238
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HMGCR mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in decreased expression of HMGCR mRNA	23649840
D005632	Fructose	"[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]"	21212096
D005632	Fructose	Fructose results in increased expression of HMGCR mRNA	19193814\|2121209
D005632	Fructose	[Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]	21212096
D005632	Fructose	Rotenone inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]	21212096
D005632	Fructose	Tea inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]	19193814
C025164	fucoxanthin	fucoxanthin results in decreased activity of HMGCR protein	20519145
C039281	furan	[Bromodeoxyuridine co-treated with furan] affects the expression of HMGCR mRNA	24910943
C039281	furan	furan results in increased expression of HMGCR mRNA	24183702
C039281	furan	furan results in increased methylation of HMGCR gene	22079235
D019833	Genistein	[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of HMGCR mRNA	27181934
D005839	Gentamicins	Gentamicins results in increased expression of HMGCR mRNA	22061828
C511282	geranyl diphosphate	HMGCR protein results in increased abundance of geranyl diphosphate	19856009
C511282	geranyl diphosphate	Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate]	19856009
C017338	geranylgeraniol	[geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein	19819230
C002963	geranylgeranyl pyrophosphate	[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate	17208200
C015234	geranyl pyrophosphate	[geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein	19819230
D005897	Glafenine	Glafenine results in increased expression of HMGCR mRNA	24136188
D005978	Glutathione	Glutathione deficiency results in increased expression of HMGCR mRNA	15345336
D006220	Haloperidol	Haloperidol results in increased activity of HMGCR protein	16027736
D006220	Haloperidol	[Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol	16027736
D006220	Haloperidol	[Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides	16027736
D006220	Haloperidol	Haloperidol results in increased expression of HMGCR mRNA	16027736\|1705236
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in increased expression of HMGCR mRNA	25270620
D006569	Hesperidin	Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]	16427799
C012351	HT-2 toxin	HT-2 toxin results in decreased expression of HMGCR mRNA	22982764
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of HMGCR mRNA	12414654
D006861	Hydrogen Peroxide	[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCR mRNA	18032389
D019161	Hydroxymethylglutaryl-CoA Reductase Inhibitors	Hydroxymethylglutaryl-CoA Reductase Inhibitors results in decreased activity of HMGCR protein	19505369
C492448	ICG 001	ICG 001 results in decreased expression of HMGCR mRNA	26191083
C011582	IMOL S-140	IMOL S-140 results in increased expression of HMGCR mRNA	26894911
D007220	Industrial Waste	Industrial Waste results in increased expression of HMGCR mRNA	26055946
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HMGCR mRNA	25613284
C051140	iron(II)-ascorbic acid complex	iron(II)-ascorbic acid complex results in increased activity of HMGCR protein	10898742
C051140	iron(II)-ascorbic acid complex	iron(II)-ascorbic acid complex results in decreased activity of HMGCR protein	10656290
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of HMGCR mRNA	16054899
D007545	Isoproterenol	7-hydroxycoumarin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]	26995004
D007545	Isoproterenol	alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]	16640830
D007545	Isoproterenol	Isoproterenol results in increased activity of HMGCR protein	16640830\|1690652
D007545	Isoproterenol	naringin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]	16906524
D007545	Isoproterenol	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]	19595682
C016527	isoquercitrin	[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of HMGCR mRNA	18032389
C544151	jinfukang	jinfukang results in decreased expression of HMGCR mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of HMGCR protein	17337753
C468270	Kangen-karyu	Kangen-karyu results in decreased expression of HMGCR mRNA	21155823
D007649	Ketamine	Ketamine results in decreased expression of HMGCR mRNA	20080153
D007653	Ketocholesterols	Ketocholesterols results in decreased activity of HMGCR protein	9779586
D007653	Ketocholesterols	Ketocholesterols results in decreased activity of HMGCR protein	9199277
D007654	Ketoconazole	[Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA	16935330
D007654	Ketoconazole	Ketoconazole results in decreased expression of HMGCR mRNA	16935330
D007654	Ketoconazole	Ketoconazole results in decreased activity of HMGCR protein	12617470
D007654	Ketoconazole	Ketoconazole results in increased activity of HMGCR protein	9199277
D007654	Ketoconazole	Ketoconazole results in increased expression of HMGCR mRNA	28263823
C032444	lanosten-3-ol-32-al	lanosten-3-ol-32-al results in decreased activity of HMGCR protein	12617470
C032444	lanosten-3-ol-32-al	lanosten-3-ol-32-al results in decreased activity of HMGCR protein	12617470
C015316	lanostenol	lanostenol results in decreased activity of HMGCR protein	18024962
D007854	Lead	Lead affects the expression of HMGCR	22001170
D007854	Lead	puerarin affects the reaction [Lead affects the expression of HMGCR]	22001170
C029891	lead chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of HMGCR mRNA	18654764
C017461	lead nitrate	[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]	22293356
C017461	lead nitrate	lead nitrate results in increased expression of HMGCR mRNA	22293356
C017461	lead nitrate	lead nitrate results in increased expression of HMGCR mRNA	15475176
C045463	leflunomide	leflunomide results in increased expression of HMGCR mRNA	24136188
C018584	linalool	linalool inhibits the reaction [KAT2B protein binds to HMGCR promoter]	21944868
C018584	linalool	linalool inhibits the reaction [SREBF2 protein binds to HMGCR promoter]	21944868
C018584	linalool	linalool results in decreased expression of and results in increased ubiquitination of HMGCR protein	21944868
C018584	linalool	linalool results in decreased expression of HMGCR mRNA	21944868
C018584	linalool	linalool results in decreased expression of HMGCR protein	24613879
C018584	linalool	linalool results in decreased expression of HMGCR mRNA	21944868
C018584	linalool	linalool results in decreased expression of HMGCR protein	21944868
D008095	Lithocholic Acid	[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of HMGCR mRNA	20359477
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA]	19109942
D008148	Lovastatin	Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate]	19856009
D008148	Lovastatin	Lovastatin results in decreased activity of HMGCR protein	17208200\|1969981
D008148	Lovastatin	[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate	17208200
D008148	Lovastatin	[Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate	17208200
D008148	Lovastatin	Lovastatin results in increased expression of HMGCR mRNA	19260826\|8517861
D008148	Lovastatin	Lovastatin affects the expression of HMGCR mRNA	27208389
D008148	Lovastatin	Lovastatin results in increased expression of HMGCR mRNA	19260826
D008148	Lovastatin	Lovastatin results in decreased activity of HMGCR protein	15616150\|1843450
D008345	Manganese	[Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein	12700418
D008345	Manganese	Manganese results in increased activity of HMGCR protein	12700418
C038654	manganese protoporphyrin	"manganese protoporphyrin inhibits the reaction [Asbestos, Crocidolite results in decreased activity of HMGCR protein]"	21257924
C038654	manganese protoporphyrin	manganese protoporphyrin inhibits the reaction [Vitamin K 3 results in decreased activity of HMGCR protein]	21257924
D008383	Margarine	Margarine results in decreased expression of HMGCR mRNA	16631440
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of HMGCR mRNA	16507785
D008687	Metformin	Metformin results in decreased expression of HMGCR mRNA	21870829
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of HMGCR mRNA	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of HMGCR mRNA	18952117
D008715	Methionine	RXRA gene mutant form promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of HMGCR mRNA]	18952117
C002950	methylformamide	methylformamide affects the expression of HMGCR mRNA	17040096
C002950	methylformamide	methylformamide analog affects the expression of HMGCR mRNA	17040096
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of HMGCR mRNA	16966085
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of HMGCR mRNA	23649840
D015741	Metribolone	Metribolone results in increased expression of HMGCR mRNA	16751804
D015741	Metribolone	Metribolone results in increased expression of HMGCR protein	16751804
D008798	Mevalonic Acid	[25-hydroxycholesterol co-treated with Mevalonic Acid] results in increased ubiquitination of HMGCR protein	21944868
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Atorvastatin Calcium results in increased activity of HMGCR protein]	12056585
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Atorvastatin Calcium results in increased expression of HMGCR mRNA]	12056585
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Clofibrate results in decreased expression of HMGCR mRNA]	12518023
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of HMGCR protein]	12056585
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]	12056585
D008798	Mevalonic Acid	HMGCR protein results in increased chemical synthesis of Mevalonic Acid	16450390\|1925492
C015367	mevalonolactone	mevalonolactone results in decreased activity of HMGCR protein	3042028
C012258	mevastatin	mevastatin results in decreased activity of HMGCR protein	10814523\|1645039
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of HMGCR mRNA	23118965
C016599	mono-(2-ethylhexyl)phthalate	[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of HMGCR mRNA	27181934
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of HMGCR mRNA	24625837
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of HMGCR protein	24625837
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of HMGCR mRNA	20024957
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of HMGCR mRNA	26924002
C105620	morelloflavone	morelloflavone results in decreased activity of HMGCR protein	24995575
C040015	myricetin	myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased activity of HMGCR protein]	25240712
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of HMGCR mRNA"	29244179
C511794	N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide	"N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide results in decreased expression of HMGCR mRNA"	22205993
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of HMGCR mRNA"	23845593
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of HMGCR mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of HMGCR mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of HMGCR mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of HMGCR mRNA	25380136
C005274	naringin	naringin affects the reaction [LEPR protein affects the activity of HMGCR protein]	16427799
C005274	naringin	naringin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]	16906524
C461488	N-benzylpiperazine	N-benzylpiperazine results in increased expression of HMGCR mRNA	26821219
C051752	nefazodone	nefazodone results in increased expression of HMGCR mRNA	24136188
C022838	nickel chloride	nickel chloride results in decreased expression of HMGCR mRNA	17312168
D009538	Nicotine	Nicotine results in increased expression of HMGCR mRNA	23416264
C012655	nimesulide	nimesulide results in increased expression of HMGCR mRNA	24136188
C570896	NSC305787	NSC305787 results in increased expression of HMGCR mRNA	27137931
C464660	obeticholic acid	obeticholic acid results in decreased expression of HMGCR mRNA	27939613
D019319	Okadaic Acid	Okadaic Acid results in decreased expression of HMGCR mRNA	28939011
C076029	olanzapine	olanzapine results in increased expression of HMGCR mRNA	17052361
C076029	olanzapine	1-(carboxymethylthio)tetradecane promotes the reaction [olanzapine results in decreased expression of HMGCR mRNA]	23226405
C076029	olanzapine	olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of HMGCR mRNA]	23226405
C076029	olanzapine	olanzapine results in decreased expression of HMGCR mRNA	23226405
D009840	Oligomycins	[7-ketocholesterol co-treated with Oligomycins] results in decreased expression of HMGCR mRNA	23454145
D009840	Oligomycins	[Stigmasterol co-treated with Oligomycins] results in decreased expression of HMGCR mRNA	23454145
D009840	Oligomycins	Oligomycins results in increased expression of HMGCR mRNA	23227865
D015525	Fatty Acids, Omega-3	"[Fatty Acids, Omega-3 deficiency co-treated with Vehicle Emissions] results in increased expression of HMGCR mRNA"	29175182
D015525	Fatty Acids, Omega-3	"Fatty Acids, Omega-3 deficiency results in increased expression of HMGCR mRNA"	29175182
C055122	orlistat	orlistat inhibits the reaction [Dietary Fats results in increased expression of HMGCR protein]	25087745
D000073878	Palm Oil	Palm Oil affects the expression of HMGCR mRNA	19680557
D052638	Particulate Matter	Particulate Matter results in increased expression of HMGCR mRNA	22861003
C098189	pentabromophenol	pentabromophenol results in decreased expression of HMGCR mRNA	17447562
C098189	pentabromophenol	pentabromophenol results in increased expression of HMGCR mRNA	17447562
D010433	Pentylenetetrazole	Pentylenetetrazole affects the expression of HMGCR mRNA	21503142
C003072	perflubron	perflubron results in increased expression of HMGCR mRNA	25871633
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in increased expression of HMGCR mRNA	19617454
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in increased expression of HMGCR mRNA	21705711
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in decreased expression of HMGCR mRNA	21641976
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of HMGCR mRNA	19617454
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of HMGCR mRNA	17560707
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of HMGCR mRNA	23074026
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of HMGCR mRNA	19429403\|2093613
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased activity of HMGCR protein	1327145
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HMGCR mRNA	23399300
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HMGCR mRNA	23978341
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HMGCR mRNA	19429403\|2509218
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased activity of HMGCR protein	1327145
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of HMGCR mRNA	19162173
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of HMGCR mRNA	17097637
D026023	Permethrin	Permethrin analog results in decreased expression of HMGCR mRNA	21745691
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HMGCR mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of HMGCR mRNA	26272509
D010665	Phenylpropanolamine	Phenylpropanolamine results in increased expression of HMGCR mRNA	27756839
C018637	phorone	phorone affects the expression of HMGCR mRNA	18198479
D010713	Phosphatidylcholines	Phosphatidylcholines results in increased activity of HMGCR protein	12559476
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of HMGCR mRNA	15728792
D010840	Phytosterols	APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HMGCR mRNA]	18155511
C060836	pioglitazone	pioglitazone results in increased expression of HMGCR mRNA	12044893
C060836	pioglitazone	pioglitazone results in decreased expression of HMGCR mRNA	20503262
C008922	piperine	piperine inhibits the reaction [Dietary Fats results in increased expression of HMGCR protein]	25087745
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HMGCR mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of HMGCR mRNA	15777286\|1844570
C006253	pirinixic acid	pirinixic acid results in decreased expression of HMGCR mRNA	17126302
C016908	pirinixil	pirinixil results in decreased expression of HMGCR mRNA	9207284
D010894	Piroxicam	Piroxicam results in decreased expression of HMGCR mRNA	21858171
C108475	pitavastatin	pitavastatin results in decreased activity of HMGCR protein	15955871
D010936	Plant Extracts	Plant Extracts results in increased expression of HMGCR mRNA	23557933
D028321	Plant Preparations	"Plant Preparations inhibits the reaction [Cholesterol, Dietary results in increased expression of HMGCR mRNA]"	23900008
D011137	Polystyrenes	Polystyrenes analog results in decreased expression of HMGCR mRNA	25102311
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of HMGCR mRNA	22714537
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of HMGCR mRNA	17547211
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of HMGCR mRNA	23718831
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of HMGCR mRNA	23608068
D017035	Pravastatin	HMGCR gene SNP results in decreased susceptibility to Pravastatin	15199031
D017035	Pravastatin	Pravastatin affects the expression of HMGCR mRNA	8517861
D017035	Pravastatin	Pravastatin results in decreased activity of HMGCR protein	8593127
D017035	Pravastatin	Pravastatin results in increased expression of HMGCR mRNA	27225895
D017035	Pravastatin	Pravastatin results in increased expression of HMGCR mRNA	27225895
D017035	Pravastatin	Pravastatin affects the localization of HMGCR protein	22216116
D017035	Pravastatin	Pravastatin results in decreased activity of HMGCR protein	12044893\|1210514
D011284	Pregnenolone	Pregnenolone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]	9059514
D011284	Pregnenolone	Pregnenolone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]	9059514
D011285	Pregnenolone Carbonitrile	[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of HMGCR mRNA	20359477
D011285	Pregnenolone Carbonitrile	NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of HMGCR mRNA]	22698814
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of HMGCR mRNA	20359477\|2269881
D011374	Progesterone	Progesterone results in increased expression of HMGCR mRNA	23012394
D011374	Progesterone	Progesterone results in increased expression of HMGCR mRNA	18070364
C045950	propiconazole	propiconazole results in increased expression of HMGCR mRNA	28970091
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of HMGCR mRNA	24780913
C010313	pseudocumene	pseudocumene results in decreased expression of HMGCR protein	17337753
C033607	puerarin	puerarin affects the reaction [Lead affects the expression of HMGCR]	22001170
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased activity of HMGCR protein	3794548
D011794	Quercetin	Quercetin results in decreased expression of HMGCR mRNA	21632981
D011794	Quercetin	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Cadmium results in increased activity of HMGCR protein]	21535577
D011794	Quercetin	[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]	19595682
C502851	quinocetone	quinocetone results in increased expression of HMGCR mRNA	27046791
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of HMGCR mRNA	21632981
C059514	resveratrol	resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]	23386644
C059514	resveratrol	resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR protein]	23386644
C059514	resveratrol	resveratrol promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]	23386644\|2452419
C059514	resveratrol	resveratrol results in decreased activity of HMGCR protein	23386644
C059514	resveratrol	resveratrol results in decreased expression of HMGCR mRNA	23386644
C059514	resveratrol	resveratrol results in increased expression of HMGCR mRNA	22153697
C059514	resveratrol	resveratrol inhibits the reaction [Dietary Fats results in increased activity of HMGCR protein]	18166149
C059514	resveratrol	resveratrol inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]	18166149
C059514	resveratrol	resveratrol results in decreased activity of HMGCR protein	18611391
C059514	resveratrol	resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]	21907337
C059514	resveratrol	resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR protein]	21907337
C059514	resveratrol	resveratrol promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]	21907337
C059514	resveratrol	resveratrol results in decreased expression of and results in decreased activity of HMGCR protein	21907337
C059514	resveratrol	resveratrol results in decreased expression of HMGCR mRNA	21907337
D015474	Isotretinoin	Isotretinoin results in decreased expression of HMGCR mRNA	20436886
D018967	Risperidone	Risperidone results in increased expression of HMGCR mRNA	17052361
C105726	Ro 48-8071	Ro 48-8071 results in decreased expression of HMGCR mRNA	9763219
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of HMGCR mRNA	16054899
C089730	rosiglitazone	rosiglitazone results in decreased expression of HMGCR mRNA	20503262
C089730	rosiglitazone	rosiglitazone results in increased expression of HMGCR mRNA	21515302
D012402	Rotenone	[7-ketocholesterol co-treated with Rotenone] results in decreased expression of HMGCR mRNA	23454145
D012402	Rotenone	[Stigmasterol co-treated with Rotenone] results in decreased expression of HMGCR mRNA	23454145
D012402	Rotenone	Rotenone inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]	21212096
D012643	Selenium	Selenium promotes the reaction [Cholesterol results in decreased expression of HMGCR mRNA]	16581047
D019821	Simvastatin	Simvastatin results in increased expression of HMGCR mRNA	10652993
D019821	Simvastatin	HMGCR exon alternative form results in decreased susceptibility to Simvastatin	18559695
D019821	Simvastatin	[HMGCR intron polymorphism affects the expression of HMGCR exon alternative form] which results in decreased susceptibility to Simvastatin	18559695\|1855969
D019821	Simvastatin	HMGCR intron polymorphism affects the susceptibility to Simvastatin	17870053
D019821	Simvastatin	HMGCR polymorphism affects the susceptibility to Simvastatin	18332269\|2041373
D019821	Simvastatin	HMGCR polymorphism promotes the reaction [[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB]	20413733
D019821	Simvastatin	resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]	23386644
D019821	Simvastatin	resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR protein]	23386644
D019821	Simvastatin	resveratrol promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]	23386644\|2452419
D019821	Simvastatin	[Simvastatin co-treated with Ezetimibe] results in increased expression of HMGCR mRNA	17980884
D019821	Simvastatin	Simvastatin results in decreased activity of HMGCR protein	17980884\|2125792
D019821	Simvastatin	Simvastatin results in increased activity of HMGCR protein	1627634
D019821	Simvastatin	Simvastatin results in increased expression of and results in increased activity of HMGCR protein	9512650
D019821	Simvastatin	Simvastatin results in increased expression of HMGCR mRNA	10357840\|1627634
D019821	Simvastatin	Simvastatin results in increased expression of HMGCR protein	23386644\|2461387
D019821	Simvastatin	Simvastatin results in increased expression of HMGCR mRNA	9763219
D019821	Simvastatin	Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA]	22120639
D019821	Simvastatin	Simvastatin results in increased expression of HMGCR mRNA	16282522\|2212063
D019821	Simvastatin	Simvastatin results in increased activity of HMGCR protein	9653895
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of HMGCR protein]	12056585
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]	12056585
D019821	Simvastatin	resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]	21907337
D019821	Simvastatin	resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR protein]	21907337
D019821	Simvastatin	resveratrol promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]	21907337
D019821	Simvastatin	Simvastatin results in increased activity of HMGCR protein	12056585\|1627634
D019821	Simvastatin	Simvastatin results in increased expression of and results in decreased activity of HMGCR protein	21907337
D019821	Simvastatin	Simvastatin results in increased expression of and results in increased activity of HMGCR protein	9512650
D019821	Simvastatin	Simvastatin results in increased expression of HMGCR mRNA	12056585\|1627634
D019821	Simvastatin	Simvastatin results in increased expression of HMGCR protein	12518039
D019821	Simvastatin	Simvastatin promotes the reaction [Ezetimibe results in increased expression of HMGCR mRNA]	17130282
D019821	Simvastatin	Simvastatin results in decreased expression of HMGCR mRNA	19343539
D019821	Simvastatin	Simvastatin affects the localization of HMGCR protein	22216116
D019821	Simvastatin	Simvastatin results in decreased activity of HMGCR protein	10519734\|1561615
D020123	Sirolimus	Sirolimus results in increased expression of HMGCR mRNA	17516993
C009277	sodium arsenate	sodium arsenate affects the activity of HMGCR protein	26044777
C017947	sodium arsenite	sodium arsenite results in increased expression of HMGCR mRNA	20308225
C017947	sodium arsenite	sodium arsenite results in decreased expression of HMGCR	25367288
C017947	sodium arsenite	sodium arsenite results in decreased expression of HMGCR mRNA	22700541
C017947	sodium arsenite	sodium arsenite affects the activity of HMGCR protein	26044777
D020358	Sodium Cholate	[Sodium Cholate co-treated with Dietary Fats] results in decreased expression of HMGCR mRNA	23665937
D012989	Soil Pollutants	Soil Pollutants results in decreased expression of HMGCR mRNA	19695345
D012999	Soman	Soman results in increased expression of HMGCR mRNA	19281266
D053260	Soot	Soot results in decreased expression of HMGCR mRNA	22461453
D053260	Soot	Soot results in increased expression of HMGCR mRNA	22461453
D013024	Soybean Oil	Soybean Oil results in decreased expression of HMGCR mRNA	16631440
D013024	Soybean Oil	Soybean Oil results in increased activity of HMGCR protein	12559476
C075117	squalestatin 1	squalestatin 1 results in increased expression of HMGCR mRNA	27225895
C075117	squalestatin 1	squalestatin 1 results in increased expression of HMGCR mRNA	27225895
C525422	SRT1720	[SRT1720 results in increased activity of SIRT1 protein] which results in increased expression of HMGCR mRNA	21212096
D013261	Sterols	[ATP7B gene mutant form results in decreased expression of HMGCR protein] which affects the metabolism of Sterols	17303181
D013265	Stigmasterol	[Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA	23454145
D013265	Stigmasterol	[Stigmasterol co-treated with Oligomycins] results in decreased expression of HMGCR mRNA	23454145
D013265	Stigmasterol	[Stigmasterol co-treated with Rotenone] results in decreased expression of HMGCR mRNA	23454145
D013265	Stigmasterol	Stigmasterol results in increased expression of HMGCR mRNA	23454145
D013311	Streptozocin	Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]	20696151
D013311	Streptozocin	myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased activity of HMGCR protein]	25240712
D013311	Streptozocin	[Streptozocin co-treated with Cadmium] results in increased activity of HMGCR protein	25240712
D013311	Streptozocin	[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein	20696151
D013311	Streptozocin	Streptozocin results in increased expression of HMGCR mRNA	25905778
D013311	Streptozocin	[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]	20696151
D013311	Streptozocin	tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]	20696151
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of HMGCR mRNA	22982764
C013698	tallow	tallow affects the expression of HMGCR mRNA	19680557
D013629	Tamoxifen	Tamoxifen affects the expression of HMGCR mRNA	20937368
D013662	Tea	Tea inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]	19193814
C001803	tempol	"tempol inhibits the reaction [Asbestos, Crocidolite results in decreased activity of HMGCR protein]"	21257924
C001803	tempol	tempol inhibits the reaction [Vitamin K 3 results in decreased activity of HMGCR protein]	21257924
C501413	tesaglitazar	tesaglitazar results in increased expression of HMGCR mRNA	21515302
D013739	Testosterone	Testosterone results in increased expression of HMGCR mRNA	16579987
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HMGCR mRNA	17101203\|2010694
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in decreased expression of HMGCR mRNA]"	23756648
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HMGCR gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HMGCR mRNA	20005886\|2297716
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HMGCR mRNA	19770486\|2821309
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HMGCR mRNA	21215274
D013752	Tetracycline	Tetracycline results in decreased expression of HMGCR mRNA	19224547
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of HMGCR mRNA	12044893
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HMGCR mRNA	25613284
C096277	tetrahydrocurcumin	[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]	20696151
C096277	tetrahydrocurcumin	tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]	20696151
D019284	Thapsigargin	Thapsigargin results in decreased expression of HMGCR mRNA	22378314
D045162	Thiazolidinediones	Thiazolidinediones results in decreased expression of HMGCR mRNA	21870829
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of HMGCR mRNA	28943392
D013853	Thioacetamide	Thioacetamide results in increased expression of HMGCR mRNA	23411599
D013890	Thiourea	Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]	19931295
D013890	Thiourea	Thiourea inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein]	19931295
C009495	titanium dioxide	titanium dioxide results in increased expression of HMGCR mRNA	23557971\|2776080
C423915	TO-901317	TO-901317 results in increased expression of HMGCR mRNA	23146569
C495469	trans-3-(4'-hydroxyphenyl)-2-propenoic acid	trans-3-(4'-hydroxyphenyl)-2-propenoic acid results in decreased expression of HMGCR mRNA	21870829
D001371	trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride	"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of HMGCR mRNA"	26919959
C034613	triacsin C	triacsin C results in decreased expression of HMGCR mRNA	16704987
C032910	triadimefon	triadimefon results in increased expression of HMGCR mRNA	19363144
C032910	triadimefon	triadimefon results in increased expression of HMGCR mRNA	17178689\|1942368
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of HMGCR mRNA	25055964
C012589	trichostatin A	trichostatin A affects the expression of HMGCR mRNA	28542535
D014260	Triclosan	Triclosan results in decreased expression of HMGCR mRNA	25554385
D014280	Triglycerides	[Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides	16027736
D014280	Triglycerides	[Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides	16027736
C009564	trilinolein	trilinolein results in increased expression of HMGCR mRNA	18356535
C101314	trilinolenin	trilinolenin results in increased expression of HMGCR mRNA	18356535
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of HMGCR mRNA	19042947
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of HMGCR mRNA	17982090
D014304	Triolein	Triolein results in increased expression of HMGCR mRNA	18356535
C005445	triphenyl phosphate	triphenyl phosphate metabolite results in decreased expression of HMGCR mRNA	25350880
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HMGCR mRNA"	24273086\|2524241
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HMGCR mRNA"	26179874
C057693	troglitazone	[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased expression of HMGCR mRNA	16946405
C057693	troglitazone	[troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of HMGCR mRNA	12044893
C057693	troglitazone	troglitazone results in increased activity of HMGCR protein	12044893
C057693	troglitazone	troglitazone results in increased expression of HMGCR mRNA	12044893
D014415	Tunicamycin	Tunicamycin results in decreased expression of HMGCR mRNA	22378314
C012596	turmeric extract	[turmeric extract co-treated with Cholesterol] results in decreased expression of HMGCR mRNA	21535835
C022884	undecane	undecane results in decreased expression of HMGCR protein	17337753
D014520	Urethane	Urethane results in increased expression of HMGCR mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased activity of HMGCR protein	6832710
D014635	Valproic Acid	Valproic Acid affects the expression of HMGCR mRNA	25979313
D014635	Valproic Acid	Valproic Acid affects the reaction [Colforsin affects the expression of HMGCR mRNA]	20726872
D014635	Valproic Acid	Valproic Acid results in decreased expression of HMGCR mRNA	19566492\|2317975
D014635	Valproic Acid	Valproic Acid results in decreased methylation of HMGCR gene	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of HMGCR mRNA	22045034
D001335	Vehicle Emissions	"[Fatty Acids, Omega-3 deficiency co-treated with Vehicle Emissions] results in increased expression of HMGCR mRNA"	29175182
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of HMGCR mRNA	29175182
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of HMGCR gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of HMGCR mRNA	22861003
C025643	vinclozolin	vinclozolin results in increased expression of HMGCR mRNA	22570695
D009536	Niacinamide	Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]	20696151
D009536	Niacinamide	[Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]	21212096
D009536	Niacinamide	[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein	20696151
D009536	Niacinamide	[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]	20696151
D009536	Niacinamide	tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]	20696151
D024483	Vitamin K 3	manganese protoporphyrin inhibits the reaction [Vitamin K 3 results in decreased activity of HMGCR protein]	21257924
D024483	Vitamin K 3	tempol inhibits the reaction [Vitamin K 3 results in decreased activity of HMGCR protein]	21257924
D024483	Vitamin K 3	Vitamin K 3 results in decreased activity of HMGCR protein	21257924
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of HMGCR mRNA	12414654
C403304	zerumbone	zerumbone inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]	24709573
D015032	Zinc	Zinc affects the expression of HMGCR mRNA	17181878
D015032	Zinc	Zinc deficiency results in decreased expression of HMGCR mRNA	15671213
D015032	Zinc	Zinc results in decreased expression of HMGCR mRNA	17074742
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of HMGCR mRNA	17074742
C013738	zingerone	zingerone inhibits the reaction [Ethanol results in increased activity of HMGCR protein]	28442378
C092292	ziprasidone	ziprasidone results in increased expression of HMGCR mRNA	17052361

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	23169578
GO:0042282	hydroxymethylglutaryl-CoA reductase activity	-	IBA	21873635
GO:0042282	hydroxymethylglutaryl-CoA reductase activity	-	IDA	2991281
GO:0042803	protein homodimerization activity	-	IEA	-
GO:0050662	coenzyme binding	-	IDA	10698924
GO:0051721	protein phosphatase 2A binding	-	IEA	-
GO:0070402	NADPH binding	-	IDA	10698924

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006695	cholesterol biosynthetic process	-	IDA	23063590
GO:0006743	ubiquinone metabolic process	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0007584	response to nutrient	-	IEA	-
GO:0008299	isoprenoid biosynthetic process	-	IBA	21873635
GO:0008542	visual learning	-	IEA	-
GO:0010664	negative regulation of striated muscle cell apoptotic process	-	IEA	-
GO:0010666	positive regulation of cardiac muscle cell apoptotic process	-	IEA	-
GO:0015936	coenzyme A metabolic process	-	IEA	-
GO:0016126	sterol biosynthetic process	-	IBA	21873635
GO:0019216	regulation of lipid metabolic process	-	TAS	-
GO:0032874	positive regulation of stress-activated MAPK cascade	-	IEA	-
GO:0043407	negative regulation of MAP kinase activity	-	IEA	-
GO:0044255	cellular lipid metabolic process	-	IBA	21873635
GO:0045445	myoblast differentiation	-	IEA	-
GO:0045471	response to ethanol	-	IEA	-
GO:0045540	regulation of cholesterol biosynthetic process	-	TAS	-
GO:0048643	positive regulation of skeletal muscle tissue development	-	IEA	-
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IEA	-
GO:0051262	protein tetramerization	-	IDA	10698924
GO:0055114	oxidation-reduction process	-	IEA	-
GO:0061045	negative regulation of wound healing	-	IEA	-
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	-	IEA	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IEA	-
GO:0097756	negative regulation of blood vessel diameter	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005778	peroxisomal membrane	-	IBA	21873635
GO:0005778	peroxisomal membrane	-	IDA	17180682
GO:0005783	endoplasmic reticulum	-	IDA	17180682
GO:0005789	endoplasmic reticulum membrane	-	IBA	21873635
GO:0005789	endoplasmic reticulum membrane	-	TAS	2991281
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00900	Terpenoid backbone biosynthesis
hsa01100	Metabolic pathways
hsa04976	Bile secretion

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	TAS
R-HSA-191273	Cholesterol biosynthesis	TAS
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	TAS
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-8957322	Metabolism of steroids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20145341	Association of the functional variant in the 3-hydroxy-3-methylglutaryl-coenzyme a reductase gene with low-density lipoprotein-cholesterol in Japanese. (2010 Mar)	Hiura Y	Circ J
29096742	HMGCR and ApoE mutations may cause different responses to lipid lowering statin therapy. (2017 Oct 31)	Kirac D	Cell Mol Biol (Noisy-le-grand)
25084356	A preliminary study of the relationship between promoter methylation of the ABCG1, GALNT2 and HMGCR genes and coronary heart disease. (2014)	Peng P	PLoS One